3IXEB

Structural basis of competition between pinch1 and pinch2 for binding to the ankyrin repeat domain of integrin-linked kinase
Total Genus 12
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
70
structure length
70
Chain Sequence
NLYFQGSANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase.
pubmed doi rcsb
molecule tags Signaling protein/signaling protein
source organism Homo sapiens
molecule keywords Integrin-linked protein kinase
total genus 12
structure length 70
sequence length 70
ec nomenclature
pdb deposition date 2009-09-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00412 LIM LIM domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.110.10 Mainly Beta Ribbon Cysteine Rich Protein Cysteine Rich Protein 3ixeB00
2MIUA 1X63A 2D8XA 2DARA 3MMKA 2O10A 4HI9B 2CORA 2DJ7A 1U5SB 1X4LA 1WYHA 2XJYA 2CO8A 2EHEA 4JCJA 1M3VA 2MBVA 2L4ZA 2YPAC 2D8YA 1IMLA 1WIGA 1X68A 1J2OA 1G47A 2LXDA 1X6AA 2DFYC 2XJZA 1RUTX 1QLIA 2IYBE 2XQNT 1IBIA 3IXEB 1CXXA 1V6GA 1B8TA 2L6ZC 1CTLA 4HI8B 3F6QB 1X61A 1X3HA 2KBXB 1A7IA 2CUQA 2CURA 2JTNA 2CUPA 2L6YB 2D8ZA 2EGQA 2LZUA 2O13A 4KFZA 1NYPA 1X64A 2DLOA 2CU8A 1X62A
chains in the Genus database with same CATH superfamily
3AVSA 4HI9B 2DJ7A 2XJYA 2CO8A 1M3VA 2YPAC 5FY1A 1G47A 5FY7A 3IXEB 5FYMA 3F6QB 2CUQA 2JTNA 2CUPA 4KFZA 4EZHA 3NISA 4EZ4A 5LKUA 5FXZA 3NIJA 2DLOA 2DARA 5LKXA 5LKTA 2O10A 1U5SB 2EHEA 5LKZA 2L4ZA 1X68A 5FXVA 4EYUA 1X6AA 2DFYC 5FP3A 1QLIA 5FXXA 1B8TA 3ZPOA 4HI8B 2KBXB 1A7IA 2L6YB 4BHWA 2LZUA 2O13A 1NYPA 3NIHA 5FY0A 4UF0A 3MMKA 2XUEA 4ASKA 3ZLIA 1X4LA 4JCJA 2D8YA 1IMLA 1WIGA 1J2OA 2LXDA 1RUTX 2IYBE 5FXWA 5A1LA 1X3HA 2EGQA 1X64A 2CU8A 1X62A 2MIUA 1X63A 2D8XA 2CORA 1WYHA 4UF0B 2MBVA 2XJZA 2XQNT 1IBIA 1CXXA 1V6GA 3NIMA 3NIKA 2L6ZC 1CTLA 1X61A 3NILA 2CURA 2D8ZA 3NINA 3AVRA
chains in the Genus database with same CATH topology
3AVSA 4HI9B 2DJ7A 2XJYA 2CO8A 1M3VA 2YPAC 5FY1A 1G47A 5FY7A 3IXEB 5FYMA 3F6QB 2CUQA 2JTNA 2CUPA 4KFZA 4EZHA 3NISA 4EZ4A 5LKUA 5FXZA 3NIJA 2DLOA 2DARA 5LKXA 5LKTA 2O10A 1U5SB 2EHEA 5LKZA 2L4ZA 1X68A 5FXVA 4EYUA 1X6AA 2DFYC 5FP3A 1QLIA 5FXXA 1B8TA 3ZPOA 4HI8B 2KBXB 1A7IA 2L6YB 4BHWA 2LZUA 2O13A 1NYPA 3NIHA 5FY0A 4UF0A 3MMKA 2XUEA 4ASKA 3ZLIA 1X4LA 4JCJA 2D8YA 1IMLA 1WIGA 1J2OA 2LXDA 1RUTX 2IYBE 5FXWA 5A1LA 1X3HA 2EGQA 1X64A 2CU8A 1X62A 2MIUA 1X63A 2D8XA 2CORA 1WYHA 4UF0B 2MBVA 2XJZA 2XQNT 1IBIA 1CXXA 1V6GA 3NIMA 3NIKA 2L6ZC 1CTLA 1X61A 3NILA 2CURA 2D8ZA 3NINA 3AVRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2MIU A;  1X63 A;  2D8X A;  2DAR A;  3MMK A;  2O10 A;  4HI9 B;  2COR A;  2DJ7 A;  1U5S B;  1X4L A;  1WYH A;  2XJY A;  2CO8 A;  2EHE A;  4JCJ A;  1M3V A;  2MBV A;  2L4Z A;  2YPA C;  2D8Y A;  1IML A;  1WIG A;  1X68 A;  1J2O A;  1G47 A;  2LXD A;  1X6A A;  2DFY C;  2XJZ A;  1RUT X;  1QLI A;  2IYB E;  2XQN T;  1IBI A;  3IXE B;  1CXX A;  1V6G A;  1B8T A;  2L6Z C;  1CTL A;  4HI8 B;  3F6Q B;  1X61 A;  1X3H A;  2KBX B;  1A7I A;  2CUQ A;  2CUR A;  2JTN A;  2CUP A;  2L6Y B;  2D8Z A;  2EGQ A;  2LZU A;  2O13 A;  4KFZ A;  1NYP A;  1X64 A;  2DLO A;  2CU8 A;  1X62 A; 
#chains in the Genus database with same CATH topology
 3AVS A;  4HI9 B;  2DJ7 A;  2XJY A;  2CO8 A;  1M3V A;  2YPA C;  5FY1 A;  1G47 A;  5FY7 A;  3IXE B;  5FYM A;  3F6Q B;  2CUQ A;  2JTN A;  2CUP A;  4KFZ A;  4EZH A;  3NIS A;  4EZ4 A;  5LKU A;  5FXZ A;  3NIJ A;  2DLO A;  2DAR A;  5LKX A;  5LKT A;  2O10 A;  1U5S B;  2EHE A;  5LKZ A;  2L4Z A;  1X68 A;  5FXV A;  4EYU A;  1X6A A;  2DFY C;  5FP3 A;  1QLI A;  5FXX A;  1B8T A;  3ZPO A;  4HI8 B;  2KBX B;  1A7I A;  2L6Y B;  4BHW A;  2LZU A;  2O13 A;  1NYP A;  3NIH A;  5FY0 A;  4UF0 A;  3MMK A;  2XUE A;  4ASK A;  3ZLI A;  1X4L A;  4JCJ A;  2D8Y A;  1IML A;  1WIG A;  1J2O A;  2LXD A;  1RUT X;  2IYB E;  5FXW A;  5A1L A;  1X3H A;  2EGQ A;  1X64 A;  2CU8 A;  1X62 A;  2MIU A;  1X63 A;  2D8X A;  2COR A;  1WYH A;  4UF0 B;  2MBV A;  2XJZ A;  2XQN T;  1IBI A;  1CXX A;  1V6G A;  3NIM A;  3NIK A;  2L6Z C;  1CTL A;  1X61 A;  3NIL A;  2CUR A;  2D8Z A;  3NIN A;  3AVR A; 
#chains in the Genus database with same CATH homology
 3AVS A;  4HI9 B;  2DJ7 A;  2XJY A;  2CO8 A;  1M3V A;  2YPA C;  5FY1 A;  1G47 A;  5FY7 A;  3IXE B;  5FYM A;  3F6Q B;  2CUQ A;  2JTN A;  2CUP A;  4KFZ A;  4EZH A;  3NIS A;  4EZ4 A;  5LKU A;  5FXZ A;  3NIJ A;  2DLO A;  2DAR A;  5LKX A;  5LKT A;  2O10 A;  1U5S B;  2EHE A;  5LKZ A;  2L4Z A;  1X68 A;  5FXV A;  4EYU A;  1X6A A;  2DFY C;  5FP3 A;  1QLI A;  5FXX A;  1B8T A;  3ZPO A;  4HI8 B;  2KBX B;  1A7I A;  2L6Y B;  4BHW A;  2LZU A;  2O13 A;  1NYP A;  3NIH A;  5FY0 A;  4UF0 A;  3MMK A;  2XUE A;  4ASK A;  3ZLI A;  1X4L A;  4JCJ A;  2D8Y A;  1IML A;  1WIG A;  1J2O A;  2LXD A;  1RUT X;  2IYB E;  5FXW A;  5A1L A;  1X3H A;  2EGQ A;  1X64 A;  2CU8 A;  1X62 A;  2MIU A;  1X63 A;  2D8X A;  2COR A;  1WYH A;  4UF0 B;  2MBV A;  2XJZ A;  2XQN T;  1IBI A;  1CXX A;  1V6G A;  3NIM A;  3NIK A;  2L6Z C;  1CTL A;  1X61 A;  3NIL A;  2CUR A;  2D8Z A;  3NIN A;  3AVR A; 
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