3L33E

Human mesotrypsin complexed with amyloid precursor protein inhibitor(appi)
Total Genus 8
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
8
sequence length
52
structure length
52
Chain Sequence
VCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Determinants of affinity and proteolytic stability in interactions of Kunitz family protease inhibitors with mesotrypsin.
pubmed doi rcsb
molecule keywords Trypsin-3
molecule tags Hydrolase/cell adhesion
source organism Homo sapiens
total genus 8
structure length 52
sequence length 52
chains with identical sequence F, G, H
ec nomenclature
pdb deposition date 2009-12-16
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 3l33E00
2LFKA 4U30W 1TAWB 3TGJI 2IJOI 3AUCA 1KNTA 1BF0A 4NTWB 3BTWI 2J6DA 2ZJXA 3LDMA 1TOCR 9PTIA 1FAKI 2FI4I 1DTXA 3GYMI 5JB7A 1EJMB 3AUDA 3TGKI 2FI5I 1NAGA 1KUNA 2TGPI 2M99A 1T8NB 1MTND 2W8XA 1DEMA 1TPAI 4ISNB 3L3TE 1PITA 3BTFI 2KAII 1BPIA 7PTIA 4Y0YI 1P2II 1ADZA 6PTIA 1P2MB 3LDJA 1DENA 4WXVC 1YC0I 3P95E 1BRBI 4Y0ZI 5PTIA 4WWYC 2HEXA 2JOTA 3BTKI 3BTMI 1F7ZI 1CA0D 1QLQA 1OA55 1IRHA 3BTTI 3FP7J 3WNYA 4Y10I 3U1JE 5C67C 1TAPA 3CI7A 1P2OB 3BTHI 3AUBA 1AALA 2ZVXA 2UUXA 2M01A 1Y62A 2KCRA 3BTGI 1T8OB 2UUYB 2FTMB 1K6UA 3T62D 1AAPA 1T8LB 1JV8A 1BTIA 3P92E 4PTIA 3D65I 1ZJDB 4DG4C 3AUHA 1OA65 2ODYE 1P2QB 1JV9A 1BIKA 1D0DA 1LD5A 2DDIA 3AUGA 3BTQI 1FANA 3M7QB 2TPII 3LDIA 3OFWA 3TGII 4BQDA 8PTIA 3UOUB 1BUNB 3BTDI 1TFXC 2CA7A 4ISOB 1CO7I 1BTHP 1BRCI 1TCPA 1BHCA 1CBWD 1DTKA 2LFLA 2KNTA 2FTLI 1B0CA 3BYBA 1UUAA 4TPII 4NTXB 3FP6I 3TPII 1KTHA 1ZR0B 2R9PE 1BZXI 1D0DB 2RA3C 4U32X 1F5RI 5JB6A 1YLDB 3AUIA 5JB5A 1G6XA 1YKTB 4DTGK 3UIRC 3FP8I 4BD9B 1UUBA 1T7CB 1T8MB 1KIGI 4NTYB 1LD6A 2DDJA 3BTEI 1BPTA 3AUEA 2FI3I 2PTCI 1YLCB 1BZ5A 1EAWB 1SHPA 3OTJI 1JC6A 1P2KI 1FY8I 5JB4A 1P2NB 3L33E 4BNRI 4Y11I 1P2JI 4ISLB
chains in the Genus database with same CATH superfamily
2LFKA 4U30W 1TAWB 3TGJI 2IJOI 3AUCA 1KNTA 1BF0A 4NTWB 3BTWI 2J6DA 2ZJXA 3LDMA 1TOCR 9PTIA 1FAKI 2FI4I 1DTXA 3GYMI 5JB7A 1EJMB 3AUDA 3TGKI 2FI5I 1NAGA 1KUNA 2TGPI 2M99A 1T8NB 1MTND 2W8XA 1DEMA 1TPAI 4ISNB 3L3TE 1PITA 3BTFI 2KAII 1BPIA 7PTIA 4Y0YI 1P2II 1ADZA 6PTIA 1P2MB 3LDJA 1DENA 4WXVC 1YC0I 3P95E 1BRBI 4Y0ZI 5PTIA 4WWYC 2HEXA 2JOTA 3BTKI 3BTMI 1F7ZI 1CA0D 1QLQA 1OA55 1IRHA 3BTTI 3FP7J 3WNYA 4Y10I 3U1JE 5C67C 1TAPA 3CI7A 1P2OB 3BTHI 3AUBA 1AALA 2ZVXA 2UUXA 2M01A 1Y62A 2KCRA 3BTGI 1T8OB 2UUYB 2FTMB 1K6UA 3T62D 1AAPA 1T8LB 1JV8A 1BTIA 3P92E 4PTIA 3D65I 1ZJDB 4DG4C 3AUHA 1OA65 2ODYE 1P2QB 1JV9A 1BIKA 1D0DA 1LD5A 2DDIA 3AUGA 3BTQI 1FANA 3M7QB 2TPII 3LDIA 3OFWA 3TGII 4BQDA 8PTIA 3UOUB 1BUNB 3BTDI 1TFXC 2CA7A 4ISOB 1CO7I 1BTHP 1BRCI 1TCPA 1BHCA 1CBWD 1DTKA 2LFLA 2KNTA 2FTLI 1B0CA 3BYBA 1UUAA 4TPII 4NTXB 3FP6I 3TPII 1KTHA 1ZR0B 2R9PE 1BZXI 1D0DB 2RA3C 4U32X 1F5RI 5JB6A 1YLDB 3AUIA 5JB5A 1G6XA 1YKTB 4DTGK 3UIRC 3FP8I 4BD9B 1UUBA 1T7CB 1T8MB 1KIGI 4NTYB 1LD6A 2DDJA 3BTEI 1BPTA 3AUEA 2FI3I 2PTCI 1YLCB 1BZ5A 1EAWB 1SHPA 3OTJI 1JC6A 1P2KI 1FY8I 5JB4A 1P2NB 3L33E 4BNRI 4Y11I 1P2JI 4ISLB
chains in the Genus database with same CATH topology
2LFKA 4U30W 1TAWB 3TGJI 2IJOI 3AUCA 1KNTA 1BF0A 4NTWB 3BTWI 2J6DA 2ZJXA 3LDMA 1TOCR 9PTIA 1FAKI 2FI4I 1DTXA 3GYMI 5JB7A 1EJMB 3AUDA 3TGKI 2FI5I 1NAGA 1KUNA 2TGPI 2M99A 1T8NB 1MTND 2W8XA 1DEMA 1TPAI 4ISNB 3L3TE 1PITA 3BTFI 2KAII 1BPIA 7PTIA 4Y0YI 1P2II 1ADZA 6PTIA 1P2MB 3LDJA 1DENA 4WXVC 1YC0I 3P95E 1BRBI 4Y0ZI 5PTIA 4WWYC 2HEXA 2JOTA 3BTKI 3BTMI 1F7ZI 1CA0D 1QLQA 1OA55 1IRHA 3BTTI 3FP7J 3WNYA 4Y10I 3U1JE 5C67C 1TAPA 3CI7A 1P2OB 3BTHI 3AUBA 1AALA 2ZVXA 2UUXA 2M01A 1Y62A 2KCRA 3BTGI 1T8OB 2UUYB 2FTMB 1K6UA 3T62D 1AAPA 1T8LB 1JV8A 1BTIA 3P92E 4PTIA 3D65I 1ZJDB 4DG4C 3AUHA 1OA65 2ODYE 1P2QB 1JV9A 1BIKA 1D0DA 1LD5A 2DDIA 3AUGA 3BTQI 1FANA 3M7QB 2TPII 3LDIA 3OFWA 3TGII 4BQDA 8PTIA 3UOUB 1BUNB 3BTDI 1TFXC 2CA7A 4ISOB 1CO7I 1BTHP 1BRCI 1TCPA 1BHCA 1CBWD 1DTKA 2LFLA 2KNTA 2FTLI 1B0CA 3BYBA 1UUAA 4TPII 4NTXB 3FP6I 3TPII 1KTHA 1ZR0B 2R9PE 1BZXI 1D0DB 2RA3C 4U32X 1F5RI 5JB6A 1YLDB 3AUIA 5JB5A 1G6XA 1YKTB 4DTGK 3UIRC 3FP8I 4BD9B 1UUBA 1T7CB 1T8MB 1KIGI 4NTYB 1LD6A 2DDJA 3BTEI 1BPTA 3AUEA 2FI3I 2PTCI 1YLCB 1BZ5A 1EAWB 1SHPA 3OTJI 1JC6A 1P2KI 1FY8I 5JB4A 1P2NB 3L33E 4BNRI 4Y11I 1P2JI 4ISLB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2LFK A;  4U30 W;  1TAW B;  3TGJ I;  2IJO I;  3AUC A;  1KNT A;  1BF0 A;  4NTW B;  3BTW I;  2J6D A;  2ZJX A;  3LDM A;  1TOC R;  9PTI A;  1FAK I;  2FI4 I;  1DTX A;  3GYM I;  5JB7 A;  1EJM B;  3AUD A;  3TGK I;  2FI5 I;  1NAG A;  1KUN A;  2TGP I;  2M99 A;  1T8N B;  1MTN D;  2W8X A;  1DEM A;  1TPA I;  4ISN B;  3L3T E;  1PIT A;  3BTF I;  2KAI I;  1BPI A;  7PTI A;  4Y0Y I;  1P2I I;  1ADZ A;  6PTI A;  1P2M B;  3LDJ A;  1DEN A;  4WXV C;  1YC0 I;  3P95 E;  1BRB I;  4Y0Z I;  5PTI A;  4WWY C;  2HEX A;  2JOT A;  3BTK I;  3BTM I;  1F7Z I;  1CA0 D;  1QLQ A;  1OA5 5;  1IRH A;  3BTT I;  3FP7 J;  3WNY A;  4Y10 I;  3U1J E;  5C67 C;  1TAP A;  3CI7 A;  1P2O B;  3BTH I;  3AUB A;  1AAL A;  2ZVX A;  2UUX A;  2M01 A;  1Y62 A;  2KCR A;  3BTG I;  1T8O B;  2UUY B;  2FTM B;  1K6U A;  3T62 D;  1AAP A;  1T8L B;  1JV8 A;  1BTI A;  3P92 E;  4PTI A;  3D65 I;  1ZJD B;  4DG4 C;  3AUH A;  1OA6 5;  2ODY E;  1P2Q B;  1JV9 A;  1BIK A;  1D0D A;  1LD5 A;  2DDI A;  3AUG A;  3BTQ I;  1FAN A;  3M7Q B;  2TPI I;  3LDI A;  3OFW A;  3TGI I;  4BQD A;  8PTI A;  3UOU B;  1BUN B;  3BTD I;  1TFX C;  2CA7 A;  4ISO B;  1CO7 I;  1BTH P;  1BRC I;  1TCP A;  1BHC A;  1CBW D;  1DTK A;  2LFL A;  2KNT A;  2FTL I;  1B0C A;  3BYB A;  1UUA A;  4TPI I;  4NTX B;  3FP6 I;  3TPI I;  1KTH A;  1ZR0 B;  2R9P E;  1BZX I;  1D0D B;  2RA3 C;  4U32 X;  1F5R I;  5JB6 A;  1YLD B;  3AUI A;  5JB5 A;  1G6X A;  1YKT B;  4DTG K;  3UIR C;  3FP8 I;  4BD9 B;  1UUB A;  1T7C B;  1T8M B;  1KIG I;  4NTY B;  1LD6 A;  2DDJ A;  3BTE I;  1BPT A;  3AUE A;  2FI3 I;  2PTC I;  1YLC B;  1BZ5 A;  1EAW B;  1SHP A;  3OTJ I;  1JC6 A;  1P2K I;  1FY8 I;  5JB4 A;  1P2N B;  3L33 E;  4BNR I;  4Y11 I;  1P2J I;  4ISL B; 
#chains in the Genus database with same CATH topology
 2LFK A;  4U30 W;  1TAW B;  3TGJ I;  2IJO I;  3AUC A;  1KNT A;  1BF0 A;  4NTW B;  3BTW I;  2J6D A;  2ZJX A;  3LDM A;  1TOC R;  9PTI A;  1FAK I;  2FI4 I;  1DTX A;  3GYM I;  5JB7 A;  1EJM B;  3AUD A;  3TGK I;  2FI5 I;  1NAG A;  1KUN A;  2TGP I;  2M99 A;  1T8N B;  1MTN D;  2W8X A;  1DEM A;  1TPA I;  4ISN B;  3L3T E;  1PIT A;  3BTF I;  2KAI I;  1BPI A;  7PTI A;  4Y0Y I;  1P2I I;  1ADZ A;  6PTI A;  1P2M B;  3LDJ A;  1DEN A;  4WXV C;  1YC0 I;  3P95 E;  1BRB I;  4Y0Z I;  5PTI A;  4WWY C;  2HEX A;  2JOT A;  3BTK I;  3BTM I;  1F7Z I;  1CA0 D;  1QLQ A;  1OA5 5;  1IRH A;  3BTT I;  3FP7 J;  3WNY A;  4Y10 I;  3U1J E;  5C67 C;  1TAP A;  3CI7 A;  1P2O B;  3BTH I;  3AUB A;  1AAL A;  2ZVX A;  2UUX A;  2M01 A;  1Y62 A;  2KCR A;  3BTG I;  1T8O B;  2UUY B;  2FTM B;  1K6U A;  3T62 D;  1AAP A;  1T8L B;  1JV8 A;  1BTI A;  3P92 E;  4PTI A;  3D65 I;  1ZJD B;  4DG4 C;  3AUH A;  1OA6 5;  2ODY E;  1P2Q B;  1JV9 A;  1BIK A;  1D0D A;  1LD5 A;  2DDI A;  3AUG A;  3BTQ I;  1FAN A;  3M7Q B;  2TPI I;  3LDI A;  3OFW A;  3TGI I;  4BQD A;  8PTI A;  3UOU B;  1BUN B;  3BTD I;  1TFX C;  2CA7 A;  4ISO B;  1CO7 I;  1BTH P;  1BRC I;  1TCP A;  1BHC A;  1CBW D;  1DTK A;  2LFL A;  2KNT A;  2FTL I;  1B0C A;  3BYB A;  1UUA A;  4TPI I;  4NTX B;  3FP6 I;  3TPI I;  1KTH A;  1ZR0 B;  2R9P E;  1BZX I;  1D0D B;  2RA3 C;  4U32 X;  1F5R I;  5JB6 A;  1YLD B;  3AUI A;  5JB5 A;  1G6X A;  1YKT B;  4DTG K;  3UIR C;  3FP8 I;  4BD9 B;  1UUB A;  1T7C B;  1T8M B;  1KIG I;  4NTY B;  1LD6 A;  2DDJ A;  3BTE I;  1BPT A;  3AUE A;  2FI3 I;  2PTC I;  1YLC B;  1BZ5 A;  1EAW B;  1SHP A;  3OTJ I;  1JC6 A;  1P2K I;  1FY8 I;  5JB4 A;  1P2N B;  3L33 E;  4BNR I;  4Y11 I;  1P2J I;  4ISL B; 
#chains in the Genus database with same CATH homology
 2LFK A;  4U30 W;  1TAW B;  3TGJ I;  2IJO I;  3AUC A;  1KNT A;  1BF0 A;  4NTW B;  3BTW I;  2J6D A;  2ZJX A;  3LDM A;  1TOC R;  9PTI A;  1FAK I;  2FI4 I;  1DTX A;  3GYM I;  5JB7 A;  1EJM B;  3AUD A;  3TGK I;  2FI5 I;  1NAG A;  1KUN A;  2TGP I;  2M99 A;  1T8N B;  1MTN D;  2W8X A;  1DEM A;  1TPA I;  4ISN B;  3L3T E;  1PIT A;  3BTF I;  2KAI I;  1BPI A;  7PTI A;  4Y0Y I;  1P2I I;  1ADZ A;  6PTI A;  1P2M B;  3LDJ A;  1DEN A;  4WXV C;  1YC0 I;  3P95 E;  1BRB I;  4Y0Z I;  5PTI A;  4WWY C;  2HEX A;  2JOT A;  3BTK I;  3BTM I;  1F7Z I;  1CA0 D;  1QLQ A;  1OA5 5;  1IRH A;  3BTT I;  3FP7 J;  3WNY A;  4Y10 I;  3U1J E;  5C67 C;  1TAP A;  3CI7 A;  1P2O B;  3BTH I;  3AUB A;  1AAL A;  2ZVX A;  2UUX A;  2M01 A;  1Y62 A;  2KCR A;  3BTG I;  1T8O B;  2UUY B;  2FTM B;  1K6U A;  3T62 D;  1AAP A;  1T8L B;  1JV8 A;  1BTI A;  3P92 E;  4PTI A;  3D65 I;  1ZJD B;  4DG4 C;  3AUH A;  1OA6 5;  2ODY E;  1P2Q B;  1JV9 A;  1BIK A;  1D0D A;  1LD5 A;  2DDI A;  3AUG A;  3BTQ I;  1FAN A;  3M7Q B;  2TPI I;  3LDI A;  3OFW A;  3TGI I;  4BQD A;  8PTI A;  3UOU B;  1BUN B;  3BTD I;  1TFX C;  2CA7 A;  4ISO B;  1CO7 I;  1BTH P;  1BRC I;  1TCP A;  1BHC A;  1CBW D;  1DTK A;  2LFL A;  2KNT A;  2FTL I;  1B0C A;  3BYB A;  1UUA A;  4TPI I;  4NTX B;  3FP6 I;  3TPI I;  1KTH A;  1ZR0 B;  2R9P E;  1BZX I;  1D0D B;  2RA3 C;  4U32 X;  1F5R I;  5JB6 A;  1YLD B;  3AUI A;  5JB5 A;  1G6X A;  1YKT B;  4DTG K;  3UIR C;  3FP8 I;  4BD9 B;  1UUB A;  1T7C B;  1T8M B;  1KIG I;  4NTY B;  1LD6 A;  2DDJ A;  3BTE I;  1BPT A;  3AUE A;  2FI3 I;  2PTC I;  1YLC B;  1BZ5 A;  1EAW B;  1SHP A;  3OTJ I;  1JC6 A;  1P2K I;  1FY8 I;  5JB4 A;  1P2N B;  3L33 E;  4BNR I;  4Y11 I;  1P2J I;  4ISL B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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