3L33E

Human mesotrypsin complexed with amyloid precursor protein inhibitor(appi)
Total Genus 8
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
8
sequence length
52
structure length
52
Chain Sequence
VCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/cell adhesion
source organism Homo sapiens
publication title Determinants of affinity and proteolytic stability in interactions of Kunitz family protease inhibitors with mesotrypsin.
pubmed doi rcsb
molecule keywords Trypsin-3
total genus 8
structure length 52
sequence length 52
chains with identical sequence F, G, H
ec nomenclature
pdb deposition date 2009-12-16
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 3l33E00
1P2NB 8PTIA 1FY8I 2R9PE 2FI5I 4BQDA 2KAII 2FI3I 1G6XA 1NAGA 1P2QB 1TCPA 1DEMA 1YLDB 1BZXI 4TPII 1JV8A 5JB7A 1SHPA 2ODYE 1BIKA 4U32X 1AAPA 1DENA 1YLCB 3LDIA 1CBWD 4ISNB 4NTWB 1IRHA 1BRCI 3AUHA 2IJOI 3CI7A 1TAWB 4DG4C 1ADZA 2ZJXA 1ZJDB 3L33E 1BHCA 4BD9B 6PTIA 1MTND 4Y0YI 2LFKA 2TPII 1UUBA 2UUYB 1T8MB 2DDJA 1BZ5A 1BUNB 3BTFI 1TAPA 1DTXA 1BTIA 1BTHP 1P2OB 3AUBA 3TGKI 2LFLA 4PTIA 4WXVC 3TGJI 1D0DA 3OFWA 2UUXA 2J6DA 1TOCR 3UIRC 3FP7J 1JC6A 5JB6A 1LD6A 3BTGI 3AUCA 4BNRI 1UUAA 2FTMB 1P2II 1QLQA 1P2MB 1BRBI 3BYBA 1T8NB 2FI4I 1K6UA 2ZVXA 3U1JE 3BTTI 1T8OB 2W8XA 1P2JI 1YKTB 1FANA 9PTIA 5JB4A 5JB5A 1T7CB 3AUGA 3AUEA 3TPII 1B0CA 1P2KI 4NTYB 3FP6I 2KNTA 2CA7A 3BTHI 3BTWI 3BTMI 1YC0I 1KUNA 1KTHA 3BTKI 3GYMI 7PTIA 4ISOB 1EJMB 3AUDA 1KNTA 3UOUB 1CO7I 2RA3C 2PTCI 1D0DB 1AALA 2JOTA 3FP8I 3WNYA 1BF0A 3L3TE 4ISLB 2DDIA 3TGII 1BPIA 1EAWB 3LDJA 4Y0ZI 3BTEI 1KIGI 1JV9A 1OA65 3M7QB 4NTXB 1F5RI 1TFXC 2HEXA 3OTJI 2M99A 1FAKI 1T8LB 1OA55 5PTIA 3BTQI 2KCRA 1F7ZI 4DTGK 1CA0D 3P95E 5C67C 3AUIA 4U30W 1TPAI 1Y62A 1DTKA 1LD5A 2TGPI 3D65I 3P92E 3LDMA 1BPTA 4Y10I 2M01A 1ZR0B 3BTDI 3T62D 4Y11I 1PITA 4WWYC 2FTLI
chains in the Genus database with same CATH superfamily
1P2NB 8PTIA 1FY8I 2R9PE 2FI5I 4BQDA 2KAII 2FI3I 1G6XA 1NAGA 1P2QB 1TCPA 1DEMA 1YLDB 1BZXI 4TPII 1JV8A 5JB7A 1SHPA 2ODYE 1BIKA 4U32X 1AAPA 1DENA 1YLCB 3LDIA 1CBWD 4ISNB 4NTWB 1IRHA 1BRCI 3AUHA 2IJOI 3CI7A 1TAWB 4DG4C 1ADZA 2ZJXA 1ZJDB 3L33E 1BHCA 4BD9B 6PTIA 1MTND 4Y0YI 2LFKA 2TPII 1UUBA 2UUYB 1T8MB 2DDJA 1BZ5A 1BUNB 3BTFI 1TAPA 1DTXA 1BTIA 1BTHP 1P2OB 3AUBA 3TGKI 2LFLA 4PTIA 4WXVC 3TGJI 1D0DA 3OFWA 2UUXA 2J6DA 1TOCR 3UIRC 3FP7J 1JC6A 5JB6A 1LD6A 3BTGI 3AUCA 4BNRI 1UUAA 2FTMB 1P2II 1QLQA 1P2MB 1BRBI 3BYBA 1T8NB 2FI4I 1K6UA 2ZVXA 3U1JE 3BTTI 1T8OB 2W8XA 1P2JI 1YKTB 1FANA 9PTIA 5JB4A 5JB5A 1T7CB 3AUGA 3AUEA 3TPII 1B0CA 1P2KI 4NTYB 3FP6I 2KNTA 2CA7A 3BTHI 3BTWI 3BTMI 1YC0I 1KUNA 1KTHA 3BTKI 3GYMI 7PTIA 4ISOB 1EJMB 3AUDA 1KNTA 3UOUB 1CO7I 2RA3C 2PTCI 1D0DB 1AALA 2JOTA 3FP8I 3WNYA 1BF0A 3L3TE 4ISLB 2DDIA 3TGII 1BPIA 1EAWB 3LDJA 4Y0ZI 3BTEI 1KIGI 1JV9A 1OA65 3M7QB 4NTXB 1F5RI 1TFXC 2HEXA 3OTJI 2M99A 1FAKI 1T8LB 1OA55 5PTIA 3BTQI 2KCRA 1F7ZI 4DTGK 1CA0D 3P95E 5C67C 3AUIA 4U30W 1TPAI 1Y62A 1DTKA 1LD5A 2TGPI 3D65I 3P92E 3LDMA 1BPTA 4Y10I 2M01A 1ZR0B 3BTDI 3T62D 4Y11I 1PITA 4WWYC 2FTLI
chains in the Genus database with same CATH topology
1P2NB 8PTIA 1FY8I 2R9PE 2FI5I 4BQDA 2KAII 2FI3I 1G6XA 1NAGA 1P2QB 1TCPA 1DEMA 1YLDB 1BZXI 4TPII 1JV8A 5JB7A 1SHPA 2ODYE 1BIKA 4U32X 1AAPA 1DENA 1YLCB 3LDIA 1CBWD 4ISNB 4NTWB 1IRHA 1BRCI 3AUHA 2IJOI 3CI7A 1TAWB 4DG4C 1ADZA 2ZJXA 1ZJDB 3L33E 1BHCA 4BD9B 6PTIA 1MTND 4Y0YI 2LFKA 2TPII 1UUBA 2UUYB 1T8MB 2DDJA 1BZ5A 1BUNB 3BTFI 1TAPA 1DTXA 1BTIA 1BTHP 1P2OB 3AUBA 3TGKI 2LFLA 4PTIA 4WXVC 3TGJI 1D0DA 3OFWA 2UUXA 2J6DA 1TOCR 3UIRC 3FP7J 1JC6A 5JB6A 1LD6A 3BTGI 3AUCA 4BNRI 1UUAA 2FTMB 1P2II 1QLQA 1P2MB 1BRBI 3BYBA 1T8NB 2FI4I 1K6UA 2ZVXA 3U1JE 3BTTI 1T8OB 2W8XA 1P2JI 1YKTB 1FANA 9PTIA 5JB4A 5JB5A 1T7CB 3AUGA 3AUEA 3TPII 1B0CA 1P2KI 4NTYB 3FP6I 2KNTA 2CA7A 3BTHI 3BTWI 3BTMI 1YC0I 1KUNA 1KTHA 3BTKI 3GYMI 7PTIA 4ISOB 1EJMB 3AUDA 1KNTA 3UOUB 1CO7I 2RA3C 2PTCI 1D0DB 1AALA 2JOTA 3FP8I 3WNYA 1BF0A 3L3TE 4ISLB 2DDIA 3TGII 1BPIA 1EAWB 3LDJA 4Y0ZI 3BTEI 1KIGI 1JV9A 1OA65 3M7QB 4NTXB 1F5RI 1TFXC 2HEXA 3OTJI 2M99A 1FAKI 1T8LB 1OA55 5PTIA 3BTQI 2KCRA 1F7ZI 4DTGK 1CA0D 3P95E 5C67C 3AUIA 4U30W 1TPAI 1Y62A 1DTKA 1LD5A 2TGPI 3D65I 3P92E 3LDMA 1BPTA 4Y10I 2M01A 1ZR0B 3BTDI 3T62D 4Y11I 1PITA 4WWYC 2FTLI
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1P2N B;  8PTI A;  1FY8 I;  2R9P E;  2FI5 I;  4BQD A;  2KAI I;  2FI3 I;  1G6X A;  1NAG A;  1P2Q B;  1TCP A;  1DEM A;  1YLD B;  1BZX I;  4TPI I;  1JV8 A;  5JB7 A;  1SHP A;  2ODY E;  1BIK A;  4U32 X;  1AAP A;  1DEN A;  1YLC B;  3LDI A;  1CBW D;  4ISN B;  4NTW B;  1IRH A;  1BRC I;  3AUH A;  2IJO I;  3CI7 A;  1TAW B;  4DG4 C;  1ADZ A;  2ZJX A;  1ZJD B;  3L33 E;  1BHC A;  4BD9 B;  6PTI A;  1MTN D;  4Y0Y I;  2LFK A;  2TPI I;  1UUB A;  2UUY B;  1T8M B;  2DDJ A;  1BZ5 A;  1BUN B;  3BTF I;  1TAP A;  1DTX A;  1BTI A;  1BTH P;  1P2O B;  3AUB A;  3TGK I;  2LFL A;  4PTI A;  4WXV C;  3TGJ I;  1D0D A;  3OFW A;  2UUX A;  2J6D A;  1TOC R;  3UIR C;  3FP7 J;  1JC6 A;  5JB6 A;  1LD6 A;  3BTG I;  3AUC A;  4BNR I;  1UUA A;  2FTM B;  1P2I I;  1QLQ A;  1P2M B;  1BRB I;  3BYB A;  1T8N B;  2FI4 I;  1K6U A;  2ZVX A;  3U1J E;  3BTT I;  1T8O B;  2W8X A;  1P2J I;  1YKT B;  1FAN A;  9PTI A;  5JB4 A;  5JB5 A;  1T7C B;  3AUG A;  3AUE A;  3TPI I;  1B0C A;  1P2K I;  4NTY B;  3FP6 I;  2KNT A;  2CA7 A;  3BTH I;  3BTW I;  3BTM I;  1YC0 I;  1KUN A;  1KTH A;  3BTK I;  3GYM I;  7PTI A;  4ISO B;  1EJM B;  3AUD A;  1KNT A;  3UOU B;  1CO7 I;  2RA3 C;  2PTC I;  1D0D B;  1AAL A;  2JOT A;  3FP8 I;  3WNY A;  1BF0 A;  3L3T E;  4ISL B;  2DDI A;  3TGI I;  1BPI A;  1EAW B;  3LDJ A;  4Y0Z I;  3BTE I;  1KIG I;  1JV9 A;  1OA6 5;  3M7Q B;  4NTX B;  1F5R I;  1TFX C;  2HEX A;  3OTJ I;  2M99 A;  1FAK I;  1T8L B;  1OA5 5;  5PTI A;  3BTQ I;  2KCR A;  1F7Z I;  4DTG K;  1CA0 D;  3P95 E;  5C67 C;  3AUI A;  4U30 W;  1TPA I;  1Y62 A;  1DTK A;  1LD5 A;  2TGP I;  3D65 I;  3P92 E;  3LDM A;  1BPT A;  4Y10 I;  2M01 A;  1ZR0 B;  3BTD I;  3T62 D;  4Y11 I;  1PIT A;  4WWY C;  2FTL I; 
#chains in the Genus database with same CATH topology
 1P2N B;  8PTI A;  1FY8 I;  2R9P E;  2FI5 I;  4BQD A;  2KAI I;  2FI3 I;  1G6X A;  1NAG A;  1P2Q B;  1TCP A;  1DEM A;  1YLD B;  1BZX I;  4TPI I;  1JV8 A;  5JB7 A;  1SHP A;  2ODY E;  1BIK A;  4U32 X;  1AAP A;  1DEN A;  1YLC B;  3LDI A;  1CBW D;  4ISN B;  4NTW B;  1IRH A;  1BRC I;  3AUH A;  2IJO I;  3CI7 A;  1TAW B;  4DG4 C;  1ADZ A;  2ZJX A;  1ZJD B;  3L33 E;  1BHC A;  4BD9 B;  6PTI A;  1MTN D;  4Y0Y I;  2LFK A;  2TPI I;  1UUB A;  2UUY B;  1T8M B;  2DDJ A;  1BZ5 A;  1BUN B;  3BTF I;  1TAP A;  1DTX A;  1BTI A;  1BTH P;  1P2O B;  3AUB A;  3TGK I;  2LFL A;  4PTI A;  4WXV C;  3TGJ I;  1D0D A;  3OFW A;  2UUX A;  2J6D A;  1TOC R;  3UIR C;  3FP7 J;  1JC6 A;  5JB6 A;  1LD6 A;  3BTG I;  3AUC A;  4BNR I;  1UUA A;  2FTM B;  1P2I I;  1QLQ A;  1P2M B;  1BRB I;  3BYB A;  1T8N B;  2FI4 I;  1K6U A;  2ZVX A;  3U1J E;  3BTT I;  1T8O B;  2W8X A;  1P2J I;  1YKT B;  1FAN A;  9PTI A;  5JB4 A;  5JB5 A;  1T7C B;  3AUG A;  3AUE A;  3TPI I;  1B0C A;  1P2K I;  4NTY B;  3FP6 I;  2KNT A;  2CA7 A;  3BTH I;  3BTW I;  3BTM I;  1YC0 I;  1KUN A;  1KTH A;  3BTK I;  3GYM I;  7PTI A;  4ISO B;  1EJM B;  3AUD A;  1KNT A;  3UOU B;  1CO7 I;  2RA3 C;  2PTC I;  1D0D B;  1AAL A;  2JOT A;  3FP8 I;  3WNY A;  1BF0 A;  3L3T E;  4ISL B;  2DDI A;  3TGI I;  1BPI A;  1EAW B;  3LDJ A;  4Y0Z I;  3BTE I;  1KIG I;  1JV9 A;  1OA6 5;  3M7Q B;  4NTX B;  1F5R I;  1TFX C;  2HEX A;  3OTJ I;  2M99 A;  1FAK I;  1T8L B;  1OA5 5;  5PTI A;  3BTQ I;  2KCR A;  1F7Z I;  4DTG K;  1CA0 D;  3P95 E;  5C67 C;  3AUI A;  4U30 W;  1TPA I;  1Y62 A;  1DTK A;  1LD5 A;  2TGP I;  3D65 I;  3P92 E;  3LDM A;  1BPT A;  4Y10 I;  2M01 A;  1ZR0 B;  3BTD I;  3T62 D;  4Y11 I;  1PIT A;  4WWY C;  2FTL I; 
#chains in the Genus database with same CATH homology
 1P2N B;  8PTI A;  1FY8 I;  2R9P E;  2FI5 I;  4BQD A;  2KAI I;  2FI3 I;  1G6X A;  1NAG A;  1P2Q B;  1TCP A;  1DEM A;  1YLD B;  1BZX I;  4TPI I;  1JV8 A;  5JB7 A;  1SHP A;  2ODY E;  1BIK A;  4U32 X;  1AAP A;  1DEN A;  1YLC B;  3LDI A;  1CBW D;  4ISN B;  4NTW B;  1IRH A;  1BRC I;  3AUH A;  2IJO I;  3CI7 A;  1TAW B;  4DG4 C;  1ADZ A;  2ZJX A;  1ZJD B;  3L33 E;  1BHC A;  4BD9 B;  6PTI A;  1MTN D;  4Y0Y I;  2LFK A;  2TPI I;  1UUB A;  2UUY B;  1T8M B;  2DDJ A;  1BZ5 A;  1BUN B;  3BTF I;  1TAP A;  1DTX A;  1BTI A;  1BTH P;  1P2O B;  3AUB A;  3TGK I;  2LFL A;  4PTI A;  4WXV C;  3TGJ I;  1D0D A;  3OFW A;  2UUX A;  2J6D A;  1TOC R;  3UIR C;  3FP7 J;  1JC6 A;  5JB6 A;  1LD6 A;  3BTG I;  3AUC A;  4BNR I;  1UUA A;  2FTM B;  1P2I I;  1QLQ A;  1P2M B;  1BRB I;  3BYB A;  1T8N B;  2FI4 I;  1K6U A;  2ZVX A;  3U1J E;  3BTT I;  1T8O B;  2W8X A;  1P2J I;  1YKT B;  1FAN A;  9PTI A;  5JB4 A;  5JB5 A;  1T7C B;  3AUG A;  3AUE A;  3TPI I;  1B0C A;  1P2K I;  4NTY B;  3FP6 I;  2KNT A;  2CA7 A;  3BTH I;  3BTW I;  3BTM I;  1YC0 I;  1KUN A;  1KTH A;  3BTK I;  3GYM I;  7PTI A;  4ISO B;  1EJM B;  3AUD A;  1KNT A;  3UOU B;  1CO7 I;  2RA3 C;  2PTC I;  1D0D B;  1AAL A;  2JOT A;  3FP8 I;  3WNY A;  1BF0 A;  3L3T E;  4ISL B;  2DDI A;  3TGI I;  1BPI A;  1EAW B;  3LDJ A;  4Y0Z I;  3BTE I;  1KIG I;  1JV9 A;  1OA6 5;  3M7Q B;  4NTX B;  1F5R I;  1TFX C;  2HEX A;  3OTJ I;  2M99 A;  1FAK I;  1T8L B;  1OA5 5;  5PTI A;  3BTQ I;  2KCR A;  1F7Z I;  4DTG K;  1CA0 D;  3P95 E;  5C67 C;  3AUI A;  4U30 W;  1TPA I;  1Y62 A;  1DTK A;  1LD5 A;  2TGP I;  3D65 I;  3P92 E;  3LDM A;  1BPT A;  4Y10 I;  2M01 A;  1ZR0 B;  3BTD I;  3T62 D;  4Y11 I;  1PIT A;  4WWY C;  2FTL I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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