3TPII

The geometry of the reactive site and of the peptide groups in trypsin, trypsinogen and its complexes with inhibitors
Total Genus 13
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
13
sequence length
58
structure length
58
Chain Sequence
RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The Geometry of the Reactive Site and of the Peptide Groups in Trypsin, Trypsinogen and its Complexes with Inhibitors
pubmed rcsb
molecule keywords TRYPSINOGEN
molecule tags Hydrolase/hydrolase inhibitor
total genus 13
structure length 58
sequence length 58
ec nomenclature
pdb deposition date 1982-09-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 3tpiI00
2FI3I 2KCRA 1NAGA 1MTND 1CBWD 1PITA 4U32X 1BF0A 1CA0D 1EJMB 3BTFI 4WXVC 3BYBA 4NTXB 3AUGA 1ZJDB 2PTCI 1CO7I 2FI5I 3TGII 1YKTB 1P2QB 1FANA 1K6UA 2M01A 3P95E 1UUAA 2UUYB 1OA55 3L33E 3U1JE 1KTHA 1YLDB 3OTJI 4WWYC 1BTIA 9PTIA 1BRBI 2FTMB 2TPII 4DTGK 3AUEA 1P2MB 1UUBA 2UUXA 1BHCA 1BPIA 3BTEI 1B0CA 4BNRI 5C67C 2IJOI 1KUNA 3AUBA 2KNTA 4PTIA 3AUIA 1EAWB 4U30W 1D0DA 1T8OB 1BIKA 1TFXC 3BTTI 8PTIA 1ZR0B 3UIRC 1BUNB 4BD9B 1JC6A 4DG4C 2KAII 4Y0ZI 2FI4I 4ISOB 3UOUB 1AAPA 4ISLB 1BPTA 5JB7A 3OFWA 3AUDA 1TAWB 3BTKI 3BTQI 1DTKA 1P2OB 2LFLA 1T8LB 1ADZA 3M7QB 1P2NB 1SHPA 4NTYB 2J6DA 1P2II 1TOCR 1QLQA 3AUHA 3BTGI 3LDIA 1KIGI 2JOTA 3CI7A 1DENA 2ZVXA 3BTWI 1Y62A 5JB5A 3TGKI 2TGPI 1LD6A 2LFKA 2R9PE 1D0DB 1BTHP 2ODYE 1JV9A 7PTIA 3FP6I 3AUCA 1OA65 1P2KI 3LDMA 3BTDI 1IRHA 1YC0I 5JB6A 3D65I 1LD5A 1KNTA 3FP7J 1FAKI 1DEMA 4TPII 1FY8I 4Y11I 2HEXA 1YLCB 3L3TE 1F5RI 5PTIA 3WNYA 3P92E 5JB4A 4ISNB 1F7ZI 3BTMI 1P2JI 2DDJA 2M99A 6PTIA 4NTWB 1DTXA 2RA3C 3LDJA 1TPAI 1T7CB 1T8MB 2CA7A 4Y0YI 4Y10I 3TPII 1T8NB 1TCPA 1JV8A 2DDIA 3TGJI 4BQDA 2ZJXA 2W8XA 1BZ5A 2FTLI 1BZXI 3FP8I 1AALA 1BRCI 1G6XA 1TAPA 3T62D 3BTHI 3GYMI
chains in the Genus database with same CATH superfamily
2FI3I 2KCRA 1NAGA 1MTND 1CBWD 1PITA 4U32X 1BF0A 1CA0D 1EJMB 3BTFI 4WXVC 3BYBA 4NTXB 3AUGA 1ZJDB 2PTCI 1CO7I 2FI5I 3TGII 1YKTB 1P2QB 1FANA 1K6UA 2M01A 3P95E 1UUAA 2UUYB 1OA55 3L33E 3U1JE 1KTHA 1YLDB 3OTJI 4WWYC 1BTIA 9PTIA 1BRBI 2FTMB 2TPII 4DTGK 3AUEA 1P2MB 1UUBA 2UUXA 1BHCA 1BPIA 3BTEI 1B0CA 4BNRI 5C67C 2IJOI 1KUNA 3AUBA 2KNTA 4PTIA 3AUIA 1EAWB 4U30W 1D0DA 1T8OB 1BIKA 1TFXC 3BTTI 8PTIA 1ZR0B 3UIRC 1BUNB 4BD9B 1JC6A 4DG4C 2KAII 4Y0ZI 2FI4I 4ISOB 3UOUB 1AAPA 4ISLB 1BPTA 5JB7A 3OFWA 3AUDA 1TAWB 3BTKI 3BTQI 1DTKA 1P2OB 2LFLA 1T8LB 1ADZA 3M7QB 1P2NB 1SHPA 4NTYB 2J6DA 1P2II 1TOCR 1QLQA 3AUHA 3BTGI 3LDIA 1KIGI 2JOTA 3CI7A 1DENA 2ZVXA 3BTWI 1Y62A 5JB5A 3TGKI 2TGPI 1LD6A 2LFKA 2R9PE 1D0DB 1BTHP 2ODYE 1JV9A 7PTIA 3FP6I 3AUCA 1OA65 1P2KI 3LDMA 3BTDI 1IRHA 1YC0I 5JB6A 3D65I 1LD5A 1KNTA 3FP7J 1FAKI 1DEMA 4TPII 1FY8I 4Y11I 2HEXA 1YLCB 3L3TE 1F5RI 5PTIA 3WNYA 3P92E 5JB4A 4ISNB 1F7ZI 3BTMI 1P2JI 2DDJA 2M99A 6PTIA 4NTWB 1DTXA 2RA3C 3LDJA 1TPAI 1T7CB 1T8MB 2CA7A 4Y0YI 4Y10I 3TPII 1T8NB 1TCPA 1JV8A 2DDIA 3TGJI 4BQDA 2ZJXA 2W8XA 1BZ5A 2FTLI 1BZXI 3FP8I 1AALA 1BRCI 1G6XA 1TAPA 3T62D 3BTHI 3GYMI
chains in the Genus database with same CATH topology
2FI3I 2KCRA 1NAGA 1MTND 1CBWD 1PITA 4U32X 1BF0A 1CA0D 1EJMB 3BTFI 4WXVC 3BYBA 4NTXB 3AUGA 1ZJDB 2PTCI 1CO7I 2FI5I 3TGII 1YKTB 1P2QB 1FANA 1K6UA 2M01A 3P95E 1UUAA 2UUYB 1OA55 3L33E 3U1JE 1KTHA 1YLDB 3OTJI 4WWYC 1BTIA 9PTIA 1BRBI 2FTMB 2TPII 4DTGK 3AUEA 1P2MB 1UUBA 2UUXA 1BHCA 1BPIA 3BTEI 1B0CA 4BNRI 5C67C 2IJOI 1KUNA 3AUBA 2KNTA 4PTIA 3AUIA 1EAWB 4U30W 1D0DA 1T8OB 1BIKA 1TFXC 3BTTI 8PTIA 1ZR0B 3UIRC 1BUNB 4BD9B 1JC6A 4DG4C 2KAII 4Y0ZI 2FI4I 4ISOB 3UOUB 1AAPA 4ISLB 1BPTA 5JB7A 3OFWA 3AUDA 1TAWB 3BTKI 3BTQI 1DTKA 1P2OB 2LFLA 1T8LB 1ADZA 3M7QB 1P2NB 1SHPA 4NTYB 2J6DA 1P2II 1TOCR 1QLQA 3AUHA 3BTGI 3LDIA 1KIGI 2JOTA 3CI7A 1DENA 2ZVXA 3BTWI 1Y62A 5JB5A 3TGKI 2TGPI 1LD6A 2LFKA 2R9PE 1D0DB 1BTHP 2ODYE 1JV9A 7PTIA 3FP6I 3AUCA 1OA65 1P2KI 3LDMA 3BTDI 1IRHA 1YC0I 5JB6A 3D65I 1LD5A 1KNTA 3FP7J 1FAKI 1DEMA 4TPII 1FY8I 4Y11I 2HEXA 1YLCB 3L3TE 1F5RI 5PTIA 3WNYA 3P92E 5JB4A 4ISNB 1F7ZI 3BTMI 1P2JI 2DDJA 2M99A 6PTIA 4NTWB 1DTXA 2RA3C 3LDJA 1TPAI 1T7CB 1T8MB 2CA7A 4Y0YI 4Y10I 3TPII 1T8NB 1TCPA 1JV8A 2DDIA 3TGJI 4BQDA 2ZJXA 2W8XA 1BZ5A 2FTLI 1BZXI 3FP8I 1AALA 1BRCI 1G6XA 1TAPA 3T62D 3BTHI 3GYMI
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2FI3 I;  2KCR A;  1NAG A;  1MTN D;  1CBW D;  1PIT A;  4U32 X;  1BF0 A;  1CA0 D;  1EJM B;  3BTF I;  4WXV C;  3BYB A;  4NTX B;  3AUG A;  1ZJD B;  2PTC I;  1CO7 I;  2FI5 I;  3TGI I;  1YKT B;  1P2Q B;  1FAN A;  1K6U A;  2M01 A;  3P95 E;  1UUA A;  2UUY B;  1OA5 5;  3L33 E;  3U1J E;  1KTH A;  1YLD B;  3OTJ I;  4WWY C;  1BTI A;  9PTI A;  1BRB I;  2FTM B;  2TPI I;  4DTG K;  3AUE A;  1P2M B;  1UUB A;  2UUX A;  1BHC A;  1BPI A;  3BTE I;  1B0C A;  4BNR I;  5C67 C;  2IJO I;  1KUN A;  3AUB A;  2KNT A;  4PTI A;  3AUI A;  1EAW B;  4U30 W;  1D0D A;  1T8O B;  1BIK A;  1TFX C;  3BTT I;  8PTI A;  1ZR0 B;  3UIR C;  1BUN B;  4BD9 B;  1JC6 A;  4DG4 C;  2KAI I;  4Y0Z I;  2FI4 I;  4ISO B;  3UOU B;  1AAP A;  4ISL B;  1BPT A;  5JB7 A;  3OFW A;  3AUD A;  1TAW B;  3BTK I;  3BTQ I;  1DTK A;  1P2O B;  2LFL A;  1T8L B;  1ADZ A;  3M7Q B;  1P2N B;  1SHP A;  4NTY B;  2J6D A;  1P2I I;  1TOC R;  1QLQ A;  3AUH A;  3BTG I;  3LDI A;  1KIG I;  2JOT A;  3CI7 A;  1DEN A;  2ZVX A;  3BTW I;  1Y62 A;  5JB5 A;  3TGK I;  2TGP I;  1LD6 A;  2LFK A;  2R9P E;  1D0D B;  1BTH P;  2ODY E;  1JV9 A;  7PTI A;  3FP6 I;  3AUC A;  1OA6 5;  1P2K I;  3LDM A;  3BTD I;  1IRH A;  1YC0 I;  5JB6 A;  3D65 I;  1LD5 A;  1KNT A;  3FP7 J;  1FAK I;  1DEM A;  4TPI I;  1FY8 I;  4Y11 I;  2HEX A;  1YLC B;  3L3T E;  1F5R I;  5PTI A;  3WNY A;  3P92 E;  5JB4 A;  4ISN B;  1F7Z I;  3BTM I;  1P2J I;  2DDJ A;  2M99 A;  6PTI A;  4NTW B;  1DTX A;  2RA3 C;  3LDJ A;  1TPA I;  1T7C B;  1T8M B;  2CA7 A;  4Y0Y I;  4Y10 I;  3TPI I;  1T8N B;  1TCP A;  1JV8 A;  2DDI A;  3TGJ I;  4BQD A;  2ZJX A;  2W8X A;  1BZ5 A;  2FTL I;  1BZX I;  3FP8 I;  1AAL A;  1BRC I;  1G6X A;  1TAP A;  3T62 D;  3BTH I;  3GYM I; 
#chains in the Genus database with same CATH topology
 2FI3 I;  2KCR A;  1NAG A;  1MTN D;  1CBW D;  1PIT A;  4U32 X;  1BF0 A;  1CA0 D;  1EJM B;  3BTF I;  4WXV C;  3BYB A;  4NTX B;  3AUG A;  1ZJD B;  2PTC I;  1CO7 I;  2FI5 I;  3TGI I;  1YKT B;  1P2Q B;  1FAN A;  1K6U A;  2M01 A;  3P95 E;  1UUA A;  2UUY B;  1OA5 5;  3L33 E;  3U1J E;  1KTH A;  1YLD B;  3OTJ I;  4WWY C;  1BTI A;  9PTI A;  1BRB I;  2FTM B;  2TPI I;  4DTG K;  3AUE A;  1P2M B;  1UUB A;  2UUX A;  1BHC A;  1BPI A;  3BTE I;  1B0C A;  4BNR I;  5C67 C;  2IJO I;  1KUN A;  3AUB A;  2KNT A;  4PTI A;  3AUI A;  1EAW B;  4U30 W;  1D0D A;  1T8O B;  1BIK A;  1TFX C;  3BTT I;  8PTI A;  1ZR0 B;  3UIR C;  1BUN B;  4BD9 B;  1JC6 A;  4DG4 C;  2KAI I;  4Y0Z I;  2FI4 I;  4ISO B;  3UOU B;  1AAP A;  4ISL B;  1BPT A;  5JB7 A;  3OFW A;  3AUD A;  1TAW B;  3BTK I;  3BTQ I;  1DTK A;  1P2O B;  2LFL A;  1T8L B;  1ADZ A;  3M7Q B;  1P2N B;  1SHP A;  4NTY B;  2J6D A;  1P2I I;  1TOC R;  1QLQ A;  3AUH A;  3BTG I;  3LDI A;  1KIG I;  2JOT A;  3CI7 A;  1DEN A;  2ZVX A;  3BTW I;  1Y62 A;  5JB5 A;  3TGK I;  2TGP I;  1LD6 A;  2LFK A;  2R9P E;  1D0D B;  1BTH P;  2ODY E;  1JV9 A;  7PTI A;  3FP6 I;  3AUC A;  1OA6 5;  1P2K I;  3LDM A;  3BTD I;  1IRH A;  1YC0 I;  5JB6 A;  3D65 I;  1LD5 A;  1KNT A;  3FP7 J;  1FAK I;  1DEM A;  4TPI I;  1FY8 I;  4Y11 I;  2HEX A;  1YLC B;  3L3T E;  1F5R I;  5PTI A;  3WNY A;  3P92 E;  5JB4 A;  4ISN B;  1F7Z I;  3BTM I;  1P2J I;  2DDJ A;  2M99 A;  6PTI A;  4NTW B;  1DTX A;  2RA3 C;  3LDJ A;  1TPA I;  1T7C B;  1T8M B;  2CA7 A;  4Y0Y I;  4Y10 I;  3TPI I;  1T8N B;  1TCP A;  1JV8 A;  2DDI A;  3TGJ I;  4BQD A;  2ZJX A;  2W8X A;  1BZ5 A;  2FTL I;  1BZX I;  3FP8 I;  1AAL A;  1BRC I;  1G6X A;  1TAP A;  3T62 D;  3BTH I;  3GYM I; 
#chains in the Genus database with same CATH homology
 2FI3 I;  2KCR A;  1NAG A;  1MTN D;  1CBW D;  1PIT A;  4U32 X;  1BF0 A;  1CA0 D;  1EJM B;  3BTF I;  4WXV C;  3BYB A;  4NTX B;  3AUG A;  1ZJD B;  2PTC I;  1CO7 I;  2FI5 I;  3TGI I;  1YKT B;  1P2Q B;  1FAN A;  1K6U A;  2M01 A;  3P95 E;  1UUA A;  2UUY B;  1OA5 5;  3L33 E;  3U1J E;  1KTH A;  1YLD B;  3OTJ I;  4WWY C;  1BTI A;  9PTI A;  1BRB I;  2FTM B;  2TPI I;  4DTG K;  3AUE A;  1P2M B;  1UUB A;  2UUX A;  1BHC A;  1BPI A;  3BTE I;  1B0C A;  4BNR I;  5C67 C;  2IJO I;  1KUN A;  3AUB A;  2KNT A;  4PTI A;  3AUI A;  1EAW B;  4U30 W;  1D0D A;  1T8O B;  1BIK A;  1TFX C;  3BTT I;  8PTI A;  1ZR0 B;  3UIR C;  1BUN B;  4BD9 B;  1JC6 A;  4DG4 C;  2KAI I;  4Y0Z I;  2FI4 I;  4ISO B;  3UOU B;  1AAP A;  4ISL B;  1BPT A;  5JB7 A;  3OFW A;  3AUD A;  1TAW B;  3BTK I;  3BTQ I;  1DTK A;  1P2O B;  2LFL A;  1T8L B;  1ADZ A;  3M7Q B;  1P2N B;  1SHP A;  4NTY B;  2J6D A;  1P2I I;  1TOC R;  1QLQ A;  3AUH A;  3BTG I;  3LDI A;  1KIG I;  2JOT A;  3CI7 A;  1DEN A;  2ZVX A;  3BTW I;  1Y62 A;  5JB5 A;  3TGK I;  2TGP I;  1LD6 A;  2LFK A;  2R9P E;  1D0D B;  1BTH P;  2ODY E;  1JV9 A;  7PTI A;  3FP6 I;  3AUC A;  1OA6 5;  1P2K I;  3LDM A;  3BTD I;  1IRH A;  1YC0 I;  5JB6 A;  3D65 I;  1LD5 A;  1KNT A;  3FP7 J;  1FAK I;  1DEM A;  4TPI I;  1FY8 I;  4Y11 I;  2HEX A;  1YLC B;  3L3T E;  1F5R I;  5PTI A;  3WNY A;  3P92 E;  5JB4 A;  4ISN B;  1F7Z I;  3BTM I;  1P2J I;  2DDJ A;  2M99 A;  6PTI A;  4NTW B;  1DTX A;  2RA3 C;  3LDJ A;  1TPA I;  1T7C B;  1T8M B;  2CA7 A;  4Y0Y I;  4Y10 I;  3TPI I;  1T8N B;  1TCP A;  1JV8 A;  2DDI A;  3TGJ I;  4BQD A;  2ZJX A;  2W8X A;  1BZ5 A;  2FTL I;  1BZX I;  3FP8 I;  1AAL A;  1BRC I;  1G6X A;  1TAP A;  3T62 D;  3BTH I;  3GYM I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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