3CQZE

Crystal structure of 10 subunit rna polymerase ii in complex with the inhibitor alpha-amanitin
Total Genus 59
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
59
sequence length
213
structure length
213
Chain Sequence
QENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSFQANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSAMKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQRADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The RNA Polymerase II Trigger Loop Functions in Substrate Selection and is Directly Targeted by Alpha-Amanitin.
pubmed doi rcsb
molecule tags Transcription/toxin
molecule keywords DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1
total genus 59
structure length 213
sequence length 213
ec nomenclature
pdb deposition date 2008-04-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01191 RNA_pol_Rpb5_C RNA polymerase Rpb5, C-terminal domain
E PF03871 RNA_pol_Rpb5_N RNA polymerase Rpb5, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1340.10 Alpha Beta 3-Layer(aba) Sandwich Dna-directed Rna Polymerases I, Ii, And Iii 27 Kd Polypeptide; Chain: A; domain 1 RNA polymerase, Rpb5, N-terminal domain 3cqzE01
3.90.940.20 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit RPB5-like RNA polymerase subunit 3cqzE02
4A3EE 2E2HE 3HOVE 1I6HE 4A3FE 4A93E 2Y0SH 3HKZH 4QIWH 3CQZE 3S1QE 2JA7E 3GTLE 3GTQE 5IP9E 2NVTE 4C3HE 3H3VF 2JA8E 2PMZH 2R92E 4BBSE 5C4JE 3PO3E 3FKIE 4A3LE 1WCME 5M5XE 2JA6E 3HOXE 4C3JE 2E2IE 2R93E 3GTGE 4A3JE 3I4NE 1TWFE 4AYBH 3GTPE 3PO2E 1EIKA 1I3QE 5IYBE 1TWGE 3S1ME 1K83E 4X6AE 1R9TE 5M3FE 1SFOE 3GTME 3GTOE 4A3ME 3HOUE 3GTJE 4A3BE 2NVYE 4A3DE 4BY7E 3S2DE 3M4OE 3S17E 5FLME 4C3IE 5M5YE 3S15E 5C4XE 2E2JE 1Y1WE 4A3CE 5FJ8E 2R7ZE 3HOWE 2B63E 2VUME 3HOYE 2YU9E 4C2ME 5C44E 4BY1E 5M5WE 5C3EE 3S2HE 3K7AE 2NVXE 4BBRE 3I4ME 1DZFA 3S1NE 2JA5E 1TWCE 3GTKE 5IYDE 4Y7NE 2NVQE 3M3YE 5IYCE 3S14E 2WB1H 4A3GE 1TWHE 3H0GE 5IP7E 3S1RE 1TWAE 3HOZE 3RZDE 4A3KE 4Y52E 3RZOE 1I50E 1Y1VE 4BXXE 4A3IE 2WAQH 5M3ME 3S16E
chains in the Genus database with same CATH superfamily
4A3EE 2E2HE 3HOVE 1I6HE 5M3MF 3S1NF 4A3FE 3S16F 4A93E 3DXJE 2E2HF 4YFKE 1I6HF 3HOVF 2Y0SI 4A3FF 1I6VE 2Y0SH 3HKZH 4A93F 4Y7NF 4QIWH 3CQZE 5E18E 2A6HE 4XSXE 2BE5E 3S1QE 2JA7E 3GTLE 3GTQE 5IYCF 2A68E 1QKLA 3CQZF 1HQME 5IP9E 4JK1E 2NVTE 4C3HE 3S1QF 3GTQF 5IP7F 3H3VF 5IP9F 4OIPE 4C3HF 4MEYE 2JA8E 2PMZH 2NVTF 3EQLE 4Q5SE 2R92E 4GZYE 3RZDF 4BBSE 2JA8F 4A3DF 4A3KF 5C4JE 3PO3E 3FKIE 1I50F 1YNJK 2CW0E 4A3LE 1WCME 3PO3F 4BXXF 4G7ZE 5M5XE 2JA6E 3FKIF 3HOXE 4C3JE 2E2IE 2R93E 4LK1E 3GTGE 4A3LF 5M5XF 4C3JF 4A3JE 2R93F 3GTGF 3I4NE 1TWFE 4YFXE 3GTPE 3PO2E 4AYBH 4Q4ZE 4A3JF 1EIKA 1I3QE 5D4DE 4A3EF 5IYBE 1TWGE 3S1ME 1TWFF 3GTPF 3I4NF 3PO2F 1I3QF 4OINE 1K83E 3S1MF 4X6AE 1R9TE 5M3FE 1K83F 1SFOE 4KN7E 4X6AF 1R9TF 3GTME 3GTOE 5M3FF 1SFOF 4A3ME 3HOUE 3H3VG 2JA7F 4LLGE 4MEXE 3GTLF 3GTMF 3GTOF 3GTJE 4A3BE 2NVYE 2KRXA 4A3BF 4A3DE 4BY7E 3S2DE 3M4OE 2R92F 3S17E 5FLME 4BY7F 4BBSF 1ZYRE 4C3IE 1YNNK 2A69E 4KMUE 5TMFE 3S2DF 5C4JF 3S17F 4C3IF 4G7OE 4XLNE 1IW7E 2A6EE 1WCMF 5M5YE 3S15E 2JA6F 5C4XE 3HOXF 2WAQK 2E2IF 5M5YF 5D4CE 3S15F 2E2JE 5C4XF 1Y1WE 2E2JF 4A3CE 5FJ8E 2R7ZE 1Y1WF 3HOWE 5IYBF 1TWGF 5FJ8F 2B63E 4A3CF 2R7ZF 3HKZK 4ZH4E 2VUME 3HOYE 2PPBE 4QIWK 2B63F 5D4EE 2YU9E 2VUMF 3HOYF 4C2ME 5C44E 4BY1E 4A3MF 5M5WE 5C3EE 3S2HE 3HOUF 3K7AE 2NVXE 4BBRE 4G7HE 4C2MF 3GTJF 4BY1F 3I4ME 4YFNE 5M5WF 2PMZK 5C3EF 2NVYF 3K7AF 4BBRF 3S2HF 1DZFA 3I4MF 5E17E 5IPLE 3M4OF 3S1NE 2JA5E 5FLMF 1TWCE 2JA5F 3GTKE 1TWCF 5IYDE 4Y7NE 4YG2E 4OIOE 3GTKF 5IYDF 2NVQE 3M3YE 2WB1I 5IYCE 3S14E 2WB1H 4A3GE 4AYBK 1TWHE 4OIQE 3H0GE 4MQ9E 1SMYE 5IP7E 3M3YF 5BYHE 3S14F 3S1RE 4A3GF 1TWHF 3H0GF 1TWAE 3HOZE 3S1RF 3HOWF 3RZDE 4A3KE 4Y52E 1TWAF 4LJZE 3HOZF 3WODE 4XSZE 4Y52F 3RZOE 2YU9F 1I50E 1Y1VE 4KN4E 2NVQF 3RZOF 4BXXE 2O5JE 4A3IE 1Y1VF 5C44F 4XLPE 2O5IE 4OIRE 2NVXF 4A3IF 2WAQH 4LK0E 5TMCE 5M3ME 3S16E
chains in the Genus database with same CATH topology
4A3EE 2E2HE 3HOVE 1I6HE 4A3FE 4A93E 2Y0SH 3HKZH 4QIWH 3CQZE 3S1QE 2JA7E 3GTLE 3GTQE 5IP9E 2NVTE 4C3HE 3H3VF 2JA8E 2PMZH 2R92E 4BBSE 5C4JE 3PO3E 3FKIE 4A3LE 1WCME 5M5XE 2JA6E 3HOXE 4C3JE 2E2IE 2R93E 3GTGE 4A3JE 3I4NE 1TWFE 4AYBH 3GTPE 3PO2E 1EIKA 1I3QE 5IYBE 1TWGE 3S1ME 1K83E 4X6AE 1R9TE 5M3FE 1SFOE 3GTME 3GTOE 4A3ME 3HOUE 3GTJE 4A3BE 2NVYE 4A3DE 4BY7E 3S2DE 3M4OE 3S17E 5FLME 4C3IE 5M5YE 3S15E 5C4XE 2E2JE 1Y1WE 4A3CE 5FJ8E 2R7ZE 3HOWE 2B63E 2VUME 3HOYE 2YU9E 4C2ME 5C44E 4BY1E 5M5WE 5C3EE 3S2HE 3K7AE 2NVXE 4BBRE 3I4ME 1DZFA 3S1NE 2JA5E 1TWCE 3GTKE 5IYDE 4Y7NE 2NVQE 3M3YE 5IYCE 3S14E 2WB1H 4A3GE 1TWHE 3H0GE 5IP7E 3S1RE 1TWAE 3HOZE 3RZDE 4A3KE 4Y52E 3RZOE 1I50E 1Y1VE 4BXXE 4A3IE 2WAQH 5M3ME 3S16E
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4A3E E;  2E2H E;  3HOV E;  1I6H E;  4A3F E;  4A93 E;  2Y0S H;  3HKZ H;  4QIW H;  3CQZ E;  3S1Q E;  2JA7 E;  3GTL E;  3GTQ E;  5IP9 E;  2NVT E;  4C3H E;  3H3V F;  2JA8 E;  2PMZ H;  2R92 E;  4BBS E;  5C4J E;  3PO3 E;  3FKI E;  4A3L E;  1WCM E;  5M5X E;  2JA6 E;  3HOX E;  4C3J E;  2E2I E;  2R93 E;  3GTG E;  4A3J E;  3I4N E;  1TWF E;  4AYB H;  3GTP E;  3PO2 E;  1EIK A;  1I3Q E;  5IYB E;  1TWG E;  3S1M E;  1K83 E;  4X6A E;  1R9T E;  5M3F E;  1SFO E;  3GTM E;  3GTO E;  4A3M E;  3HOU E;  3GTJ E;  4A3B E;  2NVY E;  4A3D E;  4BY7 E;  3S2D E;  3M4O E;  3S17 E;  5FLM E;  4C3I E;  5M5Y E;  3S15 E;  5C4X E;  2E2J E;  1Y1W E;  4A3C E;  5FJ8 E;  2R7Z E;  3HOW E;  2B63 E;  2VUM E;  3HOY E;  2YU9 E;  4C2M E;  5C44 E;  4BY1 E;  5M5W E;  5C3E E;  3S2H E;  3K7A E;  2NVX E;  4BBR E;  3I4M E;  1DZF A;  3S1N E;  2JA5 E;  1TWC E;  3GTK E;  5IYD E;  4Y7N E;  2NVQ E;  3M3Y E;  5IYC E;  3S14 E;  2WB1 H;  4A3G E;  1TWH E;  3H0G E;  5IP7 E;  3S1R E;  1TWA E;  3HOZ E;  3RZD E;  4A3K E;  4Y52 E;  3RZO E;  1I50 E;  1Y1V E;  4BXX E;  4A3I E;  2WAQ H;  5M3M E;  3S16 E; 
#chains in the Genus database with same CATH topology
 4A3E E;  2E2H E;  3HOV E;  1I6H E;  5M3M F;  3S1N F;  4A3F E;  3S16 F;  4A93 E;  3DXJ E;  2E2H F;  4YFK E;  1I6H F;  3HOV F;  2Y0S I;  4A3F F;  1I6V E;  2Y0S H;  3HKZ H;  4A93 F;  4Y7N F;  4QIW H;  3CQZ E;  5E18 E;  2A6H E;  4XSX E;  2BE5 E;  3S1Q E;  2JA7 E;  3GTL E;  3GTQ E;  5IYC F;  2A68 E;  1QKL A;  3CQZ F;  1HQM E;  5IP9 E;  4JK1 E;  2NVT E;  4C3H E;  3S1Q F;  3GTQ F;  5IP7 F;  3H3V F;  5IP9 F;  4OIP E;  4C3H F;  4MEY E;  2JA8 E;  2PMZ H;  2NVT F;  3EQL E;  4Q5S E;  2R92 E;  4GZY E;  3RZD F;  4BBS E;  2JA8 F;  4A3D F;  4A3K F;  5C4J E;  3PO3 E;  3FKI E;  1I50 F;  1YNJ K;  2CW0 E;  4A3L E;  1WCM E;  3PO3 F;  4BXX F;  4G7Z E;  5M5X E;  2JA6 E;  3FKI F;  3HOX E;  4C3J E;  2E2I E;  2R93 E;  4LK1 E;  3GTG E;  4A3L F;  5M5X F;  4C3J F;  4A3J E;  2R93 F;  3GTG F;  3I4N E;  1TWF E;  4YFX E;  3GTP E;  3PO2 E;  4AYB H;  4Q4Z E;  4A3J F;  1EIK A;  1I3Q E;  5D4D E;  4A3E F;  5IYB E;  1TWG E;  3S1M E;  1TWF F;  3GTP F;  3I4N F;  3PO2 F;  1I3Q F;  4OIN E;  1K83 E;  3S1M F;  4X6A E;  1R9T E;  5M3F E;  1K83 F;  1SFO E;  4KN7 E;  4X6A F;  1R9T F;  3GTM E;  3GTO E;  5M3F F;  1SFO F;  4A3M E;  3HOU E;  3H3V G;  2JA7 F;  4LLG E;  4MEX E;  3GTL F;  3GTM F;  3GTO F;  3GTJ E;  4A3B E;  2NVY E;  2KRX A;  4A3B F;  4A3D E;  4BY7 E;  3S2D E;  3M4O E;  2R92 F;  3S17 E;  5FLM E;  4BY7 F;  4BBS F;  1ZYR E;  4C3I E;  1YNN K;  2A69 E;  4KMU E;  5TMF E;  3S2D F;  5C4J F;  3S17 F;  4C3I F;  4G7O E;  4XLN E;  1IW7 E;  2A6E E;  1WCM F;  5M5Y E;  3S15 E;  2JA6 F;  5C4X E;  3HOX F;  2WAQ K;  2E2I F;  5M5Y F;  5D4C E;  3S15 F;  2E2J E;  5C4X F;  1Y1W E;  2E2J F;  4A3C E;  5FJ8 E;  2R7Z E;  1Y1W F;  3HOW E;  5IYB F;  1TWG F;  5FJ8 F;  2B63 E;  4A3C F;  2R7Z F;  3HKZ K;  4ZH4 E;  2VUM E;  3HOY E;  2PPB E;  4QIW K;  2B63 F;  5D4E E;  2YU9 E;  2VUM F;  3HOY F;  4C2M E;  5C44 E;  4BY1 E;  4A3M F;  5M5W E;  5C3E E;  3S2H E;  3HOU F;  3K7A E;  2NVX E;  4BBR E;  4G7H E;  4C2M F;  3GTJ F;  4BY1 F;  3I4M E;  4YFN E;  5M5W F;  2PMZ K;  5C3E F;  2NVY F;  3K7A F;  4BBR F;  3S2H F;  1DZF A;  3I4M F;  5E17 E;  5IPL E;  3M4O F;  3S1N E;  2JA5 E;  5FLM F;  1TWC E;  2JA5 F;  3GTK E;  1TWC F;  5IYD E;  4Y7N E;  4YG2 E;  4OIO E;  3GTK F;  5IYD F;  2NVQ E;  3M3Y E;  2WB1 I;  5IYC E;  3S14 E;  2WB1 H;  4A3G E;  4AYB K;  1TWH E;  4OIQ E;  3H0G E;  4MQ9 E;  1SMY E;  5IP7 E;  3M3Y F;  5BYH E;  3S14 F;  3S1R E;  4A3G F;  1TWH F;  3H0G F;  1TWA E;  3HOZ E;  3S1R F;  3HOW F;  3RZD E;  4A3K E;  4Y52 E;  1TWA F;  4LJZ E;  3HOZ F;  3WOD E;  4XSZ E;  4Y52 F;  3RZO E;  2YU9 F;  1I50 E;  1Y1V E;  4KN4 E;  2NVQ F;  3RZO F;  4BXX E;  2O5J E;  4A3I E;  1Y1V F;  5C44 F;  4XLP E;  2O5I E;  4OIR E;  2NVX F;  4A3I F;  2WAQ H;  4LK0 E;  5TMC E;  5M3M E;  3S16 E; 
#chains in the Genus database with same CATH homology
 4A3E E;  2E2H E;  3HOV E;  1I6H E;  4A3F E;  4A93 E;  2Y0S H;  3HKZ H;  4QIW H;  3CQZ E;  3S1Q E;  2JA7 E;  3GTL E;  3GTQ E;  5IP9 E;  2NVT E;  4C3H E;  3H3V F;  2JA8 E;  2PMZ H;  2R92 E;  4BBS E;  5C4J E;  3PO3 E;  3FKI E;  4A3L E;  1WCM E;  5M5X E;  2JA6 E;  3HOX E;  4C3J E;  2E2I E;  2R93 E;  3GTG E;  4A3J E;  3I4N E;  1TWF E;  4AYB H;  3GTP E;  3PO2 E;  1EIK A;  1I3Q E;  5IYB E;  1TWG E;  3S1M E;  1K83 E;  4X6A E;  1R9T E;  5M3F E;  1SFO E;  3GTM E;  3GTO E;  4A3M E;  3HOU E;  3GTJ E;  4A3B E;  2NVY E;  4A3D E;  4BY7 E;  3S2D E;  3M4O E;  3S17 E;  5FLM E;  4C3I E;  5M5Y E;  3S15 E;  5C4X E;  2E2J E;  1Y1W E;  4A3C E;  5FJ8 E;  2R7Z E;  3HOW E;  2B63 E;  2VUM E;  3HOY E;  2YU9 E;  4C2M E;  5C44 E;  4BY1 E;  5M5W E;  5C3E E;  3S2H E;  3K7A E;  2NVX E;  4BBR E;  3I4M E;  1DZF A;  3S1N E;  2JA5 E;  1TWC E;  3GTK E;  5IYD E;  4Y7N E;  2NVQ E;  3M3Y E;  5IYC E;  3S14 E;  2WB1 H;  4A3G E;  1TWH E;  3H0G E;  5IP7 E;  3S1R E;  1TWA E;  3HOZ E;  3RZD E;  4A3K E;  4Y52 E;  3RZO E;  1I50 E;  1Y1V E;  4BXX E;  4A3I E;  2WAQ H;  5M3M E;  3S16 E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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