3CQZF

Crystal structure of 10 subunit rna polymerase ii in complex with the inhibitor alpha-amanitin
Total Genus 24
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
24
sequence length
84
structure length
84
Chain Sequence
KAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDLEGETDPLRIAMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The RNA Polymerase II Trigger Loop Functions in Substrate Selection and is Directly Targeted by Alpha-Amanitin.
pubmed doi rcsb
molecule tags Transcription/toxin
molecule keywords DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1
total genus 24
structure length 84
sequence length 84
ec nomenclature
pdb deposition date 2008-04-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
F PF01192 RNA_pol_Rpb6 RNA polymerase Rpb6
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.940.10 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit Eukaryotic RPB6 RNA polymerase subunit 3cqzF00
4YG2E 2O5JE 3I4MF 4OIRE 3RZOF 3HKZK 4LLGE 1Y1VF 4KN7E 5C44F 2E2IF 4A3LF 2A68E 3H0GF 4C3IF 2A69E 4XLPE 4A3EF 4BY7F 1I6HF 5D4EE 3HOUF 4G7ZE 4A3IF 5BYHE 3GTGF 2NVXF 5TMFE 4KN4E 2R7ZF 2R92F 2B63F 3GTMF 3HOVF 1K83F 4XSXE 5FLMF 3DXJE 4ZH4E 3GTQF 4G7OE 4BXXF 3S1NF 1Y1WF 3S1MF 2JA8F 2PPBE 4LK0E 5TMCE 4KMUE 2JA6F 3GTPF 3S1QF 1TWGF 3I4NF 1HQME 2E2JF 4A3BF 5C4XF 4C3HF 3EQLE 1TWHF 3PO3F 2JA7F 1IW7E 3WODE 2VUMF 3HOXF 4LK1E 5IYCF 5FJ8F 2CW0E 2O5IE 4A3DF 5D4CE 4BBSF 1SMYE 4A3KF 4JK1E 3CQZF 5IP7F 1YNJK 2A6HE 4XLNE 4OIQE 3S2HF 3K7AF 2PMZK 5IYBF 1I50F 5M3MF 2NVQF 4C3JF 5M5WF 3GTKF 4LJZE 4GZYE 3PO2F 4Y52F 3HOYF 5IP9F 4OIPE 5E18E 5IYDF 5D4DE 3M3YF 2E2HF 1ZYRE 5E17E 2NVYF 2NVTF 2BE5E 4OINE 2A6EE 2YU9F 3S14F 3S16F 5C4JF 4AYBK 3S15F 4A3CF 4YFKE 4Q5SE 4Q4ZE 4X6AF 1TWFF 5IPLE 4G7HE 1I6VE 1TWAF 4A3FF 4YFNE 4A3MF 1SFOF 4A3GF 2Y0SI 3FKIF 1TWCF 4C2MF 2WAQK 2R93F 4BBRF 3RZDF 4OIOE 4A3JF 1WCMF 3GTLF 3HOWF 3S17F 3GTOF 4MEXE 5M5XF 5M3FF 3S1RF 3M4OF 4XSZE 3GTJF 4Y7NF 3HOZF 4A93F 1YNNK 1R9TF 2WB1I 4BY1F 5C3EF 1I3QF 1QKLA 4MQ9E 4YFXE 3S2DF 5M5YF 4MEYE 2JA5F 3H3VG
chains in the Genus database with same CATH superfamily
4YG2E 2YU9E 3S14E 3S16E 5C4JE 2O5JE 3I4MF 3S15E 4OIRE 3RZOF 3HKZK 4LLGE 1TWFE 1Y1VF 4KN7E 5C44F 1TWAE 2E2IF 4A3LF 3I4ME 2A68E 4A3FE 3H0GF 4C3IF 3RZOE 2A69E 4XLPE 4A3EF 4BY7F 4A3ME 3S2HE 1I6HF 5D4EE 3HOUF 4G7ZE 4A3IF 5BYHE 3GTGF 2NVXF 3HOUE 5TMFE 4A3IE 2R93E 4KN4E 3RZDE 4A3JE 3HOWE 2R7ZF 3GTOE 3S17E 2R92F 2B63F 3GTMF 3HOVF 1K83F 4XSXE 5FLMF 3S1RE 3M4OE 2R7ZE 3DXJE 4ZH4E 3GTJE 4Y7NE 3GTQF 3HOZE 1R9TE 4A93E 4BXXF 4BY1E 4G7OE 5C3EE 3S1NF 1I3QE 1Y1WF 3S1MF 2JA8F 2PPBE 2Y0SH 5M5YE 4BXXE 4LK0E 5TMCE 4KMUE 4QIWH 1Y1WE 2JA5E 2JA6F 3GTME 2PMZH 3GTPF 3S1QF 1TWGF 3I4NF 1HQME 2E2JF 4A3BF 5C4XF 1EIKA 4C3HF 3EQLE 5C4XE 1Y1VE 5C44E 1TWHF 2E2IE 3H3VF 3PO3F 4A3LE 3H0GE 4C3IE 2WB1H 4A3EE 4BY7E 1I6HE 1TWHE 2JA7F 1IW7E 3WODE 2VUMF 3HOXF 3GTGE 4LK1E 5IYCF 5FJ8F 2NVXE 2CW0E 2O5IE 4A3DF 5D4CE 4BBSF 1SMYE 2R92E 4A3KF 4JK1E 3CQZF 5IP7F 1YNJK 2A6HE 1K83E 4QIWK 4AYBH 5FLME 4XLNE 3K7AF 4OIQE 3HOVE 2PMZK 3S2HF 3GTQE 5IYBF 3S1NE 1I50F 5M3MF 2KRXA 3K7AE 4C3JF 5M5WF 2NVQF 2JA8E 4LJZE 3GTKF 3S1ME 4GZYE 3PO2F 4Y52F 5IYBE 3HOYF 1I50E 5IP9F 4OIPE 5M3ME 5E18E 5IYDF 2JA6E 5D4DE 1DZFA 3GTPE 4Y52E 3HOYE 1TWGE 3I4NE 2WAQH 2E2JE 3M3YF 3S1QE 4A3BE 4C3HE 2E2HF 3M3YE 1ZYRE 5E17E 2NVYF 3PO3E 2NVTF 2BE5E 4OINE 2JA7E 2A6EE 2YU9F 2VUME 2NVTE 3S14F 5C4JF 4AYBK 3HOXE 3S16F 3S15F 4A3CF 5IYCE 4YFKE 5FJ8E 4Q5SE 4Q4ZE 4X6AF 1TWFF 5IPLE 4G7HE 1I6VE 1TWAF 4A3FF 4A3CE 4A3DE 4BBSE 4YFNE 4A3MF 4A3KE 1SFOF 3CQZE 5IP7E 2B63E 4A3GF 4X6AE 2Y0SI 3FKIF 3HKZH 1SFOE 4A3GE 1TWCF 4C2MF 2WAQK 2NVQE 4C3JE 5M5WE 3GTKE 3FKIE 2R93F 4BBRF 3RZDF 4OIOE 4A3JF 1TWCE 3PO2E 4C2ME 1WCMF 5IP9E 3GTLF 3HOWF 3S17F 5IYDE 3GTOF 4MEXE 4BBRE 5M5XF 5M3FF 1WCME 3S1RF 3GTLE 3M4OF 4XSZE 3GTJF 4Y7NF 3HOZF 4A93F 1YNNK 5M5XE 5M3FE 2WB1I 4BY1F 5C3EF 1R9TF 2E2HE 1I3QF 1QKLA 4MQ9E 2NVYE 4YFXE 3S2DF 5M5YF 4MEYE 2JA5F 3H3VG 3S2DE
chains in the Genus database with same CATH topology
4YG2E 2O5JE 3I4MF 4OIRE 3RZOF 3HKZK 4LLGE 1Y1VF 4KN7E 5C44F 2E2IF 4A3LF 2A68E 3H0GF 4C3IF 2A69E 4XLPE 4A3EF 4BY7F 1I6HF 5D4EE 3HOUF 4G7ZE 4A3IF 5BYHE 3GTGF 2NVXF 5TMFE 4KN4E 2R7ZF 2R92F 2B63F 3GTMF 3HOVF 1K83F 4XSXE 5FLMF 3DXJE 4ZH4E 3GTQF 4G7OE 4BXXF 3S1NF 1Y1WF 3S1MF 2JA8F 2PPBE 4LK0E 5TMCE 4KMUE 2JA6F 3GTPF 3S1QF 1TWGF 3I4NF 1HQME 2E2JF 4A3BF 5C4XF 4C3HF 3EQLE 1TWHF 3PO3F 2JA7F 1IW7E 3WODE 2VUMF 3HOXF 4LK1E 5IYCF 5FJ8F 2CW0E 2O5IE 4A3DF 5D4CE 4BBSF 1SMYE 4A3KF 4JK1E 3CQZF 5IP7F 1YNJK 2A6HE 4XLNE 4QIWK 4OIQE 3S2HF 3K7AF 2PMZK 5IYBF 1I50F 5M3MF 2KRXA 2NVQF 4C3JF 5M5WF 3GTKF 4LJZE 4GZYE 3PO2F 4Y52F 3HOYF 5IP9F 4OIPE 5E18E 5IYDF 5D4DE 3M3YF 2E2HF 1ZYRE 5E17E 2NVYF 2NVTF 2BE5E 4OINE 2A6EE 2YU9F 3S14F 3S16F 5C4JF 4AYBK 3S15F 4A3CF 4YFKE 4Q5SE 4Q4ZE 4X6AF 1TWFF 5IPLE 4G7HE 1I6VE 1TWAF 4A3FF 4YFNE 4A3MF 1SFOF 4A3GF 2Y0SI 3FKIF 1TWCF 4C2MF 2WAQK 2R93F 4BBRF 3RZDF 4OIOE 4A3JF 1WCMF 3GTLF 3HOWF 3S17F 3GTOF 4MEXE 5M5XF 5M3FF 3S1RF 3M4OF 4XSZE 3GTJF 4Y7NF 3HOZF 4A93F 1YNNK 1R9TF 2WB1I 4BY1F 5C3EF 1I3QF 1QKLA 4MQ9E 4YFXE 3S2DF 5M5YF 4MEYE 2JA5F 3H3VG
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4YG2 E;  2O5J E;  3I4M F;  4OIR E;  3RZO F;  3HKZ K;  4LLG E;  1Y1V F;  4KN7 E;  5C44 F;  2E2I F;  4A3L F;  2A68 E;  3H0G F;  4C3I F;  2A69 E;  4XLP E;  4A3E F;  4BY7 F;  1I6H F;  5D4E E;  3HOU F;  4G7Z E;  4A3I F;  5BYH E;  3GTG F;  2NVX F;  5TMF E;  4KN4 E;  2R7Z F;  2R92 F;  2B63 F;  3GTM F;  3HOV F;  1K83 F;  4XSX E;  5FLM F;  3DXJ E;  4ZH4 E;  3GTQ F;  4G7O E;  4BXX F;  3S1N F;  1Y1W F;  3S1M F;  2JA8 F;  2PPB E;  4LK0 E;  5TMC E;  4KMU E;  2JA6 F;  3GTP F;  3S1Q F;  1TWG F;  3I4N F;  1HQM E;  2E2J F;  4A3B F;  5C4X F;  4C3H F;  3EQL E;  1TWH F;  3PO3 F;  2JA7 F;  1IW7 E;  3WOD E;  2VUM F;  3HOX F;  4LK1 E;  5IYC F;  5FJ8 F;  2CW0 E;  2O5I E;  4A3D F;  5D4C E;  4BBS F;  1SMY E;  4A3K F;  4JK1 E;  3CQZ F;  5IP7 F;  1YNJ K;  2A6H E;  4XLN E;  4OIQ E;  3S2H F;  3K7A F;  2PMZ K;  5IYB F;  1I50 F;  5M3M F;  2NVQ F;  4C3J F;  5M5W F;  3GTK F;  4LJZ E;  4GZY E;  3PO2 F;  4Y52 F;  3HOY F;  5IP9 F;  4OIP E;  5E18 E;  5IYD F;  5D4D E;  3M3Y F;  2E2H F;  1ZYR E;  5E17 E;  2NVY F;  2NVT F;  2BE5 E;  4OIN E;  2A6E E;  2YU9 F;  3S14 F;  3S16 F;  5C4J F;  4AYB K;  3S15 F;  4A3C F;  4YFK E;  4Q5S E;  4Q4Z E;  4X6A F;  1TWF F;  5IPL E;  4G7H E;  1I6V E;  1TWA F;  4A3F F;  4YFN E;  4A3M F;  1SFO F;  4A3G F;  2Y0S I;  3FKI F;  1TWC F;  4C2M F;  2WAQ K;  2R93 F;  4BBR F;  3RZD F;  4OIO E;  4A3J F;  1WCM F;  3GTL F;  3HOW F;  3S17 F;  3GTO F;  4MEX E;  5M5X F;  5M3F F;  3S1R F;  3M4O F;  4XSZ E;  3GTJ F;  4Y7N F;  3HOZ F;  4A93 F;  1YNN K;  1R9T F;  2WB1 I;  4BY1 F;  5C3E F;  1I3Q F;  1QKL A;  4MQ9 E;  4YFX E;  3S2D F;  5M5Y F;  4MEY E;  2JA5 F;  3H3V G; 
#chains in the Genus database with same CATH topology
 4YG2 E;  2YU9 E;  3S14 E;  3S16 E;  5C4J E;  2O5J E;  3I4M F;  3S15 E;  4OIR E;  3RZO F;  3HKZ K;  4LLG E;  1TWF E;  1Y1V F;  4KN7 E;  5C44 F;  1TWA E;  2E2I F;  4A3L F;  3I4M E;  2A68 E;  4A3F E;  3H0G F;  4C3I F;  3RZO E;  2A69 E;  4XLP E;  4A3E F;  4BY7 F;  4A3M E;  3S2H E;  1I6H F;  5D4E E;  3HOU F;  4G7Z E;  4A3I F;  5BYH E;  3GTG F;  2NVX F;  3HOU E;  5TMF E;  4A3I E;  2R93 E;  4KN4 E;  3RZD E;  4A3J E;  3HOW E;  2R7Z F;  3GTO E;  3S17 E;  2R92 F;  2B63 F;  3GTM F;  3HOV F;  1K83 F;  4XSX E;  5FLM F;  3S1R E;  3M4O E;  2R7Z E;  3DXJ E;  4ZH4 E;  3GTJ E;  4Y7N E;  3GTQ F;  3HOZ E;  1R9T E;  4A93 E;  4BXX F;  4BY1 E;  4G7O E;  5C3E E;  3S1N F;  1I3Q E;  1Y1W F;  3S1M F;  2JA8 F;  2PPB E;  2Y0S H;  5M5Y E;  4BXX E;  4LK0 E;  5TMC E;  4KMU E;  4QIW H;  1Y1W E;  2JA5 E;  2JA6 F;  3GTM E;  2PMZ H;  3GTP F;  3S1Q F;  1TWG F;  3I4N F;  1HQM E;  2E2J F;  4A3B F;  5C4X F;  1EIK A;  4C3H F;  3EQL E;  5C4X E;  1Y1V E;  5C44 E;  1TWH F;  2E2I E;  3H3V F;  3PO3 F;  4A3L E;  3H0G E;  4C3I E;  2WB1 H;  4A3E E;  4BY7 E;  1I6H E;  1TWH E;  2JA7 F;  1IW7 E;  3WOD E;  2VUM F;  3HOX F;  3GTG E;  4LK1 E;  5IYC F;  5FJ8 F;  2NVX E;  2CW0 E;  2O5I E;  4A3D F;  5D4C E;  4BBS F;  1SMY E;  2R92 E;  4A3K F;  4JK1 E;  3CQZ F;  5IP7 F;  1YNJ K;  2A6H E;  1K83 E;  4QIW K;  4AYB H;  5FLM E;  4XLN E;  3K7A F;  4OIQ E;  3HOV E;  2PMZ K;  3S2H F;  3GTQ E;  5IYB F;  3S1N E;  1I50 F;  5M3M F;  2KRX A;  3K7A E;  4C3J F;  5M5W F;  2NVQ F;  2JA8 E;  4LJZ E;  3GTK F;  3S1M E;  4GZY E;  3PO2 F;  4Y52 F;  5IYB E;  3HOY F;  1I50 E;  5IP9 F;  4OIP E;  5M3M E;  5E18 E;  5IYD F;  2JA6 E;  5D4D E;  1DZF A;  3GTP E;  4Y52 E;  3HOY E;  1TWG E;  3I4N E;  2WAQ H;  2E2J E;  3M3Y F;  3S1Q E;  4A3B E;  4C3H E;  2E2H F;  3M3Y E;  1ZYR E;  5E17 E;  2NVY F;  3PO3 E;  2NVT F;  2BE5 E;  4OIN E;  2JA7 E;  2A6E E;  2YU9 F;  2VUM E;  2NVT E;  3S14 F;  5C4J F;  4AYB K;  3HOX E;  3S16 F;  3S15 F;  4A3C F;  5IYC E;  4YFK E;  5FJ8 E;  4Q5S E;  4Q4Z E;  4X6A F;  1TWF F;  5IPL E;  4G7H E;  1I6V E;  1TWA F;  4A3F F;  4A3C E;  4A3D E;  4BBS E;  4YFN E;  4A3M F;  4A3K E;  1SFO F;  3CQZ E;  5IP7 E;  2B63 E;  4A3G F;  4X6A E;  2Y0S I;  3FKI F;  3HKZ H;  1SFO E;  4A3G E;  1TWC F;  4C2M F;  2WAQ K;  2NVQ E;  4C3J E;  5M5W E;  3GTK E;  3FKI E;  2R93 F;  4BBR F;  3RZD F;  4OIO E;  4A3J F;  1TWC E;  3PO2 E;  4C2M E;  1WCM F;  5IP9 E;  3GTL F;  3HOW F;  3S17 F;  5IYD E;  3GTO F;  4MEX E;  4BBR E;  5M5X F;  5M3F F;  1WCM E;  3S1R F;  3GTL E;  3M4O F;  4XSZ E;  3GTJ F;  4Y7N F;  3HOZ F;  4A93 F;  1YNN K;  5M5X E;  5M3F E;  2WB1 I;  4BY1 F;  5C3E F;  1R9T F;  2E2H E;  1I3Q F;  1QKL A;  4MQ9 E;  2NVY E;  4YFX E;  3S2D F;  5M5Y F;  4MEY E;  2JA5 F;  3H3V G;  3S2D E; 
#chains in the Genus database with same CATH homology
 4YG2 E;  2O5J E;  3I4M F;  4OIR E;  3RZO F;  3HKZ K;  4LLG E;  1Y1V F;  4KN7 E;  5C44 F;  2E2I F;  4A3L F;  2A68 E;  3H0G F;  4C3I F;  2A69 E;  4XLP E;  4A3E F;  4BY7 F;  1I6H F;  5D4E E;  3HOU F;  4G7Z E;  4A3I F;  5BYH E;  3GTG F;  2NVX F;  5TMF E;  4KN4 E;  2R7Z F;  2R92 F;  2B63 F;  3GTM F;  3HOV F;  1K83 F;  4XSX E;  5FLM F;  3DXJ E;  4ZH4 E;  3GTQ F;  4G7O E;  4BXX F;  3S1N F;  1Y1W F;  3S1M F;  2JA8 F;  2PPB E;  4LK0 E;  5TMC E;  4KMU E;  2JA6 F;  3GTP F;  3S1Q F;  1TWG F;  3I4N F;  1HQM E;  2E2J F;  4A3B F;  5C4X F;  4C3H F;  3EQL E;  1TWH F;  3PO3 F;  2JA7 F;  1IW7 E;  3WOD E;  2VUM F;  3HOX F;  4LK1 E;  5IYC F;  5FJ8 F;  2CW0 E;  2O5I E;  4A3D F;  5D4C E;  4BBS F;  1SMY E;  4A3K F;  4JK1 E;  3CQZ F;  5IP7 F;  1YNJ K;  2A6H E;  4XLN E;  4QIW K;  4OIQ E;  3S2H F;  3K7A F;  2PMZ K;  5IYB F;  1I50 F;  5M3M F;  2KRX A;  2NVQ F;  4C3J F;  5M5W F;  3GTK F;  4LJZ E;  4GZY E;  3PO2 F;  4Y52 F;  3HOY F;  5IP9 F;  4OIP E;  5E18 E;  5IYD F;  5D4D E;  3M3Y F;  2E2H F;  1ZYR E;  5E17 E;  2NVY F;  2NVT F;  2BE5 E;  4OIN E;  2A6E E;  2YU9 F;  3S14 F;  3S16 F;  5C4J F;  4AYB K;  3S15 F;  4A3C F;  4YFK E;  4Q5S E;  4Q4Z E;  4X6A F;  1TWF F;  5IPL E;  4G7H E;  1I6V E;  1TWA F;  4A3F F;  4YFN E;  4A3M F;  1SFO F;  4A3G F;  2Y0S I;  3FKI F;  1TWC F;  4C2M F;  2WAQ K;  2R93 F;  4BBR F;  3RZD F;  4OIO E;  4A3J F;  1WCM F;  3GTL F;  3HOW F;  3S17 F;  3GTO F;  4MEX E;  5M5X F;  5M3F F;  3S1R F;  3M4O F;  4XSZ E;  3GTJ F;  4Y7N F;  3HOZ F;  4A93 F;  1YNN K;  1R9T F;  2WB1 I;  4BY1 F;  5C3E F;  1I3Q F;  1QKL A;  4MQ9 E;  4YFX E;  3S2D F;  5M5Y F;  4MEY E;  2JA5 F;  3H3V G; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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