3GYMI

Structure of prostasin in complex with aprotinin
Total Genus 9
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
9
sequence length
54
structure length
54
Chain Sequence
PDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations.
pubmed doi rcsb
molecule tags Hydrolase/inhibitor
source organism Homo sapiens
molecule keywords Prostasin
total genus 9
structure length 54
sequence length 54
chains with identical sequence J
ec nomenclature
pdb deposition date 2009-04-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 3gymI00
1F5RI 1OA65 3BTEI 1PITA 1P2QB 2ZVXA 6PTIA 2TPII 1AAPA 1BTHP 1QLQA 3TGJI 1BHCA 1ZR0B 3AUHA 1AALA 3BTMI 1P2JI 5JB6A 1T8NB 9PTIA 1LD6A 3U1JE 3P95E 3FP6I 3TPII 3AUIA 1TFXC 1T8LB 1YLDB 2KNTA 5C67C 3L33E 2ODYE 3TGKI 4ISOB 1K6UA 2UUXA 1UUAA 2ZJXA 4ISNB 1TPAI 4DG4C 4WWYC 1EJMB 5PTIA 4Y11I 3M7QB 2FI4I 3D65I 3P92E 4NTXB 2FTMB 1JC6A 2UUYB 4Y10I 1DENA 4PTIA 1NAGA 1D0DA 1FY8I 4NTYB 1JV9A 2J6DA 2TGPI 1BF0A 2KAII 1BUNB 5JB5A 7PTIA 3OTJI 1P2NB 1P2MB 3FP8I 1T7CB 3BTKI 1YC0I 1FANA 2FI3I 2R9PE 3AUGA 1MTND 1P2KI 1FAKI 4ISLB 1Y62A 2DDJA 1DTKA 2M01A 1DTXA 1YLCB 1SHPA 2PTCI 1F7ZI 4BQDA 1P2II 4WXVC 3AUEA 2W8XA 1YKTB 3GYMI 3LDJA 4BNRI 1BPTA 1BTIA 3AUCA 2RA3C 2FTLI 4TPII 3UIRC 2KCRA 1G6XA 3AUDA 4U30W 1IRHA 3WNYA 1KNTA 1CA0D 1T8MB 1D0DB 1BPIA 1KTHA 3OFWA 3TGII 2M99A 1T8OB 3T62D 4DTGK 3UOUB 3LDMA 4NTWB 2LFKA 5JB7A 2FI5I 2HEXA 2CA7A 3BTGI 1EAWB 1CBWD 4Y0YI 1TOCR 1BRCI 1ADZA 1JV8A 1P2OB 1BIKA 3BTFI 8PTIA 3BTQI 3BTHI 1DEMA 2JOTA 1KUNA 3LDIA 3L3TE 1TAPA 2LFLA 1ZJDB 2DDIA 5JB4A 1TAWB 1B0CA 1KIGI 1LD5A 1CO7I 3AUBA 3BTTI 3BYBA 1BZXI 1TCPA 1BRBI 3BTWI 1OA55 1UUBA 4U32X 4BD9B 1BZ5A 2IJOI 3BTDI 3CI7A 3FP7J 4Y0ZI
chains in the Genus database with same CATH superfamily
1F5RI 1OA65 3BTEI 1PITA 1P2QB 2ZVXA 6PTIA 2TPII 1AAPA 1BTHP 1QLQA 3TGJI 1BHCA 1ZR0B 3AUHA 1AALA 3BTMI 1P2JI 5JB6A 1T8NB 9PTIA 1LD6A 3U1JE 3P95E 3FP6I 3TPII 3AUIA 1TFXC 1T8LB 1YLDB 2KNTA 5C67C 3L33E 2ODYE 3TGKI 4ISOB 1K6UA 2UUXA 1UUAA 2ZJXA 4ISNB 1TPAI 4DG4C 4WWYC 1EJMB 5PTIA 4Y11I 3M7QB 2FI4I 3D65I 3P92E 4NTXB 2FTMB 1JC6A 2UUYB 4Y10I 1DENA 4PTIA 1NAGA 1D0DA 1FY8I 4NTYB 1JV9A 2J6DA 2TGPI 1BF0A 2KAII 1BUNB 5JB5A 7PTIA 3OTJI 1P2NB 1P2MB 3FP8I 1T7CB 3BTKI 1YC0I 1FANA 2FI3I 2R9PE 3AUGA 1MTND 1P2KI 1FAKI 4ISLB 1Y62A 2DDJA 1DTKA 2M01A 1DTXA 1YLCB 1SHPA 2PTCI 1F7ZI 4BQDA 1P2II 4WXVC 3AUEA 2W8XA 1YKTB 3GYMI 3LDJA 4BNRI 1BPTA 1BTIA 3AUCA 2RA3C 2FTLI 4TPII 3UIRC 2KCRA 1G6XA 3AUDA 4U30W 1IRHA 3WNYA 1KNTA 1CA0D 1T8MB 1D0DB 1BPIA 1KTHA 3OFWA 3TGII 2M99A 1T8OB 3T62D 4DTGK 3UOUB 3LDMA 4NTWB 2LFKA 5JB7A 2FI5I 2HEXA 2CA7A 3BTGI 1EAWB 1CBWD 4Y0YI 1TOCR 1BRCI 1ADZA 1JV8A 1P2OB 1BIKA 3BTFI 8PTIA 3BTQI 3BTHI 1DEMA 2JOTA 1KUNA 3LDIA 3L3TE 1TAPA 2LFLA 1ZJDB 2DDIA 5JB4A 1TAWB 1B0CA 1KIGI 1LD5A 1CO7I 3AUBA 3BTTI 3BYBA 1BZXI 1TCPA 1BRBI 3BTWI 1OA55 1UUBA 4U32X 4BD9B 1BZ5A 2IJOI 3BTDI 3CI7A 3FP7J 4Y0ZI
chains in the Genus database with same CATH topology
1F5RI 1OA65 3BTEI 1PITA 1P2QB 2ZVXA 6PTIA 2TPII 1AAPA 1BTHP 1QLQA 3TGJI 1BHCA 1ZR0B 3AUHA 1AALA 3BTMI 1P2JI 5JB6A 1T8NB 9PTIA 1LD6A 3U1JE 3P95E 3FP6I 3TPII 3AUIA 1TFXC 1T8LB 1YLDB 2KNTA 5C67C 3L33E 2ODYE 3TGKI 4ISOB 1K6UA 2UUXA 1UUAA 2ZJXA 4ISNB 1TPAI 4DG4C 4WWYC 1EJMB 5PTIA 4Y11I 3M7QB 2FI4I 3D65I 3P92E 4NTXB 2FTMB 1JC6A 2UUYB 4Y10I 1DENA 4PTIA 1NAGA 1D0DA 1FY8I 4NTYB 1JV9A 2J6DA 2TGPI 1BF0A 2KAII 1BUNB 5JB5A 7PTIA 3OTJI 1P2NB 1P2MB 3FP8I 1T7CB 3BTKI 1YC0I 1FANA 2FI3I 2R9PE 3AUGA 1MTND 1P2KI 1FAKI 4ISLB 1Y62A 2DDJA 1DTKA 2M01A 1DTXA 1YLCB 1SHPA 2PTCI 1F7ZI 4BQDA 1P2II 4WXVC 3AUEA 2W8XA 1YKTB 3GYMI 3LDJA 4BNRI 1BPTA 1BTIA 3AUCA 2RA3C 2FTLI 4TPII 3UIRC 2KCRA 1G6XA 3AUDA 4U30W 1IRHA 3WNYA 1KNTA 1CA0D 1T8MB 1D0DB 1BPIA 1KTHA 3OFWA 3TGII 2M99A 1T8OB 3T62D 4DTGK 3UOUB 3LDMA 4NTWB 2LFKA 5JB7A 2FI5I 2HEXA 2CA7A 3BTGI 1EAWB 1CBWD 4Y0YI 1TOCR 1BRCI 1ADZA 1JV8A 1P2OB 1BIKA 3BTFI 8PTIA 3BTQI 3BTHI 1DEMA 2JOTA 1KUNA 3LDIA 3L3TE 1TAPA 2LFLA 1ZJDB 2DDIA 5JB4A 1TAWB 1B0CA 1KIGI 1LD5A 1CO7I 3AUBA 3BTTI 3BYBA 1BZXI 1TCPA 1BRBI 3BTWI 1OA55 1UUBA 4U32X 4BD9B 1BZ5A 2IJOI 3BTDI 3CI7A 3FP7J 4Y0ZI
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1F5R I;  1OA6 5;  3BTE I;  1PIT A;  1P2Q B;  2ZVX A;  6PTI A;  2TPI I;  1AAP A;  1BTH P;  1QLQ A;  3TGJ I;  1BHC A;  1ZR0 B;  3AUH A;  1AAL A;  3BTM I;  1P2J I;  5JB6 A;  1T8N B;  9PTI A;  1LD6 A;  3U1J E;  3P95 E;  3FP6 I;  3TPI I;  3AUI A;  1TFX C;  1T8L B;  1YLD B;  2KNT A;  5C67 C;  3L33 E;  2ODY E;  3TGK I;  4ISO B;  1K6U A;  2UUX A;  1UUA A;  2ZJX A;  4ISN B;  1TPA I;  4DG4 C;  4WWY C;  1EJM B;  5PTI A;  4Y11 I;  3M7Q B;  2FI4 I;  3D65 I;  3P92 E;  4NTX B;  2FTM B;  1JC6 A;  2UUY B;  4Y10 I;  1DEN A;  4PTI A;  1NAG A;  1D0D A;  1FY8 I;  4NTY B;  1JV9 A;  2J6D A;  2TGP I;  1BF0 A;  2KAI I;  1BUN B;  5JB5 A;  7PTI A;  3OTJ I;  1P2N B;  1P2M B;  3FP8 I;  1T7C B;  3BTK I;  1YC0 I;  1FAN A;  2FI3 I;  2R9P E;  3AUG A;  1MTN D;  1P2K I;  1FAK I;  4ISL B;  1Y62 A;  2DDJ A;  1DTK A;  2M01 A;  1DTX A;  1YLC B;  1SHP A;  2PTC I;  1F7Z I;  4BQD A;  1P2I I;  4WXV C;  3AUE A;  2W8X A;  1YKT B;  3GYM I;  3LDJ A;  4BNR I;  1BPT A;  1BTI A;  3AUC A;  2RA3 C;  2FTL I;  4TPI I;  3UIR C;  2KCR A;  1G6X A;  3AUD A;  4U30 W;  1IRH A;  3WNY A;  1KNT A;  1CA0 D;  1T8M B;  1D0D B;  1BPI A;  1KTH A;  3OFW A;  3TGI I;  2M99 A;  1T8O B;  3T62 D;  4DTG K;  3UOU B;  3LDM A;  4NTW B;  2LFK A;  5JB7 A;  2FI5 I;  2HEX A;  2CA7 A;  3BTG I;  1EAW B;  1CBW D;  4Y0Y I;  1TOC R;  1BRC I;  1ADZ A;  1JV8 A;  1P2O B;  1BIK A;  3BTF I;  8PTI A;  3BTQ I;  3BTH I;  1DEM A;  2JOT A;  1KUN A;  3LDI A;  3L3T E;  1TAP A;  2LFL A;  1ZJD B;  2DDI A;  5JB4 A;  1TAW B;  1B0C A;  1KIG I;  1LD5 A;  1CO7 I;  3AUB A;  3BTT I;  3BYB A;  1BZX I;  1TCP A;  1BRB I;  3BTW I;  1OA5 5;  1UUB A;  4U32 X;  4BD9 B;  1BZ5 A;  2IJO I;  3BTD I;  3CI7 A;  3FP7 J;  4Y0Z I; 
#chains in the Genus database with same CATH topology
 1F5R I;  1OA6 5;  3BTE I;  1PIT A;  1P2Q B;  2ZVX A;  6PTI A;  2TPI I;  1AAP A;  1BTH P;  1QLQ A;  3TGJ I;  1BHC A;  1ZR0 B;  3AUH A;  1AAL A;  3BTM I;  1P2J I;  5JB6 A;  1T8N B;  9PTI A;  1LD6 A;  3U1J E;  3P95 E;  3FP6 I;  3TPI I;  3AUI A;  1TFX C;  1T8L B;  1YLD B;  2KNT A;  5C67 C;  3L33 E;  2ODY E;  3TGK I;  4ISO B;  1K6U A;  2UUX A;  1UUA A;  2ZJX A;  4ISN B;  1TPA I;  4DG4 C;  4WWY C;  1EJM B;  5PTI A;  4Y11 I;  3M7Q B;  2FI4 I;  3D65 I;  3P92 E;  4NTX B;  2FTM B;  1JC6 A;  2UUY B;  4Y10 I;  1DEN A;  4PTI A;  1NAG A;  1D0D A;  1FY8 I;  4NTY B;  1JV9 A;  2J6D A;  2TGP I;  1BF0 A;  2KAI I;  1BUN B;  5JB5 A;  7PTI A;  3OTJ I;  1P2N B;  1P2M B;  3FP8 I;  1T7C B;  3BTK I;  1YC0 I;  1FAN A;  2FI3 I;  2R9P E;  3AUG A;  1MTN D;  1P2K I;  1FAK I;  4ISL B;  1Y62 A;  2DDJ A;  1DTK A;  2M01 A;  1DTX A;  1YLC B;  1SHP A;  2PTC I;  1F7Z I;  4BQD A;  1P2I I;  4WXV C;  3AUE A;  2W8X A;  1YKT B;  3GYM I;  3LDJ A;  4BNR I;  1BPT A;  1BTI A;  3AUC A;  2RA3 C;  2FTL I;  4TPI I;  3UIR C;  2KCR A;  1G6X A;  3AUD A;  4U30 W;  1IRH A;  3WNY A;  1KNT A;  1CA0 D;  1T8M B;  1D0D B;  1BPI A;  1KTH A;  3OFW A;  3TGI I;  2M99 A;  1T8O B;  3T62 D;  4DTG K;  3UOU B;  3LDM A;  4NTW B;  2LFK A;  5JB7 A;  2FI5 I;  2HEX A;  2CA7 A;  3BTG I;  1EAW B;  1CBW D;  4Y0Y I;  1TOC R;  1BRC I;  1ADZ A;  1JV8 A;  1P2O B;  1BIK A;  3BTF I;  8PTI A;  3BTQ I;  3BTH I;  1DEM A;  2JOT A;  1KUN A;  3LDI A;  3L3T E;  1TAP A;  2LFL A;  1ZJD B;  2DDI A;  5JB4 A;  1TAW B;  1B0C A;  1KIG I;  1LD5 A;  1CO7 I;  3AUB A;  3BTT I;  3BYB A;  1BZX I;  1TCP A;  1BRB I;  3BTW I;  1OA5 5;  1UUB A;  4U32 X;  4BD9 B;  1BZ5 A;  2IJO I;  3BTD I;  3CI7 A;  3FP7 J;  4Y0Z I; 
#chains in the Genus database with same CATH homology
 1F5R I;  1OA6 5;  3BTE I;  1PIT A;  1P2Q B;  2ZVX A;  6PTI A;  2TPI I;  1AAP A;  1BTH P;  1QLQ A;  3TGJ I;  1BHC A;  1ZR0 B;  3AUH A;  1AAL A;  3BTM I;  1P2J I;  5JB6 A;  1T8N B;  9PTI A;  1LD6 A;  3U1J E;  3P95 E;  3FP6 I;  3TPI I;  3AUI A;  1TFX C;  1T8L B;  1YLD B;  2KNT A;  5C67 C;  3L33 E;  2ODY E;  3TGK I;  4ISO B;  1K6U A;  2UUX A;  1UUA A;  2ZJX A;  4ISN B;  1TPA I;  4DG4 C;  4WWY C;  1EJM B;  5PTI A;  4Y11 I;  3M7Q B;  2FI4 I;  3D65 I;  3P92 E;  4NTX B;  2FTM B;  1JC6 A;  2UUY B;  4Y10 I;  1DEN A;  4PTI A;  1NAG A;  1D0D A;  1FY8 I;  4NTY B;  1JV9 A;  2J6D A;  2TGP I;  1BF0 A;  2KAI I;  1BUN B;  5JB5 A;  7PTI A;  3OTJ I;  1P2N B;  1P2M B;  3FP8 I;  1T7C B;  3BTK I;  1YC0 I;  1FAN A;  2FI3 I;  2R9P E;  3AUG A;  1MTN D;  1P2K I;  1FAK I;  4ISL B;  1Y62 A;  2DDJ A;  1DTK A;  2M01 A;  1DTX A;  1YLC B;  1SHP A;  2PTC I;  1F7Z I;  4BQD A;  1P2I I;  4WXV C;  3AUE A;  2W8X A;  1YKT B;  3GYM I;  3LDJ A;  4BNR I;  1BPT A;  1BTI A;  3AUC A;  2RA3 C;  2FTL I;  4TPI I;  3UIR C;  2KCR A;  1G6X A;  3AUD A;  4U30 W;  1IRH A;  3WNY A;  1KNT A;  1CA0 D;  1T8M B;  1D0D B;  1BPI A;  1KTH A;  3OFW A;  3TGI I;  2M99 A;  1T8O B;  3T62 D;  4DTG K;  3UOU B;  3LDM A;  4NTW B;  2LFK A;  5JB7 A;  2FI5 I;  2HEX A;  2CA7 A;  3BTG I;  1EAW B;  1CBW D;  4Y0Y I;  1TOC R;  1BRC I;  1ADZ A;  1JV8 A;  1P2O B;  1BIK A;  3BTF I;  8PTI A;  3BTQ I;  3BTH I;  1DEM A;  2JOT A;  1KUN A;  3LDI A;  3L3T E;  1TAP A;  2LFL A;  1ZJD B;  2DDI A;  5JB4 A;  1TAW B;  1B0C A;  1KIG I;  1LD5 A;  1CO7 I;  3AUB A;  3BTT I;  3BYB A;  1BZX I;  1TCP A;  1BRB I;  3BTW I;  1OA5 5;  1UUB A;  4U32 X;  4BD9 B;  1BZ5 A;  2IJO I;  3BTD I;  3CI7 A;  3FP7 J;  4Y0Z I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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