3L33E

Human mesotrypsin complexed with amyloid precursor protein inhibitor(appi)
Total Genus 8
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
8
sequence length
52
structure length
52
Chain Sequence
VCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Determinants of affinity and proteolytic stability in interactions of Kunitz family protease inhibitors with mesotrypsin.
pubmed doi rcsb
molecule tags Hydrolase/cell adhesion
source organism Homo sapiens
molecule keywords Trypsin-3
total genus 8
structure length 52
sequence length 52
chains with identical sequence F, G, H
ec nomenclature
pdb deposition date 2009-12-16
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 3l33E00
2TPII 2JOTA 1T7CB 1AAPA 1P2NB 4ISOB 2J6DA 1DENA 5JB4A 1TPAI 1BZ5A 3OTJI 4U30W 1TOCR 1F5RI 1BTHP 2ZVXA 3BTTI 1LD6A 2FTLI 7PTIA 3FP8I 1ADZA 1P2QB 3TGKI 1EAWB 2R9PE 3UOUB 9PTIA 1T8MB 3BYBA 6PTIA 3GYMI 3BTMI 2KNTA 1LD5A 3BTEI 2ZJXA 3TPII 1CA0D 3CI7A 1TAPA 3BTGI 1FY8I 1UUAA 2KCRA 1D0DA 4DG4C 3P92E 4Y11I 1TAWB 3AUIA 2DDIA 3AUHA 1TFXC 3AUDA 8PTIA 1DTKA 4Y0ZI 1JC6A 2M99A 3BTQI 1ZR0B 1TCPA 1FANA 3LDMA 3AUCA 3BTFI 1JV9A 3FP7J 2CA7A 4Y0YI 5PTIA 1F7ZI 1BTIA 4NTWB 1T8NB 3T62D 1CBWD 1K6UA 1KUNA 2FTMB 1IRHA 1B0CA 3UIRC 2M01A 1BRCI 5JB7A 3AUEA 1KNTA 3FP6I 2UUXA 2FI5I 3D65I 1AALA 1OA55 1BHCA 2FI3I 4PTIA 1P2KI 1YKTB 1P2JI 1G6XA 3BTHI 1OA65 2TGPI 3M7QB 1BF0A 4DTGK 2PTCI 1T8LB 4ISNB 2DDJA 2W8XA 5JB5A 2ODYE 1BUNB 3U1JE 4BD9B 1QLQA 3AUBA 1JV8A 1Y62A 1DEMA 2LFKA 3AUGA 3LDIA 4U32X 5C67C 2HEXA 1BIKA 2LFLA 2IJOI 1SHPA 4TPII 2UUYB 4WWYC 1P2MB 1BRBI 1BZXI 3WNYA 3TGJI 1KIGI 1UUBA 2KAII 3P95E 1EJMB 4Y10I 3LDJA 1YLCB 1NAGA 1ZJDB 4BNRI 3BTDI 5JB6A 1DTXA 4WXVC 4NTYB 1FAKI 1KTHA 4NTXB 4BQDA 3L33E 1P2II 3BTKI 3OFWA 2FI4I 2RA3C 1YLDB 1PITA 1T8OB 1BPTA 1BPIA 1CO7I 1YC0I 1D0DB 3BTWI 1MTND 3TGII 4ISLB 3L3TE 1P2OB
chains in the Genus database with same CATH superfamily
2TPII 2JOTA 1T7CB 1AAPA 1P2NB 4ISOB 2J6DA 1DENA 5JB4A 1TPAI 1BZ5A 3OTJI 4U30W 1TOCR 1F5RI 1BTHP 2ZVXA 3BTTI 1LD6A 2FTLI 7PTIA 3FP8I 1ADZA 1P2QB 3TGKI 1EAWB 2R9PE 3UOUB 9PTIA 1T8MB 3BYBA 6PTIA 3GYMI 3BTMI 2KNTA 1LD5A 3BTEI 2ZJXA 3TPII 1CA0D 3CI7A 1TAPA 3BTGI 1FY8I 1UUAA 2KCRA 1D0DA 4DG4C 3P92E 4Y11I 1TAWB 3AUIA 2DDIA 3AUHA 1TFXC 3AUDA 8PTIA 1DTKA 4Y0ZI 1JC6A 2M99A 3BTQI 1ZR0B 1TCPA 1FANA 3LDMA 3AUCA 3BTFI 1JV9A 3FP7J 2CA7A 4Y0YI 5PTIA 1F7ZI 1BTIA 4NTWB 1T8NB 3T62D 1CBWD 1K6UA 1KUNA 2FTMB 1IRHA 1B0CA 3UIRC 2M01A 1BRCI 5JB7A 3AUEA 1KNTA 3FP6I 2UUXA 2FI5I 3D65I 1AALA 1OA55 1BHCA 2FI3I 4PTIA 1P2KI 1YKTB 1P2JI 1G6XA 3BTHI 1OA65 2TGPI 3M7QB 1BF0A 4DTGK 2PTCI 1T8LB 4ISNB 2DDJA 2W8XA 5JB5A 2ODYE 1BUNB 3U1JE 4BD9B 1QLQA 3AUBA 1JV8A 1Y62A 1DEMA 2LFKA 3AUGA 3LDIA 4U32X 5C67C 2HEXA 1BIKA 2LFLA 2IJOI 1SHPA 4TPII 2UUYB 4WWYC 1P2MB 1BRBI 1BZXI 3WNYA 3TGJI 1KIGI 1UUBA 2KAII 3P95E 1EJMB 4Y10I 3LDJA 1YLCB 1NAGA 1ZJDB 4BNRI 3BTDI 5JB6A 1DTXA 4WXVC 4NTYB 1FAKI 1KTHA 4NTXB 4BQDA 3L33E 1P2II 3BTKI 3OFWA 2FI4I 2RA3C 1YLDB 1PITA 1T8OB 1BPTA 1BPIA 1CO7I 1YC0I 1D0DB 3BTWI 1MTND 3TGII 4ISLB 3L3TE 1P2OB
chains in the Genus database with same CATH topology
2TPII 2JOTA 1T7CB 1AAPA 1P2NB 4ISOB 2J6DA 1DENA 5JB4A 1TPAI 1BZ5A 3OTJI 4U30W 1TOCR 1F5RI 1BTHP 2ZVXA 3BTTI 1LD6A 2FTLI 7PTIA 3FP8I 1ADZA 1P2QB 3TGKI 1EAWB 2R9PE 3UOUB 9PTIA 1T8MB 3BYBA 6PTIA 3GYMI 3BTMI 2KNTA 1LD5A 3BTEI 2ZJXA 3TPII 1CA0D 3CI7A 1TAPA 3BTGI 1FY8I 1UUAA 2KCRA 1D0DA 4DG4C 3P92E 4Y11I 1TAWB 3AUIA 2DDIA 3AUHA 1TFXC 3AUDA 8PTIA 1DTKA 4Y0ZI 1JC6A 2M99A 3BTQI 1ZR0B 1TCPA 1FANA 3LDMA 3AUCA 3BTFI 1JV9A 3FP7J 2CA7A 4Y0YI 5PTIA 1F7ZI 1BTIA 4NTWB 1T8NB 3T62D 1CBWD 1K6UA 1KUNA 2FTMB 1IRHA 1B0CA 3UIRC 2M01A 1BRCI 5JB7A 3AUEA 1KNTA 3FP6I 2UUXA 2FI5I 3D65I 1AALA 1OA55 1BHCA 2FI3I 4PTIA 1P2KI 1YKTB 1P2JI 1G6XA 3BTHI 1OA65 2TGPI 3M7QB 1BF0A 4DTGK 2PTCI 1T8LB 4ISNB 2DDJA 2W8XA 5JB5A 2ODYE 1BUNB 3U1JE 4BD9B 1QLQA 3AUBA 1JV8A 1Y62A 1DEMA 2LFKA 3AUGA 3LDIA 4U32X 5C67C 2HEXA 1BIKA 2LFLA 2IJOI 1SHPA 4TPII 2UUYB 4WWYC 1P2MB 1BRBI 1BZXI 3WNYA 3TGJI 1KIGI 1UUBA 2KAII 3P95E 1EJMB 4Y10I 3LDJA 1YLCB 1NAGA 1ZJDB 4BNRI 3BTDI 5JB6A 1DTXA 4WXVC 4NTYB 1FAKI 1KTHA 4NTXB 4BQDA 3L33E 1P2II 3BTKI 3OFWA 2FI4I 2RA3C 1YLDB 1PITA 1T8OB 1BPTA 1BPIA 1CO7I 1YC0I 1D0DB 3BTWI 1MTND 3TGII 4ISLB 3L3TE 1P2OB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2TPI I;  2JOT A;  1T7C B;  1AAP A;  1P2N B;  4ISO B;  2J6D A;  1DEN A;  5JB4 A;  1TPA I;  1BZ5 A;  3OTJ I;  4U30 W;  1TOC R;  1F5R I;  1BTH P;  2ZVX A;  3BTT I;  1LD6 A;  2FTL I;  7PTI A;  3FP8 I;  1ADZ A;  1P2Q B;  3TGK I;  1EAW B;  2R9P E;  3UOU B;  9PTI A;  1T8M B;  3BYB A;  6PTI A;  3GYM I;  3BTM I;  2KNT A;  1LD5 A;  3BTE I;  2ZJX A;  3TPI I;  1CA0 D;  3CI7 A;  1TAP A;  3BTG I;  1FY8 I;  1UUA A;  2KCR A;  1D0D A;  4DG4 C;  3P92 E;  4Y11 I;  1TAW B;  3AUI A;  2DDI A;  3AUH A;  1TFX C;  3AUD A;  8PTI A;  1DTK A;  4Y0Z I;  1JC6 A;  2M99 A;  3BTQ I;  1ZR0 B;  1TCP A;  1FAN A;  3LDM A;  3AUC A;  3BTF I;  1JV9 A;  3FP7 J;  2CA7 A;  4Y0Y I;  5PTI A;  1F7Z I;  1BTI A;  4NTW B;  1T8N B;  3T62 D;  1CBW D;  1K6U A;  1KUN A;  2FTM B;  1IRH A;  1B0C A;  3UIR C;  2M01 A;  1BRC I;  5JB7 A;  3AUE A;  1KNT A;  3FP6 I;  2UUX A;  2FI5 I;  3D65 I;  1AAL A;  1OA5 5;  1BHC A;  2FI3 I;  4PTI A;  1P2K I;  1YKT B;  1P2J I;  1G6X A;  3BTH I;  1OA6 5;  2TGP I;  3M7Q B;  1BF0 A;  4DTG K;  2PTC I;  1T8L B;  4ISN B;  2DDJ A;  2W8X A;  5JB5 A;  2ODY E;  1BUN B;  3U1J E;  4BD9 B;  1QLQ A;  3AUB A;  1JV8 A;  1Y62 A;  1DEM A;  2LFK A;  3AUG A;  3LDI A;  4U32 X;  5C67 C;  2HEX A;  1BIK A;  2LFL A;  2IJO I;  1SHP A;  4TPI I;  2UUY B;  4WWY C;  1P2M B;  1BRB I;  1BZX I;  3WNY A;  3TGJ I;  1KIG I;  1UUB A;  2KAI I;  3P95 E;  1EJM B;  4Y10 I;  3LDJ A;  1YLC B;  1NAG A;  1ZJD B;  4BNR I;  3BTD I;  5JB6 A;  1DTX A;  4WXV C;  4NTY B;  1FAK I;  1KTH A;  4NTX B;  4BQD A;  3L33 E;  1P2I I;  3BTK I;  3OFW A;  2FI4 I;  2RA3 C;  1YLD B;  1PIT A;  1T8O B;  1BPT A;  1BPI A;  1CO7 I;  1YC0 I;  1D0D B;  3BTW I;  1MTN D;  3TGI I;  4ISL B;  3L3T E;  1P2O B; 
#chains in the Genus database with same CATH topology
 2TPI I;  2JOT A;  1T7C B;  1AAP A;  1P2N B;  4ISO B;  2J6D A;  1DEN A;  5JB4 A;  1TPA I;  1BZ5 A;  3OTJ I;  4U30 W;  1TOC R;  1F5R I;  1BTH P;  2ZVX A;  3BTT I;  1LD6 A;  2FTL I;  7PTI A;  3FP8 I;  1ADZ A;  1P2Q B;  3TGK I;  1EAW B;  2R9P E;  3UOU B;  9PTI A;  1T8M B;  3BYB A;  6PTI A;  3GYM I;  3BTM I;  2KNT A;  1LD5 A;  3BTE I;  2ZJX A;  3TPI I;  1CA0 D;  3CI7 A;  1TAP A;  3BTG I;  1FY8 I;  1UUA A;  2KCR A;  1D0D A;  4DG4 C;  3P92 E;  4Y11 I;  1TAW B;  3AUI A;  2DDI A;  3AUH A;  1TFX C;  3AUD A;  8PTI A;  1DTK A;  4Y0Z I;  1JC6 A;  2M99 A;  3BTQ I;  1ZR0 B;  1TCP A;  1FAN A;  3LDM A;  3AUC A;  3BTF I;  1JV9 A;  3FP7 J;  2CA7 A;  4Y0Y I;  5PTI A;  1F7Z I;  1BTI A;  4NTW B;  1T8N B;  3T62 D;  1CBW D;  1K6U A;  1KUN A;  2FTM B;  1IRH A;  1B0C A;  3UIR C;  2M01 A;  1BRC I;  5JB7 A;  3AUE A;  1KNT A;  3FP6 I;  2UUX A;  2FI5 I;  3D65 I;  1AAL A;  1OA5 5;  1BHC A;  2FI3 I;  4PTI A;  1P2K I;  1YKT B;  1P2J I;  1G6X A;  3BTH I;  1OA6 5;  2TGP I;  3M7Q B;  1BF0 A;  4DTG K;  2PTC I;  1T8L B;  4ISN B;  2DDJ A;  2W8X A;  5JB5 A;  2ODY E;  1BUN B;  3U1J E;  4BD9 B;  1QLQ A;  3AUB A;  1JV8 A;  1Y62 A;  1DEM A;  2LFK A;  3AUG A;  3LDI A;  4U32 X;  5C67 C;  2HEX A;  1BIK A;  2LFL A;  2IJO I;  1SHP A;  4TPI I;  2UUY B;  4WWY C;  1P2M B;  1BRB I;  1BZX I;  3WNY A;  3TGJ I;  1KIG I;  1UUB A;  2KAI I;  3P95 E;  1EJM B;  4Y10 I;  3LDJ A;  1YLC B;  1NAG A;  1ZJD B;  4BNR I;  3BTD I;  5JB6 A;  1DTX A;  4WXV C;  4NTY B;  1FAK I;  1KTH A;  4NTX B;  4BQD A;  3L33 E;  1P2I I;  3BTK I;  3OFW A;  2FI4 I;  2RA3 C;  1YLD B;  1PIT A;  1T8O B;  1BPT A;  1BPI A;  1CO7 I;  1YC0 I;  1D0D B;  3BTW I;  1MTN D;  3TGI I;  4ISL B;  3L3T E;  1P2O B; 
#chains in the Genus database with same CATH homology
 2TPI I;  2JOT A;  1T7C B;  1AAP A;  1P2N B;  4ISO B;  2J6D A;  1DEN A;  5JB4 A;  1TPA I;  1BZ5 A;  3OTJ I;  4U30 W;  1TOC R;  1F5R I;  1BTH P;  2ZVX A;  3BTT I;  1LD6 A;  2FTL I;  7PTI A;  3FP8 I;  1ADZ A;  1P2Q B;  3TGK I;  1EAW B;  2R9P E;  3UOU B;  9PTI A;  1T8M B;  3BYB A;  6PTI A;  3GYM I;  3BTM I;  2KNT A;  1LD5 A;  3BTE I;  2ZJX A;  3TPI I;  1CA0 D;  3CI7 A;  1TAP A;  3BTG I;  1FY8 I;  1UUA A;  2KCR A;  1D0D A;  4DG4 C;  3P92 E;  4Y11 I;  1TAW B;  3AUI A;  2DDI A;  3AUH A;  1TFX C;  3AUD A;  8PTI A;  1DTK A;  4Y0Z I;  1JC6 A;  2M99 A;  3BTQ I;  1ZR0 B;  1TCP A;  1FAN A;  3LDM A;  3AUC A;  3BTF I;  1JV9 A;  3FP7 J;  2CA7 A;  4Y0Y I;  5PTI A;  1F7Z I;  1BTI A;  4NTW B;  1T8N B;  3T62 D;  1CBW D;  1K6U A;  1KUN A;  2FTM B;  1IRH A;  1B0C A;  3UIR C;  2M01 A;  1BRC I;  5JB7 A;  3AUE A;  1KNT A;  3FP6 I;  2UUX A;  2FI5 I;  3D65 I;  1AAL A;  1OA5 5;  1BHC A;  2FI3 I;  4PTI A;  1P2K I;  1YKT B;  1P2J I;  1G6X A;  3BTH I;  1OA6 5;  2TGP I;  3M7Q B;  1BF0 A;  4DTG K;  2PTC I;  1T8L B;  4ISN B;  2DDJ A;  2W8X A;  5JB5 A;  2ODY E;  1BUN B;  3U1J E;  4BD9 B;  1QLQ A;  3AUB A;  1JV8 A;  1Y62 A;  1DEM A;  2LFK A;  3AUG A;  3LDI A;  4U32 X;  5C67 C;  2HEX A;  1BIK A;  2LFL A;  2IJO I;  1SHP A;  4TPI I;  2UUY B;  4WWY C;  1P2M B;  1BRB I;  1BZX I;  3WNY A;  3TGJ I;  1KIG I;  1UUB A;  2KAI I;  3P95 E;  1EJM B;  4Y10 I;  3LDJ A;  1YLC B;  1NAG A;  1ZJD B;  4BNR I;  3BTD I;  5JB6 A;  1DTX A;  4WXV C;  4NTY B;  1FAK I;  1KTH A;  4NTX B;  4BQD A;  3L33 E;  1P2I I;  3BTK I;  3OFW A;  2FI4 I;  2RA3 C;  1YLD B;  1PIT A;  1T8O B;  1BPT A;  1BPI A;  1CO7 I;  1YC0 I;  1D0D B;  3BTW I;  1MTN D;  3TGI I;  4ISL B;  3L3T E;  1P2O B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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