3L3TE

Human mesotrypsin complexed with amyloid precursor protein inhibitor variant (appir15k)
Total Genus 9
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
9
sequence length
57
structure length
57
Chain Sequence
EVCSEQAETGPCKAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Determinants of affinity and proteolytic stability in interactions of Kunitz family protease inhibitors with mesotrypsin.
pubmed doi rcsb
molecule tags Hydrolase/cell adhesion
source organism Homo sapiens
molecule keywords PRSS3 protein
total genus 9
structure length 57
sequence length 57
chains with identical sequence F, G, H
ec nomenclature
pdb deposition date 2009-12-17
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 3l3tE00
3BTQI 4BD9B 2JOTA 1BZ5A 3BYBA 1D0DB 2CA7A 2TPII 1SHPA 1CO7I 3T62D 1P2NB 1YKTB 1TPAI 1LD6A 3LDMA 4Y0YI 4U32X 2DDIA 7PTIA 5JB6A 3P92E 1ZR0B 1BTHP 3AUCA 4PTIA 1B0CA 4WXVC 1UUBA 4ISLB 1JV9A 2LFKA 1TOCR 3BTMI 4NTXB 1BTIA 2RA3C 5JB4A 1OA65 3BTTI 4U30W 3P95E 2J6DA 1CA0D 3BTWI 1KTHA 1BUNB 3OFWA 3TGII 3LDIA 2FTLI 2M01A 2KAII 1QLQA 3BTFI 1UUAA 4Y10I 3AUIA 3AUDA 3UOUB 3BTHI 3FP6I 2ZJXA 3UIRC 4BNRI 3AUBA 4NTYB 3BTDI 1BPIA 1TAWB 2IJOI 1BZXI 3D65I 1LD5A 3LDJA 1KNTA 1BF0A 1TAPA 2FI3I 2HEXA 4DG4C 1P2OB 2DDJA 3FP7J 2PTCI 1BRCI 3BTEI 5PTIA 1P2QB 4ISOB 1YLDB 1EJMB 1KIGI 1DTXA 3L3TE 3CI7A 1T7CB 2W8XA 2ZVXA 1Y62A 3GYMI 1T8LB 2FI5I 2UUYB 3BTGI 4Y11I 1EAWB 2KCRA 6PTIA 2M99A 1F7ZI 4TPII 1FY8I 2LFLA 9PTIA 1G6XA 1NAGA 1P2JI 2R9PE 1TFXC 2TGPI 4ISNB 1JV8A 1FANA 1KUNA 1F5RI 3TPII 3AUHA 4WWYC 5JB5A 1YC0I 1DEMA 1TCPA 3M7QB 3U1JE 3FP8I 1BIKA 1P2MB 3TGKI 3TGJI 1P2II 8PTIA 1JC6A 2FTMB 3AUEA 4Y0ZI 1P2KI 4BQDA 1K6UA 1DENA 3WNYA 1T8OB 1AALA 1BHCA 1T8NB 4NTWB 1PITA 1ADZA 1DTKA 3L33E 1FAKI 2UUXA 5C67C 1YLCB 2KNTA 1MTND 1ZJDB 3OTJI 2FI4I 1IRHA 1OA55 1BPTA 2ODYE 1T8MB 5JB7A 1D0DA 1AAPA 1CBWD 1BRBI 3AUGA 4DTGK 3BTKI
chains in the Genus database with same CATH superfamily
3BTQI 4BD9B 2JOTA 1BZ5A 3BYBA 1D0DB 2CA7A 2TPII 1SHPA 1CO7I 3T62D 1P2NB 1YKTB 1TPAI 1LD6A 3LDMA 4Y0YI 4U32X 2DDIA 7PTIA 5JB6A 3P92E 1ZR0B 1BTHP 3AUCA 4PTIA 1B0CA 4WXVC 1UUBA 4ISLB 1JV9A 2LFKA 1TOCR 3BTMI 4NTXB 1BTIA 2RA3C 5JB4A 1OA65 3BTTI 4U30W 3P95E 2J6DA 1CA0D 3BTWI 1KTHA 1BUNB 3OFWA 3TGII 3LDIA 2FTLI 2M01A 2KAII 1QLQA 3BTFI 1UUAA 4Y10I 3AUIA 3AUDA 3UOUB 3BTHI 3FP6I 2ZJXA 3UIRC 4BNRI 3AUBA 4NTYB 3BTDI 1BPIA 1TAWB 2IJOI 1BZXI 3D65I 1LD5A 3LDJA 1KNTA 1BF0A 1TAPA 2FI3I 2HEXA 4DG4C 1P2OB 2DDJA 3FP7J 2PTCI 1BRCI 3BTEI 5PTIA 1P2QB 4ISOB 1YLDB 1EJMB 1KIGI 1DTXA 3L3TE 3CI7A 1T7CB 2W8XA 2ZVXA 1Y62A 3GYMI 1T8LB 2FI5I 2UUYB 3BTGI 4Y11I 1EAWB 2KCRA 6PTIA 2M99A 1F7ZI 4TPII 1FY8I 2LFLA 9PTIA 1G6XA 1NAGA 1P2JI 2R9PE 1TFXC 2TGPI 4ISNB 1JV8A 1FANA 1KUNA 1F5RI 3TPII 3AUHA 4WWYC 5JB5A 1YC0I 1DEMA 1TCPA 3M7QB 3U1JE 3FP8I 1BIKA 1P2MB 3TGKI 3TGJI 1P2II 8PTIA 1JC6A 2FTMB 3AUEA 4Y0ZI 1P2KI 4BQDA 1K6UA 1DENA 3WNYA 1T8OB 1AALA 1BHCA 1T8NB 4NTWB 1PITA 1ADZA 1DTKA 3L33E 1FAKI 2UUXA 5C67C 1YLCB 2KNTA 1MTND 1ZJDB 3OTJI 2FI4I 1IRHA 1OA55 1BPTA 2ODYE 1T8MB 5JB7A 1D0DA 1AAPA 1CBWD 1BRBI 3AUGA 4DTGK 3BTKI
chains in the Genus database with same CATH topology
3BTQI 4BD9B 2JOTA 1BZ5A 3BYBA 1D0DB 2CA7A 2TPII 1SHPA 1CO7I 3T62D 1P2NB 1YKTB 1TPAI 1LD6A 3LDMA 4Y0YI 4U32X 2DDIA 7PTIA 5JB6A 3P92E 1ZR0B 1BTHP 3AUCA 4PTIA 1B0CA 4WXVC 1UUBA 4ISLB 1JV9A 2LFKA 1TOCR 3BTMI 4NTXB 1BTIA 2RA3C 5JB4A 1OA65 3BTTI 4U30W 3P95E 2J6DA 1CA0D 3BTWI 1KTHA 1BUNB 3OFWA 3TGII 3LDIA 2FTLI 2M01A 2KAII 1QLQA 3BTFI 1UUAA 4Y10I 3AUIA 3AUDA 3UOUB 3BTHI 3FP6I 2ZJXA 3UIRC 4BNRI 3AUBA 4NTYB 3BTDI 1BPIA 1TAWB 2IJOI 1BZXI 3D65I 1LD5A 3LDJA 1KNTA 1BF0A 1TAPA 2FI3I 2HEXA 4DG4C 1P2OB 2DDJA 3FP7J 2PTCI 1BRCI 3BTEI 5PTIA 1P2QB 4ISOB 1YLDB 1EJMB 1KIGI 1DTXA 3L3TE 3CI7A 1T7CB 2W8XA 2ZVXA 1Y62A 3GYMI 1T8LB 2FI5I 2UUYB 3BTGI 4Y11I 1EAWB 2KCRA 6PTIA 2M99A 1F7ZI 4TPII 1FY8I 2LFLA 9PTIA 1G6XA 1NAGA 1P2JI 2R9PE 1TFXC 2TGPI 4ISNB 1JV8A 1FANA 1KUNA 1F5RI 3TPII 3AUHA 4WWYC 5JB5A 1YC0I 1DEMA 1TCPA 3M7QB 3U1JE 3FP8I 1BIKA 1P2MB 3TGKI 3TGJI 1P2II 8PTIA 1JC6A 2FTMB 3AUEA 4Y0ZI 1P2KI 4BQDA 1K6UA 1DENA 3WNYA 1T8OB 1AALA 1BHCA 1T8NB 4NTWB 1PITA 1ADZA 1DTKA 3L33E 1FAKI 2UUXA 5C67C 1YLCB 2KNTA 1MTND 1ZJDB 3OTJI 2FI4I 1IRHA 1OA55 1BPTA 2ODYE 1T8MB 5JB7A 1D0DA 1AAPA 1CBWD 1BRBI 3AUGA 4DTGK 3BTKI
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BTQ I;  4BD9 B;  2JOT A;  1BZ5 A;  3BYB A;  1D0D B;  2CA7 A;  2TPI I;  1SHP A;  1CO7 I;  3T62 D;  1P2N B;  1YKT B;  1TPA I;  1LD6 A;  3LDM A;  4Y0Y I;  4U32 X;  2DDI A;  7PTI A;  5JB6 A;  3P92 E;  1ZR0 B;  1BTH P;  3AUC A;  4PTI A;  1B0C A;  4WXV C;  1UUB A;  4ISL B;  1JV9 A;  2LFK A;  1TOC R;  3BTM I;  4NTX B;  1BTI A;  2RA3 C;  5JB4 A;  1OA6 5;  3BTT I;  4U30 W;  3P95 E;  2J6D A;  1CA0 D;  3BTW I;  1KTH A;  1BUN B;  3OFW A;  3TGI I;  3LDI A;  2FTL I;  2M01 A;  2KAI I;  1QLQ A;  3BTF I;  1UUA A;  4Y10 I;  3AUI A;  3AUD A;  3UOU B;  3BTH I;  3FP6 I;  2ZJX A;  3UIR C;  4BNR I;  3AUB A;  4NTY B;  3BTD I;  1BPI A;  1TAW B;  2IJO I;  1BZX I;  3D65 I;  1LD5 A;  3LDJ A;  1KNT A;  1BF0 A;  1TAP A;  2FI3 I;  2HEX A;  4DG4 C;  1P2O B;  2DDJ A;  3FP7 J;  2PTC I;  1BRC I;  3BTE I;  5PTI A;  1P2Q B;  4ISO B;  1YLD B;  1EJM B;  1KIG I;  1DTX A;  3L3T E;  3CI7 A;  1T7C B;  2W8X A;  2ZVX A;  1Y62 A;  3GYM I;  1T8L B;  2FI5 I;  2UUY B;  3BTG I;  4Y11 I;  1EAW B;  2KCR A;  6PTI A;  2M99 A;  1F7Z I;  4TPI I;  1FY8 I;  2LFL A;  9PTI A;  1G6X A;  1NAG A;  1P2J I;  2R9P E;  1TFX C;  2TGP I;  4ISN B;  1JV8 A;  1FAN A;  1KUN A;  1F5R I;  3TPI I;  3AUH A;  4WWY C;  5JB5 A;  1YC0 I;  1DEM A;  1TCP A;  3M7Q B;  3U1J E;  3FP8 I;  1BIK A;  1P2M B;  3TGK I;  3TGJ I;  1P2I I;  8PTI A;  1JC6 A;  2FTM B;  3AUE A;  4Y0Z I;  1P2K I;  4BQD A;  1K6U A;  1DEN A;  3WNY A;  1T8O B;  1AAL A;  1BHC A;  1T8N B;  4NTW B;  1PIT A;  1ADZ A;  1DTK A;  3L33 E;  1FAK I;  2UUX A;  5C67 C;  1YLC B;  2KNT A;  1MTN D;  1ZJD B;  3OTJ I;  2FI4 I;  1IRH A;  1OA5 5;  1BPT A;  2ODY E;  1T8M B;  5JB7 A;  1D0D A;  1AAP A;  1CBW D;  1BRB I;  3AUG A;  4DTG K;  3BTK I; 
#chains in the Genus database with same CATH topology
 3BTQ I;  4BD9 B;  2JOT A;  1BZ5 A;  3BYB A;  1D0D B;  2CA7 A;  2TPI I;  1SHP A;  1CO7 I;  3T62 D;  1P2N B;  1YKT B;  1TPA I;  1LD6 A;  3LDM A;  4Y0Y I;  4U32 X;  2DDI A;  7PTI A;  5JB6 A;  3P92 E;  1ZR0 B;  1BTH P;  3AUC A;  4PTI A;  1B0C A;  4WXV C;  1UUB A;  4ISL B;  1JV9 A;  2LFK A;  1TOC R;  3BTM I;  4NTX B;  1BTI A;  2RA3 C;  5JB4 A;  1OA6 5;  3BTT I;  4U30 W;  3P95 E;  2J6D A;  1CA0 D;  3BTW I;  1KTH A;  1BUN B;  3OFW A;  3TGI I;  3LDI A;  2FTL I;  2M01 A;  2KAI I;  1QLQ A;  3BTF I;  1UUA A;  4Y10 I;  3AUI A;  3AUD A;  3UOU B;  3BTH I;  3FP6 I;  2ZJX A;  3UIR C;  4BNR I;  3AUB A;  4NTY B;  3BTD I;  1BPI A;  1TAW B;  2IJO I;  1BZX I;  3D65 I;  1LD5 A;  3LDJ A;  1KNT A;  1BF0 A;  1TAP A;  2FI3 I;  2HEX A;  4DG4 C;  1P2O B;  2DDJ A;  3FP7 J;  2PTC I;  1BRC I;  3BTE I;  5PTI A;  1P2Q B;  4ISO B;  1YLD B;  1EJM B;  1KIG I;  1DTX A;  3L3T E;  3CI7 A;  1T7C B;  2W8X A;  2ZVX A;  1Y62 A;  3GYM I;  1T8L B;  2FI5 I;  2UUY B;  3BTG I;  4Y11 I;  1EAW B;  2KCR A;  6PTI A;  2M99 A;  1F7Z I;  4TPI I;  1FY8 I;  2LFL A;  9PTI A;  1G6X A;  1NAG A;  1P2J I;  2R9P E;  1TFX C;  2TGP I;  4ISN B;  1JV8 A;  1FAN A;  1KUN A;  1F5R I;  3TPI I;  3AUH A;  4WWY C;  5JB5 A;  1YC0 I;  1DEM A;  1TCP A;  3M7Q B;  3U1J E;  3FP8 I;  1BIK A;  1P2M B;  3TGK I;  3TGJ I;  1P2I I;  8PTI A;  1JC6 A;  2FTM B;  3AUE A;  4Y0Z I;  1P2K I;  4BQD A;  1K6U A;  1DEN A;  3WNY A;  1T8O B;  1AAL A;  1BHC A;  1T8N B;  4NTW B;  1PIT A;  1ADZ A;  1DTK A;  3L33 E;  1FAK I;  2UUX A;  5C67 C;  1YLC B;  2KNT A;  1MTN D;  1ZJD B;  3OTJ I;  2FI4 I;  1IRH A;  1OA5 5;  1BPT A;  2ODY E;  1T8M B;  5JB7 A;  1D0D A;  1AAP A;  1CBW D;  1BRB I;  3AUG A;  4DTG K;  3BTK I; 
#chains in the Genus database with same CATH homology
 3BTQ I;  4BD9 B;  2JOT A;  1BZ5 A;  3BYB A;  1D0D B;  2CA7 A;  2TPI I;  1SHP A;  1CO7 I;  3T62 D;  1P2N B;  1YKT B;  1TPA I;  1LD6 A;  3LDM A;  4Y0Y I;  4U32 X;  2DDI A;  7PTI A;  5JB6 A;  3P92 E;  1ZR0 B;  1BTH P;  3AUC A;  4PTI A;  1B0C A;  4WXV C;  1UUB A;  4ISL B;  1JV9 A;  2LFK A;  1TOC R;  3BTM I;  4NTX B;  1BTI A;  2RA3 C;  5JB4 A;  1OA6 5;  3BTT I;  4U30 W;  3P95 E;  2J6D A;  1CA0 D;  3BTW I;  1KTH A;  1BUN B;  3OFW A;  3TGI I;  3LDI A;  2FTL I;  2M01 A;  2KAI I;  1QLQ A;  3BTF I;  1UUA A;  4Y10 I;  3AUI A;  3AUD A;  3UOU B;  3BTH I;  3FP6 I;  2ZJX A;  3UIR C;  4BNR I;  3AUB A;  4NTY B;  3BTD I;  1BPI A;  1TAW B;  2IJO I;  1BZX I;  3D65 I;  1LD5 A;  3LDJ A;  1KNT A;  1BF0 A;  1TAP A;  2FI3 I;  2HEX A;  4DG4 C;  1P2O B;  2DDJ A;  3FP7 J;  2PTC I;  1BRC I;  3BTE I;  5PTI A;  1P2Q B;  4ISO B;  1YLD B;  1EJM B;  1KIG I;  1DTX A;  3L3T E;  3CI7 A;  1T7C B;  2W8X A;  2ZVX A;  1Y62 A;  3GYM I;  1T8L B;  2FI5 I;  2UUY B;  3BTG I;  4Y11 I;  1EAW B;  2KCR A;  6PTI A;  2M99 A;  1F7Z I;  4TPI I;  1FY8 I;  2LFL A;  9PTI A;  1G6X A;  1NAG A;  1P2J I;  2R9P E;  1TFX C;  2TGP I;  4ISN B;  1JV8 A;  1FAN A;  1KUN A;  1F5R I;  3TPI I;  3AUH A;  4WWY C;  5JB5 A;  1YC0 I;  1DEM A;  1TCP A;  3M7Q B;  3U1J E;  3FP8 I;  1BIK A;  1P2M B;  3TGK I;  3TGJ I;  1P2I I;  8PTI A;  1JC6 A;  2FTM B;  3AUE A;  4Y0Z I;  1P2K I;  4BQD A;  1K6U A;  1DEN A;  3WNY A;  1T8O B;  1AAL A;  1BHC A;  1T8N B;  4NTW B;  1PIT A;  1ADZ A;  1DTK A;  3L33 E;  1FAK I;  2UUX A;  5C67 C;  1YLC B;  2KNT A;  1MTN D;  1ZJD B;  3OTJ I;  2FI4 I;  1IRH A;  1OA5 5;  1BPT A;  2ODY E;  1T8M B;  5JB7 A;  1D0D A;  1AAP A;  1CBW D;  1BRB I;  3AUG A;  4DTG K;  3BTK I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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