3LDIA

Crystal structure of aprotinin in complex with sucrose octasulfate: unusual interactions and implication for heparin binding
Total Genus 8
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
8
sequence length
57
structure length
57
Chain Sequence
RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structures of aprotinin and its complex with sucrose octasulfate reveal multiple modes of interactions with implications for heparin binding
pubmed doi rcsb
molecule tags Hydrolase inhibitor
molecule keywords Pancreatic trypsin inhibitor
total genus 8
structure length 57
sequence length 57
chains with identical sequence B, C, D, E
ec nomenclature
pdb deposition date 2010-01-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 3ldiA00
2PTCI 1T8OB 1TAWB 1ZR0B 1P2KI 2ODYE 2ZJXA 8PTIA 3BTTI 1YLDB 4Y0ZI 1AALA 2KNTA 9PTIA 1BRBI 4U32X 2FI3I 3AUGA 4BD9B 1T7CB 1EAWB 3OFWA 2FTLI 3WNYA 3AUIA 1DTXA 1MTND 3BTWI 1TCPA 2M01A 2FI5I 1BTIA 1BRCI 3AUHA 4PTIA 1NAGA 3BYBA 1UUAA 1P2JI 1DENA 3LDJA 4ISOB 4WXVC 3U1JE 2ZVXA 1YKTB 1D0DB 2UUYB 3AUEA 3AUDA 3CI7A 3L3TE 3LDMA 4DG4C 2LFLA 1P2QB 3BTEI 6PTIA 3T62D 1P2II 4TPII 2M99A 2TGPI 3P92E 1AAPA 3UOUB 1CO7I 1OA55 3M7QB 2DDIA 3BTHI 2KCRA 1BPIA 1F7ZI 1P2OB 2TPII 1TOCR 3TPII 2FTMB 2W8XA 1F5RI 1BF0A 1DTKA 3BTGI 1Y62A 1UUBA 1TPAI 2FI4I 2CA7A 1LD5A 1BUNB 1JV9A 3TGII 1ADZA 1P2MB 4DTGK 3UIRC 3BTDI 5C67C 4Y10I 7PTIA 1BZXI 1K6UA 4Y11I 3FP7J 1FAKI 3BTKI 1BZ5A 2HEXA 1JC6A 5JB6A 4Y0YI 3BTQI 1PITA 1B0CA 2IJOI 1CBWD 1T8NB 1SHPA 3D65I 1YC0I 2RA3C 4WWYC 5JB5A 1DEMA 2LFKA 1G6XA 1QLQA 1T8LB 2KAII 1OA65 3P95E 1LD6A 5JB7A 1KUNA 1TFXC 5JB4A 1IRHA 1FANA 2J6DA 1FY8I 4NTXB 4NTWB 1JV8A 1CA0D 1KNTA 3LDIA 3TGKI 4BNRI 2JOTA 1BTHP 1YLCB 1T8MB 1ZJDB 3BTFI 3OTJI 3FP6I 1TAPA 4NTYB 4U30W 1BHCA 2R9PE 5PTIA 3AUBA 3L33E 4ISNB 3GYMI 1D0DA 1P2NB 1KIGI 4ISLB 3TGJI 3FP8I 1KTHA 3BTMI 1BIKA 1EJMB 1BPTA 4BQDA 2DDJA 3AUCA 2UUXA
chains in the Genus database with same CATH superfamily
2PTCI 1T8OB 1TAWB 1ZR0B 1P2KI 2ODYE 2ZJXA 8PTIA 3BTTI 1YLDB 4Y0ZI 1AALA 2KNTA 9PTIA 1BRBI 4U32X 2FI3I 3AUGA 4BD9B 1T7CB 1EAWB 3OFWA 2FTLI 3WNYA 3AUIA 1DTXA 1MTND 3BTWI 1TCPA 2M01A 2FI5I 1BTIA 1BRCI 3AUHA 4PTIA 1NAGA 3BYBA 1UUAA 1P2JI 1DENA 3LDJA 4ISOB 4WXVC 3U1JE 2ZVXA 1YKTB 1D0DB 2UUYB 3AUEA 3AUDA 3CI7A 3L3TE 3LDMA 4DG4C 2LFLA 1P2QB 3BTEI 6PTIA 3T62D 1P2II 4TPII 2M99A 2TGPI 3P92E 1AAPA 3UOUB 1CO7I 1OA55 3M7QB 2DDIA 3BTHI 2KCRA 1BPIA 1F7ZI 1P2OB 2TPII 1TOCR 3TPII 2FTMB 2W8XA 1F5RI 1BF0A 1DTKA 3BTGI 1Y62A 1UUBA 1TPAI 2FI4I 2CA7A 1LD5A 1BUNB 1JV9A 3TGII 1ADZA 1P2MB 4DTGK 3UIRC 3BTDI 5C67C 4Y10I 7PTIA 1BZXI 1K6UA 4Y11I 3FP7J 1FAKI 3BTKI 1BZ5A 2HEXA 1JC6A 5JB6A 4Y0YI 3BTQI 1PITA 1B0CA 2IJOI 1CBWD 1T8NB 1SHPA 3D65I 1YC0I 2RA3C 4WWYC 5JB5A 1DEMA 2LFKA 1G6XA 1QLQA 1T8LB 2KAII 1OA65 3P95E 1LD6A 5JB7A 1KUNA 1TFXC 5JB4A 1IRHA 1FANA 2J6DA 1FY8I 4NTXB 4NTWB 1JV8A 1CA0D 1KNTA 3LDIA 3TGKI 4BNRI 2JOTA 1BTHP 1YLCB 1T8MB 1ZJDB 3BTFI 3OTJI 3FP6I 1TAPA 4NTYB 4U30W 1BHCA 2R9PE 5PTIA 3AUBA 3L33E 4ISNB 3GYMI 1D0DA 1P2NB 1KIGI 4ISLB 3TGJI 3FP8I 1KTHA 3BTMI 1BIKA 1EJMB 1BPTA 4BQDA 2DDJA 3AUCA 2UUXA
chains in the Genus database with same CATH topology
2PTCI 1T8OB 1TAWB 1ZR0B 1P2KI 2ODYE 2ZJXA 8PTIA 3BTTI 1YLDB 4Y0ZI 1AALA 2KNTA 9PTIA 1BRBI 4U32X 2FI3I 3AUGA 4BD9B 1T7CB 1EAWB 3OFWA 2FTLI 3WNYA 3AUIA 1DTXA 1MTND 3BTWI 1TCPA 2M01A 2FI5I 1BTIA 1BRCI 3AUHA 4PTIA 1NAGA 3BYBA 1UUAA 1P2JI 1DENA 3LDJA 4ISOB 4WXVC 3U1JE 2ZVXA 1YKTB 1D0DB 2UUYB 3AUEA 3AUDA 3CI7A 3L3TE 3LDMA 4DG4C 2LFLA 1P2QB 3BTEI 6PTIA 3T62D 1P2II 4TPII 2M99A 2TGPI 3P92E 1AAPA 3UOUB 1CO7I 1OA55 3M7QB 2DDIA 3BTHI 2KCRA 1BPIA 1F7ZI 1P2OB 2TPII 1TOCR 3TPII 2FTMB 2W8XA 1F5RI 1BF0A 1DTKA 3BTGI 1Y62A 1UUBA 1TPAI 2FI4I 2CA7A 1LD5A 1BUNB 1JV9A 3TGII 1ADZA 1P2MB 4DTGK 3UIRC 3BTDI 5C67C 4Y10I 7PTIA 1BZXI 1K6UA 4Y11I 3FP7J 1FAKI 3BTKI 1BZ5A 2HEXA 1JC6A 5JB6A 4Y0YI 3BTQI 1PITA 1B0CA 2IJOI 1CBWD 1T8NB 1SHPA 3D65I 1YC0I 2RA3C 4WWYC 5JB5A 1DEMA 2LFKA 1G6XA 1QLQA 1T8LB 2KAII 1OA65 3P95E 1LD6A 5JB7A 1KUNA 1TFXC 5JB4A 1IRHA 1FANA 2J6DA 1FY8I 4NTXB 4NTWB 1JV8A 1CA0D 1KNTA 3LDIA 3TGKI 4BNRI 2JOTA 1BTHP 1YLCB 1T8MB 1ZJDB 3BTFI 3OTJI 3FP6I 1TAPA 4NTYB 4U30W 1BHCA 2R9PE 5PTIA 3AUBA 3L33E 4ISNB 3GYMI 1D0DA 1P2NB 1KIGI 4ISLB 3TGJI 3FP8I 1KTHA 3BTMI 1BIKA 1EJMB 1BPTA 4BQDA 2DDJA 3AUCA 2UUXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2PTC I;  1T8O B;  1TAW B;  1ZR0 B;  1P2K I;  2ODY E;  2ZJX A;  8PTI A;  3BTT I;  1YLD B;  4Y0Z I;  1AAL A;  2KNT A;  9PTI A;  1BRB I;  4U32 X;  2FI3 I;  3AUG A;  4BD9 B;  1T7C B;  1EAW B;  3OFW A;  2FTL I;  3WNY A;  3AUI A;  1DTX A;  1MTN D;  3BTW I;  1TCP A;  2M01 A;  2FI5 I;  1BTI A;  1BRC I;  3AUH A;  4PTI A;  1NAG A;  3BYB A;  1UUA A;  1P2J I;  1DEN A;  3LDJ A;  4ISO B;  4WXV C;  3U1J E;  2ZVX A;  1YKT B;  1D0D B;  2UUY B;  3AUE A;  3AUD A;  3CI7 A;  3L3T E;  3LDM A;  4DG4 C;  2LFL A;  1P2Q B;  3BTE I;  6PTI A;  3T62 D;  1P2I I;  4TPI I;  2M99 A;  2TGP I;  3P92 E;  1AAP A;  3UOU B;  1CO7 I;  1OA5 5;  3M7Q B;  2DDI A;  3BTH I;  2KCR A;  1BPI A;  1F7Z I;  1P2O B;  2TPI I;  1TOC R;  3TPI I;  2FTM B;  2W8X A;  1F5R I;  1BF0 A;  1DTK A;  3BTG I;  1Y62 A;  1UUB A;  1TPA I;  2FI4 I;  2CA7 A;  1LD5 A;  1BUN B;  1JV9 A;  3TGI I;  1ADZ A;  1P2M B;  4DTG K;  3UIR C;  3BTD I;  5C67 C;  4Y10 I;  7PTI A;  1BZX I;  1K6U A;  4Y11 I;  3FP7 J;  1FAK I;  3BTK I;  1BZ5 A;  2HEX A;  1JC6 A;  5JB6 A;  4Y0Y I;  3BTQ I;  1PIT A;  1B0C A;  2IJO I;  1CBW D;  1T8N B;  1SHP A;  3D65 I;  1YC0 I;  2RA3 C;  4WWY C;  5JB5 A;  1DEM A;  2LFK A;  1G6X A;  1QLQ A;  1T8L B;  2KAI I;  1OA6 5;  3P95 E;  1LD6 A;  5JB7 A;  1KUN A;  1TFX C;  5JB4 A;  1IRH A;  1FAN A;  2J6D A;  1FY8 I;  4NTX B;  4NTW B;  1JV8 A;  1CA0 D;  1KNT A;  3LDI A;  3TGK I;  4BNR I;  2JOT A;  1BTH P;  1YLC B;  1T8M B;  1ZJD B;  3BTF I;  3OTJ I;  3FP6 I;  1TAP A;  4NTY B;  4U30 W;  1BHC A;  2R9P E;  5PTI A;  3AUB A;  3L33 E;  4ISN B;  3GYM I;  1D0D A;  1P2N B;  1KIG I;  4ISL B;  3TGJ I;  3FP8 I;  1KTH A;  3BTM I;  1BIK A;  1EJM B;  1BPT A;  4BQD A;  2DDJ A;  3AUC A;  2UUX A; 
#chains in the Genus database with same CATH topology
 2PTC I;  1T8O B;  1TAW B;  1ZR0 B;  1P2K I;  2ODY E;  2ZJX A;  8PTI A;  3BTT I;  1YLD B;  4Y0Z I;  1AAL A;  2KNT A;  9PTI A;  1BRB I;  4U32 X;  2FI3 I;  3AUG A;  4BD9 B;  1T7C B;  1EAW B;  3OFW A;  2FTL I;  3WNY A;  3AUI A;  1DTX A;  1MTN D;  3BTW I;  1TCP A;  2M01 A;  2FI5 I;  1BTI A;  1BRC I;  3AUH A;  4PTI A;  1NAG A;  3BYB A;  1UUA A;  1P2J I;  1DEN A;  3LDJ A;  4ISO B;  4WXV C;  3U1J E;  2ZVX A;  1YKT B;  1D0D B;  2UUY B;  3AUE A;  3AUD A;  3CI7 A;  3L3T E;  3LDM A;  4DG4 C;  2LFL A;  1P2Q B;  3BTE I;  6PTI A;  3T62 D;  1P2I I;  4TPI I;  2M99 A;  2TGP I;  3P92 E;  1AAP A;  3UOU B;  1CO7 I;  1OA5 5;  3M7Q B;  2DDI A;  3BTH I;  2KCR A;  1BPI A;  1F7Z I;  1P2O B;  2TPI I;  1TOC R;  3TPI I;  2FTM B;  2W8X A;  1F5R I;  1BF0 A;  1DTK A;  3BTG I;  1Y62 A;  1UUB A;  1TPA I;  2FI4 I;  2CA7 A;  1LD5 A;  1BUN B;  1JV9 A;  3TGI I;  1ADZ A;  1P2M B;  4DTG K;  3UIR C;  3BTD I;  5C67 C;  4Y10 I;  7PTI A;  1BZX I;  1K6U A;  4Y11 I;  3FP7 J;  1FAK I;  3BTK I;  1BZ5 A;  2HEX A;  1JC6 A;  5JB6 A;  4Y0Y I;  3BTQ I;  1PIT A;  1B0C A;  2IJO I;  1CBW D;  1T8N B;  1SHP A;  3D65 I;  1YC0 I;  2RA3 C;  4WWY C;  5JB5 A;  1DEM A;  2LFK A;  1G6X A;  1QLQ A;  1T8L B;  2KAI I;  1OA6 5;  3P95 E;  1LD6 A;  5JB7 A;  1KUN A;  1TFX C;  5JB4 A;  1IRH A;  1FAN A;  2J6D A;  1FY8 I;  4NTX B;  4NTW B;  1JV8 A;  1CA0 D;  1KNT A;  3LDI A;  3TGK I;  4BNR I;  2JOT A;  1BTH P;  1YLC B;  1T8M B;  1ZJD B;  3BTF I;  3OTJ I;  3FP6 I;  1TAP A;  4NTY B;  4U30 W;  1BHC A;  2R9P E;  5PTI A;  3AUB A;  3L33 E;  4ISN B;  3GYM I;  1D0D A;  1P2N B;  1KIG I;  4ISL B;  3TGJ I;  3FP8 I;  1KTH A;  3BTM I;  1BIK A;  1EJM B;  1BPT A;  4BQD A;  2DDJ A;  3AUC A;  2UUX A; 
#chains in the Genus database with same CATH homology
 2PTC I;  1T8O B;  1TAW B;  1ZR0 B;  1P2K I;  2ODY E;  2ZJX A;  8PTI A;  3BTT I;  1YLD B;  4Y0Z I;  1AAL A;  2KNT A;  9PTI A;  1BRB I;  4U32 X;  2FI3 I;  3AUG A;  4BD9 B;  1T7C B;  1EAW B;  3OFW A;  2FTL I;  3WNY A;  3AUI A;  1DTX A;  1MTN D;  3BTW I;  1TCP A;  2M01 A;  2FI5 I;  1BTI A;  1BRC I;  3AUH A;  4PTI A;  1NAG A;  3BYB A;  1UUA A;  1P2J I;  1DEN A;  3LDJ A;  4ISO B;  4WXV C;  3U1J E;  2ZVX A;  1YKT B;  1D0D B;  2UUY B;  3AUE A;  3AUD A;  3CI7 A;  3L3T E;  3LDM A;  4DG4 C;  2LFL A;  1P2Q B;  3BTE I;  6PTI A;  3T62 D;  1P2I I;  4TPI I;  2M99 A;  2TGP I;  3P92 E;  1AAP A;  3UOU B;  1CO7 I;  1OA5 5;  3M7Q B;  2DDI A;  3BTH I;  2KCR A;  1BPI A;  1F7Z I;  1P2O B;  2TPI I;  1TOC R;  3TPI I;  2FTM B;  2W8X A;  1F5R I;  1BF0 A;  1DTK A;  3BTG I;  1Y62 A;  1UUB A;  1TPA I;  2FI4 I;  2CA7 A;  1LD5 A;  1BUN B;  1JV9 A;  3TGI I;  1ADZ A;  1P2M B;  4DTG K;  3UIR C;  3BTD I;  5C67 C;  4Y10 I;  7PTI A;  1BZX I;  1K6U A;  4Y11 I;  3FP7 J;  1FAK I;  3BTK I;  1BZ5 A;  2HEX A;  1JC6 A;  5JB6 A;  4Y0Y I;  3BTQ I;  1PIT A;  1B0C A;  2IJO I;  1CBW D;  1T8N B;  1SHP A;  3D65 I;  1YC0 I;  2RA3 C;  4WWY C;  5JB5 A;  1DEM A;  2LFK A;  1G6X A;  1QLQ A;  1T8L B;  2KAI I;  1OA6 5;  3P95 E;  1LD6 A;  5JB7 A;  1KUN A;  1TFX C;  5JB4 A;  1IRH A;  1FAN A;  2J6D A;  1FY8 I;  4NTX B;  4NTW B;  1JV8 A;  1CA0 D;  1KNT A;  3LDI A;  3TGK I;  4BNR I;  2JOT A;  1BTH P;  1YLC B;  1T8M B;  1ZJD B;  3BTF I;  3OTJ I;  3FP6 I;  1TAP A;  4NTY B;  4U30 W;  1BHC A;  2R9P E;  5PTI A;  3AUB A;  3L33 E;  4ISN B;  3GYM I;  1D0D A;  1P2N B;  1KIG I;  4ISL B;  3TGJ I;  3FP8 I;  1KTH A;  3BTM I;  1BIK A;  1EJM B;  1BPT A;  4BQD A;  2DDJ A;  3AUC A;  2UUX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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