3LDJA

Crystal structure of aprotinin in complex with sucrose octasulfate: unusual interactions and implication for heparin binding
Total Genus 8
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
8
sequence length
56
structure length
56
Chain Sequence
RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structures of aprotinin and its complex with sucrose octasulfate reveal multiple modes of interactions with implications for heparin binding.
pubmed doi rcsb
molecule tags Hydrolase inhibitor
molecule keywords Pancreatic trypsin inhibitor
total genus 8
structure length 56
sequence length 56
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2010-01-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 3ldjA00
2LFLA 3OFWA 3BTEI 2RA3C 3BTTI 1YLCB 1FAKI 1P2QB 5C67C 1LD6A 1D0DA 4BQDA 1QLQA 7PTIA 4Y11I 3TGJI 1BRCI 2FI5I 3AUGA 1F5RI 1DTXA 3AUDA 1FANA 4PTIA 1T8LB 3LDJA 1NAGA 1UUBA 1CO7I 3CI7A 1AAPA 2PTCI 1P2MB 3L3TE 1YLDB 3AUBA 3BTGI 1DEMA 1DENA 1PITA 1OA65 1BZXI 3FP7J 1ZJDB 2ZJXA 4Y10I 3GYMI 3FP6I 2LFKA 1BTIA 1TAWB 3U1JE 3BTDI 1B0CA 3AUIA 3BTKI 1FY8I 2CA7A 1BHCA 1ADZA 1JC6A 1BUNB 3TGII 2M99A 1OA55 2ODYE 1BIKA 1TFXC 1BPIA 2IJOI 2DDJA 1G6XA 1T8MB 3BTMI 4ISLB 4NTXB 4NTWB 3TGKI 1DTKA 1SHPA 3AUCA 6PTIA 1P2KI 1MTND 2KCRA 2R9PE 1TPAI 2KNTA 3T62D 2KAII 3AUHA 3LDIA 3D65I 3P92E 9PTIA 5JB5A 3UOUB 1P2II 1CBWD 1ZR0B 4DG4C 3LDMA 1JV8A 1BTHP 3BTWI 5JB4A 4TPII 3BTQI 2TPII 4WWYC 2ZVXA 3AUEA 2W8XA 1AALA 1IRHA 2FTMB 1D0DB 1P2NB 1YC0I 1K6UA 3L33E 1BF0A 1UUAA 2JOTA 1P2OB 3UIRC 2FTLI 4BD9B 3TPII 1BPTA 1F7ZI 2UUXA 3BTFI 1BRBI 2M01A 1KNTA 1T8NB 1TOCR 1KTHA 1KUNA 1EAWB 5PTIA 1BZ5A 1TAPA 2FI3I 3M7QB 4ISNB 1Y62A 5JB6A 3WNYA 1YKTB 1JV9A 4DTGK 2HEXA 1TCPA 2TGPI 4Y0ZI 2DDIA 8PTIA 1EJMB 4ISOB 1T7CB 4Y0YI 1T8OB 4WXVC 1KIGI 1LD5A 1P2JI 3P95E 3FP8I 1CA0D 3BYBA 4NTYB 2J6DA 3OTJI 4BNRI 4U32X 2UUYB 4U30W 5JB7A 3BTHI 2FI4I
chains in the Genus database with same CATH superfamily
2LFLA 3OFWA 3BTEI 2RA3C 3BTTI 1YLCB 1FAKI 1P2QB 5C67C 1LD6A 1D0DA 4BQDA 1QLQA 7PTIA 4Y11I 3TGJI 1BRCI 2FI5I 3AUGA 1F5RI 1DTXA 3AUDA 1FANA 4PTIA 1T8LB 3LDJA 1NAGA 1UUBA 1CO7I 3CI7A 1AAPA 2PTCI 1P2MB 3L3TE 1YLDB 3AUBA 3BTGI 1DEMA 1DENA 1PITA 1OA65 1BZXI 3FP7J 1ZJDB 2ZJXA 4Y10I 3GYMI 3FP6I 2LFKA 1BTIA 1TAWB 3U1JE 3BTDI 1B0CA 3AUIA 3BTKI 1FY8I 2CA7A 1BHCA 1ADZA 1JC6A 1BUNB 3TGII 2M99A 1OA55 2ODYE 1BIKA 1TFXC 1BPIA 2IJOI 2DDJA 1G6XA 1T8MB 3BTMI 4ISLB 4NTXB 4NTWB 3TGKI 1DTKA 1SHPA 3AUCA 6PTIA 1P2KI 1MTND 2KCRA 2R9PE 1TPAI 2KNTA 3T62D 2KAII 3AUHA 3LDIA 3D65I 3P92E 9PTIA 5JB5A 3UOUB 1P2II 1CBWD 1ZR0B 4DG4C 3LDMA 1JV8A 1BTHP 3BTWI 5JB4A 4TPII 3BTQI 2TPII 4WWYC 2ZVXA 3AUEA 2W8XA 1AALA 1IRHA 2FTMB 1D0DB 1P2NB 1YC0I 1K6UA 3L33E 1BF0A 1UUAA 2JOTA 1P2OB 3UIRC 2FTLI 4BD9B 3TPII 1BPTA 1F7ZI 2UUXA 3BTFI 1BRBI 2M01A 1KNTA 1T8NB 1TOCR 1KTHA 1KUNA 1EAWB 5PTIA 1BZ5A 1TAPA 2FI3I 3M7QB 4ISNB 1Y62A 5JB6A 3WNYA 1YKTB 1JV9A 4DTGK 2HEXA 1TCPA 2TGPI 4Y0ZI 2DDIA 8PTIA 1EJMB 4ISOB 1T7CB 4Y0YI 1T8OB 4WXVC 1KIGI 1LD5A 1P2JI 3P95E 3FP8I 1CA0D 3BYBA 4NTYB 2J6DA 3OTJI 4BNRI 4U32X 2UUYB 4U30W 5JB7A 3BTHI 2FI4I
chains in the Genus database with same CATH topology
2LFLA 3OFWA 3BTEI 2RA3C 3BTTI 1YLCB 1FAKI 1P2QB 5C67C 1LD6A 1D0DA 4BQDA 1QLQA 7PTIA 4Y11I 3TGJI 1BRCI 2FI5I 3AUGA 1F5RI 1DTXA 3AUDA 1FANA 4PTIA 1T8LB 3LDJA 1NAGA 1UUBA 1CO7I 3CI7A 1AAPA 2PTCI 1P2MB 3L3TE 1YLDB 3AUBA 3BTGI 1DEMA 1DENA 1PITA 1OA65 1BZXI 3FP7J 1ZJDB 2ZJXA 4Y10I 3GYMI 3FP6I 2LFKA 1BTIA 1TAWB 3U1JE 3BTDI 1B0CA 3AUIA 3BTKI 1FY8I 2CA7A 1BHCA 1ADZA 1JC6A 1BUNB 3TGII 2M99A 1OA55 2ODYE 1BIKA 1TFXC 1BPIA 2IJOI 2DDJA 1G6XA 1T8MB 3BTMI 4ISLB 4NTXB 4NTWB 3TGKI 1DTKA 1SHPA 3AUCA 6PTIA 1P2KI 1MTND 2KCRA 2R9PE 1TPAI 2KNTA 3T62D 2KAII 3AUHA 3LDIA 3D65I 3P92E 9PTIA 5JB5A 3UOUB 1P2II 1CBWD 1ZR0B 4DG4C 3LDMA 1JV8A 1BTHP 3BTWI 5JB4A 4TPII 3BTQI 2TPII 4WWYC 2ZVXA 3AUEA 2W8XA 1AALA 1IRHA 2FTMB 1D0DB 1P2NB 1YC0I 1K6UA 3L33E 1BF0A 1UUAA 2JOTA 1P2OB 3UIRC 2FTLI 4BD9B 3TPII 1BPTA 1F7ZI 2UUXA 3BTFI 1BRBI 2M01A 1KNTA 1T8NB 1TOCR 1KTHA 1KUNA 1EAWB 5PTIA 1BZ5A 1TAPA 2FI3I 3M7QB 4ISNB 1Y62A 5JB6A 3WNYA 1YKTB 1JV9A 4DTGK 2HEXA 1TCPA 2TGPI 4Y0ZI 2DDIA 8PTIA 1EJMB 4ISOB 1T7CB 4Y0YI 1T8OB 4WXVC 1KIGI 1LD5A 1P2JI 3P95E 3FP8I 1CA0D 3BYBA 4NTYB 2J6DA 3OTJI 4BNRI 4U32X 2UUYB 4U30W 5JB7A 3BTHI 2FI4I
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2LFL A;  3OFW A;  3BTE I;  2RA3 C;  3BTT I;  1YLC B;  1FAK I;  1P2Q B;  5C67 C;  1LD6 A;  1D0D A;  4BQD A;  1QLQ A;  7PTI A;  4Y11 I;  3TGJ I;  1BRC I;  2FI5 I;  3AUG A;  1F5R I;  1DTX A;  3AUD A;  1FAN A;  4PTI A;  1T8L B;  3LDJ A;  1NAG A;  1UUB A;  1CO7 I;  3CI7 A;  1AAP A;  2PTC I;  1P2M B;  3L3T E;  1YLD B;  3AUB A;  3BTG I;  1DEM A;  1DEN A;  1PIT A;  1OA6 5;  1BZX I;  3FP7 J;  1ZJD B;  2ZJX A;  4Y10 I;  3GYM I;  3FP6 I;  2LFK A;  1BTI A;  1TAW B;  3U1J E;  3BTD I;  1B0C A;  3AUI A;  3BTK I;  1FY8 I;  2CA7 A;  1BHC A;  1ADZ A;  1JC6 A;  1BUN B;  3TGI I;  2M99 A;  1OA5 5;  2ODY E;  1BIK A;  1TFX C;  1BPI A;  2IJO I;  2DDJ A;  1G6X A;  1T8M B;  3BTM I;  4ISL B;  4NTX B;  4NTW B;  3TGK I;  1DTK A;  1SHP A;  3AUC A;  6PTI A;  1P2K I;  1MTN D;  2KCR A;  2R9P E;  1TPA I;  2KNT A;  3T62 D;  2KAI I;  3AUH A;  3LDI A;  3D65 I;  3P92 E;  9PTI A;  5JB5 A;  3UOU B;  1P2I I;  1CBW D;  1ZR0 B;  4DG4 C;  3LDM A;  1JV8 A;  1BTH P;  3BTW I;  5JB4 A;  4TPI I;  3BTQ I;  2TPI I;  4WWY C;  2ZVX A;  3AUE A;  2W8X A;  1AAL A;  1IRH A;  2FTM B;  1D0D B;  1P2N B;  1YC0 I;  1K6U A;  3L33 E;  1BF0 A;  1UUA A;  2JOT A;  1P2O B;  3UIR C;  2FTL I;  4BD9 B;  3TPI I;  1BPT A;  1F7Z I;  2UUX A;  3BTF I;  1BRB I;  2M01 A;  1KNT A;  1T8N B;  1TOC R;  1KTH A;  1KUN A;  1EAW B;  5PTI A;  1BZ5 A;  1TAP A;  2FI3 I;  3M7Q B;  4ISN B;  1Y62 A;  5JB6 A;  3WNY A;  1YKT B;  1JV9 A;  4DTG K;  2HEX A;  1TCP A;  2TGP I;  4Y0Z I;  2DDI A;  8PTI A;  1EJM B;  4ISO B;  1T7C B;  4Y0Y I;  1T8O B;  4WXV C;  1KIG I;  1LD5 A;  1P2J I;  3P95 E;  3FP8 I;  1CA0 D;  3BYB A;  4NTY B;  2J6D A;  3OTJ I;  4BNR I;  4U32 X;  2UUY B;  4U30 W;  5JB7 A;  3BTH I;  2FI4 I; 
#chains in the Genus database with same CATH topology
 2LFL A;  3OFW A;  3BTE I;  2RA3 C;  3BTT I;  1YLC B;  1FAK I;  1P2Q B;  5C67 C;  1LD6 A;  1D0D A;  4BQD A;  1QLQ A;  7PTI A;  4Y11 I;  3TGJ I;  1BRC I;  2FI5 I;  3AUG A;  1F5R I;  1DTX A;  3AUD A;  1FAN A;  4PTI A;  1T8L B;  3LDJ A;  1NAG A;  1UUB A;  1CO7 I;  3CI7 A;  1AAP A;  2PTC I;  1P2M B;  3L3T E;  1YLD B;  3AUB A;  3BTG I;  1DEM A;  1DEN A;  1PIT A;  1OA6 5;  1BZX I;  3FP7 J;  1ZJD B;  2ZJX A;  4Y10 I;  3GYM I;  3FP6 I;  2LFK A;  1BTI A;  1TAW B;  3U1J E;  3BTD I;  1B0C A;  3AUI A;  3BTK I;  1FY8 I;  2CA7 A;  1BHC A;  1ADZ A;  1JC6 A;  1BUN B;  3TGI I;  2M99 A;  1OA5 5;  2ODY E;  1BIK A;  1TFX C;  1BPI A;  2IJO I;  2DDJ A;  1G6X A;  1T8M B;  3BTM I;  4ISL B;  4NTX B;  4NTW B;  3TGK I;  1DTK A;  1SHP A;  3AUC A;  6PTI A;  1P2K I;  1MTN D;  2KCR A;  2R9P E;  1TPA I;  2KNT A;  3T62 D;  2KAI I;  3AUH A;  3LDI A;  3D65 I;  3P92 E;  9PTI A;  5JB5 A;  3UOU B;  1P2I I;  1CBW D;  1ZR0 B;  4DG4 C;  3LDM A;  1JV8 A;  1BTH P;  3BTW I;  5JB4 A;  4TPI I;  3BTQ I;  2TPI I;  4WWY C;  2ZVX A;  3AUE A;  2W8X A;  1AAL A;  1IRH A;  2FTM B;  1D0D B;  1P2N B;  1YC0 I;  1K6U A;  3L33 E;  1BF0 A;  1UUA A;  2JOT A;  1P2O B;  3UIR C;  2FTL I;  4BD9 B;  3TPI I;  1BPT A;  1F7Z I;  2UUX A;  3BTF I;  1BRB I;  2M01 A;  1KNT A;  1T8N B;  1TOC R;  1KTH A;  1KUN A;  1EAW B;  5PTI A;  1BZ5 A;  1TAP A;  2FI3 I;  3M7Q B;  4ISN B;  1Y62 A;  5JB6 A;  3WNY A;  1YKT B;  1JV9 A;  4DTG K;  2HEX A;  1TCP A;  2TGP I;  4Y0Z I;  2DDI A;  8PTI A;  1EJM B;  4ISO B;  1T7C B;  4Y0Y I;  1T8O B;  4WXV C;  1KIG I;  1LD5 A;  1P2J I;  3P95 E;  3FP8 I;  1CA0 D;  3BYB A;  4NTY B;  2J6D A;  3OTJ I;  4BNR I;  4U32 X;  2UUY B;  4U30 W;  5JB7 A;  3BTH I;  2FI4 I; 
#chains in the Genus database with same CATH homology
 2LFL A;  3OFW A;  3BTE I;  2RA3 C;  3BTT I;  1YLC B;  1FAK I;  1P2Q B;  5C67 C;  1LD6 A;  1D0D A;  4BQD A;  1QLQ A;  7PTI A;  4Y11 I;  3TGJ I;  1BRC I;  2FI5 I;  3AUG A;  1F5R I;  1DTX A;  3AUD A;  1FAN A;  4PTI A;  1T8L B;  3LDJ A;  1NAG A;  1UUB A;  1CO7 I;  3CI7 A;  1AAP A;  2PTC I;  1P2M B;  3L3T E;  1YLD B;  3AUB A;  3BTG I;  1DEM A;  1DEN A;  1PIT A;  1OA6 5;  1BZX I;  3FP7 J;  1ZJD B;  2ZJX A;  4Y10 I;  3GYM I;  3FP6 I;  2LFK A;  1BTI A;  1TAW B;  3U1J E;  3BTD I;  1B0C A;  3AUI A;  3BTK I;  1FY8 I;  2CA7 A;  1BHC A;  1ADZ A;  1JC6 A;  1BUN B;  3TGI I;  2M99 A;  1OA5 5;  2ODY E;  1BIK A;  1TFX C;  1BPI A;  2IJO I;  2DDJ A;  1G6X A;  1T8M B;  3BTM I;  4ISL B;  4NTX B;  4NTW B;  3TGK I;  1DTK A;  1SHP A;  3AUC A;  6PTI A;  1P2K I;  1MTN D;  2KCR A;  2R9P E;  1TPA I;  2KNT A;  3T62 D;  2KAI I;  3AUH A;  3LDI A;  3D65 I;  3P92 E;  9PTI A;  5JB5 A;  3UOU B;  1P2I I;  1CBW D;  1ZR0 B;  4DG4 C;  3LDM A;  1JV8 A;  1BTH P;  3BTW I;  5JB4 A;  4TPI I;  3BTQ I;  2TPI I;  4WWY C;  2ZVX A;  3AUE A;  2W8X A;  1AAL A;  1IRH A;  2FTM B;  1D0D B;  1P2N B;  1YC0 I;  1K6U A;  3L33 E;  1BF0 A;  1UUA A;  2JOT A;  1P2O B;  3UIR C;  2FTL I;  4BD9 B;  3TPI I;  1BPT A;  1F7Z I;  2UUX A;  3BTF I;  1BRB I;  2M01 A;  1KNT A;  1T8N B;  1TOC R;  1KTH A;  1KUN A;  1EAW B;  5PTI A;  1BZ5 A;  1TAP A;  2FI3 I;  3M7Q B;  4ISN B;  1Y62 A;  5JB6 A;  3WNY A;  1YKT B;  1JV9 A;  4DTG K;  2HEX A;  1TCP A;  2TGP I;  4Y0Z I;  2DDI A;  8PTI A;  1EJM B;  4ISO B;  1T7C B;  4Y0Y I;  1T8O B;  4WXV C;  1KIG I;  1LD5 A;  1P2J I;  3P95 E;  3FP8 I;  1CA0 D;  3BYB A;  4NTY B;  2J6D A;  3OTJ I;  4BNR I;  4U32 X;  2UUY B;  4U30 W;  5JB7 A;  3BTH I;  2FI4 I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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