3LDMA

Crystal structure of aprotinin in complex with sucrose octasulfate: unusual interactions and implication for heparin binding
Total Genus 9
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
9
sequence length
56
structure length
56
Chain Sequence
RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structures of aprotinin and its complex with sucrose octasulfate reveal multiple modes of interactions with implications for heparin binding.
pubmed doi rcsb
molecule tags Hydrolase inhibitor
molecule keywords Pancreatic trypsin inhibitor
total genus 9
structure length 56
sequence length 56
chains with identical sequence B, C, D, E
ec nomenclature
pdb deposition date 2010-01-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 3ldmA00
1YLDB 1BPIA 1EAWB 1YC0I 3BTKI 2UUXA 2ODYE 3L33E 1B0CA 1D0DB 1JC6A 1FY8I 4DTGK 3U1JE 1BTHP 1BF0A 1SHPA 2TGPI 3GYMI 3BTGI 2M01A 3UOUB 4ISLB 4NTXB 5JB6A 1PITA 1P2OB 1P2MB 1F7ZI 1Y62A 1CA0D 1YKTB 1YLCB 4WXVC 1DTXA 1KNTA 3FP7J 3BTQI 2TPII 3TPII 3P92E 1CBWD 1JV9A 1BTIA 1UUBA 1NAGA 3AUGA 3AUHA 4ISOB 2FI4I 4Y0ZI 1AALA 2IJOI 3BTMI 3OTJI 5PTIA 1P2KI 3AUCA 1BZXI 4U30W 9PTIA 4TPII 1BRCI 1P2NB 2ZJXA 3AUIA 1BZ5A 1ZR0B 3AUEA 3BYBA 3CI7A 5JB7A 1TOCR 1T8NB 3AUBA 4WWYC 2KCRA 1P2JI 5JB4A 4BNRI 1QLQA 2ZVXA 3TGJI 2LFKA 3WNYA 1CO7I 1T8MB 3BTTI 1BPTA 1BUNB 1IRHA 4DG4C 3BTDI 4ISNB 1KTHA 1FAKI 3M7QB 2M99A 1T7CB 3LDMA 3FP6I 2RA3C 1BIKA 4Y10I 2HEXA 3BTHI 3LDIA 3LDJA 1AAPA 2KNTA 4BQDA 1TAPA 2R9PE 2DDIA 3BTEI 2FI5I 2FTMB 2J6DA 1OA65 3TGII 1DENA 1TFXC 2JOTA 3L3TE 3BTFI 3FP8I 8PTIA 3D65I 3UIRC 6PTIA 3BTWI 1UUAA 3TGKI 1TPAI 1DEMA 5C67C 4PTIA 1LD5A 2CA7A 3OFWA 1BRBI 1D0DA 2KAII 1ZJDB 1DTKA 3AUDA 2PTCI 1BHCA 1T8LB 1KIGI 1P2II 1LD6A 4Y0YI 4Y11I 1OA55 5JB5A 2LFLA 2FTLI 1P2QB 1K6UA 2W8XA 1JV8A 1MTND 4BD9B 1G6XA 1F5RI 4U32X 1KUNA 4NTYB 1FANA 1T8OB 1TCPA 4NTWB 7PTIA 3P95E 3T62D 1EJMB 1ADZA 2DDJA 2FI3I 2UUYB 1TAWB
chains in the Genus database with same CATH superfamily
1YLDB 1BPIA 1EAWB 1YC0I 3BTKI 2UUXA 2ODYE 3L33E 1B0CA 1D0DB 1JC6A 1FY8I 4DTGK 3U1JE 1BTHP 1BF0A 1SHPA 2TGPI 3GYMI 3BTGI 2M01A 3UOUB 4ISLB 4NTXB 5JB6A 1PITA 1P2OB 1P2MB 1F7ZI 1Y62A 1CA0D 1YKTB 1YLCB 4WXVC 1DTXA 1KNTA 3FP7J 3BTQI 2TPII 3TPII 3P92E 1CBWD 1JV9A 1BTIA 1UUBA 1NAGA 3AUGA 3AUHA 4ISOB 2FI4I 4Y0ZI 1AALA 2IJOI 3BTMI 3OTJI 5PTIA 1P2KI 3AUCA 1BZXI 4U30W 9PTIA 4TPII 1BRCI 1P2NB 2ZJXA 3AUIA 1BZ5A 1ZR0B 3AUEA 3BYBA 3CI7A 5JB7A 1TOCR 1T8NB 3AUBA 4WWYC 2KCRA 1P2JI 5JB4A 4BNRI 1QLQA 2ZVXA 3TGJI 2LFKA 3WNYA 1CO7I 1T8MB 3BTTI 1BPTA 1BUNB 1IRHA 4DG4C 3BTDI 4ISNB 1KTHA 1FAKI 3M7QB 2M99A 1T7CB 3LDMA 3FP6I 2RA3C 1BIKA 4Y10I 2HEXA 3BTHI 3LDIA 3LDJA 1AAPA 2KNTA 4BQDA 1TAPA 2R9PE 2DDIA 3BTEI 2FI5I 2FTMB 2J6DA 1OA65 3TGII 1DENA 1TFXC 2JOTA 3L3TE 3BTFI 3FP8I 8PTIA 3D65I 3UIRC 6PTIA 3BTWI 1UUAA 3TGKI 1TPAI 1DEMA 5C67C 4PTIA 1LD5A 2CA7A 3OFWA 1BRBI 1D0DA 2KAII 1ZJDB 1DTKA 3AUDA 2PTCI 1BHCA 1T8LB 1KIGI 1P2II 1LD6A 4Y0YI 4Y11I 1OA55 5JB5A 2LFLA 2FTLI 1P2QB 1K6UA 2W8XA 1JV8A 1MTND 4BD9B 1G6XA 1F5RI 4U32X 1KUNA 4NTYB 1FANA 1T8OB 1TCPA 4NTWB 7PTIA 3P95E 3T62D 1EJMB 1ADZA 2DDJA 2FI3I 2UUYB 1TAWB
chains in the Genus database with same CATH topology
1YLDB 1BPIA 1EAWB 1YC0I 3BTKI 2UUXA 2ODYE 3L33E 1B0CA 1D0DB 1JC6A 1FY8I 4DTGK 3U1JE 1BTHP 1BF0A 1SHPA 2TGPI 3GYMI 3BTGI 2M01A 3UOUB 4ISLB 4NTXB 5JB6A 1PITA 1P2OB 1P2MB 1F7ZI 1Y62A 1CA0D 1YKTB 1YLCB 4WXVC 1DTXA 1KNTA 3FP7J 3BTQI 2TPII 3TPII 3P92E 1CBWD 1JV9A 1BTIA 1UUBA 1NAGA 3AUGA 3AUHA 4ISOB 2FI4I 4Y0ZI 1AALA 2IJOI 3BTMI 3OTJI 5PTIA 1P2KI 3AUCA 1BZXI 4U30W 9PTIA 4TPII 1BRCI 1P2NB 2ZJXA 3AUIA 1BZ5A 1ZR0B 3AUEA 3BYBA 3CI7A 5JB7A 1TOCR 1T8NB 3AUBA 4WWYC 2KCRA 1P2JI 5JB4A 4BNRI 1QLQA 2ZVXA 3TGJI 2LFKA 3WNYA 1CO7I 1T8MB 3BTTI 1BPTA 1BUNB 1IRHA 4DG4C 3BTDI 4ISNB 1KTHA 1FAKI 3M7QB 2M99A 1T7CB 3LDMA 3FP6I 2RA3C 1BIKA 4Y10I 2HEXA 3BTHI 3LDIA 3LDJA 1AAPA 2KNTA 4BQDA 1TAPA 2R9PE 2DDIA 3BTEI 2FI5I 2FTMB 2J6DA 1OA65 3TGII 1DENA 1TFXC 2JOTA 3L3TE 3BTFI 3FP8I 8PTIA 3D65I 3UIRC 6PTIA 3BTWI 1UUAA 3TGKI 1TPAI 1DEMA 5C67C 4PTIA 1LD5A 2CA7A 3OFWA 1BRBI 1D0DA 2KAII 1ZJDB 1DTKA 3AUDA 2PTCI 1BHCA 1T8LB 1KIGI 1P2II 1LD6A 4Y0YI 4Y11I 1OA55 5JB5A 2LFLA 2FTLI 1P2QB 1K6UA 2W8XA 1JV8A 1MTND 4BD9B 1G6XA 1F5RI 4U32X 1KUNA 4NTYB 1FANA 1T8OB 1TCPA 4NTWB 7PTIA 3P95E 3T62D 1EJMB 1ADZA 2DDJA 2FI3I 2UUYB 1TAWB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YLD B;  1BPI A;  1EAW B;  1YC0 I;  3BTK I;  2UUX A;  2ODY E;  3L33 E;  1B0C A;  1D0D B;  1JC6 A;  1FY8 I;  4DTG K;  3U1J E;  1BTH P;  1BF0 A;  1SHP A;  2TGP I;  3GYM I;  3BTG I;  2M01 A;  3UOU B;  4ISL B;  4NTX B;  5JB6 A;  1PIT A;  1P2O B;  1P2M B;  1F7Z I;  1Y62 A;  1CA0 D;  1YKT B;  1YLC B;  4WXV C;  1DTX A;  1KNT A;  3FP7 J;  3BTQ I;  2TPI I;  3TPI I;  3P92 E;  1CBW D;  1JV9 A;  1BTI A;  1UUB A;  1NAG A;  3AUG A;  3AUH A;  4ISO B;  2FI4 I;  4Y0Z I;  1AAL A;  2IJO I;  3BTM I;  3OTJ I;  5PTI A;  1P2K I;  3AUC A;  1BZX I;  4U30 W;  9PTI A;  4TPI I;  1BRC I;  1P2N B;  2ZJX A;  3AUI A;  1BZ5 A;  1ZR0 B;  3AUE A;  3BYB A;  3CI7 A;  5JB7 A;  1TOC R;  1T8N B;  3AUB A;  4WWY C;  2KCR A;  1P2J I;  5JB4 A;  4BNR I;  1QLQ A;  2ZVX A;  3TGJ I;  2LFK A;  3WNY A;  1CO7 I;  1T8M B;  3BTT I;  1BPT A;  1BUN B;  1IRH A;  4DG4 C;  3BTD I;  4ISN B;  1KTH A;  1FAK I;  3M7Q B;  2M99 A;  1T7C B;  3LDM A;  3FP6 I;  2RA3 C;  1BIK A;  4Y10 I;  2HEX A;  3BTH I;  3LDI A;  3LDJ A;  1AAP A;  2KNT A;  4BQD A;  1TAP A;  2R9P E;  2DDI A;  3BTE I;  2FI5 I;  2FTM B;  2J6D A;  1OA6 5;  3TGI I;  1DEN A;  1TFX C;  2JOT A;  3L3T E;  3BTF I;  3FP8 I;  8PTI A;  3D65 I;  3UIR C;  6PTI A;  3BTW I;  1UUA A;  3TGK I;  1TPA I;  1DEM A;  5C67 C;  4PTI A;  1LD5 A;  2CA7 A;  3OFW A;  1BRB I;  1D0D A;  2KAI I;  1ZJD B;  1DTK A;  3AUD A;  2PTC I;  1BHC A;  1T8L B;  1KIG I;  1P2I I;  1LD6 A;  4Y0Y I;  4Y11 I;  1OA5 5;  5JB5 A;  2LFL A;  2FTL I;  1P2Q B;  1K6U A;  2W8X A;  1JV8 A;  1MTN D;  4BD9 B;  1G6X A;  1F5R I;  4U32 X;  1KUN A;  4NTY B;  1FAN A;  1T8O B;  1TCP A;  4NTW B;  7PTI A;  3P95 E;  3T62 D;  1EJM B;  1ADZ A;  2DDJ A;  2FI3 I;  2UUY B;  1TAW B; 
#chains in the Genus database with same CATH topology
 1YLD B;  1BPI A;  1EAW B;  1YC0 I;  3BTK I;  2UUX A;  2ODY E;  3L33 E;  1B0C A;  1D0D B;  1JC6 A;  1FY8 I;  4DTG K;  3U1J E;  1BTH P;  1BF0 A;  1SHP A;  2TGP I;  3GYM I;  3BTG I;  2M01 A;  3UOU B;  4ISL B;  4NTX B;  5JB6 A;  1PIT A;  1P2O B;  1P2M B;  1F7Z I;  1Y62 A;  1CA0 D;  1YKT B;  1YLC B;  4WXV C;  1DTX A;  1KNT A;  3FP7 J;  3BTQ I;  2TPI I;  3TPI I;  3P92 E;  1CBW D;  1JV9 A;  1BTI A;  1UUB A;  1NAG A;  3AUG A;  3AUH A;  4ISO B;  2FI4 I;  4Y0Z I;  1AAL A;  2IJO I;  3BTM I;  3OTJ I;  5PTI A;  1P2K I;  3AUC A;  1BZX I;  4U30 W;  9PTI A;  4TPI I;  1BRC I;  1P2N B;  2ZJX A;  3AUI A;  1BZ5 A;  1ZR0 B;  3AUE A;  3BYB A;  3CI7 A;  5JB7 A;  1TOC R;  1T8N B;  3AUB A;  4WWY C;  2KCR A;  1P2J I;  5JB4 A;  4BNR I;  1QLQ A;  2ZVX A;  3TGJ I;  2LFK A;  3WNY A;  1CO7 I;  1T8M B;  3BTT I;  1BPT A;  1BUN B;  1IRH A;  4DG4 C;  3BTD I;  4ISN B;  1KTH A;  1FAK I;  3M7Q B;  2M99 A;  1T7C B;  3LDM A;  3FP6 I;  2RA3 C;  1BIK A;  4Y10 I;  2HEX A;  3BTH I;  3LDI A;  3LDJ A;  1AAP A;  2KNT A;  4BQD A;  1TAP A;  2R9P E;  2DDI A;  3BTE I;  2FI5 I;  2FTM B;  2J6D A;  1OA6 5;  3TGI I;  1DEN A;  1TFX C;  2JOT A;  3L3T E;  3BTF I;  3FP8 I;  8PTI A;  3D65 I;  3UIR C;  6PTI A;  3BTW I;  1UUA A;  3TGK I;  1TPA I;  1DEM A;  5C67 C;  4PTI A;  1LD5 A;  2CA7 A;  3OFW A;  1BRB I;  1D0D A;  2KAI I;  1ZJD B;  1DTK A;  3AUD A;  2PTC I;  1BHC A;  1T8L B;  1KIG I;  1P2I I;  1LD6 A;  4Y0Y I;  4Y11 I;  1OA5 5;  5JB5 A;  2LFL A;  2FTL I;  1P2Q B;  1K6U A;  2W8X A;  1JV8 A;  1MTN D;  4BD9 B;  1G6X A;  1F5R I;  4U32 X;  1KUN A;  4NTY B;  1FAN A;  1T8O B;  1TCP A;  4NTW B;  7PTI A;  3P95 E;  3T62 D;  1EJM B;  1ADZ A;  2DDJ A;  2FI3 I;  2UUY B;  1TAW B; 
#chains in the Genus database with same CATH homology
 1YLD B;  1BPI A;  1EAW B;  1YC0 I;  3BTK I;  2UUX A;  2ODY E;  3L33 E;  1B0C A;  1D0D B;  1JC6 A;  1FY8 I;  4DTG K;  3U1J E;  1BTH P;  1BF0 A;  1SHP A;  2TGP I;  3GYM I;  3BTG I;  2M01 A;  3UOU B;  4ISL B;  4NTX B;  5JB6 A;  1PIT A;  1P2O B;  1P2M B;  1F7Z I;  1Y62 A;  1CA0 D;  1YKT B;  1YLC B;  4WXV C;  1DTX A;  1KNT A;  3FP7 J;  3BTQ I;  2TPI I;  3TPI I;  3P92 E;  1CBW D;  1JV9 A;  1BTI A;  1UUB A;  1NAG A;  3AUG A;  3AUH A;  4ISO B;  2FI4 I;  4Y0Z I;  1AAL A;  2IJO I;  3BTM I;  3OTJ I;  5PTI A;  1P2K I;  3AUC A;  1BZX I;  4U30 W;  9PTI A;  4TPI I;  1BRC I;  1P2N B;  2ZJX A;  3AUI A;  1BZ5 A;  1ZR0 B;  3AUE A;  3BYB A;  3CI7 A;  5JB7 A;  1TOC R;  1T8N B;  3AUB A;  4WWY C;  2KCR A;  1P2J I;  5JB4 A;  4BNR I;  1QLQ A;  2ZVX A;  3TGJ I;  2LFK A;  3WNY A;  1CO7 I;  1T8M B;  3BTT I;  1BPT A;  1BUN B;  1IRH A;  4DG4 C;  3BTD I;  4ISN B;  1KTH A;  1FAK I;  3M7Q B;  2M99 A;  1T7C B;  3LDM A;  3FP6 I;  2RA3 C;  1BIK A;  4Y10 I;  2HEX A;  3BTH I;  3LDI A;  3LDJ A;  1AAP A;  2KNT A;  4BQD A;  1TAP A;  2R9P E;  2DDI A;  3BTE I;  2FI5 I;  2FTM B;  2J6D A;  1OA6 5;  3TGI I;  1DEN A;  1TFX C;  2JOT A;  3L3T E;  3BTF I;  3FP8 I;  8PTI A;  3D65 I;  3UIR C;  6PTI A;  3BTW I;  1UUA A;  3TGK I;  1TPA I;  1DEM A;  5C67 C;  4PTI A;  1LD5 A;  2CA7 A;  3OFW A;  1BRB I;  1D0D A;  2KAI I;  1ZJD B;  1DTK A;  3AUD A;  2PTC I;  1BHC A;  1T8L B;  1KIG I;  1P2I I;  1LD6 A;  4Y0Y I;  4Y11 I;  1OA5 5;  5JB5 A;  2LFL A;  2FTL I;  1P2Q B;  1K6U A;  2W8X A;  1JV8 A;  1MTN D;  4BD9 B;  1G6X A;  1F5R I;  4U32 X;  1KUN A;  4NTY B;  1FAN A;  1T8O B;  1TCP A;  4NTW B;  7PTI A;  3P95 E;  3T62 D;  1EJM B;  1ADZ A;  2DDJ A;  2FI3 I;  2UUY B;  1TAW B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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