3TGKI

Trypsinogen mutant d194n and deletion of ile 16-val 17 complexed with bovine pancreatic trypsin inhibitor (bpti)
Total Genus 9
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
9
sequence length
56
structure length
56
Chain Sequence
RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The energetic cost of induced fit catalysis: Crystal structures of trypsinogen mutants with enhanced activity and inhibitor affinity.
pubmed doi rcsb
molecule tags Hydrolase/ hydrolase inhibitor
source organism Rattus norvegicus
molecule keywords TRYPSIN II, ANIONIC
total genus 9
structure length 56
sequence length 56
ec nomenclature
pdb deposition date 1998-07-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 3tgkI00
3BTHI 1TFXC 1T8NB 2KCRA 2M01A 2CA7A 3BTEI 4ISLB 1OA65 2LFLA 1QLQA 1TAWB 3BTWI 1BTIA 1P2JI 2FTLI 1BTHP 1T8MB 1DENA 1D0DA 2FI5I 2LFKA 1JV9A 5JB7A 2UUXA 1DEMA 4NTWB 1UUAA 1AALA 1ZR0B 1P2MB 3AUCA 3BTFI 3M7QB 3AUEA 1CBWD 4WXVC 1JV8A 3TGII 6PTIA 3WNYA 1F7ZI 2IJOI 1KNTA 3CI7A 1F5RI 2FI3I 2DDJA 3AUDA 3LDIA 3UOUB 1FAKI 1Y62A 7PTIA 1P2OB 4Y10I 1BRBI 3BYBA 3TPII 1DTXA 1BZ5A 3LDJA 3D65I 1P2QB 2RA3C 3BTTI 4ISNB 4Y0YI 3L3TE 3OTJI 3FP6I 1T7CB 4TPII 8PTIA 1EAWB 3BTDI 3BTMI 1YLCB 1D0DB 3AUGA 4U32X 1MTND 2R9PE 4PTIA 3TGJI 1BUNB 3U1JE 1BZXI 1P2KI 2ODYE 2W8XA 3GYMI 1PITA 3AUBA 4NTXB 3TGKI 1BRCI 1B0CA 1AAPA 2TPII 4Y11I 1ZJDB 2TGPI 1G6XA 9PTIA 3FP7J 3LDMA 1K6UA 4NTYB 1CA0D 1NAGA 2M99A 3P95E 3BTQI 1P2NB 4Y0ZI 1BPIA 1TCPA 1FANA 1KTHA 3BTKI 3T62D 2J6DA 1TOCR 1BF0A 2JOTA 1IRHA 1FY8I 5JB4A 1BIKA 4WWYC 5JB6A 1KUNA 1BHCA 1T8OB 3BTGI 1TAPA 1T8LB 1CO7I 4ISOB 1YC0I 5C67C 1UUBA 1YKTB 5PTIA 3AUIA 2PTCI 1LD5A 2FI4I 1P2II 1TPAI 2DDIA 2UUYB 3AUHA 4BQDA 1JC6A 1SHPA 1BPTA 4BNRI 3P92E 1ADZA 1KIGI 1YLDB 1DTKA 1EJMB 2ZJXA 3L33E 4DTGK 1OA55 2KNTA 4DG4C 2FTMB 2KAII 3UIRC 1LD6A 4U30W 2HEXA 2ZVXA 3OFWA 4BD9B 3FP8I 5JB5A
chains in the Genus database with same CATH superfamily
3BTHI 1TFXC 1T8NB 2KCRA 2M01A 2CA7A 3BTEI 4ISLB 1OA65 2LFLA 1QLQA 1TAWB 3BTWI 1BTIA 1P2JI 2FTLI 1BTHP 1T8MB 1DENA 1D0DA 2FI5I 2LFKA 1JV9A 5JB7A 2UUXA 1DEMA 4NTWB 1UUAA 1AALA 1ZR0B 1P2MB 3AUCA 3BTFI 3M7QB 3AUEA 1CBWD 4WXVC 1JV8A 3TGII 6PTIA 3WNYA 1F7ZI 2IJOI 1KNTA 3CI7A 1F5RI 2FI3I 2DDJA 3AUDA 3LDIA 3UOUB 1FAKI 1Y62A 7PTIA 1P2OB 4Y10I 1BRBI 3BYBA 3TPII 1DTXA 1BZ5A 3LDJA 3D65I 1P2QB 2RA3C 3BTTI 4ISNB 4Y0YI 3L3TE 3OTJI 3FP6I 1T7CB 4TPII 8PTIA 1EAWB 3BTDI 3BTMI 1YLCB 1D0DB 3AUGA 4U32X 1MTND 2R9PE 4PTIA 3TGJI 1BUNB 3U1JE 1BZXI 1P2KI 2ODYE 2W8XA 3GYMI 1PITA 3AUBA 4NTXB 3TGKI 1BRCI 1B0CA 1AAPA 2TPII 4Y11I 1ZJDB 2TGPI 1G6XA 9PTIA 3FP7J 3LDMA 1K6UA 4NTYB 1CA0D 1NAGA 2M99A 3P95E 3BTQI 1P2NB 4Y0ZI 1BPIA 1TCPA 1FANA 1KTHA 3BTKI 3T62D 2J6DA 1TOCR 1BF0A 2JOTA 1IRHA 1FY8I 5JB4A 1BIKA 4WWYC 5JB6A 1KUNA 1BHCA 1T8OB 3BTGI 1TAPA 1T8LB 1CO7I 4ISOB 1YC0I 5C67C 1UUBA 1YKTB 5PTIA 3AUIA 2PTCI 1LD5A 2FI4I 1P2II 1TPAI 2DDIA 2UUYB 3AUHA 4BQDA 1JC6A 1SHPA 1BPTA 4BNRI 3P92E 1ADZA 1KIGI 1YLDB 1DTKA 1EJMB 2ZJXA 3L33E 4DTGK 1OA55 2KNTA 4DG4C 2FTMB 2KAII 3UIRC 1LD6A 4U30W 2HEXA 2ZVXA 3OFWA 4BD9B 3FP8I 5JB5A
chains in the Genus database with same CATH topology
3BTHI 1TFXC 1T8NB 2KCRA 2M01A 2CA7A 3BTEI 4ISLB 1OA65 2LFLA 1QLQA 1TAWB 3BTWI 1BTIA 1P2JI 2FTLI 1BTHP 1T8MB 1DENA 1D0DA 2FI5I 2LFKA 1JV9A 5JB7A 2UUXA 1DEMA 4NTWB 1UUAA 1AALA 1ZR0B 1P2MB 3AUCA 3BTFI 3M7QB 3AUEA 1CBWD 4WXVC 1JV8A 3TGII 6PTIA 3WNYA 1F7ZI 2IJOI 1KNTA 3CI7A 1F5RI 2FI3I 2DDJA 3AUDA 3LDIA 3UOUB 1FAKI 1Y62A 7PTIA 1P2OB 4Y10I 1BRBI 3BYBA 3TPII 1DTXA 1BZ5A 3LDJA 3D65I 1P2QB 2RA3C 3BTTI 4ISNB 4Y0YI 3L3TE 3OTJI 3FP6I 1T7CB 4TPII 8PTIA 1EAWB 3BTDI 3BTMI 1YLCB 1D0DB 3AUGA 4U32X 1MTND 2R9PE 4PTIA 3TGJI 1BUNB 3U1JE 1BZXI 1P2KI 2ODYE 2W8XA 3GYMI 1PITA 3AUBA 4NTXB 3TGKI 1BRCI 1B0CA 1AAPA 2TPII 4Y11I 1ZJDB 2TGPI 1G6XA 9PTIA 3FP7J 3LDMA 1K6UA 4NTYB 1CA0D 1NAGA 2M99A 3P95E 3BTQI 1P2NB 4Y0ZI 1BPIA 1TCPA 1FANA 1KTHA 3BTKI 3T62D 2J6DA 1TOCR 1BF0A 2JOTA 1IRHA 1FY8I 5JB4A 1BIKA 4WWYC 5JB6A 1KUNA 1BHCA 1T8OB 3BTGI 1TAPA 1T8LB 1CO7I 4ISOB 1YC0I 5C67C 1UUBA 1YKTB 5PTIA 3AUIA 2PTCI 1LD5A 2FI4I 1P2II 1TPAI 2DDIA 2UUYB 3AUHA 4BQDA 1JC6A 1SHPA 1BPTA 4BNRI 3P92E 1ADZA 1KIGI 1YLDB 1DTKA 1EJMB 2ZJXA 3L33E 4DTGK 1OA55 2KNTA 4DG4C 2FTMB 2KAII 3UIRC 1LD6A 4U30W 2HEXA 2ZVXA 3OFWA 4BD9B 3FP8I 5JB5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BTH I;  1TFX C;  1T8N B;  2KCR A;  2M01 A;  2CA7 A;  3BTE I;  4ISL B;  1OA6 5;  2LFL A;  1QLQ A;  1TAW B;  3BTW I;  1BTI A;  1P2J I;  2FTL I;  1BTH P;  1T8M B;  1DEN A;  1D0D A;  2FI5 I;  2LFK A;  1JV9 A;  5JB7 A;  2UUX A;  1DEM A;  4NTW B;  1UUA A;  1AAL A;  1ZR0 B;  1P2M B;  3AUC A;  3BTF I;  3M7Q B;  3AUE A;  1CBW D;  4WXV C;  1JV8 A;  3TGI I;  6PTI A;  3WNY A;  1F7Z I;  2IJO I;  1KNT A;  3CI7 A;  1F5R I;  2FI3 I;  2DDJ A;  3AUD A;  3LDI A;  3UOU B;  1FAK I;  1Y62 A;  7PTI A;  1P2O B;  4Y10 I;  1BRB I;  3BYB A;  3TPI I;  1DTX A;  1BZ5 A;  3LDJ A;  3D65 I;  1P2Q B;  2RA3 C;  3BTT I;  4ISN B;  4Y0Y I;  3L3T E;  3OTJ I;  3FP6 I;  1T7C B;  4TPI I;  8PTI A;  1EAW B;  3BTD I;  3BTM I;  1YLC B;  1D0D B;  3AUG A;  4U32 X;  1MTN D;  2R9P E;  4PTI A;  3TGJ I;  1BUN B;  3U1J E;  1BZX I;  1P2K I;  2ODY E;  2W8X A;  3GYM I;  1PIT A;  3AUB A;  4NTX B;  3TGK I;  1BRC I;  1B0C A;  1AAP A;  2TPI I;  4Y11 I;  1ZJD B;  2TGP I;  1G6X A;  9PTI A;  3FP7 J;  3LDM A;  1K6U A;  4NTY B;  1CA0 D;  1NAG A;  2M99 A;  3P95 E;  3BTQ I;  1P2N B;  4Y0Z I;  1BPI A;  1TCP A;  1FAN A;  1KTH A;  3BTK I;  3T62 D;  2J6D A;  1TOC R;  1BF0 A;  2JOT A;  1IRH A;  1FY8 I;  5JB4 A;  1BIK A;  4WWY C;  5JB6 A;  1KUN A;  1BHC A;  1T8O B;  3BTG I;  1TAP A;  1T8L B;  1CO7 I;  4ISO B;  1YC0 I;  5C67 C;  1UUB A;  1YKT B;  5PTI A;  3AUI A;  2PTC I;  1LD5 A;  2FI4 I;  1P2I I;  1TPA I;  2DDI A;  2UUY B;  3AUH A;  4BQD A;  1JC6 A;  1SHP A;  1BPT A;  4BNR I;  3P92 E;  1ADZ A;  1KIG I;  1YLD B;  1DTK A;  1EJM B;  2ZJX A;  3L33 E;  4DTG K;  1OA5 5;  2KNT A;  4DG4 C;  2FTM B;  2KAI I;  3UIR C;  1LD6 A;  4U30 W;  2HEX A;  2ZVX A;  3OFW A;  4BD9 B;  3FP8 I;  5JB5 A; 
#chains in the Genus database with same CATH topology
 3BTH I;  1TFX C;  1T8N B;  2KCR A;  2M01 A;  2CA7 A;  3BTE I;  4ISL B;  1OA6 5;  2LFL A;  1QLQ A;  1TAW B;  3BTW I;  1BTI A;  1P2J I;  2FTL I;  1BTH P;  1T8M B;  1DEN A;  1D0D A;  2FI5 I;  2LFK A;  1JV9 A;  5JB7 A;  2UUX A;  1DEM A;  4NTW B;  1UUA A;  1AAL A;  1ZR0 B;  1P2M B;  3AUC A;  3BTF I;  3M7Q B;  3AUE A;  1CBW D;  4WXV C;  1JV8 A;  3TGI I;  6PTI A;  3WNY A;  1F7Z I;  2IJO I;  1KNT A;  3CI7 A;  1F5R I;  2FI3 I;  2DDJ A;  3AUD A;  3LDI A;  3UOU B;  1FAK I;  1Y62 A;  7PTI A;  1P2O B;  4Y10 I;  1BRB I;  3BYB A;  3TPI I;  1DTX A;  1BZ5 A;  3LDJ A;  3D65 I;  1P2Q B;  2RA3 C;  3BTT I;  4ISN B;  4Y0Y I;  3L3T E;  3OTJ I;  3FP6 I;  1T7C B;  4TPI I;  8PTI A;  1EAW B;  3BTD I;  3BTM I;  1YLC B;  1D0D B;  3AUG A;  4U32 X;  1MTN D;  2R9P E;  4PTI A;  3TGJ I;  1BUN B;  3U1J E;  1BZX I;  1P2K I;  2ODY E;  2W8X A;  3GYM I;  1PIT A;  3AUB A;  4NTX B;  3TGK I;  1BRC I;  1B0C A;  1AAP A;  2TPI I;  4Y11 I;  1ZJD B;  2TGP I;  1G6X A;  9PTI A;  3FP7 J;  3LDM A;  1K6U A;  4NTY B;  1CA0 D;  1NAG A;  2M99 A;  3P95 E;  3BTQ I;  1P2N B;  4Y0Z I;  1BPI A;  1TCP A;  1FAN A;  1KTH A;  3BTK I;  3T62 D;  2J6D A;  1TOC R;  1BF0 A;  2JOT A;  1IRH A;  1FY8 I;  5JB4 A;  1BIK A;  4WWY C;  5JB6 A;  1KUN A;  1BHC A;  1T8O B;  3BTG I;  1TAP A;  1T8L B;  1CO7 I;  4ISO B;  1YC0 I;  5C67 C;  1UUB A;  1YKT B;  5PTI A;  3AUI A;  2PTC I;  1LD5 A;  2FI4 I;  1P2I I;  1TPA I;  2DDI A;  2UUY B;  3AUH A;  4BQD A;  1JC6 A;  1SHP A;  1BPT A;  4BNR I;  3P92 E;  1ADZ A;  1KIG I;  1YLD B;  1DTK A;  1EJM B;  2ZJX A;  3L33 E;  4DTG K;  1OA5 5;  2KNT A;  4DG4 C;  2FTM B;  2KAI I;  3UIR C;  1LD6 A;  4U30 W;  2HEX A;  2ZVX A;  3OFW A;  4BD9 B;  3FP8 I;  5JB5 A; 
#chains in the Genus database with same CATH homology
 3BTH I;  1TFX C;  1T8N B;  2KCR A;  2M01 A;  2CA7 A;  3BTE I;  4ISL B;  1OA6 5;  2LFL A;  1QLQ A;  1TAW B;  3BTW I;  1BTI A;  1P2J I;  2FTL I;  1BTH P;  1T8M B;  1DEN A;  1D0D A;  2FI5 I;  2LFK A;  1JV9 A;  5JB7 A;  2UUX A;  1DEM A;  4NTW B;  1UUA A;  1AAL A;  1ZR0 B;  1P2M B;  3AUC A;  3BTF I;  3M7Q B;  3AUE A;  1CBW D;  4WXV C;  1JV8 A;  3TGI I;  6PTI A;  3WNY A;  1F7Z I;  2IJO I;  1KNT A;  3CI7 A;  1F5R I;  2FI3 I;  2DDJ A;  3AUD A;  3LDI A;  3UOU B;  1FAK I;  1Y62 A;  7PTI A;  1P2O B;  4Y10 I;  1BRB I;  3BYB A;  3TPI I;  1DTX A;  1BZ5 A;  3LDJ A;  3D65 I;  1P2Q B;  2RA3 C;  3BTT I;  4ISN B;  4Y0Y I;  3L3T E;  3OTJ I;  3FP6 I;  1T7C B;  4TPI I;  8PTI A;  1EAW B;  3BTD I;  3BTM I;  1YLC B;  1D0D B;  3AUG A;  4U32 X;  1MTN D;  2R9P E;  4PTI A;  3TGJ I;  1BUN B;  3U1J E;  1BZX I;  1P2K I;  2ODY E;  2W8X A;  3GYM I;  1PIT A;  3AUB A;  4NTX B;  3TGK I;  1BRC I;  1B0C A;  1AAP A;  2TPI I;  4Y11 I;  1ZJD B;  2TGP I;  1G6X A;  9PTI A;  3FP7 J;  3LDM A;  1K6U A;  4NTY B;  1CA0 D;  1NAG A;  2M99 A;  3P95 E;  3BTQ I;  1P2N B;  4Y0Z I;  1BPI A;  1TCP A;  1FAN A;  1KTH A;  3BTK I;  3T62 D;  2J6D A;  1TOC R;  1BF0 A;  2JOT A;  1IRH A;  1FY8 I;  5JB4 A;  1BIK A;  4WWY C;  5JB6 A;  1KUN A;  1BHC A;  1T8O B;  3BTG I;  1TAP A;  1T8L B;  1CO7 I;  4ISO B;  1YC0 I;  5C67 C;  1UUB A;  1YKT B;  5PTI A;  3AUI A;  2PTC I;  1LD5 A;  2FI4 I;  1P2I I;  1TPA I;  2DDI A;  2UUY B;  3AUH A;  4BQD A;  1JC6 A;  1SHP A;  1BPT A;  4BNR I;  3P92 E;  1ADZ A;  1KIG I;  1YLD B;  1DTK A;  1EJM B;  2ZJX A;  3L33 E;  4DTG K;  1OA5 5;  2KNT A;  4DG4 C;  2FTM B;  2KAI I;  3UIR C;  1LD6 A;  4U30 W;  2HEX A;  2ZVX A;  3OFW A;  4BD9 B;  3FP8 I;  5JB5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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