4A3GE

Rna polymerase ii initial transcribing complex with a 2nt dna-rna hybrid
Total Genus 63
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
63
sequence length
214
structure length
214
Chain Sequence
DQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSFQANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSAMKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQRADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of initial RNA polymerase II transcription.
pubmed doi rcsb
molecule tags Transcription
molecule keywords DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1
total genus 63
structure length 214
sequence length 214
ec nomenclature
pdb deposition date 2011-09-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01191 RNA_pol_Rpb5_C RNA polymerase Rpb5, C-terminal domain
E PF03871 RNA_pol_Rpb5_N RNA polymerase Rpb5, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1340.10 Alpha Beta 3-Layer(aba) Sandwich Dna-directed Rna Polymerases I, Ii, And Iii 27 Kd Polypeptide; Chain: A; domain 1 RNA polymerase, Rpb5, N-terminal domain 4a3gE01
3.90.940.20 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit RPB5-like RNA polymerase subunit 4a3gE02
5C4JE 3H3VF 3HOUE 3HOYE 3GTOE 4QIWH 3HOZE 3S17E 5M3ME 4BBSE 4C3IE 1I50E 1K83E 2R93E 2E2JE 1TWGE 4A3DE 4AYBH 3S2HE 5M5WE 3M3YE 4A3ME 3S15E 4A3KE 2B63E 3HOXE 2YU9E 4A93E 1I6HE 3PO2E 3S14E 1SFOE 4BBRE 2VUME 4C3HE 5IP7E 2E2HE 2Y0SH 3S16E 4C2ME 2JA8E 3S1NE 1TWHE 3S2DE 3GTGE 2JA7E 1DZFA 3M4OE 3GTPE 1Y1VE 3H0GE 1R9TE 4A3EE 3GTJE 2JA5E 4A3LE 5FJ8E 3HOWE 4C3JE 5M5YE 3PO3E 3GTME 3FKIE 2E2IE 4BXXE 3CQZE 2PMZH 3RZDE 5IYDE 5IYBE 3HKZH 1TWAE 3GTLE 1TWCE 3GTQE 2WB1H 2R7ZE 2R92E 2NVXE 5C44E 5M3FE 3S1ME 3HOVE 1Y1WE 4A3JE 3S1RE 3RZOE 1EIKA 4A3BE 2NVQE 3I4NE 4BY7E 3K7AE 5IYCE 4BY1E 4Y52E 2WAQH 5C4XE 5M5XE 1TWFE 4A3GE 2JA6E 3GTKE 1I3QE 5IP9E 5FLME 5C3EE 4Y7NE 1WCME 2NVTE 3I4ME 4A3IE 4X6AE 4A3FE 4A3CE 3S1QE 2NVYE
chains in the Genus database with same CATH superfamily
2A6EE 4MEYE 3H3VG 5C4JE 3HOUF 3H3VF 3WODE 5IP7F 1I6VE 4LLGE 3GTOF 4G7OE 3HOUE 3HOZF 3HOYE 3GTOE 5M3MF 4BBSF 4QIWH 3HOZE 3S17E 4C3IF 1TWHF 4YG2E 5M3ME 1K83F 4BBSE 3S2DF 4KMUE 3GTGF 2E2JF 4C3IE 1TWGF 4A3DF 1I50E 1K83E 2R93E 2E2JE 4OINE 3GTPF 1TWGE 4A3DE 4A3MF 3S15F 4A3KF 4AYBH 3S2HE 3GTJF 5M5WE 3M3YE 4A3ME 3S15E 3HOXF 2B63F 4A3LF 4A3KE 2A6HE 2YU9F 4A93F 2B63E 4JK1E 3HOXE 4KN7E 3PO2F 4MEXE 2YU9E 4A93E 5M5YF 1SFOF 4OIQE 4BBRF 1I6HE 2VUMF 3PO2E 3S14E 4YFKE 1SFOE 4C3HF 4BBRE 2VUME 2WB1I 3FKIF 4LJZE 2E2HF 1QKLA 4BXXF 4C3HE 5IP7E 2E2HE 3S16F 2Y0SH 3DXJE 5D4CE 4C2MF 4QIWK 2JA8F 3S16E 3S1NF 1YNNK 3GTLF 4C2ME 4OIOE 2JA8E 2JA7F 3S1NE 4GZYE 1TWHE 3S2DE 1HQME 3M4OF 5E17E 3GTGE 2JA7E 1DZFA 1Y1VF 3H0GF 2NVXF 3M4OE 1R9TF 2R92F 3GTPE 4A3EF 1Y1VE 3H0GE 4ZH4E 4KN4E 1R9TE 3HOVF 4AYBK 2JA5F 4A3EE 4A3BF 4Q5SE 4YFNE 5TMCE 5BYHE 3GTJE 2NVQF 2JA5E 4A3LE 5FJ8F 3HOWF 4C3JF 4XLNE 2KRXA 2O5JE 4G7ZE 5FJ8E 3HOWE 2A69E 4C3JE 4YFXE 4LK1E 4XLPE 4G7HE 3GTMF 5M5YE 3K7AF 4BY1F 5IYCF 3PO3F 4LK0E 3PO3E 2E2IF 3GTME 5E18E 3CQZF 3FKIE 3RZDF 2JA6F 2E2IE 4BXXE 4Q4ZE 5IYDF 3GTKF 3CQZE 2PMZH 5IYBF 3RZDE 5IYDE 1TWAF 5C3EF 1YNJK 5IYBE 1TWCF 3HKZH 3HKZK 3GTQF 1TWAE 3GTLE 3I4MF 4MQ9E 4XSZE 4OIPE 1TWCE 2R7ZF 3GTQE 2WB1H 5C44F 3EQLE 1SMYE 1ZYRE 5M3FF 3S1MF 2R7ZE 2NVYF 2R92E 2NVXE 5C44E 5M3FE 1Y1WF 3S1ME 5C4JF 4A3JF 3S1RF 3RZOF 1IW7E 3HOVE 1Y1WE 4A3JE 3S1RE 3RZOE 2A68E 4OIRE 3I4NF 3HOYF 1EIKA 4A3BE 2NVQE 3I4NE 4BY7F 3S17F 2O5IE 2BE5E 4Y52F 5C4XF 4BY7E 4XSXE 5M5XF 1TWFF 1I50F 4A3GF 3K7AE 5IYCE 4BY1E 4Y52E 2WAQH 2R93F 5C4XE 2WAQK 5M5XE 1TWFE 4A3GE 1I3QF 5IP9F 5FLMF 2JA6E 2CW0E 3GTKE 2PMZK 5D4EE 1I3QE 5IP9E 5FLME 3S2HF 5TMFE 1WCMF 4Y7NF 5M5WF 2NVTF 3M3YF 5C3EE 5D4DE 4A3IF 4X6AF 4Y7NE 1WCME 2NVTE 2Y0SI 4A3FF 3I4ME 4A3IE 4A3CF 4X6AE 3S1QF 1I6HF 5IPLE 4A3FE 3S14F 2PPBE 4A3CE 3S1QE 2NVYE
chains in the Genus database with same CATH topology
5C4JE 3H3VF 3HOUE 3HOYE 3GTOE 4QIWH 3HOZE 3S17E 5M3ME 4BBSE 4C3IE 1I50E 1K83E 2R93E 2E2JE 1TWGE 4A3DE 4AYBH 3S2HE 5M5WE 3M3YE 4A3ME 3S15E 4A3KE 2B63E 3HOXE 2YU9E 4A93E 1I6HE 3PO2E 3S14E 1SFOE 4BBRE 2VUME 4C3HE 5IP7E 2E2HE 2Y0SH 3S16E 4C2ME 2JA8E 3S1NE 1TWHE 3S2DE 3GTGE 2JA7E 1DZFA 3M4OE 3GTPE 1Y1VE 3H0GE 1R9TE 4A3EE 3GTJE 2JA5E 4A3LE 5FJ8E 3HOWE 4C3JE 5M5YE 3PO3E 3GTME 3FKIE 2E2IE 4BXXE 3CQZE 2PMZH 3RZDE 5IYDE 5IYBE 3HKZH 1TWAE 3GTLE 1TWCE 3GTQE 2WB1H 2R7ZE 2R92E 2NVXE 5C44E 5M3FE 3S1ME 3HOVE 1Y1WE 4A3JE 3S1RE 3RZOE 1EIKA 4A3BE 2NVQE 3I4NE 4BY7E 3K7AE 5IYCE 4BY1E 4Y52E 2WAQH 5C4XE 5M5XE 1TWFE 4A3GE 2JA6E 3GTKE 1I3QE 5IP9E 5FLME 5C3EE 4Y7NE 1WCME 2NVTE 3I4ME 4A3IE 4X6AE 4A3FE 4A3CE 3S1QE 2NVYE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5C4J E;  3H3V F;  3HOU E;  3HOY E;  3GTO E;  4QIW H;  3HOZ E;  3S17 E;  5M3M E;  4BBS E;  4C3I E;  1I50 E;  1K83 E;  2R93 E;  2E2J E;  1TWG E;  4A3D E;  4AYB H;  3S2H E;  5M5W E;  3M3Y E;  4A3M E;  3S15 E;  4A3K E;  2B63 E;  3HOX E;  2YU9 E;  4A93 E;  1I6H E;  3PO2 E;  3S14 E;  1SFO E;  4BBR E;  2VUM E;  4C3H E;  5IP7 E;  2E2H E;  2Y0S H;  3S16 E;  4C2M E;  2JA8 E;  3S1N E;  1TWH E;  3S2D E;  3GTG E;  2JA7 E;  1DZF A;  3M4O E;  3GTP E;  1Y1V E;  3H0G E;  1R9T E;  4A3E E;  3GTJ E;  2JA5 E;  4A3L E;  5FJ8 E;  3HOW E;  4C3J E;  5M5Y E;  3PO3 E;  3GTM E;  3FKI E;  2E2I E;  4BXX E;  3CQZ E;  2PMZ H;  3RZD E;  5IYD E;  5IYB E;  3HKZ H;  1TWA E;  3GTL E;  1TWC E;  3GTQ E;  2WB1 H;  2R7Z E;  2R92 E;  2NVX E;  5C44 E;  5M3F E;  3S1M E;  3HOV E;  1Y1W E;  4A3J E;  3S1R E;  3RZO E;  1EIK A;  4A3B E;  2NVQ E;  3I4N E;  4BY7 E;  3K7A E;  5IYC E;  4BY1 E;  4Y52 E;  2WAQ H;  5C4X E;  5M5X E;  1TWF E;  4A3G E;  2JA6 E;  3GTK E;  1I3Q E;  5IP9 E;  5FLM E;  5C3E E;  4Y7N E;  1WCM E;  2NVT E;  3I4M E;  4A3I E;  4X6A E;  4A3F E;  4A3C E;  3S1Q E;  2NVY E; 
#chains in the Genus database with same CATH topology
 2A6E E;  4MEY E;  3H3V G;  5C4J E;  3HOU F;  3H3V F;  3WOD E;  5IP7 F;  1I6V E;  4LLG E;  3GTO F;  4G7O E;  3HOU E;  3HOZ F;  3HOY E;  3GTO E;  5M3M F;  4BBS F;  4QIW H;  3HOZ E;  3S17 E;  4C3I F;  1TWH F;  4YG2 E;  5M3M E;  1K83 F;  4BBS E;  3S2D F;  4KMU E;  3GTG F;  2E2J F;  4C3I E;  1TWG F;  4A3D F;  1I50 E;  1K83 E;  2R93 E;  2E2J E;  4OIN E;  3GTP F;  1TWG E;  4A3D E;  4A3M F;  3S15 F;  4A3K F;  4AYB H;  3S2H E;  3GTJ F;  5M5W E;  3M3Y E;  4A3M E;  3S15 E;  3HOX F;  2B63 F;  4A3L F;  4A3K E;  2A6H E;  2YU9 F;  4A93 F;  2B63 E;  4JK1 E;  3HOX E;  4KN7 E;  3PO2 F;  4MEX E;  2YU9 E;  4A93 E;  5M5Y F;  1SFO F;  4OIQ E;  4BBR F;  1I6H E;  2VUM F;  3PO2 E;  3S14 E;  4YFK E;  1SFO E;  4C3H F;  4BBR E;  2VUM E;  2WB1 I;  3FKI F;  4LJZ E;  2E2H F;  1QKL A;  4BXX F;  4C3H E;  5IP7 E;  2E2H E;  3S16 F;  2Y0S H;  3DXJ E;  5D4C E;  4C2M F;  4QIW K;  2JA8 F;  3S16 E;  3S1N F;  1YNN K;  3GTL F;  4C2M E;  4OIO E;  2JA8 E;  2JA7 F;  3S1N E;  4GZY E;  1TWH E;  3S2D E;  1HQM E;  3M4O F;  5E17 E;  3GTG E;  2JA7 E;  1DZF A;  1Y1V F;  3H0G F;  2NVX F;  3M4O E;  1R9T F;  2R92 F;  3GTP E;  4A3E F;  1Y1V E;  3H0G E;  4ZH4 E;  4KN4 E;  1R9T E;  3HOV F;  4AYB K;  2JA5 F;  4A3E E;  4A3B F;  4Q5S E;  4YFN E;  5TMC E;  5BYH E;  3GTJ E;  2NVQ F;  2JA5 E;  4A3L E;  5FJ8 F;  3HOW F;  4C3J F;  4XLN E;  2KRX A;  2O5J E;  4G7Z E;  5FJ8 E;  3HOW E;  2A69 E;  4C3J E;  4YFX E;  4LK1 E;  4XLP E;  4G7H E;  3GTM F;  5M5Y E;  3K7A F;  4BY1 F;  5IYC F;  3PO3 F;  4LK0 E;  3PO3 E;  2E2I F;  3GTM E;  5E18 E;  3CQZ F;  3FKI E;  3RZD F;  2JA6 F;  2E2I E;  4BXX E;  4Q4Z E;  5IYD F;  3GTK F;  3CQZ E;  2PMZ H;  5IYB F;  3RZD E;  5IYD E;  1TWA F;  5C3E F;  1YNJ K;  5IYB E;  1TWC F;  3HKZ H;  3HKZ K;  3GTQ F;  1TWA E;  3GTL E;  3I4M F;  4MQ9 E;  4XSZ E;  4OIP E;  1TWC E;  2R7Z F;  3GTQ E;  2WB1 H;  5C44 F;  3EQL E;  1SMY E;  1ZYR E;  5M3F F;  3S1M F;  2R7Z E;  2NVY F;  2R92 E;  2NVX E;  5C44 E;  5M3F E;  1Y1W F;  3S1M E;  5C4J F;  4A3J F;  3S1R F;  3RZO F;  1IW7 E;  3HOV E;  1Y1W E;  4A3J E;  3S1R E;  3RZO E;  2A68 E;  4OIR E;  3I4N F;  3HOY F;  1EIK A;  4A3B E;  2NVQ E;  3I4N E;  4BY7 F;  3S17 F;  2O5I E;  2BE5 E;  4Y52 F;  5C4X F;  4BY7 E;  4XSX E;  5M5X F;  1TWF F;  1I50 F;  4A3G F;  3K7A E;  5IYC E;  4BY1 E;  4Y52 E;  2WAQ H;  2R93 F;  5C4X E;  2WAQ K;  5M5X E;  1TWF E;  4A3G E;  1I3Q F;  5IP9 F;  5FLM F;  2JA6 E;  2CW0 E;  3GTK E;  2PMZ K;  5D4E E;  1I3Q E;  5IP9 E;  5FLM E;  3S2H F;  5TMF E;  1WCM F;  4Y7N F;  5M5W F;  2NVT F;  3M3Y F;  5C3E E;  5D4D E;  4A3I F;  4X6A F;  4Y7N E;  1WCM E;  2NVT E;  2Y0S I;  4A3F F;  3I4M E;  4A3I E;  4A3C F;  4X6A E;  3S1Q F;  1I6H F;  5IPL E;  4A3F E;  3S14 F;  2PPB E;  4A3C E;  3S1Q E;  2NVY E; 
#chains in the Genus database with same CATH homology
 5C4J E;  3H3V F;  3HOU E;  3HOY E;  3GTO E;  4QIW H;  3HOZ E;  3S17 E;  5M3M E;  4BBS E;  4C3I E;  1I50 E;  1K83 E;  2R93 E;  2E2J E;  1TWG E;  4A3D E;  4AYB H;  3S2H E;  5M5W E;  3M3Y E;  4A3M E;  3S15 E;  4A3K E;  2B63 E;  3HOX E;  2YU9 E;  4A93 E;  1I6H E;  3PO2 E;  3S14 E;  1SFO E;  4BBR E;  2VUM E;  4C3H E;  5IP7 E;  2E2H E;  2Y0S H;  3S16 E;  4C2M E;  2JA8 E;  3S1N E;  1TWH E;  3S2D E;  3GTG E;  2JA7 E;  1DZF A;  3M4O E;  3GTP E;  1Y1V E;  3H0G E;  1R9T E;  4A3E E;  3GTJ E;  2JA5 E;  4A3L E;  5FJ8 E;  3HOW E;  4C3J E;  5M5Y E;  3PO3 E;  3GTM E;  3FKI E;  2E2I E;  4BXX E;  3CQZ E;  2PMZ H;  3RZD E;  5IYD E;  5IYB E;  3HKZ H;  1TWA E;  3GTL E;  1TWC E;  3GTQ E;  2WB1 H;  2R7Z E;  2R92 E;  2NVX E;  5C44 E;  5M3F E;  3S1M E;  3HOV E;  1Y1W E;  4A3J E;  3S1R E;  3RZO E;  1EIK A;  4A3B E;  2NVQ E;  3I4N E;  4BY7 E;  3K7A E;  5IYC E;  4BY1 E;  4Y52 E;  2WAQ H;  5C4X E;  5M5X E;  1TWF E;  4A3G E;  2JA6 E;  3GTK E;  1I3Q E;  5IP9 E;  5FLM E;  5C3E E;  4Y7N E;  1WCM E;  2NVT E;  3I4M E;  4A3I E;  4X6A E;  4A3F E;  4A3C E;  3S1Q E;  2NVY E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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