4AMMA

Crystal structure of the acyltransferase domain of the iterative polyketide synthase in enediyne biosynthesis reveals the molecular basis of substrate specificity
Total Genus 130
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
130
sequence length
401
structure length
384
Chain Sequence
PDHELVVCGAPDAAALTGLLTRVRAAATALSRPELTDLAAGLAAAHRGDVPARFAAAVRDADGLVAALDRALGHLAEGGRRLLDAGRGLFLVVGGPLRVGLLFPGQAAPVHADRGALGHKPAEPVDTAVAQPAIIADSLAGIRWLDRLGARPVGALGHSLGELAALSWAGALDADDTLALARARGEAMSAATEAPSGMLSLRADLAAARELAAGTGAVVAVDNGERHVVVAGTRPELDRVAEAARHAGIEATPLAVSHAFHSPLMAPAAEALRRAAGRLPWRRPERPVASTVTGAWWADEDPVEVLVRQLTGPVRFREALGLLDADLLVEVGPGRMLSALAEAAGRTAVSLDAGAASAAGMAAGTAALFAAGAVDDATPFFAGR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis.
pubmed doi rcsb
molecule keywords DYNE8
molecule tags Transferase
source organism Micromonospora chersina
total genus 130
structure length 384
sequence length 401
ec nomenclature
pdb deposition date 2012-03-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00698 Acyl_transf_1 Acyl transferase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.366.20 Alpha Beta 3-Layer(aba) Sandwich Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 4ammA00
3TZWA 4AMNA 4AMMA 3TZZA 4AMOA 3TZYA 3TZXA 4AMPA
chains in the Genus database with same CATH superfamily
2G2ZA 3HMJG 3TQEA 4QBUA 2C2NA 2JFDA 3HJVA 4RL1A 2CUYA 1NM2A 5DZ7A 3TZYA 3IM8A 3PTWA 2VZ9A 1MLAA 2PFFB 4AMPA 2QO3A 3TZWA 2H1YA 2UV8G 5DZ6A 4AMNA 2G1HA 3EZOA 3R97A 3TZZA 4AMOA 3G87A 2VKZG 2HG4A 3RGIA 5CZDA 3QATA 4AMMA 2G2OA 3K89A 3IM9A 3H0PA 2QC3A 5CZCA 2JFKA 4RR5A 3SBMA 2QJ3A 2G2YA 3TZXA 2VZ8A 3HHDA
chains in the Genus database with same CATH topology
3TZWA 4AMNA 4AMMA 3TZZA 4AMOA 3TZYA 3TZXA 4AMPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3TZW A;  4AMN A;  4AMM A;  3TZZ A;  4AMO A;  3TZY A;  3TZX A;  4AMP A; 
#chains in the Genus database with same CATH topology
 2G2Z A;  3HMJ G;  3TQE A;  4QBU A;  2C2N A;  2JFD A;  3HJV A;  4RL1 A;  2CUY A;  1NM2 A;  5DZ7 A;  3TZY A;  3IM8 A;  3PTW A;  2VZ9 A;  1MLA A;  2PFF B;  4AMP A;  2QO3 A;  3TZW A;  2H1Y A;  2UV8 G;  5DZ6 A;  4AMN A;  2G1H A;  3EZO A;  3R97 A;  3TZZ A;  4AMO A;  3G87 A;  2VKZ G;  2HG4 A;  3RGI A;  5CZD A;  3QAT A;  4AMM A;  2G2O A;  3K89 A;  3IM9 A;  3H0P A;  2QC3 A;  5CZC A;  2JFK A;  4RR5 A;  3SBM A;  2QJ3 A;  2G2Y A;  3TZX A;  2VZ8 A;  3HHD A; 
#chains in the Genus database with same CATH homology
 3TZW A;  4AMN A;  4AMM A;  3TZZ A;  4AMO A;  3TZY A;  3TZX A;  4AMP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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