4AMMA

Crystal structure of the acyltransferase domain of the iterative polyketide synthase in enediyne biosynthesis reveals the molecular basis of substrate specificity
Total Genus 130
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
130
sequence length
401
structure length
384
Chain Sequence
PDHELVVCGAPDAAALTGLLTRVRAAATALSRPELTDLAAGLAAAHRGDVPARFAAAVRDADGLVAALDRALGHLAEGGRRLLDAGRGLFLVVGGPLRVGLLFPGQAAPVHADRGALGHKPAEPVDTAVAQPAIIADSLAGIRWLDRLGARPVGALGHSLGELAALSWAGALDADDTLALARARGEAMSAATEAPSGMLSLRADLAAARELAAGTGAVVAVDNGERHVVVAGTRPELDRVAEAARHAGIEATPLAVSHAFHSPLMAPAAEALRRAAGRLPWRRPERPVASTVTGAWWADEDPVEVLVRQLTGPVRFREALGLLDADLLVEVGPGRMLSALAEAAGRTAVSLDAGAASAAGMAAGTAALFAAGAVDDATPFFAGR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis.
pubmed doi rcsb
molecule keywords DYNE8
molecule tags Transferase
source organism Micromonospora chersina
total genus 130
structure length 384
sequence length 401
ec nomenclature
pdb deposition date 2012-03-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00698 Acyl_transf_1 Acyl transferase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.366.20 Alpha Beta 3-Layer(aba) Sandwich Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 4ammA00
4AMNA 4AMPA 3TZYA 4AMMA 3TZWA 4AMOA 3TZZA 3TZXA
chains in the Genus database with same CATH superfamily
3QATA 3TQEA 1MLAA 2HG4A 3TZYA 3PTWA 5DZ7A 2QJ3A 2G2ZA 3TZWA 2UV8G 5DZ6A 3TZXA 2JFKA 3SBMA 1NM2A 2QO3A 2G1HA 4RR5A 2QC3A 3IM9A 2VZ9A 2H1YA 5CZCA 4AMMA 2G2YA 2G2OA 2PFFB 2VZ8A 4AMPA 4QBUA 2C2NA 3HMJG 3R97A 2VKZG 3G87A 3HHDA 3H0PA 2JFDA 4AMNA 2CUYA 5CZDA 3RGIA 3IM8A 3K89A 4AMOA 3TZZA 3HJVA 3EZOA 4RL1A
chains in the Genus database with same CATH topology
4AMNA 4AMPA 3TZYA 4AMMA 3TZWA 4AMOA 3TZZA 3TZXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4AMN A;  4AMP A;  3TZY A;  4AMM A;  3TZW A;  4AMO A;  3TZZ A;  3TZX A; 
#chains in the Genus database with same CATH topology
 3QAT A;  3TQE A;  1MLA A;  2HG4 A;  3TZY A;  3PTW A;  5DZ7 A;  2QJ3 A;  2G2Z A;  3TZW A;  2UV8 G;  5DZ6 A;  3TZX A;  2JFK A;  3SBM A;  1NM2 A;  2QO3 A;  2G1H A;  4RR5 A;  2QC3 A;  3IM9 A;  2VZ9 A;  2H1Y A;  5CZC A;  4AMM A;  2G2Y A;  2G2O A;  2PFF B;  2VZ8 A;  4AMP A;  4QBU A;  2C2N A;  3HMJ G;  3R97 A;  2VKZ G;  3G87 A;  3HHD A;  3H0P A;  2JFD A;  4AMN A;  2CUY A;  5CZD A;  3RGI A;  3IM8 A;  3K89 A;  4AMO A;  3TZZ A;  3HJV A;  3EZO A;  4RL1 A; 
#chains in the Genus database with same CATH homology
 4AMN A;  4AMP A;  3TZY A;  4AMM A;  3TZW A;  4AMO A;  3TZZ A;  3TZX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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