4AMNA

Crystal structure of the acyltransferase domain of the iterative polyketide synthase in enediyne biosynthesis reveals the molecular basis of substrate specificity
Total Genus 126
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
126
sequence length
401
structure length
384
Chain Sequence
PDHELVVCGAPDAAALTGLLTRVRAAATALSRPELTDLAAGLAAAHRGDVPARFAAAVRDADGLVAALDRALGHLAEGGRRLLDAGRGLFLVVGGPLRVGLLFPGQAAPVHADRGALGHLPAEPVDTAVAQPAIIADSLAGIRWLDRLGARPVGALGHSLGELAALSWAGALDADDTLALARARGEAMSAATEAPSGMLSLRADLAAARELAAGTGAVVAVDNGERHVVVAGTRPELDRVAEAARHAGIEATPLAVSHAFHSPLMAPAAEALRRAAGRLPWRRPERPVASTVTGAWWADEDPVEVLVRQLTGPVRFREALGLLDADLLVEVGPGRMLSALAEAAGRTAVSLDAGAASAAGMAAGTAALFAAGAVDDATPFFAGR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis.
pubmed doi rcsb
molecule keywords DYNE8
molecule tags Transferase
source organism Micromonospora chersina
total genus 126
structure length 384
sequence length 401
ec nomenclature
pdb deposition date 2012-03-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00698 Acyl_transf_1 Acyl transferase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.366.20 Alpha Beta 3-Layer(aba) Sandwich Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 4amnA00
4AMMA 4AMPA 3TZWA 4AMNA 3TZYA 3TZZA 4AMOA 3TZXA
chains in the Genus database with same CATH superfamily
3PTWA 4QBUA 3SBMA 3TZWA 2CUYA 3TZYA 2VZ9A 4AMOA 2JFKA 4AMMA 2G2YA 2QC3A 3HJVA 3K89A 2C2NA 4RR5A 3IM8A 2QO3A 3TZZA 3TQEA 3R97A 3TZXA 2VZ8A 3EZOA 2QJ3A 3HHDA 2G2ZA 2H1YA 5DZ7A 4AMPA 4AMNA 2JFDA 2PFFB 3H0PA 3G87A 3IM9A 1MLAA 5CZCA 2HG4A 5DZ6A 5CZDA 2G2OA 3HMJG 2UV8G 1NM2A 4RL1A 2VKZG 3RGIA 3QATA 2G1HA
chains in the Genus database with same CATH topology
4AMMA 4AMPA 3TZWA 4AMNA 3TZYA 3TZZA 4AMOA 3TZXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4AMM A;  4AMP A;  3TZW A;  4AMN A;  3TZY A;  3TZZ A;  4AMO A;  3TZX A; 
#chains in the Genus database with same CATH topology
 3PTW A;  4QBU A;  3SBM A;  3TZW A;  2CUY A;  3TZY A;  2VZ9 A;  4AMO A;  2JFK A;  4AMM A;  2G2Y A;  2QC3 A;  3HJV A;  3K89 A;  2C2N A;  4RR5 A;  3IM8 A;  2QO3 A;  3TZZ A;  3TQE A;  3R97 A;  3TZX A;  2VZ8 A;  3EZO A;  2QJ3 A;  3HHD A;  2G2Z A;  2H1Y A;  5DZ7 A;  4AMP A;  4AMN A;  2JFD A;  2PFF B;  3H0P A;  3G87 A;  3IM9 A;  1MLA A;  5CZC A;  2HG4 A;  5DZ6 A;  5CZD A;  2G2O A;  3HMJ G;  2UV8 G;  1NM2 A;  4RL1 A;  2VKZ G;  3RGI A;  3QAT A;  2G1H A; 
#chains in the Genus database with same CATH homology
 4AMM A;  4AMP A;  3TZW A;  4AMN A;  3TZY A;  3TZZ A;  4AMO A;  3TZX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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