4AMNA

Crystal structure of the acyltransferase domain of the iterative polyketide synthase in enediyne biosynthesis reveals the molecular basis of substrate specificity
Total Genus 126
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
126
sequence length
401
structure length
384
Chain Sequence
PDHELVVCGAPDAAALTGLLTRVRAAATALSRPELTDLAAGLAAAHRGDVPARFAAAVRDADGLVAALDRALGHLAEGGRRLLDAGRGLFLVVGGPLRVGLLFPGQAAPVHADRGALGHLPAEPVDTAVAQPAIIADSLAGIRWLDRLGARPVGALGHSLGELAALSWAGALDADDTLALARARGEAMSAATEAPSGMLSLRADLAAARELAAGTGAVVAVDNGERHVVVAGTRPELDRVAEAARHAGIEATPLAVSHAFHSPLMAPAAEALRRAAGRLPWRRPERPVASTVTGAWWADEDPVEVLVRQLTGPVRFREALGLLDADLLVEVGPGRMLSALAEAAGRTAVSLDAGAASAAGMAAGTAALFAAGAVDDATPFFAGR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis.
pubmed doi rcsb
molecule keywords DYNE8
molecule tags Transferase
source organism Micromonospora chersina
total genus 126
structure length 384
sequence length 401
ec nomenclature
pdb deposition date 2012-03-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00698 Acyl_transf_1 Acyl transferase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.366.20 Alpha Beta 3-Layer(aba) Sandwich Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 4amnA00
3TZZA 4AMNA 3TZWA 4AMMA 3TZXA 4AMPA 3TZYA 4AMOA
chains in the Genus database with same CATH superfamily
3IM9A 4QBUA 3HMJG 4RR5A 3TZXA 3IM8A 3TZYA 3G87A 2HG4A 1NM2A 3QATA 4AMNA 4AMMA 2QJ3A 3TZZA 2QC3A 3SBMA 3K89A 2VZ8A 3PTWA 5CZCA 4AMOA 2UV8G 2G1HA 2CUYA 2H1YA 5CZDA 2JFKA 2G2OA 4AMPA 3HJVA 2G2ZA 2PFFB 1MLAA 2VKZG 3HHDA 4RL1A 3TZWA 3RGIA 2G2YA 3EZOA 3H0PA 2VZ9A 5DZ6A 2C2NA 5DZ7A 2JFDA 2QO3A 3TQEA 3R97A
chains in the Genus database with same CATH topology
3TZZA 4AMNA 3TZWA 4AMMA 3TZXA 4AMPA 3TZYA 4AMOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3TZZ A;  4AMN A;  3TZW A;  4AMM A;  3TZX A;  4AMP A;  3TZY A;  4AMO A; 
#chains in the Genus database with same CATH topology
 3IM9 A;  4QBU A;  3HMJ G;  4RR5 A;  3TZX A;  3IM8 A;  3TZY A;  3G87 A;  2HG4 A;  1NM2 A;  3QAT A;  4AMN A;  4AMM A;  2QJ3 A;  3TZZ A;  2QC3 A;  3SBM A;  3K89 A;  2VZ8 A;  3PTW A;  5CZC A;  4AMO A;  2UV8 G;  2G1H A;  2CUY A;  2H1Y A;  5CZD A;  2JFK A;  2G2O A;  4AMP A;  3HJV A;  2G2Z A;  2PFF B;  1MLA A;  2VKZ G;  3HHD A;  4RL1 A;  3TZW A;  3RGI A;  2G2Y A;  3EZO A;  3H0P A;  2VZ9 A;  5DZ6 A;  2C2N A;  5DZ7 A;  2JFD A;  2QO3 A;  3TQE A;  3R97 A; 
#chains in the Genus database with same CATH homology
 3TZZ A;  4AMN A;  3TZW A;  4AMM A;  3TZX A;  4AMP A;  3TZY A;  4AMO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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