4AMNA

Crystal structure of the acyltransferase domain of the iterative polyketide synthase in enediyne biosynthesis reveals the molecular basis of substrate specificity
Total Genus 126
50100150200250300350020406080100120
Genus TraceResidueGenus

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
126
sequence length
401
structure length
384
Chain Sequence
PDHELVVCGAPDAAALTGLLTRVRAAATALSRPELTDLAAGLAAAHRGDVPARFAAAVRDADGLVAALDRALGHLAEGGRRLLDAGRGLFLVVGGPLRVGLLFPGQAAPVHADRGALGHLPAEPVDTAVAQPAIIADSLAGIRWLDRLGARPVGALGHSLGELAALSWAGALDADDTLALARARGEAMSAATEAPSGMLSLRADLAAARELAAGTGAVVAVDNGERHVVVAGTRPELDRVAEAARHAGIEATPLAVSHAFHSPLMAPAAEALRRAAGRLPWRRPERPVASTVTGAWWADEDPVEVLVRQLTGPVRFREALGLLDADLLVEVGPGRMLSALAEAAGRTAVSLDAGAASAAGMAAGTAALFAAGAVDDATPFFAGR
5010015020025030035035030025020015010050
020406080100120Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
source organism Micromonospora chersina
publication title Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis.
pubmed doi rcsb
molecule keywords DYNE8
total genus 126
structure length 384
sequence length 401
ec nomenclature
pdb deposition date 2012-03-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00698 Acyl_transf_1 Acyl transferase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.366.20 Alpha Beta 3-Layer(aba) Sandwich Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 4amnA00
4AMPA 4AMMA 3TZYA 4AMOA 3TZZA 3TZXA 4AMNA 3TZWA
chains in the Genus database with same CATH superfamily
4AMPA 3QATA 2VKZG 4AMMA 2QO3A 3EZOA 2JFDA 4RL1A 3HMJG 2HG4A 3TZXA 3IM8A 2QJ3A 4AMOA 3IM9A 2PFFB 4RR5A 5CZDA 3SBMA 2G2YA 3TQEA 4AMNA 2G2OA 3TZWA 2G1HA 3R97A 3HHDA 5CZCA 4QBUA 3G87A 1MLAA 2G2ZA 2H1YA 2JFKA 3K89A 2C2NA 3HJVA 2VZ8A 3TZYA 2VZ9A 2UV8G 2QC3A 5DZ6A 3H0PA 2CUYA 3RGIA 1NM2A 3TZZA 3PTWA 5DZ7A
chains in the Genus database with same CATH topology
4AMPA 4AMMA 3TZYA 4AMOA 3TZZA 3TZXA 4AMNA 3TZWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4AMP A;  4AMM A;  3TZY A;  4AMO A;  3TZZ A;  3TZX A;  4AMN A;  3TZW A; 
#chains in the Genus database with same CATH topology
 4AMP A;  3QAT A;  2VKZ G;  4AMM A;  2QO3 A;  3EZO A;  2JFD A;  4RL1 A;  3HMJ G;  2HG4 A;  3TZX A;  3IM8 A;  2QJ3 A;  4AMO A;  3IM9 A;  2PFF B;  4RR5 A;  5CZD A;  3SBM A;  2G2Y A;  3TQE A;  4AMN A;  2G2O A;  3TZW A;  2G1H A;  3R97 A;  3HHD A;  5CZC A;  4QBU A;  3G87 A;  1MLA A;  2G2Z A;  2H1Y A;  2JFK A;  3K89 A;  2C2N A;  3HJV A;  2VZ8 A;  3TZY A;  2VZ9 A;  2UV8 G;  2QC3 A;  5DZ6 A;  3H0P A;  2CUY A;  3RGI A;  1NM2 A;  3TZZ A;  3PTW A;  5DZ7 A; 
#chains in the Genus database with same CATH homology
 4AMP A;  4AMM A;  3TZY A;  4AMO A;  3TZZ A;  3TZX A;  4AMN A;  3TZW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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