4AMOA

Crystal structure of the acyltransferase domain of the iterative polyketide synthase in enediyne biosynthesis reveals the molecular basis of substrate specificity
Total Genus 124
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
124
sequence length
401
structure length
371
Chain Sequence
PDHELVVCGAPDAAALTGLLTRVRAAATALSRPELTDLAAGLAAAHRGDVPARFAAAVRDADGLVAALDRALGHLAEGGRRLLDAGRGLFLVVGGPLRVGLLFPGQAAPVPVDTAVAQPAIIADSLAGIRWLDRLGARPVGALGHSLGELAALSWAGALDADDTLALARARGEAMSVATEAPSGMLSLRADLAAARELAAGTGAVVAVDNGERHVVVAGTRPELDRVAEAARHAGIEATPLAVSHAFHSPLMAPAAEALRRAAGRLPWRRPERPVASTVTGAWWADEDPVEVLVRQLTGPVRFREALGLLDADLLVEVGPGRMLSALAEAAGRTAVSLDAGAASAAGMAAGTAALFAAGAVDDATPFFAGR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis.
pubmed doi rcsb
molecule keywords DYNE8
molecule tags Transferase
source organism Micromonospora chersina
total genus 124
structure length 371
sequence length 401
ec nomenclature
pdb deposition date 2012-03-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00698 Acyl_transf_1 Acyl transferase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.366.20 Alpha Beta 3-Layer(aba) Sandwich Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 4amoA00
3TZXA 3TZYA 3TZZA 4AMNA 4AMOA 3TZWA 4AMMA 4AMPA
chains in the Genus database with same CATH superfamily
3G87A 2G2OA 3H0PA 2CUYA 2G1HA 4RL1A 3TZYA 5CZCA 2VKZG 3HMJG 3R97A 4RR5A 2QJ3A 3TZWA 4QBUA 3EZOA 2H1YA 5CZDA 3TZZA 2JFKA 3QATA 1NM2A 1MLAA 3TQEA 4AMMA 3PTWA 3IM9A 3IM8A 2UV8G 5DZ6A 2PFFB 2G2ZA 4AMNA 3K89A 2QO3A 2JFDA 5DZ7A 2C2NA 3SBMA 4AMPA 3TZXA 2HG4A 2G2YA 3HJVA 3HHDA 2VZ8A 2VZ9A 4AMOA 2QC3A 3RGIA
chains in the Genus database with same CATH topology
3TZXA 3TZYA 3TZZA 4AMNA 4AMOA 3TZWA 4AMMA 4AMPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3TZX A;  3TZY A;  3TZZ A;  4AMN A;  4AMO A;  3TZW A;  4AMM A;  4AMP A; 
#chains in the Genus database with same CATH topology
 3G87 A;  2G2O A;  3H0P A;  2CUY A;  2G1H A;  4RL1 A;  3TZY A;  5CZC A;  2VKZ G;  3HMJ G;  3R97 A;  4RR5 A;  2QJ3 A;  3TZW A;  4QBU A;  3EZO A;  2H1Y A;  5CZD A;  3TZZ A;  2JFK A;  3QAT A;  1NM2 A;  1MLA A;  3TQE A;  4AMM A;  3PTW A;  3IM9 A;  3IM8 A;  2UV8 G;  5DZ6 A;  2PFF B;  2G2Z A;  4AMN A;  3K89 A;  2QO3 A;  2JFD A;  5DZ7 A;  2C2N A;  3SBM A;  4AMP A;  3TZX A;  2HG4 A;  2G2Y A;  3HJV A;  3HHD A;  2VZ8 A;  2VZ9 A;  4AMO A;  2QC3 A;  3RGI A; 
#chains in the Genus database with same CATH homology
 3TZX A;  3TZY A;  3TZZ A;  4AMN A;  4AMO A;  3TZW A;  4AMM A;  4AMP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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