4AMOA

Crystal structure of the acyltransferase domain of the iterative polyketide synthase in enediyne biosynthesis reveals the molecular basis of substrate specificity
Total Genus 124
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
124
sequence length
401
structure length
371
Chain Sequence
PDHELVVCGAPDAAALTGLLTRVRAAATALSRPELTDLAAGLAAAHRGDVPARFAAAVRDADGLVAALDRALGHLAEGGRRLLDAGRGLFLVVGGPLRVGLLFPGQAAPVPVDTAVAQPAIIADSLAGIRWLDRLGARPVGALGHSLGELAALSWAGALDADDTLALARARGEAMSVATEAPSGMLSLRADLAAARELAAGTGAVVAVDNGERHVVVAGTRPELDRVAEAARHAGIEATPLAVSHAFHSPLMAPAAEALRRAAGRLPWRRPERPVASTVTGAWWADEDPVEVLVRQLTGPVRFREALGLLDADLLVEVGPGRMLSALAEAAGRTAVSLDAGAASAAGMAAGTAALFAAGAVDDATPFFAGR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis.
pubmed doi rcsb
molecule keywords DYNE8
molecule tags Transferase
source organism Micromonospora chersina
total genus 124
structure length 371
sequence length 401
ec nomenclature
pdb deposition date 2012-03-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00698 Acyl_transf_1 Acyl transferase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.366.20 Alpha Beta 3-Layer(aba) Sandwich Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 4amoA00
4AMOA 3TZYA 4AMMA 4AMPA 3TZZA 3TZWA 4AMNA 3TZXA
chains in the Genus database with same CATH superfamily
2CUYA 3K89A 3TZYA 2JFDA 3EZOA 3HJVA 2G2ZA 5DZ7A 3TZWA 2VZ8A 3IM8A 2UV8G 3H0PA 3PTWA 2HG4A 2JFKA 5CZCA 2C2NA 3SBMA 3RGIA 3QATA 3R97A 3IM9A 2VKZG 3HHDA 4AMOA 2G1HA 4AMMA 5CZDA 3G87A 1NM2A 3TQEA 4AMNA 2QC3A 2H1YA 4QBUA 1MLAA 2PFFB 2G2OA 2QJ3A 3HMJG 4AMPA 4RL1A 2QO3A 3TZZA 5DZ6A 3TZXA 2G2YA 2VZ9A 4RR5A
chains in the Genus database with same CATH topology
4AMOA 3TZYA 4AMMA 4AMPA 3TZZA 3TZWA 4AMNA 3TZXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4AMO A;  3TZY A;  4AMM A;  4AMP A;  3TZZ A;  3TZW A;  4AMN A;  3TZX A; 
#chains in the Genus database with same CATH topology
 2CUY A;  3K89 A;  3TZY A;  2JFD A;  3EZO A;  3HJV A;  2G2Z A;  5DZ7 A;  3TZW A;  2VZ8 A;  3IM8 A;  2UV8 G;  3H0P A;  3PTW A;  2HG4 A;  2JFK A;  5CZC A;  2C2N A;  3SBM A;  3RGI A;  3QAT A;  3R97 A;  3IM9 A;  2VKZ G;  3HHD A;  4AMO A;  2G1H A;  4AMM A;  5CZD A;  3G87 A;  1NM2 A;  3TQE A;  4AMN A;  2QC3 A;  2H1Y A;  4QBU A;  1MLA A;  2PFF B;  2G2O A;  2QJ3 A;  3HMJ G;  4AMP A;  4RL1 A;  2QO3 A;  3TZZ A;  5DZ6 A;  3TZX A;  2G2Y A;  2VZ9 A;  4RR5 A; 
#chains in the Genus database with same CATH homology
 4AMO A;  3TZY A;  4AMM A;  4AMP A;  3TZZ A;  3TZW A;  4AMN A;  3TZX A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...