4AMPA

Crystal structure of the acyltransferase domain of the iterative polyketide synthase in enediyne biosynthesis reveals the molecular basis of substrate specificity
Total Genus 128
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
128
sequence length
401
structure length
372
Chain Sequence
PDHELVVCGAPDAAALTGLLTRVRAAATALSRPELTDLAAGLAAAHRGDVPARFAAAVRDADGLVAALDRALGHLAEGGRRLLDAGRGLFLVVGGPLRVGLLFPGQAAPVHPVDTAVAQPAIIADSLAGIRWLDRLGARPVGALGHSLGELAALSWAGALDADDTLALARARGEAMSAATEAPSGMLSLRADLAAARELAAGTGAVVAVDNGERHVVVAGTRPELDRVAEAARHAGIEATPLAVSHAFHSPLMAPAAEALRRAAGRLPWRRPERPVASTVTGAWWADEDPVEVLVRQLTGPVRFREALGLLDADLLVEVGPGRMLSALAEAAGRTAVSLDAGAASAAGMAAGTAALFAAGAVDDATPFFAGR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis.
pubmed doi rcsb
molecule tags Transferase
source organism Micromonospora chersina
molecule keywords DYNE8
total genus 128
structure length 372
sequence length 401
ec nomenclature
pdb deposition date 2012-03-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00698 Acyl_transf_1 Acyl transferase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.366.20 Alpha Beta 3-Layer(aba) Sandwich Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 4ampA00
4AMPA 4AMMA 3TZWA 3TZYA 4AMOA 3TZXA 4AMNA 3TZZA
chains in the Genus database with same CATH superfamily
5CZCA 5DZ7A 4AMMA 4QBUA 3EZOA 5CZDA 3G87A 2QO3A 2UV8G 4AMOA 2G2YA 3IM8A 4AMPA 3IM9A 3HHDA 2JFDA 3PTWA 3R97A 2PFFB 3QATA 1MLAA 3TZXA 4RR5A 3HMJG 4RL1A 5DZ6A 2G2ZA 3TZWA 2JFKA 3TZYA 3HJVA 3H0PA 2VZ8A 2C2NA 1NM2A 4AMNA 3TZZA 2G2OA 3RGIA 2G1HA 3SBMA 2CUYA 2HG4A 2VZ9A 2QJ3A 3TQEA 3K89A 2H1YA 2VKZG 2QC3A
chains in the Genus database with same CATH topology
4AMPA 4AMMA 3TZWA 3TZYA 4AMOA 3TZXA 4AMNA 3TZZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4AMP A;  4AMM A;  3TZW A;  3TZY A;  4AMO A;  3TZX A;  4AMN A;  3TZZ A; 
#chains in the Genus database with same CATH topology
 5CZC A;  5DZ7 A;  4AMM A;  4QBU A;  3EZO A;  5CZD A;  3G87 A;  2QO3 A;  2UV8 G;  4AMO A;  2G2Y A;  3IM8 A;  4AMP A;  3IM9 A;  3HHD A;  2JFD A;  3PTW A;  3R97 A;  2PFF B;  3QAT A;  1MLA A;  3TZX A;  4RR5 A;  3HMJ G;  4RL1 A;  5DZ6 A;  2G2Z A;  3TZW A;  2JFK A;  3TZY A;  3HJV A;  3H0P A;  2VZ8 A;  2C2N A;  1NM2 A;  4AMN A;  3TZZ A;  2G2O A;  3RGI A;  2G1H A;  3SBM A;  2CUY A;  2HG4 A;  2VZ9 A;  2QJ3 A;  3TQE A;  3K89 A;  2H1Y A;  2VKZ G;  2QC3 A; 
#chains in the Genus database with same CATH homology
 4AMP A;  4AMM A;  3TZW A;  3TZY A;  4AMO A;  3TZX A;  4AMN A;  3TZZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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