4AMPA

Crystal structure of the acyltransferase domain of the iterative polyketide synthase in enediyne biosynthesis reveals the molecular basis of substrate specificity
Total Genus 128
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
128
sequence length
401
structure length
372
Chain Sequence
PDHELVVCGAPDAAALTGLLTRVRAAATALSRPELTDLAAGLAAAHRGDVPARFAAAVRDADGLVAALDRALGHLAEGGRRLLDAGRGLFLVVGGPLRVGLLFPGQAAPVHPVDTAVAQPAIIADSLAGIRWLDRLGARPVGALGHSLGELAALSWAGALDADDTLALARARGEAMSAATEAPSGMLSLRADLAAARELAAGTGAVVAVDNGERHVVVAGTRPELDRVAEAARHAGIEATPLAVSHAFHSPLMAPAAEALRRAAGRLPWRRPERPVASTVTGAWWADEDPVEVLVRQLTGPVRFREALGLLDADLLVEVGPGRMLSALAEAAGRTAVSLDAGAASAAGMAAGTAALFAAGAVDDATPFFAGR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis.
pubmed doi rcsb
molecule keywords DYNE8
molecule tags Transferase
source organism Micromonospora chersina
total genus 128
structure length 372
sequence length 401
ec nomenclature
pdb deposition date 2012-03-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00698 Acyl_transf_1 Acyl transferase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.366.20 Alpha Beta 3-Layer(aba) Sandwich Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 4ampA00
4AMNA 3TZZA 4AMOA 4AMPA 3TZWA 3TZYA 4AMMA 3TZXA
chains in the Genus database with same CATH superfamily
1MLAA 5CZDA 2G2OA 3G87A 3TQEA 2JFKA 2UV8G 4RL1A 5DZ7A 3R97A 3HHDA 2QC3A 1NM2A 3EZOA 5DZ6A 2VKZG 3IM8A 3TZZA 3HJVA 3PTWA 4QBUA 4AMOA 2H1YA 3TZYA 4AMNA 2VZ8A 3RGIA 3IM9A 2G2YA 3TZWA 2CUYA 2JFDA 2VZ9A 3HMJG 4AMMA 2PFFB 2G1HA 5CZCA 3H0PA 2C2NA 3SBMA 4AMPA 2QJ3A 4RR5A 3QATA 2QO3A 3K89A 2HG4A 3TZXA 2G2ZA
chains in the Genus database with same CATH topology
4AMNA 3TZZA 4AMOA 4AMPA 3TZWA 3TZYA 4AMMA 3TZXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4AMN A;  3TZZ A;  4AMO A;  4AMP A;  3TZW A;  3TZY A;  4AMM A;  3TZX A; 
#chains in the Genus database with same CATH topology
 1MLA A;  5CZD A;  2G2O A;  3G87 A;  3TQE A;  2JFK A;  2UV8 G;  4RL1 A;  5DZ7 A;  3R97 A;  3HHD A;  2QC3 A;  1NM2 A;  3EZO A;  5DZ6 A;  2VKZ G;  3IM8 A;  3TZZ A;  3HJV A;  3PTW A;  4QBU A;  4AMO A;  2H1Y A;  3TZY A;  4AMN A;  2VZ8 A;  3RGI A;  3IM9 A;  2G2Y A;  3TZW A;  2CUY A;  2JFD A;  2VZ9 A;  3HMJ G;  4AMM A;  2PFF B;  2G1H A;  5CZC A;  3H0P A;  2C2N A;  3SBM A;  4AMP A;  2QJ3 A;  4RR5 A;  3QAT A;  2QO3 A;  3K89 A;  2HG4 A;  3TZX A;  2G2Z A; 
#chains in the Genus database with same CATH homology
 4AMN A;  3TZZ A;  4AMO A;  4AMP A;  3TZW A;  3TZY A;  4AMM A;  3TZX A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...