4AMPA

Crystal structure of the acyltransferase domain of the iterative polyketide synthase in enediyne biosynthesis reveals the molecular basis of substrate specificity
Total Genus 128
50100150200250300350020406080100120
Genus TraceResidueGenus

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
128
sequence length
401
structure length
372
Chain Sequence
PDHELVVCGAPDAAALTGLLTRVRAAATALSRPELTDLAAGLAAAHRGDVPARFAAAVRDADGLVAALDRALGHLAEGGRRLLDAGRGLFLVVGGPLRVGLLFPGQAAPVHPVDTAVAQPAIIADSLAGIRWLDRLGARPVGALGHSLGELAALSWAGALDADDTLALARARGEAMSAATEAPSGMLSLRADLAAARELAAGTGAVVAVDNGERHVVVAGTRPELDRVAEAARHAGIEATPLAVSHAFHSPLMAPAAEALRRAAGRLPWRRPERPVASTVTGAWWADEDPVEVLVRQLTGPVRFREALGLLDADLLVEVGPGRMLSALAEAAGRTAVSLDAGAASAAGMAAGTAALFAAGAVDDATPFFAGR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
source organism Micromonospora chersina
publication title Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis.
pubmed doi rcsb
molecule keywords DYNE8
total genus 128
structure length 372
sequence length 401
ec nomenclature
pdb deposition date 2012-03-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00698 Acyl_transf_1 Acyl transferase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.366.20 Alpha Beta 3-Layer(aba) Sandwich Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 4ampA00
3TZZA 4AMNA 4AMPA 4AMOA 4AMMA 3TZXA 3TZYA 3TZWA
chains in the Genus database with same CATH superfamily
2QO3A 2VKZG 3HHDA 3IM9A 3QATA 5CZDA 2JFKA 2QC3A 3HMJG 3K89A 2HG4A 5CZCA 1MLAA 4RL1A 2C2NA 4AMPA 3TZXA 2G2YA 3EZOA 2PFFB 3G87A 5DZ6A 4RR5A 2G2OA 2CUYA 2QJ3A 3TZZA 2H1YA 2G1HA 4AMNA 4AMOA 2UV8G 3SBMA 3TQEA 3R97A 3TZYA 2VZ8A 2VZ9A 3RGIA 4QBUA 3H0PA 4AMMA 5DZ7A 3PTWA 2G2ZA 1NM2A 3TZWA 3IM8A 2JFDA 3HJVA
chains in the Genus database with same CATH topology
3TZZA 4AMNA 4AMPA 4AMOA 4AMMA 3TZXA 3TZYA 3TZWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3TZZ A;  4AMN A;  4AMP A;  4AMO A;  4AMM A;  3TZX A;  3TZY A;  3TZW A; 
#chains in the Genus database with same CATH topology
 2QO3 A;  2VKZ G;  3HHD A;  3IM9 A;  3QAT A;  5CZD A;  2JFK A;  2QC3 A;  3HMJ G;  3K89 A;  2HG4 A;  5CZC A;  1MLA A;  4RL1 A;  2C2N A;  4AMP A;  3TZX A;  2G2Y A;  3EZO A;  2PFF B;  3G87 A;  5DZ6 A;  4RR5 A;  2G2O A;  2CUY A;  2QJ3 A;  3TZZ A;  2H1Y A;  2G1H A;  4AMN A;  4AMO A;  2UV8 G;  3SBM A;  3TQE A;  3R97 A;  3TZY A;  2VZ8 A;  2VZ9 A;  3RGI A;  4QBU A;  3H0P A;  4AMM A;  5DZ7 A;  3PTW A;  2G2Z A;  1NM2 A;  3TZW A;  3IM8 A;  2JFD A;  3HJV A; 
#chains in the Genus database with same CATH homology
 3TZZ A;  4AMN A;  4AMP A;  4AMO A;  4AMM A;  3TZX A;  3TZY A;  3TZW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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