4CU4A

Fhua from e. coli in complex with the lasso peptide microcin j25 (mccj25)
Total Genus 209
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
209
sequence length
706
structure length
693
Chain Sequence
SAWGPAATIAARQSATGTKTDTPIQKVPQSISVVTAEEMALHQPKSVKEALSYTPGVSVGTRGASNTYDHLIIRGFAAEGQSQNNYLNGLKLQGNFYNDAVIDPYMLERAEIMRGPVSVLYGKSSPGGLLNMVSKRPTTEPLKEVQFKAGTDSLFQTGFDFSDSLDDDGVYSYRLTGLARSANAQQKGSEEQRYAIAPAFTWRPDDKTNFTFLSYFQNEPETGYYGWLPKEGTVEPLPNGKRLPTDFNEGAKNNTYSRNEKMVGYSFDHEFNDTFTVRQNLRFAENKTSQNSVYGYGVCSDPANAYSKQCAALAPADKGHYLARKYVVDDEKLQNFSVDTQLQSKFATGDIDHTLLTGVDFMRMRNDINAWFGYDDSVPLLNLYNNTDFDFNAKDPANSGPYRILNKQKQTGVYVQDQAQWDKVLVTLGGRYDWADQESLNRVAGTTDKRDDKQFTWRGGVNYLFDNGVTPYFSYSESFEPSSQVGKDGNIFAPSKGKQYEVGVKYVPEDRPIVVTGAVYNLTKTNNLMADPEGSFFSVEGGEIRARGVEIEAKAALSASVNVVGSYTYTDAEYTTDTTYKGNTPAQVPKHMASLWADYTFFDGPLSGLTLGTGGRYTGSSYGDPANSFKVGSYTVVDALVRYDLARVGMAGSNVALHVNNLFDREYVASCFNTYGCFWGAERQVVATATFRF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Basis for Hijacking Siderophore Receptors by Antimicrobial Lasso Peptides.
pubmed doi rcsb
molecule tags Transport protein/antibiotic
source organism Escherichia coli str. k-12 substr. mg1655
molecule keywords FERRICHROME-IRON RECEPTOR
total genus 209
structure length 693
sequence length 706
ec nomenclature
pdb deposition date 2014-03-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00593 TonB_dep_Rec TonB dependent receptor
A PF07715 Plug TonB-dependent Receptor Plug Domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.170.20 Mainly Beta Beta Barrel Maltoporin; Chain A TonB-dependent receptor, beta-barrel domain 4cu4A02
2.170.130.10 Mainly Beta Beta Complex Ferric Hydroxamate Uptake Protein; Chain A, domain 1 TonB-dependent receptor, plug domain 4cu4A01
3RGNA 1NQFA 3V89A 1XKHA 1PNZA 1NQEA 2GRXA 1QKCA 2O5PA 4RDRA 2W75A 2W16A 3RGMA 2GUFA 4EPAA 2FCPA 1QFGA 2HDFA 2HDIA 3V8XA 3M8BA 1KMPA 4RDTA 2W6TA 2W6UA 1NQHA 3M8DA 1XKWA 1BY3A 1BY5A 5FOKA 3DDRA 2W76A 4CU4A 3QLBA 4B7OA 2YSUA 1NQGA 3CSNA 1PO3A 1PO0A 1QJQA 3CSLA 1UJWA 3FHHA 2IAHA 4AIPA 4AIQA 1KMOA 1FEPA 2GSKA 1FI1A 1FCPA 3EFMA 2W78A 1QFFA 2W77A
chains in the Genus database with same CATH superfamily
1OH2Q 1NQFA 3RGNA 3V89A 1PNZA 1NQEA 1XKHA 2GRXA 1QKCA 2O5PA 4RDRA 2W75A 2W16A 3RGMA 2GUFA 4EPAA 2FCPA 1QFGA 2HDFA 2HDIA 1A0SP 1MPNA 1A0TP 3V8XA 3M8BA 1KMPA 4RDTA 2W6TA 1MPQA 1OH2P 1NQHA 1MPOA 1BY3A 1XKWA 2W6UA 1BY5A 3M8DA 5FOKA 3DDRA 1JBIA 2W76A 1MPMA 4CU4A 3QLBA 4B7OA 1MPRA 2YSUA 1NQGA 3CSNA 1PO3A 1PO0A 1QJQA 3CSLA 1UJWA 3FHHA 2IAHA 2MPRA 4AIPA 4AIQA 1KMOA 1FEPA 2GSKA 1AF6A 1FI1A 1MALA 1FCPA 3EFMA 2W78A 1QFFA 2W77A
chains in the Genus database with same CATH topology
3RGNA 1NQFA 3V89A 1XKHA 1PNZA 1NQEA 2GRXA 1QKCA 2O5PA 4RDRA 2W75A 2W16A 3RGMA 2GUFA 4EPAA 2FCPA 1QFGA 2HDFA 2HDIA 3V8XA 3M8BA 1KMPA 4RDTA 2W6TA 2W6UA 1NQHA 3M8DA 1XKWA 1BY3A 1BY5A 5FOKA 3DDRA 2W76A 4CU4A 3QLBA 4B7OA 2YSUA 1NQGA 3CSNA 1PO3A 1PO0A 1QJQA 3CSLA 1UJWA 3FHHA 2IAHA 4AIPA 4AIQA 1KMOA 1FEPA 2GSKA 1FI1A 1FCPA 3EFMA 2W78A 1QFFA 2W77A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3RGN A;  1NQF A;  3V89 A;  1XKH A;  1PNZ A;  1NQE A;  2GRX A;  1QKC A;  2O5P A;  4RDR A;  2W75 A;  2W16 A;  3RGM A;  2GUF A;  4EPA A;  2FCP A;  1QFG A;  2HDF A;  2HDI A;  3V8X A;  3M8B A;  1KMP A;  4RDT A;  2W6T A;  2W6U A;  1NQH A;  3M8D A;  1XKW A;  1BY3 A;  1BY5 A;  5FOK A;  3DDR A;  2W76 A;  4CU4 A;  3QLB A;  4B7O A;  2YSU A;  1NQG A;  3CSN A;  1PO3 A;  1PO0 A;  1QJQ A;  3CSL A;  1UJW A;  3FHH A;  2IAH A;  4AIP A;  4AIQ A;  1KMO A;  1FEP A;  2GSK A;  1FI1 A;  1FCP A;  3EFM A;  2W78 A;  1QFF A;  2W77 A; 
#chains in the Genus database with same CATH topology
 1OH2 Q;  1NQF A;  3RGN A;  3V89 A;  1PNZ A;  1NQE A;  1XKH A;  2GRX A;  1QKC A;  2O5P A;  4RDR A;  2W75 A;  2W16 A;  3RGM A;  2GUF A;  4EPA A;  2FCP A;  1QFG A;  2HDF A;  2HDI A;  1A0S P;  1MPN A;  1A0T P;  3V8X A;  3M8B A;  1KMP A;  4RDT A;  2W6T A;  1MPQ A;  1OH2 P;  1NQH A;  1MPO A;  1BY3 A;  1XKW A;  2W6U A;  1BY5 A;  3M8D A;  5FOK A;  3DDR A;  1JBI A;  2W76 A;  1MPM A;  4CU4 A;  3QLB A;  4B7O A;  1MPR A;  2YSU A;  1NQG A;  3CSN A;  1PO3 A;  1PO0 A;  1QJQ A;  3CSL A;  1UJW A;  3FHH A;  2IAH A;  2MPR A;  4AIP A;  4AIQ A;  1KMO A;  1FEP A;  2GSK A;  1AF6 A;  1FI1 A;  1MAL A;  1FCP A;  3EFM A;  2W78 A;  1QFF A;  2W77 A; 
#chains in the Genus database with same CATH homology
 3RGN A;  1NQF A;  3V89 A;  1XKH A;  1PNZ A;  1NQE A;  2GRX A;  1QKC A;  2O5P A;  4RDR A;  2W75 A;  2W16 A;  3RGM A;  2GUF A;  4EPA A;  2FCP A;  1QFG A;  2HDF A;  2HDI A;  3V8X A;  3M8B A;  1KMP A;  4RDT A;  2W6T A;  2W6U A;  1NQH A;  3M8D A;  1XKW A;  1BY3 A;  1BY5 A;  5FOK A;  3DDR A;  2W76 A;  4CU4 A;  3QLB A;  4B7O A;  2YSU A;  1NQG A;  3CSN A;  1PO3 A;  1PO0 A;  1QJQ A;  3CSL A;  1UJW A;  3FHH A;  2IAH A;  4AIP A;  4AIQ A;  1KMO A;  1FEP A;  2GSK A;  1FI1 A;  1FCP A;  3EFM A;  2W78 A;  1QFF A;  2W77 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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