4HKIC

Tankyrase 2 in complex with flavone
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
47
structure length
47
Chain Sequence
MAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
source organism Homo sapiens
publication title Screening and structural analysis of flavones inhibiting tankyrases.
pubmed doi rcsb
molecule keywords Tankyrase-2
total genus 1
structure length 47
sequence length 47
chains with identical sequence D
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2012-10-15
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1620.50 Alpha Beta 3-Layer(aba) Sandwich YefM-like fold YefM-like fold 4hkiC00
4L0VC 4HLHC 4L0SC 5C5QC 4HLGC 4HLKC 4UI5C 4L32C 4L2GC 4HKNC 4L33C 4L31C 4L09C 5ADTB 4HMHC 4UI3C 4HKKB 5C5RC 5ADQB 4L0BC 4L0IC 4UI7C 5ADSB 4HKIC 4HLFC 5C5PC 4KZUC 4L10C 5ADRB 4L34C 4L2KC 4L0TC 4HLMC 4UI8C 4L2FC 4HL5C 4KZLC 4UVPB 4UI6C 4UI4C 4KZQC 5FPFC
chains in the Genus database with same CATH superfamily
2ODKA 4L0VC 4HLHC 4ZM2A 3CTOA 3D55A 4L0SC 4ZLXA 5C5QC 3KH2E 4HLGC 3HJ6A 4HLKC 4UI5C 3OEIE 4L32C 4L2GC 4HKNC 4L33C 4L31C 4L09C 5ADTB 4HMHC 4UI3C 4HKKB 3G5OA 5C5RC 5ADQB 4L0BC 2ZIXB 4L0IC 4UI7C 5ADSB 4HKIC 4HLFC 5C5PC 4KZUC 4L10C 5ADRB 4L34C 4L2KC 4L0TC 4HLMC 4UI8C 3HS2A 4HL5C 3K6QA 4L2FC 4KZLC 4UVPB 3HRYA 4UI6C 2A6QA 3OEIA 4ZM0A 4UI4C 4KZQC 5FPFC 3K33B
chains in the Genus database with same CATH topology
4L0VC 4HLHC 4L0SC 5C5QC 4HLGC 3HJ6A 4HLKC 4UI5C 4L32C 4L2GC 4HKNC 4L33C 4L31C 4L09C 5ADTB 4HMHC 4UI3C 4HKKB 5C5RC 5ADQB 4L0BC 2ZIXB 4L0IC 4UI7C 5ADSB 4HKIC 4HLFC 5C5PC 4KZUC 4L10C 5ADRB 4L34C 4L2KC 4L0TC 4HLMC 4UI8C 4L2FC 4HL5C 4KZLC 4UVPB 4UI6C 4UI4C 4KZQC 5FPFC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4L0V C;  4HLH C;  4L0S C;  5C5Q C;  4HLG C;  4HLK C;  4UI5 C;  4L32 C;  4L2G C;  4HKN C;  4L33 C;  4L31 C;  4L09 C;  5ADT B;  4HMH C;  4UI3 C;  4HKK B;  5C5R C;  5ADQ B;  4L0B C;  4L0I C;  4UI7 C;  5ADS B;  4HKI C;  4HLF C;  5C5P C;  4KZU C;  4L10 C;  5ADR B;  4L34 C;  4L2K C;  4L0T C;  4HLM C;  4UI8 C;  4L2F C;  4HL5 C;  4KZL C;  4UVP B;  4UI6 C;  4UI4 C;  4KZQ C;  5FPF C; 
#chains in the Genus database with same CATH topology
 2ODK A;  4L0V C;  4HLH C;  4ZM2 A;  3CTO A;  3D55 A;  4L0S C;  4ZLX A;  5C5Q C;  3KH2 E;  4HLG C;  3HJ6 A;  4HLK C;  4UI5 C;  3OEI E;  4L32 C;  4L2G C;  4HKN C;  4L33 C;  4L31 C;  4L09 C;  5ADT B;  4HMH C;  4UI3 C;  4HKK B;  3G5O A;  5C5R C;  5ADQ B;  4L0B C;  2ZIX B;  4L0I C;  4UI7 C;  5ADS B;  4HKI C;  4HLF C;  5C5P C;  4KZU C;  4L10 C;  5ADR B;  4L34 C;  4L2K C;  4L0T C;  4HLM C;  4UI8 C;  3HS2 A;  4HL5 C;  3K6Q A;  4L2F C;  4KZL C;  4UVP B;  3HRY A;  4UI6 C;  2A6Q A;  3OEI A;  4ZM0 A;  4UI4 C;  4KZQ C;  5FPF C;  3K33 B; 
#chains in the Genus database with same CATH homology
 4L0V C;  4HLH C;  4L0S C;  5C5Q C;  4HLG C;  3HJ6 A;  4HLK C;  4UI5 C;  4L32 C;  4L2G C;  4HKN C;  4L33 C;  4L31 C;  4L09 C;  5ADT B;  4HMH C;  4UI3 C;  4HKK B;  5C5R C;  5ADQ B;  4L0B C;  2ZIX B;  4L0I C;  4UI7 C;  5ADS B;  4HKI C;  4HLF C;  5C5P C;  4KZU C;  4L10 C;  5ADR B;  4L34 C;  4L2K C;  4L0T C;  4HLM C;  4UI8 C;  4L2F C;  4HL5 C;  4KZL C;  4UVP B;  4UI6 C;  4UI4 C;  4KZQ C;  5FPF C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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