4HLMC

Crystal structure of tankyrase 2 in complex with 3',4'-dihydroxyflavone
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
47
structure length
47
Chain Sequence
MAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
molecule keywords Tankyrase-2
publication title Screening and structural analysis of flavones inhibiting tankyrases.
pubmed doi rcsb
source organism Homo sapiens
total genus 1
structure length 47
sequence length 47
chains with identical sequence D
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2012-10-17
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1620.50 Alpha Beta 3-Layer(aba) Sandwich YefM-like fold YefM-like fold 4hlmC00
4L2FC 4UI6C 5C5RC 4HL5C 4L31C 4L2KC 4KZUC 4HLKC 4KZQC 4L0SC 4UVPB 4UI4C 4L0IC 4UI5C 4UI7C 4HMHC 4KZLC 5ADQB 4HKNC 4UI8C 4UI3C 5C5QC 5ADRB 4HLFC 4L0VC 4L0TC 5ADSB 4HKIC 5FPFC 4HKKB 4L2GC 4HLGC 4L32C 4L34C 4L33C 5C5PC 5ADTB 4HLMC 4L09C 4HLHC 4L10C 4L0BC
chains in the Genus database with same CATH superfamily
4L2FC 4UI6C 5C5RC 4HL5C 4L31C 4L2KC 3HS2A 4KZUC 4KZQC 4L0SC 4UVPB 3D55A 4UI4C 4L0IC 4UI5C 4UI7C 4HMHC 3OEIE 4KZLC 2ODKA 3G5OA 5ADQB 2ZIXB 4HKNC 4UI8C 4ZLXA 3HJ6A 4UI3C 5C5QC 5ADRB 4HLFC 4L0VC 4L0TC 3KH2E 5ADSB 3HRYA 4HKIC 2A6QA 5FPFC 4ZM2A 4HKKB 3OEIA 4HLGC 4L2GC 4L09C 4L32C 4ZM0A 3K33B 4L34C 4L33C 5C5PC 3K6QA 5ADTB 4HLMC 4HLKC 4HLHC 4L10C 3CTOA 4L0BC
chains in the Genus database with same CATH topology
4L2FC 4UI6C 5C5RC 4HL5C 4L31C 4L2KC 4KZUC 4KZQC 4L0SC 4UVPB 4UI4C 4L0IC 4UI5C 4UI7C 4HMHC 4KZLC 5ADQB 2ZIXB 4HKNC 4UI8C 3HJ6A 4UI3C 5C5QC 5ADRB 4HLFC 4L0VC 4L0TC 5ADSB 4HKIC 5FPFC 4HKKB 4L2GC 4HLGC 4L09C 4L32C 4L34C 4L33C 5C5PC 5ADTB 4HLMC 4HLKC 4HLHC 4L10C 4L0BC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4L2F C;  4UI6 C;  5C5R C;  4HL5 C;  4L31 C;  4L2K C;  4KZU C;  4HLK C;  4KZQ C;  4L0S C;  4UVP B;  4UI4 C;  4L0I C;  4UI5 C;  4UI7 C;  4HMH C;  4KZL C;  5ADQ B;  4HKN C;  4UI8 C;  4UI3 C;  5C5Q C;  5ADR B;  4HLF C;  4L0V C;  4L0T C;  5ADS B;  4HKI C;  5FPF C;  4HKK B;  4L2G C;  4HLG C;  4L32 C;  4L34 C;  4L33 C;  5C5P C;  5ADT B;  4HLM C;  4L09 C;  4HLH C;  4L10 C;  4L0B C; 
#chains in the Genus database with same CATH topology
 4L2F C;  4UI6 C;  5C5R C;  4HL5 C;  4L31 C;  4L2K C;  3HS2 A;  4KZU C;  4KZQ C;  4L0S C;  4UVP B;  3D55 A;  4UI4 C;  4L0I C;  4UI5 C;  4UI7 C;  4HMH C;  3OEI E;  4KZL C;  2ODK A;  3G5O A;  5ADQ B;  2ZIX B;  4HKN C;  4UI8 C;  4ZLX A;  3HJ6 A;  4UI3 C;  5C5Q C;  5ADR B;  4HLF C;  4L0V C;  4L0T C;  3KH2 E;  5ADS B;  3HRY A;  4HKI C;  2A6Q A;  5FPF C;  4ZM2 A;  4HKK B;  3OEI A;  4HLG C;  4L2G C;  4L09 C;  4L32 C;  4ZM0 A;  3K33 B;  4L34 C;  4L33 C;  5C5P C;  3K6Q A;  5ADT B;  4HLM C;  4HLK C;  4HLH C;  4L10 C;  3CTO A;  4L0B C; 
#chains in the Genus database with same CATH homology
 4L2F C;  4UI6 C;  5C5R C;  4HL5 C;  4L31 C;  4L2K C;  4KZU C;  4KZQ C;  4L0S C;  4UVP B;  4UI4 C;  4L0I C;  4UI5 C;  4UI7 C;  4HMH C;  4KZL C;  5ADQ B;  2ZIX B;  4HKN C;  4UI8 C;  3HJ6 A;  4UI3 C;  5C5Q C;  5ADR B;  4HLF C;  4L0V C;  4L0T C;  5ADS B;  4HKI C;  5FPF C;  4HKK B;  4L2G C;  4HLG C;  4L09 C;  4L32 C;  4L34 C;  4L33 C;  5C5P C;  5ADT B;  4HLM C;  4HLK C;  4HLH C;  4L10 C;  4L0B C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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