5FPFC

Crystal structure of human tankyrase 2 in complex with ta-91
Total Genus 0
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
0
sequence length
46
structure length
46
Chain Sequence
AHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
molecule keywords TANKYRASE-2
publication title Design, Synthesis and Evaluation of Novel Dual- Binding Inhibitors of the Tankyrases and Wnt Signalling.
rcsb
source organism Homo sapiens
structure length 46
sequence length 46
chains with identical sequence D
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2015-11-30
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1620.50 Alpha Beta 3-Layer(aba) Sandwich YefM-like fold YefM-like fold 5fpfC00
4HL5C 5ADTB 4KZQC 5ADQB 4L10C 4HLHC 4L0IC 4HKNC 4UI5C 4KZUC 5C5RC 4HKKB 4KZLC 4L32C 5ADSB 4HKIC 4HLMC 4HLKC 4L0VC 4L2GC 5C5PC 4HLFC 4HMHC 5ADRB 5FPFC 4UI4C 4HLGC 4L33C 4UI7C 4L0TC 4L31C 4UI3C 4L2KC 4L0SC 4UI6C 4UI8C 4L2FC 4UVPB 5C5QC 4L34C 4L09C 4L0BC
chains in the Genus database with same CATH superfamily
4HL5C 5ADTB 4KZQC 5ADQB 4ZM2A 4L10C 4HLHC 4L0IC 4HKNC 4UI5C 4KZUC 5C5RC 3OEIA 4HKKB 4KZLC 4L32C 3HJ6A 5ADSB 4HKIC 3HRYA 4HLMC 3OEIE 3D55A 4HLKC 4L0VC 4L2GC 4ZM0A 5C5PC 4HLFC 4ZLXA 4HMHC 5ADRB 3KH2E 2A6QA 5FPFC 4UI4C 3K6QA 3HS2A 4HLGC 4L33C 4UI7C 4L0TC 4L31C 4UI3C 4L2KC 4L0SC 4UI6C 4UI8C 4L2FC 4UVPB 2ZIXB 3K33B 3G5OA 4L34C 4L0BC 2ODKA 4L09C 5C5QC 3CTOA
chains in the Genus database with same CATH topology
4HL5C 5ADTB 4KZQC 5ADQB 4L10C 4HLHC 4L0IC 4HKNC 4UI5C 4KZUC 5C5RC 4HKKB 4KZLC 4L32C 3HJ6A 5ADSB 4HKIC 4HLMC 4HLKC 4L0VC 4L2GC 5C5PC 4HLFC 4HMHC 5ADRB 5FPFC 4UI4C 4HLGC 4L33C 4UI7C 4L0TC 4L31C 4UI3C 4L2KC 4L0SC 4UI6C 4UI8C 4L2FC 4UVPB 2ZIXB 5C5QC 4L34C 4L09C 4L0BC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4HL5 C;  5ADT B;  4KZQ C;  5ADQ B;  4L10 C;  4HLH C;  4L0I C;  4HKN C;  4UI5 C;  4KZU C;  5C5R C;  4HKK B;  4KZL C;  4L32 C;  5ADS B;  4HKI C;  4HLM C;  4HLK C;  4L0V C;  4L2G C;  5C5P C;  4HLF C;  4HMH C;  5ADR B;  5FPF C;  4UI4 C;  4HLG C;  4L33 C;  4UI7 C;  4L0T C;  4L31 C;  4UI3 C;  4L2K C;  4L0S C;  4UI6 C;  4UI8 C;  4L2F C;  4UVP B;  5C5Q C;  4L34 C;  4L09 C;  4L0B C; 
#chains in the Genus database with same CATH topology
 4HL5 C;  5ADT B;  4KZQ C;  5ADQ B;  4ZM2 A;  4L10 C;  4HLH C;  4L0I C;  4HKN C;  4UI5 C;  4KZU C;  5C5R C;  3OEI A;  4HKK B;  4KZL C;  4L32 C;  3HJ6 A;  5ADS B;  4HKI C;  3HRY A;  4HLM C;  3OEI E;  3D55 A;  4HLK C;  4L0V C;  4L2G C;  4ZM0 A;  5C5P C;  4HLF C;  4ZLX A;  4HMH C;  5ADR B;  3KH2 E;  2A6Q A;  5FPF C;  4UI4 C;  3K6Q A;  3HS2 A;  4HLG C;  4L33 C;  4UI7 C;  4L0T C;  4L31 C;  4UI3 C;  4L2K C;  4L0S C;  4UI6 C;  4UI8 C;  4L2F C;  4UVP B;  2ZIX B;  3K33 B;  3G5O A;  4L34 C;  4L0B C;  2ODK A;  4L09 C;  5C5Q C;  3CTO A; 
#chains in the Genus database with same CATH homology
 4HL5 C;  5ADT B;  4KZQ C;  5ADQ B;  4L10 C;  4HLH C;  4L0I C;  4HKN C;  4UI5 C;  4KZU C;  5C5R C;  4HKK B;  4KZL C;  4L32 C;  3HJ6 A;  5ADS B;  4HKI C;  4HLM C;  4HLK C;  4L0V C;  4L2G C;  5C5P C;  4HLF C;  4HMH C;  5ADR B;  5FPF C;  4UI4 C;  4HLG C;  4L33 C;  4UI7 C;  4L0T C;  4L31 C;  4UI3 C;  4L2K C;  4L0S C;  4UI6 C;  4UI8 C;  4L2F C;  4UVP B;  2ZIX B;  5C5Q C;  4L34 C;  4L09 C;  4L0B C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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