4HLGC

Crystal structure of tankyrase 2 in complex with 3'-hydroxyflavone
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
47
structure length
47
Chain Sequence
MAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
molecule keywords Tankyrase-2
publication title Screening and structural analysis of flavones inhibiting tankyrases.
pubmed doi rcsb
source organism Homo sapiens
total genus 1
structure length 47
sequence length 47
chains with identical sequence D
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2012-10-17
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1620.50 Alpha Beta 3-Layer(aba) Sandwich YefM-like fold YefM-like fold 4hlgC00
5C5PC 4HKNC 4HMHC 5ADQB 4L0VC 4KZQC 4L2KC 5C5QC 4L0SC 4UVPB 4L2GC 4L0BC 4KZLC 4L09C 4L0TC 4KZUC 5ADTB 4HKIC 4L34C 4HLFC 5ADSB 4HL5C 4HKKB 4L31C 5ADRB 4UI5C 4HLKC 4L2FC 4UI6C 4HLHC 4UI8C 4UI4C 4L32C 5C5RC 4L10C 4UI3C 4L33C 4UI7C 5FPFC 4HLMC 4HLGC 4L0IC
chains in the Genus database with same CATH superfamily
5C5PC 4HKNC 4HMHC 5ADQB 4HLMC 4L0VC 4KZQC 4L2KC 5C5QC 4L0SC 4UVPB 4L2GC 3K6QA 2A6QA 4L0BC 3HRYA 4KZLC 4L09C 4L0TC 4KZUC 5ADTB 3HJ6A 4ZM0A 4HKIC 4L34C 3G5OA 3CTOA 4HLFC 5ADSB 4HL5C 4ZM2A 4HKKB 4L31C 5ADRB 4UI5C 4HLKC 3KH2E 4L2FC 4UI6C 3K33B 4HLHC 3OEIA 4UI8C 3D55A 3HS2A 4UI4C 4L32C 5C5RC 2ZIXB 4L10C 4UI3C 3OEIE 4ZLXA 4L33C 4UI7C 5FPFC 2ODKA 4HLGC 4L0IC
chains in the Genus database with same CATH topology
5C5PC 4HKNC 4HMHC 5ADQB 4L0VC 4KZQC 4L2KC 5C5QC 4L0SC 4UVPB 4L2GC 4L0BC 4KZLC 4L09C 4L0TC 4KZUC 5ADTB 3HJ6A 4HKIC 4L34C 4HLFC 5ADSB 4HL5C 4HKKB 4L31C 5ADRB 4UI5C 4HLKC 4L2FC 4UI6C 4HLHC 4UI8C 4UI4C 4L32C 5C5RC 2ZIXB 4L10C 4UI3C 4L33C 4UI7C 5FPFC 4HLMC 4HLGC 4L0IC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5C5P C;  4HKN C;  4HMH C;  5ADQ B;  4L0V C;  4KZQ C;  4L2K C;  5C5Q C;  4L0S C;  4UVP B;  4L2G C;  4L0B C;  4KZL C;  4L09 C;  4L0T C;  4KZU C;  5ADT B;  4HKI C;  4L34 C;  4HLF C;  5ADS B;  4HL5 C;  4HKK B;  4L31 C;  5ADR B;  4UI5 C;  4HLK C;  4L2F C;  4UI6 C;  4HLH C;  4UI8 C;  4UI4 C;  4L32 C;  5C5R C;  4L10 C;  4UI3 C;  4L33 C;  4UI7 C;  5FPF C;  4HLM C;  4HLG C;  4L0I C; 
#chains in the Genus database with same CATH topology
 5C5P C;  4HKN C;  4HMH C;  5ADQ B;  4HLM C;  4L0V C;  4KZQ C;  4L2K C;  5C5Q C;  4L0S C;  4UVP B;  4L2G C;  3K6Q A;  2A6Q A;  4L0B C;  3HRY A;  4KZL C;  4L09 C;  4L0T C;  4KZU C;  5ADT B;  3HJ6 A;  4ZM0 A;  4HKI C;  4L34 C;  3G5O A;  3CTO A;  4HLF C;  5ADS B;  4HL5 C;  4ZM2 A;  4HKK B;  4L31 C;  5ADR B;  4UI5 C;  4HLK C;  3KH2 E;  4L2F C;  4UI6 C;  3K33 B;  4HLH C;  3OEI A;  4UI8 C;  3D55 A;  3HS2 A;  4UI4 C;  4L32 C;  5C5R C;  2ZIX B;  4L10 C;  4UI3 C;  3OEI E;  4ZLX A;  4L33 C;  4UI7 C;  5FPF C;  2ODK A;  4HLG C;  4L0I C; 
#chains in the Genus database with same CATH homology
 5C5P C;  4HKN C;  4HMH C;  5ADQ B;  4L0V C;  4KZQ C;  4L2K C;  5C5Q C;  4L0S C;  4UVP B;  4L2G C;  4L0B C;  4KZL C;  4L09 C;  4L0T C;  4KZU C;  5ADT B;  3HJ6 A;  4HKI C;  4L34 C;  4HLF C;  5ADS B;  4HL5 C;  4HKK B;  4L31 C;  5ADR B;  4UI5 C;  4HLK C;  4L2F C;  4UI6 C;  4HLH C;  4UI8 C;  4UI4 C;  4L32 C;  5C5R C;  2ZIX B;  4L10 C;  4UI3 C;  4L33 C;  4UI7 C;  5FPF C;  4HLM C;  4HLG C;  4L0I C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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