4HLFC

Crystal structure of tankyrase 2 in complex with 7,3',4'-trihydroxyflavone
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
47
structure length
47
Chain Sequence
MAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
molecule keywords Tankyrase-2
publication title Screening and structural analysis of flavones inhibiting tankyrases.
pubmed doi rcsb
source organism Homo sapiens
total genus 1
structure length 47
sequence length 47
chains with identical sequence D
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2012-10-17
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1620.50 Alpha Beta 3-Layer(aba) Sandwich YefM-like fold YefM-like fold 4hlfC00
4UVPB 4L33C 5ADRB 4L2KC 4L2GC 4HLHC 4L0SC 4UI7C 5C5QC 4KZLC 4L09C 4HKKB 4L0IC 4L34C 5ADSB 4KZUC 4HKIC 4HLMC 4HL5C 4UI6C 5C5PC 4UI3C 4UI8C 4L0TC 5C5RC 4L31C 5ADTB 4UI4C 4KZQC 4UI5C 4HKNC 4HLKC 4L2FC 4L32C 4HLGC 4L0VC 4HMHC 5FPFC 5ADQB 4L0BC 4HLFC 4L10C
chains in the Genus database with same CATH superfamily
4UVPB 3HRYA 4L33C 5ADRB 3K33B 4L2KC 4L2GC 4HLHC 4L0SC 4ZM2A 4UI7C 3KH2E 5C5QC 3OEIA 4KZLC 4L09C 4HKKB 4L0IC 4L34C 5ADSB 4KZUC 4ZM0A 3HJ6A 4HKIC 4HLMC 4HL5C 3OEIE 4UI6C 4UI3C 5C5PC 3CTOA 4L0TC 4UI8C 5C5RC 4L31C 5ADTB 4UI4C 2A6QA 4KZQC 4HKNC 4UI5C 2ODKA 4ZLXA 3D55A 4HLKC 4L2FC 4L32C 4L10C 4HLGC 4L0VC 4HMHC 5FPFC 2ZIXB 3G5OA 3K6QA 5ADQB 4L0BC 4HLFC 3HS2A
chains in the Genus database with same CATH topology
4UVPB 4L33C 5ADRB 4L2KC 4L2GC 4HLHC 4L0SC 4UI7C 5C5QC 4KZLC 4L09C 4HKKB 4L0IC 4L34C 5ADSB 4KZUC 3HJ6A 4HKIC 4HLMC 4HL5C 4UI6C 5C5PC 4UI3C 4UI8C 4L0TC 5C5RC 4L31C 5ADTB 4UI4C 4KZQC 4UI5C 4HKNC 4HLKC 4L2FC 4L32C 4HLGC 4L0VC 4HMHC 5FPFC 2ZIXB 5ADQB 4L0BC 4HLFC 4L10C
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4UVP B;  4L33 C;  5ADR B;  4L2K C;  4L2G C;  4HLH C;  4L0S C;  4UI7 C;  5C5Q C;  4KZL C;  4L09 C;  4HKK B;  4L0I C;  4L34 C;  5ADS B;  4KZU C;  4HKI C;  4HLM C;  4HL5 C;  4UI6 C;  5C5P C;  4UI3 C;  4UI8 C;  4L0T C;  5C5R C;  4L31 C;  5ADT B;  4UI4 C;  4KZQ C;  4UI5 C;  4HKN C;  4HLK C;  4L2F C;  4L32 C;  4HLG C;  4L0V C;  4HMH C;  5FPF C;  5ADQ B;  4L0B C;  4HLF C;  4L10 C; 
#chains in the Genus database with same CATH topology
 4UVP B;  3HRY A;  4L33 C;  5ADR B;  3K33 B;  4L2K C;  4L2G C;  4HLH C;  4L0S C;  4ZM2 A;  4UI7 C;  3KH2 E;  5C5Q C;  3OEI A;  4KZL C;  4L09 C;  4HKK B;  4L0I C;  4L34 C;  5ADS B;  4KZU C;  4ZM0 A;  3HJ6 A;  4HKI C;  4HLM C;  4HL5 C;  3OEI E;  4UI6 C;  4UI3 C;  5C5P C;  3CTO A;  4L0T C;  4UI8 C;  5C5R C;  4L31 C;  5ADT B;  4UI4 C;  2A6Q A;  4KZQ C;  4HKN C;  4UI5 C;  2ODK A;  4ZLX A;  3D55 A;  4HLK C;  4L2F C;  4L32 C;  4L10 C;  4HLG C;  4L0V C;  4HMH C;  5FPF C;  2ZIX B;  3G5O A;  3K6Q A;  5ADQ B;  4L0B C;  4HLF C;  3HS2 A; 
#chains in the Genus database with same CATH homology
 4UVP B;  4L33 C;  5ADR B;  4L2K C;  4L2G C;  4HLH C;  4L0S C;  4UI7 C;  5C5Q C;  4KZL C;  4L09 C;  4HKK B;  4L0I C;  4L34 C;  5ADS B;  4KZU C;  3HJ6 A;  4HKI C;  4HLM C;  4HL5 C;  4UI6 C;  5C5P C;  4UI3 C;  4UI8 C;  4L0T C;  5C5R C;  4L31 C;  5ADT B;  4UI4 C;  4KZQ C;  4UI5 C;  4HKN C;  4HLK C;  4L2F C;  4L32 C;  4HLG C;  4L0V C;  4HMH C;  5FPF C;  2ZIX B;  5ADQ B;  4L0B C;  4HLF C;  4L10 C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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