4HL5C

Complex structure of human tankyrase 2 with 7-hydroxy -4'-methoxyflavone
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
47
structure length
47
Chain Sequence
MAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Screening and structural analysis of flavones inhibiting tankyrases.
pubmed doi rcsb
molecule keywords Tankyrase-2
molecule tags Transferase
source organism Homo sapiens
total genus 1
structure length 47
sequence length 47
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2012-10-16
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1620.50 Alpha Beta 3-Layer(aba) Sandwich YefM-like fold YefM-like fold 4hl5C00
4L31C 4L0TC 4HKKB 5C5PC 5ADSB 4HMHC 5ADQB 4L10C 4HLHC 5C5RC 4HKNC 4L2KC 5ADRB 4L32C 4L09C 4KZQC 4L0IC 4HLMC 4HLGC 4L0BC 4UI6C 4UI3C 4L2GC 4HLKC 4L2FC 4UI5C 4L0VC 4L33C 4L34C 5C5QC 5FPFC 4HL5C 4UI8C 4HKIC 4UI7C 4KZLC 4UVPB 4KZUC 5ADTB 4HLFC 4L0SC 4UI4C
chains in the Genus database with same CATH superfamily
4L31C 3K6QA 4L0TC 4HKKB 5C5PC 5ADSB 4HMHC 3OEIE 5ADQB 3HS2A 3CTOA 4L10C 4HLHC 5C5RC 3HRYA 4HKNC 4L2KC 5ADRB 4L32C 3HJ6A 4L09C 4KZQC 4L0IC 4HLMC 4HLGC 4L0BC 4UI6C 2ODKA 4ZM0A 4UI3C 4L0SC 4ZM2A 4L2GC 4ZLXA 3D55A 4HLKC 2A6QA 4L2FC 4UI5C 4L0VC 3K33B 4L33C 4L34C 5C5QC 5FPFC 4HL5C 4UI8C 3G5OA 3KH2E 3OEIA 4HKIC 4UI7C 4KZLC 4UVPB 4KZUC 5ADTB 4HLFC 2ZIXB 4UI4C
chains in the Genus database with same CATH topology
4L31C 4L0TC 4HKKB 5C5PC 5ADSB 4HMHC 5ADQB 4L10C 4HLHC 5C5RC 4HKNC 4L2KC 5ADRB 4L32C 3HJ6A 4L09C 4KZQC 4L0IC 4HLMC 4HLGC 4L0BC 4UI6C 4UI3C 4L0SC 4L2GC 4HLKC 4L2FC 4UI5C 4L0VC 4L33C 4L34C 5C5QC 5FPFC 4HL5C 4UI8C 4HKIC 4UI7C 4KZLC 4UVPB 4KZUC 5ADTB 4HLFC 2ZIXB 4UI4C
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4L31 C;  4L0T C;  4HKK B;  5C5P C;  5ADS B;  4HMH C;  5ADQ B;  4L10 C;  4HLH C;  5C5R C;  4HKN C;  4L2K C;  5ADR B;  4L32 C;  4L09 C;  4KZQ C;  4L0I C;  4HLM C;  4HLG C;  4L0B C;  4UI6 C;  4UI3 C;  4L2G C;  4HLK C;  4L2F C;  4UI5 C;  4L0V C;  4L33 C;  4L34 C;  5C5Q C;  5FPF C;  4HL5 C;  4UI8 C;  4HKI C;  4UI7 C;  4KZL C;  4UVP B;  4KZU C;  5ADT B;  4HLF C;  4L0S C;  4UI4 C; 
#chains in the Genus database with same CATH topology
 4L31 C;  3K6Q A;  4L0T C;  4HKK B;  5C5P C;  5ADS B;  4HMH C;  3OEI E;  5ADQ B;  3HS2 A;  3CTO A;  4L10 C;  4HLH C;  5C5R C;  3HRY A;  4HKN C;  4L2K C;  5ADR B;  4L32 C;  3HJ6 A;  4L09 C;  4KZQ C;  4L0I C;  4HLM C;  4HLG C;  4L0B C;  4UI6 C;  2ODK A;  4ZM0 A;  4UI3 C;  4L0S C;  4ZM2 A;  4L2G C;  4ZLX A;  3D55 A;  4HLK C;  2A6Q A;  4L2F C;  4UI5 C;  4L0V C;  3K33 B;  4L33 C;  4L34 C;  5C5Q C;  5FPF C;  4HL5 C;  4UI8 C;  3G5O A;  3KH2 E;  3OEI A;  4HKI C;  4UI7 C;  4KZL C;  4UVP B;  4KZU C;  5ADT B;  4HLF C;  2ZIX B;  4UI4 C; 
#chains in the Genus database with same CATH homology
 4L31 C;  4L0T C;  4HKK B;  5C5P C;  5ADS B;  4HMH C;  5ADQ B;  4L10 C;  4HLH C;  5C5R C;  4HKN C;  4L2K C;  5ADR B;  4L32 C;  3HJ6 A;  4L09 C;  4KZQ C;  4L0I C;  4HLM C;  4HLG C;  4L0B C;  4UI6 C;  4UI3 C;  4L0S C;  4L2G C;  4HLK C;  4L2F C;  4UI5 C;  4L0V C;  4L33 C;  4L34 C;  5C5Q C;  5FPF C;  4HL5 C;  4UI8 C;  4HKI C;  4UI7 C;  4KZL C;  4UVP B;  4KZU C;  5ADT B;  4HLF C;  2ZIX B;  4UI4 C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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