4HLFC

Crystal structure of tankyrase 2 in complex with 7,3',4'-trihydroxyflavone
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
47
structure length
47
Chain Sequence
MAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Screening and structural analysis of flavones inhibiting tankyrases.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Tankyrase-2
total genus 1
structure length 47
sequence length 47
chains with identical sequence D
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2012-10-17
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1620.50 Alpha Beta 3-Layer(aba) Sandwich YefM-like fold YefM-like fold 4hlfC00
4UI5C 4L09C 4UVPB 4UI8C 5ADSB 4HLHC 4UI7C 4KZLC 4HKKB 4HLMC 4HLKC 5FPFC 4HLFC 5ADRB 4HLGC 4L0IC 4L2KC 4HMHC 4L0VC 4L32C 4KZUC 5ADQB 4L0TC 4L2FC 5C5QC 4HL5C 4KZQC 4L34C 4L0BC 5ADTB 5C5PC 5C5RC 4HKIC 4L2GC 4UI6C 4L0SC 4UI4C 4HKNC 4L33C 4L10C 4L31C 4UI3C
chains in the Genus database with same CATH superfamily
3KH2E 4UI5C 4L09C 3OEIA 3HJ6A 4UVPB 4UI8C 5ADSB 3K6QA 4HLHC 4UI7C 4KZLC 3D55A 4HKKB 4HLMC 4HLKC 3G5OA 5FPFC 4ZM0A 4HLFC 3HRYA 5ADRB 4HLGC 4L0IC 4L2KC 4HMHC 4L0VC 4L32C 4ZLXA 4KZUC 5ADQB 4L0TC 4L2FC 5C5QC 2ZIXB 4HL5C 4KZQC 4L34C 4L0BC 5ADTB 2ODKA 3CTOA 5C5PC 2A6QA 5C5RC 3OEIE 4HKIC 3K33B 4L2GC 4UI6C 4L0SC 4UI4C 3HS2A 4HKNC 4L10C 4L33C 4ZM2A 4L31C 4UI3C
chains in the Genus database with same CATH topology
4UI5C 4L09C 3HJ6A 4UVPB 4UI8C 5ADSB 4HLHC 4UI7C 4KZLC 4HKKB 4HLMC 4HLKC 5FPFC 4HLFC 5ADRB 4HLGC 4L0IC 4L2KC 4HMHC 4L0VC 4L32C 4KZUC 5ADQB 4L0TC 4L2FC 5C5QC 2ZIXB 4HL5C 4KZQC 4L34C 4L0BC 5ADTB 5C5PC 5C5RC 4HKIC 4L2GC 4UI6C 4L0SC 4UI4C 4HKNC 4L33C 4L10C 4L31C 4UI3C
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4UI5 C;  4L09 C;  4UVP B;  4UI8 C;  5ADS B;  4HLH C;  4UI7 C;  4KZL C;  4HKK B;  4HLM C;  4HLK C;  5FPF C;  4HLF C;  5ADR B;  4HLG C;  4L0I C;  4L2K C;  4HMH C;  4L0V C;  4L32 C;  4KZU C;  5ADQ B;  4L0T C;  4L2F C;  5C5Q C;  4HL5 C;  4KZQ C;  4L34 C;  4L0B C;  5ADT B;  5C5P C;  5C5R C;  4HKI C;  4L2G C;  4UI6 C;  4L0S C;  4UI4 C;  4HKN C;  4L33 C;  4L10 C;  4L31 C;  4UI3 C; 
#chains in the Genus database with same CATH topology
 3KH2 E;  4UI5 C;  4L09 C;  3OEI A;  3HJ6 A;  4UVP B;  4UI8 C;  5ADS B;  3K6Q A;  4HLH C;  4UI7 C;  4KZL C;  3D55 A;  4HKK B;  4HLM C;  4HLK C;  3G5O A;  5FPF C;  4ZM0 A;  4HLF C;  3HRY A;  5ADR B;  4HLG C;  4L0I C;  4L2K C;  4HMH C;  4L0V C;  4L32 C;  4ZLX A;  4KZU C;  5ADQ B;  4L0T C;  4L2F C;  5C5Q C;  2ZIX B;  4HL5 C;  4KZQ C;  4L34 C;  4L0B C;  5ADT B;  2ODK A;  3CTO A;  5C5P C;  2A6Q A;  5C5R C;  3OEI E;  4HKI C;  3K33 B;  4L2G C;  4UI6 C;  4L0S C;  4UI4 C;  3HS2 A;  4HKN C;  4L10 C;  4L33 C;  4ZM2 A;  4L31 C;  4UI3 C; 
#chains in the Genus database with same CATH homology
 4UI5 C;  4L09 C;  3HJ6 A;  4UVP B;  4UI8 C;  5ADS B;  4HLH C;  4UI7 C;  4KZL C;  4HKK B;  4HLM C;  4HLK C;  5FPF C;  4HLF C;  5ADR B;  4HLG C;  4L0I C;  4L2K C;  4HMH C;  4L0V C;  4L32 C;  4KZU C;  5ADQ B;  4L0T C;  4L2F C;  5C5Q C;  2ZIX B;  4HL5 C;  4KZQ C;  4L34 C;  4L0B C;  5ADT B;  5C5P C;  5C5R C;  4HKI C;  4L2G C;  4UI6 C;  4L0S C;  4UI4 C;  4HKN C;  4L33 C;  4L10 C;  4L31 C;  4UI3 C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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