4HLFC

Crystal structure of tankyrase 2 in complex with 7,3',4'-trihydroxyflavone
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
47
structure length
47
Chain Sequence
MAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Screening and structural analysis of flavones inhibiting tankyrases.
pubmed doi rcsb
molecule keywords Tankyrase-2
molecule tags Transferase
source organism Homo sapiens
total genus 1
structure length 47
sequence length 47
chains with identical sequence D
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2012-10-17
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1620.50 Alpha Beta 3-Layer(aba) Sandwich YefM-like fold YefM-like fold 4hlfC00
4HLHC 4KZLC 4L32C 5ADRB 4L0BC 4UVPB 5FPFC 5C5RC 4L09C 4L10C 4UI3C 4UI4C 4L34C 5ADSB 4L0VC 4UI6C 4HLFC 4HLGC 4UI5C 4L2KC 4UI8C 5C5PC 5C5QC 4L0TC 4L0SC 4L31C 4HMHC 5ADQB 4HLMC 4HLKC 4L2GC 4HKNC 4L33C 4L0IC 4KZUC 4UI7C 4HL5C 5ADTB 4HKKB 4KZQC 4L2FC 4HKIC
chains in the Genus database with same CATH superfamily
4HLHC 3KH2E 4KZLC 4L32C 4ZLXA 5ADRB 4L0BC 4UVPB 2A6QA 5FPFC 5C5RC 4L09C 4L10C 4UI3C 4UI4C 4L34C 5ADSB 4L0VC 4UI6C 4HLFC 4HLGC 2ODKA 4UI5C 4L2KC 4UI8C 5C5PC 5C5QC 4L0TC 4L0SC 4L31C 4HMHC 5ADQB 3HS2A 3K6QA 3CTOA 4HLMC 4HLKC 3OEIA 2ZIXB 4HKNC 3K33B 4L2GC 4L33C 3HRYA 3D55A 4KZUC 4L0IC 4ZM0A 3OEIE 4UI7C 3G5OA 4HL5C 5ADTB 4HKKB 4ZM2A 3HJ6A 4KZQC 4L2FC 4HKIC
chains in the Genus database with same CATH topology
4HLHC 4KZLC 4L32C 5ADRB 4L0BC 4UVPB 5FPFC 5C5RC 4L09C 4L10C 4UI3C 4UI4C 4L34C 5ADSB 4L0VC 4UI6C 4HLFC 4HLGC 4UI5C 4L2KC 4UI8C 5C5PC 5C5QC 4L0TC 4L0SC 4L31C 4HMHC 5ADQB 4HLMC 4HLKC 4L2GC 4HKNC 2ZIXB 4L33C 4L0IC 4KZUC 4UI7C 4HL5C 5ADTB 4HKKB 3HJ6A 4KZQC 4L2FC 4HKIC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4HLH C;  4KZL C;  4L32 C;  5ADR B;  4L0B C;  4UVP B;  5FPF C;  5C5R C;  4L09 C;  4L10 C;  4UI3 C;  4UI4 C;  4L34 C;  5ADS B;  4L0V C;  4UI6 C;  4HLF C;  4HLG C;  4UI5 C;  4L2K C;  4UI8 C;  5C5P C;  5C5Q C;  4L0T C;  4L0S C;  4L31 C;  4HMH C;  5ADQ B;  4HLM C;  4HLK C;  4L2G C;  4HKN C;  4L33 C;  4L0I C;  4KZU C;  4UI7 C;  4HL5 C;  5ADT B;  4HKK B;  4KZQ C;  4L2F C;  4HKI C; 
#chains in the Genus database with same CATH topology
 4HLH C;  3KH2 E;  4KZL C;  4L32 C;  4ZLX A;  5ADR B;  4L0B C;  4UVP B;  2A6Q A;  5FPF C;  5C5R C;  4L09 C;  4L10 C;  4UI3 C;  4UI4 C;  4L34 C;  5ADS B;  4L0V C;  4UI6 C;  4HLF C;  4HLG C;  2ODK A;  4UI5 C;  4L2K C;  4UI8 C;  5C5P C;  5C5Q C;  4L0T C;  4L0S C;  4L31 C;  4HMH C;  5ADQ B;  3HS2 A;  3K6Q A;  3CTO A;  4HLM C;  4HLK C;  3OEI A;  2ZIX B;  4HKN C;  3K33 B;  4L2G C;  4L33 C;  3HRY A;  3D55 A;  4KZU C;  4L0I C;  4ZM0 A;  3OEI E;  4UI7 C;  3G5O A;  4HL5 C;  5ADT B;  4HKK B;  4ZM2 A;  3HJ6 A;  4KZQ C;  4L2F C;  4HKI C; 
#chains in the Genus database with same CATH homology
 4HLH C;  4KZL C;  4L32 C;  5ADR B;  4L0B C;  4UVP B;  5FPF C;  5C5R C;  4L09 C;  4L10 C;  4UI3 C;  4UI4 C;  4L34 C;  5ADS B;  4L0V C;  4UI6 C;  4HLF C;  4HLG C;  4UI5 C;  4L2K C;  4UI8 C;  5C5P C;  5C5Q C;  4L0T C;  4L0S C;  4L31 C;  4HMH C;  5ADQ B;  4HLM C;  4HLK C;  4L2G C;  4HKN C;  2ZIX B;  4L33 C;  4L0I C;  4KZU C;  4UI7 C;  4HL5 C;  5ADT B;  4HKK B;  3HJ6 A;  4KZQ C;  4L2F C;  4HKI C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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