4HLHC

Crystal structure of tankyrase 2 in complex with 4'-fluoroflavone
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
47
structure length
47
Chain Sequence
MAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Screening and structural analysis of flavones inhibiting tankyrases.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Tankyrase-2
total genus 1
structure length 47
sequence length 47
chains with identical sequence D
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2012-10-17
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1620.50 Alpha Beta 3-Layer(aba) Sandwich YefM-like fold YefM-like fold 4hlhC00
4L33C 4UI3C 4HLHC 4UI5C 4HKKB 4HKIC 4KZQC 4L2FC 4HLFC 4L0IC 4HMHC 4UVPB 5ADSB 4L31C 5C5RC 4UI8C 4HLMC 4L0BC 4L0VC 4HLKC 4L2KC 4L09C 4L10C 4KZLC 4L2GC 4UI6C 4UI4C 5ADTB 4HL5C 4HLGC 4L0TC 4HKNC 4L32C 4UI7C 4L34C 5ADQB 5C5QC 5ADRB 5C5PC 4L0SC 4KZUC 5FPFC
chains in the Genus database with same CATH superfamily
3K6QA 3HJ6A 4L33C 4UI3C 3OEIA 4HLHC 4UI5C 4HKKB 4HKIC 3KH2E 4KZQC 4L2FC 4HLFC 4L0IC 4HMHC 4UVPB 5ADSB 4ZLXA 2ODKA 3CTOA 4L31C 4ZM0A 2A6QA 5C5RC 4UI8C 3K33B 4HLMC 4L0BC 4L0VC 4HLKC 4L2KC 3D55A 4L10C 4L09C 4KZLC 4L2GC 3HS2A 4UI6C 4UI4C 5ADTB 4HL5C 4HLGC 3HRYA 4HKNC 4L0TC 4L32C 4UI7C 4ZM2A 3OEIE 4L34C 5ADQB 5C5QC 3G5OA 5ADRB 5C5PC 4L0SC 2ZIXB 4KZUC 5FPFC
chains in the Genus database with same CATH topology
3HJ6A 4L33C 4UI3C 4HLHC 4UI5C 4HKKB 4HKIC 4KZQC 4L2FC 4HLFC 4L0IC 4HMHC 4UVPB 5ADSB 4L31C 5C5RC 4UI8C 4HLMC 4L0BC 4L0VC 4HLKC 4L2KC 4L09C 4L10C 4KZLC 4L2GC 4UI6C 4UI4C 5ADTB 4HLGC 4HL5C 4HKNC 4L0TC 4L32C 4UI7C 4L34C 5ADQB 5C5QC 5ADRB 5C5PC 4L0SC 2ZIXB 4KZUC 5FPFC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4L33 C;  4UI3 C;  4HLH C;  4UI5 C;  4HKK B;  4HKI C;  4KZQ C;  4L2F C;  4HLF C;  4L0I C;  4HMH C;  4UVP B;  5ADS B;  4L31 C;  5C5R C;  4UI8 C;  4HLM C;  4L0B C;  4L0V C;  4HLK C;  4L2K C;  4L09 C;  4L10 C;  4KZL C;  4L2G C;  4UI6 C;  4UI4 C;  5ADT B;  4HL5 C;  4HLG C;  4L0T C;  4HKN C;  4L32 C;  4UI7 C;  4L34 C;  5ADQ B;  5C5Q C;  5ADR B;  5C5P C;  4L0S C;  4KZU C;  5FPF C; 
#chains in the Genus database with same CATH topology
 3K6Q A;  3HJ6 A;  4L33 C;  4UI3 C;  3OEI A;  4HLH C;  4UI5 C;  4HKK B;  4HKI C;  3KH2 E;  4KZQ C;  4L2F C;  4HLF C;  4L0I C;  4HMH C;  4UVP B;  5ADS B;  4ZLX A;  2ODK A;  3CTO A;  4L31 C;  4ZM0 A;  2A6Q A;  5C5R C;  4UI8 C;  3K33 B;  4HLM C;  4L0B C;  4L0V C;  4HLK C;  4L2K C;  3D55 A;  4L10 C;  4L09 C;  4KZL C;  4L2G C;  3HS2 A;  4UI6 C;  4UI4 C;  5ADT B;  4HL5 C;  4HLG C;  3HRY A;  4HKN C;  4L0T C;  4L32 C;  4UI7 C;  4ZM2 A;  3OEI E;  4L34 C;  5ADQ B;  5C5Q C;  3G5O A;  5ADR B;  5C5P C;  4L0S C;  2ZIX B;  4KZU C;  5FPF C; 
#chains in the Genus database with same CATH homology
 3HJ6 A;  4L33 C;  4UI3 C;  4HLH C;  4UI5 C;  4HKK B;  4HKI C;  4KZQ C;  4L2F C;  4HLF C;  4L0I C;  4HMH C;  4UVP B;  5ADS B;  4L31 C;  5C5R C;  4UI8 C;  4HLM C;  4L0B C;  4L0V C;  4HLK C;  4L2K C;  4L09 C;  4L10 C;  4KZL C;  4L2G C;  4UI6 C;  4UI4 C;  5ADT B;  4HLG C;  4HL5 C;  4HKN C;  4L0T C;  4L32 C;  4UI7 C;  4L34 C;  5ADQ B;  5C5Q C;  5ADR B;  5C5P C;  4L0S C;  2ZIX B;  4KZU C;  5FPF C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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