4HLKC

Crystal structure of tankyrase 2 in complex with 4'-methylflavone
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
47
structure length
47
Chain Sequence
MAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Screening and structural analysis of flavones inhibiting tankyrases.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Tankyrase-2
total genus 1
structure length 47
sequence length 47
chains with identical sequence D
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2012-10-17
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1620.50 Alpha Beta 3-Layer(aba) Sandwich YefM-like fold YefM-like fold 4hlkC00
4L2GC 4HLFC 4UI8C 4L2FC 5C5RC 4L0IC 5C5QC 4HLGC 4L0SC 4L10C 4KZUC 4L2KC 4UI7C 4L0VC 5ADRB 5ADQB 5FPFC 4L34C 4HMHC 4L09C 4KZLC 4L0BC 4L33C 4HLHC 4KZQC 4UI6C 4HKIC 4L0TC 4HKKB 4UVPB 4L31C 4HLKC 4UI3C 5ADTB 4L32C 5ADSB 4HLMC 4HKNC 4UI5C 4UI4C 5C5PC 4HL5C
chains in the Genus database with same CATH superfamily
3HS2A 4L2GC 4HLFC 3G5OA 3OEIE 4UI8C 4L2FC 5C5RC 4L0IC 3KH2E 5C5QC 4HLGC 3K33B 4L0SC 4L10C 4KZUC 4L2KC 4UI7C 3HRYA 4L0VC 3K6QA 4ZM0A 5ADRB 5ADQB 5FPFC 2ZIXB 3OEIA 4L34C 4HMHC 3HJ6A 4L09C 4KZLC 4L0BC 4L33C 4HLHC 4KZQC 4UI6C 4HKIC 4L0TC 4HKKB 4UVPB 4ZLXA 4L31C 4HLKC 4UI3C 2A6QA 5ADTB 4L32C 5ADSB 3D55A 4HLMC 4HKNC 4UI5C 4UI4C 3CTOA 5C5PC 2ODKA 4ZM2A 4HL5C
chains in the Genus database with same CATH topology
4L2GC 4HLFC 4UI8C 4L2FC 5C5RC 4L0IC 5C5QC 4HLGC 4L0SC 4L10C 4KZUC 4L2KC 4UI7C 4L0VC 5ADRB 5ADQB 5FPFC 2ZIXB 4L34C 4HMHC 3HJ6A 4L09C 4KZLC 4L0BC 4L33C 4HLHC 4KZQC 4UI6C 4HKIC 4L0TC 4HKKB 4UVPB 4L31C 4HLKC 4UI3C 5ADTB 4L32C 5ADSB 4HLMC 4HKNC 4UI5C 4UI4C 5C5PC 4HL5C
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4L2G C;  4HLF C;  4UI8 C;  4L2F C;  5C5R C;  4L0I C;  5C5Q C;  4HLG C;  4L0S C;  4L10 C;  4KZU C;  4L2K C;  4UI7 C;  4L0V C;  5ADR B;  5ADQ B;  5FPF C;  4L34 C;  4HMH C;  4L09 C;  4KZL C;  4L0B C;  4L33 C;  4HLH C;  4KZQ C;  4UI6 C;  4HKI C;  4L0T C;  4HKK B;  4UVP B;  4L31 C;  4HLK C;  4UI3 C;  5ADT B;  4L32 C;  5ADS B;  4HLM C;  4HKN C;  4UI5 C;  4UI4 C;  5C5P C;  4HL5 C; 
#chains in the Genus database with same CATH topology
 3HS2 A;  4L2G C;  4HLF C;  3G5O A;  3OEI E;  4UI8 C;  4L2F C;  5C5R C;  4L0I C;  3KH2 E;  5C5Q C;  4HLG C;  3K33 B;  4L0S C;  4L10 C;  4KZU C;  4L2K C;  4UI7 C;  3HRY A;  4L0V C;  3K6Q A;  4ZM0 A;  5ADR B;  5ADQ B;  5FPF C;  2ZIX B;  3OEI A;  4L34 C;  4HMH C;  3HJ6 A;  4L09 C;  4KZL C;  4L0B C;  4L33 C;  4HLH C;  4KZQ C;  4UI6 C;  4HKI C;  4L0T C;  4HKK B;  4UVP B;  4ZLX A;  4L31 C;  4HLK C;  4UI3 C;  2A6Q A;  5ADT B;  4L32 C;  5ADS B;  3D55 A;  4HLM C;  4HKN C;  4UI5 C;  4UI4 C;  3CTO A;  5C5P C;  2ODK A;  4ZM2 A;  4HL5 C; 
#chains in the Genus database with same CATH homology
 4L2G C;  4HLF C;  4UI8 C;  4L2F C;  5C5R C;  4L0I C;  5C5Q C;  4HLG C;  4L0S C;  4L10 C;  4KZU C;  4L2K C;  4UI7 C;  4L0V C;  5ADR B;  5ADQ B;  5FPF C;  2ZIX B;  4L34 C;  4HMH C;  3HJ6 A;  4L09 C;  4KZL C;  4L0B C;  4L33 C;  4HLH C;  4KZQ C;  4UI6 C;  4HKI C;  4L0T C;  4HKK B;  4UVP B;  4L31 C;  4HLK C;  4UI3 C;  5ADT B;  4L32 C;  5ADS B;  4HLM C;  4HKN C;  4UI5 C;  4UI4 C;  5C5P C;  4HL5 C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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