4HLMC

Crystal structure of tankyrase 2 in complex with 3',4'-dihydroxyflavone
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
47
structure length
47
Chain Sequence
MAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Screening and structural analysis of flavones inhibiting tankyrases.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Tankyrase-2
total genus 1
structure length 47
sequence length 47
chains with identical sequence D
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2012-10-17
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1620.50 Alpha Beta 3-Layer(aba) Sandwich YefM-like fold YefM-like fold 4hlmC00
4HLKC 4L0SC 4L0BC 5ADRB 5FPFC 4UI7C 4L09C 4KZLC 4HLMC 4L0TC 4L32C 4KZUC 4L31C 4HLHC 4L0IC 4L33C 4UI3C 4UI6C 5ADQB 5ADSB 5C5PC 4HMHC 4L2FC 4KZQC 5ADTB 4L34C 4UI8C 4L0VC 4HLFC 4UI4C 4HL5C 4HKNC 4L2KC 5C5RC 4HKKB 4L10C 4UVPB 4HLGC 4HKIC 4UI5C 5C5QC 4L2GC
chains in the Genus database with same CATH superfamily
4HLKC 4L0SC 4L0BC 5ADRB 5FPFC 4UI7C 4L09C 4ZM2A 4ZLXA 4KZLC 4HLMC 4L0TC 3G5OA 4L32C 4KZUC 3OEIA 2ODKA 4L31C 3K6QA 4HLHC 4L0IC 4ZM0A 3CTOA 4L33C 4UI3C 4UI6C 2ZIXB 5ADQB 5ADSB 5C5PC 4HMHC 4L2FC 4KZQC 5C5QC 5ADTB 3HRYA 4L34C 4UI8C 3D55A 4L0VC 3OEIE 4HLFC 4UI4C 3KH2E 4HL5C 4HKNC 4L2KC 5C5RC 4HKKB 3HS2A 4L2GC 4L10C 4UVPB 4HLGC 4HKIC 4UI5C 2A6QA 3HJ6A 3K33B
chains in the Genus database with same CATH topology
4HLKC 4L0SC 4L0BC 5ADRB 5FPFC 4UI7C 4L09C 4KZLC 4HLMC 4L0TC 4L32C 4KZUC 4L31C 4HLHC 4L0IC 4L33C 4UI3C 4UI6C 2ZIXB 5ADQB 5ADSB 5C5PC 4HMHC 4L2FC 4KZQC 5ADTB 4L34C 4UI8C 4L0VC 4HLFC 4UI4C 4HL5C 4HKNC 4L2KC 5C5RC 4HKKB 4L10C 4UVPB 4HLGC 4HKIC 4UI5C 3HJ6A 5C5QC 4L2GC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4HLK C;  4L0S C;  4L0B C;  5ADR B;  5FPF C;  4UI7 C;  4L09 C;  4KZL C;  4HLM C;  4L0T C;  4L32 C;  4KZU C;  4L31 C;  4HLH C;  4L0I C;  4L33 C;  4UI3 C;  4UI6 C;  5ADQ B;  5ADS B;  5C5P C;  4HMH C;  4L2F C;  4KZQ C;  5ADT B;  4L34 C;  4UI8 C;  4L0V C;  4HLF C;  4UI4 C;  4HL5 C;  4HKN C;  4L2K C;  5C5R C;  4HKK B;  4L10 C;  4UVP B;  4HLG C;  4HKI C;  4UI5 C;  5C5Q C;  4L2G C; 
#chains in the Genus database with same CATH topology
 4HLK C;  4L0S C;  4L0B C;  5ADR B;  5FPF C;  4UI7 C;  4L09 C;  4ZM2 A;  4ZLX A;  4KZL C;  4HLM C;  4L0T C;  3G5O A;  4L32 C;  4KZU C;  3OEI A;  2ODK A;  4L31 C;  3K6Q A;  4HLH C;  4L0I C;  4ZM0 A;  3CTO A;  4L33 C;  4UI3 C;  4UI6 C;  2ZIX B;  5ADQ B;  5ADS B;  5C5P C;  4HMH C;  4L2F C;  4KZQ C;  5C5Q C;  5ADT B;  3HRY A;  4L34 C;  4UI8 C;  3D55 A;  4L0V C;  3OEI E;  4HLF C;  4UI4 C;  3KH2 E;  4HL5 C;  4HKN C;  4L2K C;  5C5R C;  4HKK B;  3HS2 A;  4L2G C;  4L10 C;  4UVP B;  4HLG C;  4HKI C;  4UI5 C;  2A6Q A;  3HJ6 A;  3K33 B; 
#chains in the Genus database with same CATH homology
 4HLK C;  4L0S C;  4L0B C;  5ADR B;  5FPF C;  4UI7 C;  4L09 C;  4KZL C;  4HLM C;  4L0T C;  4L32 C;  4KZU C;  4L31 C;  4HLH C;  4L0I C;  4L33 C;  4UI3 C;  4UI6 C;  2ZIX B;  5ADQ B;  5ADS B;  5C5P C;  4HMH C;  4L2F C;  4KZQ C;  5ADT B;  4L34 C;  4UI8 C;  4L0V C;  4HLF C;  4UI4 C;  4HL5 C;  4HKN C;  4L2K C;  5C5R C;  4HKK B;  4L10 C;  4UVP B;  4HLG C;  4HKI C;  4UI5 C;  3HJ6 A;  5C5Q C;  4L2G C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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