4JCJA

Crystal structure of isl1 lim domains with ldb1 lim-interaction domain
Total Genus 22
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
22
sequence length
165
structure length
144
Chain Sequence
ISLCVGCGNQIHDQYILRVSPDLEWHAACLKCAECNQYLDESCTCFVRDGKTYCKRDYIRLYGIKCAKCSIGFSKNDFVMRARSKVYHIECFRCVACSRQLIPGDEFALREDGLFCRADHDDVMVVGEPTLMDEDERLITRLEN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A structural basis for the regulation of the LIM-homeodomain protein islet 1 (Isl1) by intra- and intermolecular interactions.
pubmed doi rcsb
molecule tags Protein binding
source organism Mus musculus
molecule keywords Insulin gene enhancer protein ISL-1,LIM domain-binding prote
total genus 22
structure length 144
sequence length 165
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2013-02-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00412 LIM LIM domain
A PF17916 LID LIM interaction domain (LID)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.110.10 Mainly Beta Ribbon Cysteine Rich Protein Cysteine Rich Protein 4jcjA01
2.10.110.10 Mainly Beta Ribbon Cysteine Rich Protein Cysteine Rich Protein 4jcjA02
1X4LA 2DARA 4HI9B 1G47A 1X61A 2D8ZA 2O10A 2CO8A 1RUTX 1B8TA 1U5SB 2MBVA 3MMKA 1X3HA 2EGQA 1IMLA 4HI8B 2JTNA 4KFZA 2D8XA 2MIUA 2DJ7A 2XJZA 1M3VA 3IXEB 2KBXB 3F6QB 2XJYA 1QLIA 2L6YB 1J2OA 1WIGA 1A7IA 2CUQA 2CUPA 1IBIA 2EHEA 1X6AA 1X68A 2LZUA 2CU8A 2DFYC 2L6ZC 2O13A 2XQNT 1CXXA 2D8YA 1CTLA 2YPAC 1V6GA 2LXDA 1X64A 1X62A 2IYBE 2CURA 1X63A 1NYPA 2L4ZA 4JCJA 2DLOA 1WYHA 2CORA
chains in the Genus database with same CATH superfamily
3NIHA 1X4LA 2O10A 5LKTA 2MBVA 4HI8B 1M3VA 2KBXB 5LKXA 2CUPA 1IBIA 2EHEA 1X68A 2DFYC 1V6GA 2LXDA 2IYBE 4UF0B 5FY0A 2XUEA 4JCJA 3ZLIA 4ASKA 2CORA 2DARA 5FY7A 4BHWA 5FYMA 4EZHA 2CO8A 1B8TA 1U5SB 5FXVA 1X3HA 3AVSA 2MIUA 1J2OA 1QLIA 1WIGA 1A7IA 3NINA 1X6AA 2XQNT 5FP3A 1X64A 3NIKA 2CURA 1NYPA 2L4ZA 1IMLA 1G47A 3ZPOA 1X61A 2D8ZA 3MMKA 5A1LA 4EYUA 5FXZA 5LKUA 2XJZA 5LKZA 2L6ZC 2O13A 2D8YA 2YPAC 3NISA 1X63A 2DLOA 5FXWA 4EZ4A 4HI9B 3NIMA 1RUTX 4UF0A 3NIJA 5FY1A 2EGQA 2JTNA 4KFZA 2D8XA 2DJ7A 3IXEB 3F6QB 3NILA 2L6YB 2CUQA 2LZUA 2CU8A 1CXXA 1CTLA 1X62A 5FXXA 1WYHA 3AVRA 2XJYA
chains in the Genus database with same CATH topology
3NIHA 1X4LA 2O10A 5LKTA 2MBVA 4HI8B 1M3VA 2KBXB 5LKXA 2CUPA 1IBIA 2EHEA 1X68A 2DFYC 1V6GA 2LXDA 2IYBE 4UF0B 5FY0A 2XUEA 4JCJA 3ZLIA 4ASKA 2CORA 2DARA 5FY7A 4BHWA 5FYMA 4EZHA 2CO8A 1B8TA 1U5SB 5FXVA 1X3HA 3AVSA 2MIUA 1J2OA 1QLIA 1WIGA 1A7IA 3NINA 1X6AA 2XQNT 5FP3A 1X64A 3NIKA 2CURA 1NYPA 2L4ZA 1IMLA 1G47A 3ZPOA 1X61A 2D8ZA 3MMKA 5A1LA 4EYUA 5FXZA 5LKUA 2XJZA 5LKZA 2L6ZC 2O13A 2D8YA 2YPAC 3NISA 1X63A 2DLOA 5FXWA 4EZ4A 4HI9B 3NIMA 1RUTX 4UF0A 3NIJA 5FY1A 2EGQA 2JTNA 4KFZA 2D8XA 2DJ7A 3IXEB 3F6QB 3NILA 2L6YB 2CUQA 2LZUA 2CU8A 1CXXA 1CTLA 1X62A 5FXXA 1WYHA 3AVRA 2XJYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1X4L A;  2DAR A;  4HI9 B;  1G47 A;  1X61 A;  2D8Z A;  2O10 A;  2CO8 A;  1RUT X;  1B8T A;  1U5S B;  2MBV A;  3MMK A;  1X3H A;  2EGQ A;  1IML A;  4HI8 B;  2JTN A;  4KFZ A;  2D8X A;  2MIU A;  2DJ7 A;  2XJZ A;  1M3V A;  3IXE B;  2KBX B;  3F6Q B;  2XJY A;  1QLI A;  2L6Y B;  1J2O A;  1WIG A;  1A7I A;  2CUQ A;  2CUP A;  1IBI A;  2EHE A;  1X6A A;  1X68 A;  2LZU A;  2CU8 A;  2DFY C;  2L6Z C;  2O13 A;  2XQN T;  1CXX A;  2D8Y A;  1CTL A;  2YPA C;  1V6G A;  2LXD A;  1X64 A;  1X62 A;  2IYB E;  2CUR A;  1X63 A;  1NYP A;  2L4Z A;  4JCJ A;  2DLO A;  1WYH A;  2COR A; 
#chains in the Genus database with same CATH topology
 3NIH A;  1X4L A;  2O10 A;  5LKT A;  2MBV A;  4HI8 B;  1M3V A;  2KBX B;  5LKX A;  2CUP A;  1IBI A;  2EHE A;  1X68 A;  2DFY C;  1V6G A;  2LXD A;  2IYB E;  4UF0 B;  5FY0 A;  2XUE A;  4JCJ A;  3ZLI A;  4ASK A;  2COR A;  2DAR A;  5FY7 A;  4BHW A;  5FYM A;  4EZH A;  2CO8 A;  1B8T A;  1U5S B;  5FXV A;  1X3H A;  3AVS A;  2MIU A;  1J2O A;  1QLI A;  1WIG A;  1A7I A;  3NIN A;  1X6A A;  2XQN T;  5FP3 A;  1X64 A;  3NIK A;  2CUR A;  1NYP A;  2L4Z A;  1IML A;  1G47 A;  3ZPO A;  1X61 A;  2D8Z A;  3MMK A;  5A1L A;  4EYU A;  5FXZ A;  5LKU A;  2XJZ A;  5LKZ A;  2L6Z C;  2O13 A;  2D8Y A;  2YPA C;  3NIS A;  1X63 A;  2DLO A;  5FXW A;  4EZ4 A;  4HI9 B;  3NIM A;  1RUT X;  4UF0 A;  3NIJ A;  5FY1 A;  2EGQ A;  2JTN A;  4KFZ A;  2D8X A;  2DJ7 A;  3IXE B;  3F6Q B;  3NIL A;  2L6Y B;  2CUQ A;  2LZU A;  2CU8 A;  1CXX A;  1CTL A;  1X62 A;  5FXX A;  1WYH A;  3AVR A;  2XJY A; 
#chains in the Genus database with same CATH homology
 3NIH A;  1X4L A;  2O10 A;  5LKT A;  2MBV A;  4HI8 B;  1M3V A;  2KBX B;  5LKX A;  2CUP A;  1IBI A;  2EHE A;  1X68 A;  2DFY C;  1V6G A;  2LXD A;  2IYB E;  4UF0 B;  5FY0 A;  2XUE A;  4JCJ A;  3ZLI A;  4ASK A;  2COR A;  2DAR A;  5FY7 A;  4BHW A;  5FYM A;  4EZH A;  2CO8 A;  1B8T A;  1U5S B;  5FXV A;  1X3H A;  3AVS A;  2MIU A;  1J2O A;  1QLI A;  1WIG A;  1A7I A;  3NIN A;  1X6A A;  2XQN T;  5FP3 A;  1X64 A;  3NIK A;  2CUR A;  1NYP A;  2L4Z A;  1IML A;  1G47 A;  3ZPO A;  1X61 A;  2D8Z A;  3MMK A;  5A1L A;  4EYU A;  5FXZ A;  5LKU A;  2XJZ A;  5LKZ A;  2L6Z C;  2O13 A;  2D8Y A;  2YPA C;  3NIS A;  1X63 A;  2DLO A;  5FXW A;  4EZ4 A;  4HI9 B;  3NIM A;  1RUT X;  4UF0 A;  3NIJ A;  5FY1 A;  2EGQ A;  2JTN A;  4KFZ A;  2D8X A;  2DJ7 A;  3IXE B;  3F6Q B;  3NIL A;  2L6Y B;  2CUQ A;  2LZU A;  2CU8 A;  1CXX A;  1CTL A;  1X62 A;  5FXX A;  1WYH A;  3AVR A;  2XJY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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