4L0SC

Tankyrase 2 in complex with 4'-cyano flavone
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
47
structure length
47
Chain Sequence
MAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase/transferase inhibitor
source organism Homo sapiens
publication title Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.
pubmed doi rcsb
molecule keywords Tankyrase-2
total genus 1
structure length 47
sequence length 47
chains with identical sequence D
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2013-06-01
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1620.50 Alpha Beta 3-Layer(aba) Sandwich YefM-like fold YefM-like fold 4l0sC00
4L31C 4L32C 4L0BC 5C5PC 4HKKB 4L0SC 4HLKC 4KZLC 4UI3C 4L0IC 4L10C 4UI8C 4L2GC 4HL5C 4HLHC 4KZQC 4UI4C 4HLFC 4HKNC 4L33C 4L34C 4L0TC 5ADRB 5C5QC 5ADSB 4L2FC 4HLMC 4UVPB 4HKIC 5FPFC 5ADQB 4KZUC 4L09C 4UI5C 4L0VC 4HMHC 5ADTB 5C5RC 4UI7C 4HLGC 4UI6C 4L2KC
chains in the Genus database with same CATH superfamily
4L31C 4L32C 3HS2A 4L0BC 5C5PC 4HKKB 4L0SC 3CTOA 4HLKC 4KZLC 4UI3C 3D55A 4L0IC 4L10C 3K6QA 3OEIA 4ZLXA 4UI8C 4L2GC 4HL5C 4HLHC 4KZQC 4UI4C 4HLFC 4HKNC 3OEIE 4L33C 4L34C 4L0TC 2A6QA 5ADRB 5C5QC 5ADSB 4L2FC 4HLMC 4UI6C 4UVPB 4HKIC 3HRYA 5FPFC 2ZIXB 3HJ6A 5ADQB 4KZUC 3KH2E 3K33B 4L09C 4UI5C 4L0VC 4ZM2A 4HMHC 4ZM0A 5ADTB 5C5RC 4UI7C 4HLGC 2ODKA 3G5OA 4L2KC
chains in the Genus database with same CATH topology
4L31C 4L32C 4L0BC 5C5PC 4HKKB 4L0SC 4HLKC 4KZLC 4UI3C 4L0IC 4L10C 4UI8C 4L2GC 4HL5C 4HLHC 4KZQC 4UI4C 4HLFC 4HKNC 4L33C 4L34C 4L0TC 5ADRB 5C5QC 5ADSB 4L2FC 4HLMC 4UVPB 4HKIC 5FPFC 2ZIXB 3HJ6A 5ADQB 4KZUC 4L09C 4UI5C 4L0VC 4HMHC 5ADTB 5C5RC 4UI7C 4HLGC 4UI6C 4L2KC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4L31 C;  4L32 C;  4L0B C;  5C5P C;  4HKK B;  4L0S C;  4HLK C;  4KZL C;  4UI3 C;  4L0I C;  4L10 C;  4UI8 C;  4L2G C;  4HL5 C;  4HLH C;  4KZQ C;  4UI4 C;  4HLF C;  4HKN C;  4L33 C;  4L34 C;  4L0T C;  5ADR B;  5C5Q C;  5ADS B;  4L2F C;  4HLM C;  4UVP B;  4HKI C;  5FPF C;  5ADQ B;  4KZU C;  4L09 C;  4UI5 C;  4L0V C;  4HMH C;  5ADT B;  5C5R C;  4UI7 C;  4HLG C;  4UI6 C;  4L2K C; 
#chains in the Genus database with same CATH topology
 4L31 C;  4L32 C;  3HS2 A;  4L0B C;  5C5P C;  4HKK B;  4L0S C;  3CTO A;  4HLK C;  4KZL C;  4UI3 C;  3D55 A;  4L0I C;  4L10 C;  3K6Q A;  3OEI A;  4ZLX A;  4UI8 C;  4L2G C;  4HL5 C;  4HLH C;  4KZQ C;  4UI4 C;  4HLF C;  4HKN C;  3OEI E;  4L33 C;  4L34 C;  4L0T C;  2A6Q A;  5ADR B;  5C5Q C;  5ADS B;  4L2F C;  4HLM C;  4UI6 C;  4UVP B;  4HKI C;  3HRY A;  5FPF C;  2ZIX B;  3HJ6 A;  5ADQ B;  4KZU C;  3KH2 E;  3K33 B;  4L09 C;  4UI5 C;  4L0V C;  4ZM2 A;  4HMH C;  4ZM0 A;  5ADT B;  5C5R C;  4UI7 C;  4HLG C;  2ODK A;  3G5O A;  4L2K C; 
#chains in the Genus database with same CATH homology
 4L31 C;  4L32 C;  4L0B C;  5C5P C;  4HKK B;  4L0S C;  4HLK C;  4KZL C;  4UI3 C;  4L0I C;  4L10 C;  4UI8 C;  4L2G C;  4HL5 C;  4HLH C;  4KZQ C;  4UI4 C;  4HLF C;  4HKN C;  4L33 C;  4L34 C;  4L0T C;  5ADR B;  5C5Q C;  5ADS B;  4L2F C;  4HLM C;  4UVP B;  4HKI C;  5FPF C;  2ZIX B;  3HJ6 A;  5ADQ B;  4KZU C;  4L09 C;  4UI5 C;  4L0V C;  4HMH C;  5ADT B;  5C5R C;  4UI7 C;  4HLG C;  4UI6 C;  4L2K C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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