4L2KC

Tankyrase 2 in complex with 2-(1,3-benzodioxol-5-yl)-4h-chromen-4-one
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
47
structure length
47
Chain Sequence
MAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.
pubmed doi rcsb
molecule tags Transferase/transferase inhibitor
source organism Homo sapiens
molecule keywords Tankyrase-2
total genus 1
structure length 47
sequence length 47
chains with identical sequence D
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2013-06-04
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1620.50 Alpha Beta 3-Layer(aba) Sandwich YefM-like fold YefM-like fold 4l2kC00
4UI7C 4L2GC 5C5PC 4HLMC 4HL5C 4KZQC 4L0VC 4L2KC 4UI8C 4L2FC 4L0IC 4KZUC 4UI6C 4HLGC 4HMHC 5ADQB 4UI4C 5ADTB 4L0BC 4L0SC 4UI5C 5C5QC 4L31C 4UI3C 4UVPB 4HKNC 4L32C 5ADRB 4L33C 4HLFC 4L10C 4L0TC 4L09C 5ADSB 4HLHC 4KZLC 4L34C 4HLKC 5FPFC 4HKKB 4HKIC 5C5RC
chains in the Genus database with same CATH superfamily
4UI7C 4L2GC 3G5OA 2ZIXB 4HLMC 3KH2E 5C5PC 4HL5C 3HRYA 4KZQC 4L0VC 4L2KC 4UI8C 3K33B 4ZLXA 4L2FC 4L0IC 3K6QA 4KZUC 4HLGC 4UI6C 4HMHC 5ADQB 4UI4C 5ADTB 4L0BC 4L0SC 4UI5C 4ZM2A 5C5QC 4L31C 4UI3C 4ZM0A 4UVPB 3OEIE 4HKNC 4L32C 5ADRB 4L33C 4HLFC 4L10C 4L0TC 4L09C 3CTOA 4HLHC 5ADSB 3OEIA 4KZLC 4L34C 3HS2A 4HLKC 5FPFC 2A6QA 3HJ6A 2ODKA 4HKKB 4HKIC 3D55A 5C5RC
chains in the Genus database with same CATH topology
4UI7C 4L2GC 5C5PC 2ZIXB 4HLMC 4HL5C 4KZQC 4L0VC 4L2KC 4UI8C 4L2FC 4L0IC 4KZUC 4UI6C 4HLGC 4HMHC 5ADQB 4UI4C 5ADTB 4L0BC 4L0SC 4UI5C 5C5QC 4L31C 4UI3C 4UVPB 4HKNC 4L32C 5ADRB 4L33C 4HLFC 4L10C 4L0TC 4L09C 5ADSB 4HLHC 4KZLC 4L34C 4HLKC 5FPFC 3HJ6A 4HKKB 4HKIC 5C5RC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4UI7 C;  4L2G C;  5C5P C;  4HLM C;  4HL5 C;  4KZQ C;  4L0V C;  4L2K C;  4UI8 C;  4L2F C;  4L0I C;  4KZU C;  4UI6 C;  4HLG C;  4HMH C;  5ADQ B;  4UI4 C;  5ADT B;  4L0B C;  4L0S C;  4UI5 C;  5C5Q C;  4L31 C;  4UI3 C;  4UVP B;  4HKN C;  4L32 C;  5ADR B;  4L33 C;  4HLF C;  4L10 C;  4L0T C;  4L09 C;  5ADS B;  4HLH C;  4KZL C;  4L34 C;  4HLK C;  5FPF C;  4HKK B;  4HKI C;  5C5R C; 
#chains in the Genus database with same CATH topology
 4UI7 C;  4L2G C;  3G5O A;  2ZIX B;  4HLM C;  3KH2 E;  5C5P C;  4HL5 C;  3HRY A;  4KZQ C;  4L0V C;  4L2K C;  4UI8 C;  3K33 B;  4ZLX A;  4L2F C;  4L0I C;  3K6Q A;  4KZU C;  4HLG C;  4UI6 C;  4HMH C;  5ADQ B;  4UI4 C;  5ADT B;  4L0B C;  4L0S C;  4UI5 C;  4ZM2 A;  5C5Q C;  4L31 C;  4UI3 C;  4ZM0 A;  4UVP B;  3OEI E;  4HKN C;  4L32 C;  5ADR B;  4L33 C;  4HLF C;  4L10 C;  4L0T C;  4L09 C;  3CTO A;  4HLH C;  5ADS B;  3OEI A;  4KZL C;  4L34 C;  3HS2 A;  4HLK C;  5FPF C;  2A6Q A;  3HJ6 A;  2ODK A;  4HKK B;  4HKI C;  3D55 A;  5C5R C; 
#chains in the Genus database with same CATH homology
 4UI7 C;  4L2G C;  5C5P C;  2ZIX B;  4HLM C;  4HL5 C;  4KZQ C;  4L0V C;  4L2K C;  4UI8 C;  4L2F C;  4L0I C;  4KZU C;  4UI6 C;  4HLG C;  4HMH C;  5ADQ B;  4UI4 C;  5ADT B;  4L0B C;  4L0S C;  4UI5 C;  5C5Q C;  4L31 C;  4UI3 C;  4UVP B;  4HKN C;  4L32 C;  5ADR B;  4L33 C;  4HLF C;  4L10 C;  4L0T C;  4L09 C;  5ADS B;  4HLH C;  4KZL C;  4L34 C;  4HLK C;  5FPF C;  3HJ6 A;  4HKK B;  4HKI C;  5C5R C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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