4L2KC

Tankyrase 2 in complex with 2-(1,3-benzodioxol-5-yl)-4h-chromen-4-one
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
47
structure length
47
Chain Sequence
MAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.
pubmed doi rcsb
molecule tags Transferase/transferase inhibitor
source organism Homo sapiens
molecule keywords Tankyrase-2
total genus 1
structure length 47
sequence length 47
chains with identical sequence D
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2013-06-04
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1620.50 Alpha Beta 3-Layer(aba) Sandwich YefM-like fold YefM-like fold 4l2kC00
4UI6C 4HLKC 4L34C 4L0IC 4UVPB 4L10C 4L2FC 4L32C 5C5RC 4L0BC 4HKNC 4L0TC 5C5QC 4HKKB 4UI5C 4HLGC 4UI8C 4KZQC 4KZUC 4UI7C 4L2GC 4L31C 5ADQB 4HKIC 4KZLC 4HLMC 5C5PC 4L0VC 4HLFC 4L0SC 4UI3C 5FPFC 5ADTB 4HLHC 4L2KC 5ADRB 4UI4C 4HL5C 4L09C 4L33C 5ADSB 4HMHC
chains in the Genus database with same CATH superfamily
4UI6C 3HRYA 4HLKC 4L0IC 4L34C 4UVPB 4L10C 4L2FC 4L32C 5C5RC 4L0BC 3K33B 4HKNC 4ZM0A 2A6QA 4L0TC 5C5QC 3K6QA 4HKKB 4UI5C 4HLGC 4UI8C 4KZQC 4KZUC 2ZIXB 4UI7C 4L2GC 3KH2E 4L31C 5ADQB 3HJ6A 4HKIC 4KZLC 4HLMC 3OEIE 4L0VC 3G5OA 5C5PC 4HLFC 3CTOA 4ZLXA 4L0SC 4UI3C 5FPFC 3OEIA 5ADTB 2ODKA 4HLHC 4L2KC 4ZM2A 5ADRB 3D55A 4UI4C 4HL5C 4L09C 4L33C 5ADSB 4HMHC 3HS2A
chains in the Genus database with same CATH topology
4UI6C 4HLKC 4L34C 4L0IC 4UVPB 4L10C 4L2FC 4L32C 5C5RC 4L0BC 4HKNC 4L0TC 5C5QC 4HKKB 4UI5C 4HLGC 4UI8C 4KZQC 4KZUC 2ZIXB 4UI7C 4L2GC 4L31C 5ADQB 3HJ6A 4HKIC 4KZLC 4HLMC 5C5PC 4L0VC 4HLFC 4L0SC 4UI3C 5FPFC 5ADTB 4HLHC 4L2KC 5ADRB 4UI4C 4HL5C 4L09C 4L33C 5ADSB 4HMHC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4UI6 C;  4HLK C;  4L34 C;  4L0I C;  4UVP B;  4L10 C;  4L2F C;  4L32 C;  5C5R C;  4L0B C;  4HKN C;  4L0T C;  5C5Q C;  4HKK B;  4UI5 C;  4HLG C;  4UI8 C;  4KZQ C;  4KZU C;  4UI7 C;  4L2G C;  4L31 C;  5ADQ B;  4HKI C;  4KZL C;  4HLM C;  5C5P C;  4L0V C;  4HLF C;  4L0S C;  4UI3 C;  5FPF C;  5ADT B;  4HLH C;  4L2K C;  5ADR B;  4UI4 C;  4HL5 C;  4L09 C;  4L33 C;  5ADS B;  4HMH C; 
#chains in the Genus database with same CATH topology
 4UI6 C;  3HRY A;  4HLK C;  4L0I C;  4L34 C;  4UVP B;  4L10 C;  4L2F C;  4L32 C;  5C5R C;  4L0B C;  3K33 B;  4HKN C;  4ZM0 A;  2A6Q A;  4L0T C;  5C5Q C;  3K6Q A;  4HKK B;  4UI5 C;  4HLG C;  4UI8 C;  4KZQ C;  4KZU C;  2ZIX B;  4UI7 C;  4L2G C;  3KH2 E;  4L31 C;  5ADQ B;  3HJ6 A;  4HKI C;  4KZL C;  4HLM C;  3OEI E;  4L0V C;  3G5O A;  5C5P C;  4HLF C;  3CTO A;  4ZLX A;  4L0S C;  4UI3 C;  5FPF C;  3OEI A;  5ADT B;  2ODK A;  4HLH C;  4L2K C;  4ZM2 A;  5ADR B;  3D55 A;  4UI4 C;  4HL5 C;  4L09 C;  4L33 C;  5ADS B;  4HMH C;  3HS2 A; 
#chains in the Genus database with same CATH homology
 4UI6 C;  4HLK C;  4L34 C;  4L0I C;  4UVP B;  4L10 C;  4L2F C;  4L32 C;  5C5R C;  4L0B C;  4HKN C;  4L0T C;  5C5Q C;  4HKK B;  4UI5 C;  4HLG C;  4UI8 C;  4KZQ C;  4KZU C;  2ZIX B;  4UI7 C;  4L2G C;  4L31 C;  5ADQ B;  3HJ6 A;  4HKI C;  4KZL C;  4HLM C;  5C5P C;  4L0V C;  4HLF C;  4L0S C;  4UI3 C;  5FPF C;  5ADT B;  4HLH C;  4L2K C;  5ADR B;  4UI4 C;  4HL5 C;  4L09 C;  4L33 C;  5ADS B;  4HMH C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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