4L31C

Tankyrase 2 in complex with methyl 4-(4-oxochromen-2-yl)benzoate
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
47
structure length
47
Chain Sequence
MAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.
pubmed doi rcsb
molecule tags Transferase/transferase inhibitor
source organism Homo sapiens
molecule keywords Tankyrase-2
total genus 1
structure length 47
sequence length 47
chains with identical sequence D
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2013-06-05
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1620.50 Alpha Beta 3-Layer(aba) Sandwich YefM-like fold YefM-like fold 4l31C00
4L2GC 4L0VC 4UI4C 4HKIC 4L09C 4L2FC 5C5RC 4L2KC 4HL5C 4KZUC 4UI3C 5C5QC 4L0BC 4HLHC 5ADRB 4UI8C 4HLGC 4L33C 4UI7C 4L0TC 4L0IC 5FPFC 4KZQC 4L10C 4L31C 4KZLC 4HLMC 4UI5C 4HLFC 4HLKC 5ADQB 5C5PC 4UI6C 4UVPB 5ADSB 4L0SC 4HMHC 4L32C 4L34C 4HKKB 4HKNC 5ADTB
chains in the Genus database with same CATH superfamily
3HS2A 4L2GC 4ZLXA 4L0VC 4UI4C 4HKIC 4ZM2A 4L09C 4L2FC 3KH2E 2ODKA 5C5RC 4L2KC 4HL5C 4KZUC 4UI3C 5C5QC 4L0BC 3G5OA 3OEIE 3D55A 3CTOA 3K33B 4HLHC 5ADRB 4UI8C 4HLGC 4L33C 4UI7C 3K6QA 4L0IC 3HRYA 4L0TC 2ZIXB 3HJ6A 5FPFC 2A6QA 4KZQC 4L10C 4L31C 4KZLC 4HLMC 4UI5C 4HLFC 4HLKC 5ADQB 5C5PC 4UI6C 4UVPB 5ADSB 4ZM0A 3OEIA 4HMHC 4L0SC 4L32C 4L34C 4HKKB 4HKNC 5ADTB
chains in the Genus database with same CATH topology
4L2GC 4L0VC 4UI4C 4HKIC 4L09C 4L2FC 5C5RC 4L2KC 4HL5C 4KZUC 4UI3C 5C5QC 4L0BC 4HLHC 5ADRB 4UI8C 4HLGC 4L33C 4UI7C 4L0TC 4L0IC 2ZIXB 3HJ6A 5FPFC 4KZQC 4L10C 4L31C 4KZLC 4HLMC 4UI5C 4HLFC 4HLKC 5ADQB 5C5PC 4UI6C 4UVPB 5ADSB 4L0SC 4HMHC 4L32C 4L34C 4HKKB 4HKNC 5ADTB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4L2G C;  4L0V C;  4UI4 C;  4HKI C;  4L09 C;  4L2F C;  5C5R C;  4L2K C;  4HL5 C;  4KZU C;  4UI3 C;  5C5Q C;  4L0B C;  4HLH C;  5ADR B;  4UI8 C;  4HLG C;  4L33 C;  4UI7 C;  4L0T C;  4L0I C;  5FPF C;  4KZQ C;  4L10 C;  4L31 C;  4KZL C;  4HLM C;  4UI5 C;  4HLF C;  4HLK C;  5ADQ B;  5C5P C;  4UI6 C;  4UVP B;  5ADS B;  4L0S C;  4HMH C;  4L32 C;  4L34 C;  4HKK B;  4HKN C;  5ADT B; 
#chains in the Genus database with same CATH topology
 3HS2 A;  4L2G C;  4ZLX A;  4L0V C;  4UI4 C;  4HKI C;  4ZM2 A;  4L09 C;  4L2F C;  3KH2 E;  2ODK A;  5C5R C;  4L2K C;  4HL5 C;  4KZU C;  4UI3 C;  5C5Q C;  4L0B C;  3G5O A;  3OEI E;  3D55 A;  3CTO A;  3K33 B;  4HLH C;  5ADR B;  4UI8 C;  4HLG C;  4L33 C;  4UI7 C;  3K6Q A;  4L0I C;  3HRY A;  4L0T C;  2ZIX B;  3HJ6 A;  5FPF C;  2A6Q A;  4KZQ C;  4L10 C;  4L31 C;  4KZL C;  4HLM C;  4UI5 C;  4HLF C;  4HLK C;  5ADQ B;  5C5P C;  4UI6 C;  4UVP B;  5ADS B;  4ZM0 A;  3OEI A;  4HMH C;  4L0S C;  4L32 C;  4L34 C;  4HKK B;  4HKN C;  5ADT B; 
#chains in the Genus database with same CATH homology
 4L2G C;  4L0V C;  4UI4 C;  4HKI C;  4L09 C;  4L2F C;  5C5R C;  4L2K C;  4HL5 C;  4KZU C;  4UI3 C;  5C5Q C;  4L0B C;  4HLH C;  5ADR B;  4UI8 C;  4HLG C;  4L33 C;  4UI7 C;  4L0T C;  4L0I C;  2ZIX B;  3HJ6 A;  5FPF C;  4KZQ C;  4L10 C;  4L31 C;  4KZL C;  4HLM C;  4UI5 C;  4HLF C;  4HLK C;  5ADQ B;  5C5P C;  4UI6 C;  4UVP B;  5ADS B;  4L0S C;  4HMH C;  4L32 C;  4L34 C;  4HKK B;  4HKN C;  5ADT B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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