4LIFA

Crystal structure of the jcv large t-antigen origin binding domain
Total Genus 28
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
28
sequence length
127
structure length
127
Chain Sequence
VEDPKDFPVDLHAFLSQAVFSNRTVASFAVYTTKEKAQILYKKLMEKYSVTFISRHGFGGHNILFFLTPHRHRVSAINNYCQKLCTFSFLICKGVNKEYLFYSALCRQPYAVVEESIQGGLKEHDFN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Insights into the Initiation of JC Virus DNA Replication Derived from the Crystal Structure of the T-Antigen Origin Binding Domain.
pubmed doi rcsb
molecule tags Hydrolase, dna binding protein
source organism Jc polyomavirus
molecule keywords Large T antigen
total genus 28
structure length 127
sequence length 127
ec nomenclature ec 3.6.4.-:
pdb deposition date 2013-07-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02217 T_Ag_DNA_bind Origin of replication binding protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1310.20 Alpha Beta 3-Layer(aba) Sandwich Replication Protein E1; Chain: A, Replication Protein E1; Chain: A, 4lifA00
2NTCA 2TBDA 4ZO0A 1UUTA 4LIFA 2HW0A 2FUFA 4LMDA 2ITJA 4FB3A 4ZQ9A 2IF9A 2ITLA 3QK2A 4FGNA 1M55A 5BYGA 2IPRA 1L2MA 5D9IA 5CYNA 1L5IA 2NL8A 4NBPA 3QN2A 3QFQA 1TBDA 1Z1DB 4GDFA 5DCXA 1RZ9A
chains in the Genus database with same CATH superfamily
2NTCA 1KSXA 2TBDA 4ZO0A 4U87A 1UUTA 4LIFA 2HW0A 2FUFA 2ITJA 4LMDA 3DKXA 4FB3A 4ZQ9A 2IF9A 2ITLA 3QK2A 1F08A 4FGNA 1M55A 5BYGA 2IPRA 1L2MA 5D9IA 4KW3A 3DKYA 1R9WA 5CYNA 1KSYA 1L5IA 2NL8A 4NBPA 3QN2A 3QFQA 1TBDA 1Z1DB 4GDFA 5DCXA 1RZ9A
chains in the Genus database with same CATH topology
2NTCA 1KSXA 2TBDA 4ZO0A 4U87A 1UUTA 4LIFA 2HW0A 2FUFA 2ITJA 4LMDA 3DKXA 4FB3A 4ZQ9A 2IF9A 2ITLA 3QK2A 1F08A 4FGNA 1M55A 5BYGA 2IPRA 1L2MA 5D9IA 4KW3A 3DKYA 1R9WA 5CYNA 1KSYA 1L5IA 2NL8A 4NBPA 3QN2A 3QFQA 1TBDA 1Z1DB 4GDFA 5DCXA 1RZ9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2NTC A;  2TBD A;  4ZO0 A;  1UUT A;  4LIF A;  2HW0 A;  2FUF A;  4LMD A;  2ITJ A;  4FB3 A;  4ZQ9 A;  2IF9 A;  2ITL A;  3QK2 A;  4FGN A;  1M55 A;  5BYG A;  2IPR A;  1L2M A;  5D9I A;  5CYN A;  1L5I A;  2NL8 A;  4NBP A;  3QN2 A;  3QFQ A;  1TBD A;  1Z1D B;  4GDF A;  5DCX A;  1RZ9 A; 
#chains in the Genus database with same CATH topology
 2NTC A;  1KSX A;  2TBD A;  4ZO0 A;  4U87 A;  1UUT A;  4LIF A;  2HW0 A;  2FUF A;  2ITJ A;  4LMD A;  3DKX A;  4FB3 A;  4ZQ9 A;  2IF9 A;  2ITL A;  3QK2 A;  1F08 A;  4FGN A;  1M55 A;  5BYG A;  2IPR A;  1L2M A;  5D9I A;  4KW3 A;  3DKY A;  1R9W A;  5CYN A;  1KSY A;  1L5I A;  2NL8 A;  4NBP A;  3QN2 A;  3QFQ A;  1TBD A;  1Z1D B;  4GDF A;  5DCX A;  1RZ9 A; 
#chains in the Genus database with same CATH homology
 2NTC A;  1KSX A;  2TBD A;  4ZO0 A;  4U87 A;  1UUT A;  4LIF A;  2HW0 A;  2FUF A;  2ITJ A;  4LMD A;  3DKX A;  4FB3 A;  4ZQ9 A;  2IF9 A;  2ITL A;  3QK2 A;  1F08 A;  4FGN A;  1M55 A;  5BYG A;  2IPR A;  1L2M A;  5D9I A;  4KW3 A;  3DKY A;  1R9W A;  5CYN A;  1KSY A;  1L5I A;  2NL8 A;  4NBP A;  3QN2 A;  3QFQ A;  1TBD A;  1Z1D B;  4GDF A;  5DCX A;  1RZ9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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