4LK1E

Crystal structure analysis of the e.coli holoenzyme
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
89
structure length
89
Chain Sequence
ARVTVQDAVEKIGNRFDLVLVAARRARQMQVGGKDPLVPEENDKTTVIALREIEEGLINNQILDVRERQEQQEQEAAELQAVTAIAEGR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of sigma 70 domain 1.1.
pubmed doi rcsb
molecule tags Transferase
source organism Escherichia coli
molecule keywords DNA-directed RNA polymerase subunit alpha
total genus 25
structure length 89
sequence length 89
chains with identical sequence K
ec nomenclature ec 2.7.7.6: DNA-directed RNA polymerase.
pdb deposition date 2013-07-05
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.940.10 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit Eukaryotic RPB6 RNA polymerase subunit 4lk1E00
4A3DF 3HOYF 2WB1I 3EQLE 4OIOE 3HKZK 4KN4E 4C2MF 4A3KF 1YNNK 3H0GF 3GTGF 4XLNE 3HOVF 3HOWF 2NVYF 4G7OE 3S1RF 3S15F 4OIQE 1HQME 5M5XF 4MEXE 5IP7F 2E2HF 2A68E 4MEYE 4AYBK 5BYHE 4A3MF 3GTQF 5D4CE 3DXJE 1WCMF 4G7ZE 1TWGF 4BBSF 5FLMF 1I3QF 2JA6F 4X6AF 4A3FF 3S14F 2JA7F 4YG2E 4C3JF 2O5IE 3GTMF 3HOZF 4XSXE 2JA8F 3GTPF 3PO3F 5D4DE 5E18E 4XSZE 2NVQF 5C3EF 4GZYE 3GTKF 4Y7NF 1R9TF 4A3EF 4A3JF 1TWFF 3HOXF 4KMUE 4BY1F 5M5YF 2E2IF 2CW0E 4OIRE 5M3FF 3S2DF 3RZDF 4KN7E 3M3YF 2JA5F 2R92F 4Q4ZE 4A3BF 4A3LF 4YFXE 2A6EE 3GTLF 4LK0E 3S16F 1Y1VF 4Q5SE 1TWCF 1QKLA 4BY7F 2E2JF 4LJZE 3I4NF 4G7HE 4Y52F 4JK1E 1TWHF 3S1QF 5E17E 5TMFE 1Y1WF 1YNJK 2PMZK 3S1NF 5IPLE 5C44F 2O5JE 4YFNE 2Y0SI 3CQZF 2R7ZF 4A3CF 1I6HF 2VUMF 4A3IF 5FJ8F 2R93F 3I4MF 4C3IF 2B63F 1TWAF 2A6HE 1IW7E 5IYCF 3GTOF 5IP9F 3WODE 3M4OF 2A69E 1SMYE 3PO2F 5D4EE 3S17F 1ZYRE 2YU9F 4MQ9E 1SFOF 2WAQK 5M3MF 2PPBE 1K83F 4ZH4E 3H3VG 1I6VE 2NVTF 3RZOF 3S1MF 4A3GF 3S2HF 5IYDF 4BBRF 1I50F 5C4JF 4OINE 2NVXF 5IYBF 5C4XF 3K7AF 4XLPE 3HOUF 4OIPE 3FKIF 4A93F 4LLGE 4BXXF 5TMCE 4C3HF 5M5WF 3GTJF 4YFKE 2BE5E 4LK1E
chains in the Genus database with same CATH superfamily
4A3DF 3HOYF 2R93E 2WB1I 3EQLE 4OIOE 3HKZK 4KN4E 4C2MF 4C3IE 4A3KF 2WAQH 1YNNK 3H0GF 4QIWK 2B63E 3FKIE 4XLNE 1TWAE 3GTGF 3HOUE 3HOVF 5IYCE 3HOWF 2NVYF 4G7OE 5IP9E 3S1RF 3S15F 4OIQE 4C3HE 1HQME 5M5WE 5M5XF 4AYBH 3GTJE 4MEXE 5IP7F 2E2HF 2A68E 4MEYE 4AYBK 5BYHE 4A3MF 3GTQF 5D4CE 3DXJE 1WCMF 4G7ZE 1TWGF 3HOYE 3PO2E 3S17E 4BBSF 2YU9E 4C2ME 5FLMF 1I3QF 4A3KE 1SFOE 3I4ME 3GTGE 2JA6F 5M3ME 3HOVE 4X6AF 4A3FF 2NVYE 1K83E 3HOWE 2JA7F 4YG2E 4C3JF 3S1RE 2O5IE 3GTMF 3HOZF 4XSXE 2JA8F 3GTPF 3RZOE 5M5XE 3S1ME 3PO3F 3S2HE 5IP7E 5E18E 5D4DE 4BBRE 5C4JE 4XSZE 4A3ME 4BBSE 1WCME 2NVQF 2NVXE 5C3EF 4GZYE 1I3QE 3HKZH 4QIWH 4Y7NF 3GTKF 4X6AE 1R9TF 3S14E 4A3EF 3GTME 4C3JE 3HOZE 4A93E 4A3JF 1TWFF 3HOXF 4KMUE 4BY1F 5M5YF 2E2IF 2CW0E 4BXXE 4OIRE 5M3FF 3S2DF 3RZDF 5C3EE 4KN7E 3M3YF 2JA5F 2R92F 4Q4ZE 4A3BF 4A3LF 4YFXE 3GTKE 4Y7NE 2A6EE 1DZFA 3H0GE 4LK0E 4A3EE 1Y1VF 3GTLF 4Q5SE 3S16F 1TWCF 1TWFE 3HOXE 1QKLA 4BY7F 5M5YE 4LJZE 2E2JF 2E2IE 4BY1E 5M3FE 3I4NF 4A3DE 4G7HE 4Y52F 3RZDE 2E2HE 4JK1E 1TWHF 3S1QF 3M3YE 2JA5E 3GTQE 4A3BE 4A3LE 2R92E 5E17E 1TWGE 5TMFE 1Y1WF 1YNJK 5FLME 2WB1H 2PMZK 3S16E 3S1NF 1EIKA 5IPLE 5C44F 2JA6E 1TWCE 2O5JE 4A3FE 4BY7E 3I4NE 4YFNE 2JA7E 2Y0SI 3CQZF 2JA8E 3GTPE 2R7ZF 3PO3E 1I6HF 2VUMF 4A3CF 4Y52E 3H3VF 1TWHE 4A3IF 3S1QE 5FJ8F 2R93F 2NVQE 3I4MF 4C3IF 2B63F 3S1NE 1TWAF 5C44E 2A6HE 1IW7E 1R9TE 5IYCF 3GTOF 5IP9F 4A3JE 2KRXA 4A3CE 2VUME 3WODE 3M4OF 3S2DE 2A69E 1SMYE 4A3IE 3PO2F 5D4EE 3S17F 1ZYRE 2YU9F 4MQ9E 3S14F 1SFOF 2PMZH 2WAQK 3S15E 5M3MF 2PPBE 3GTLE 1K83F 1Y1VE 4ZH4E 3GTOE 3H3VG 1I6VE 2NVTF 3RZOF 2E2JE 3S1MF 4A3GF 3M4OE 3S2HF 2Y0SH 5IYDF 4BBRF 1I50F 5FJ8E 5C4JF 4OINE 2NVXF 5IYBF 5C4XF 3K7AF 1Y1WE 4XLPE 3HOUF 4OIPE 3FKIF 4A93F 2NVTE 4LLGE 4A3GE 4BXXF 5IYDE 3CQZE 1I50E 5TMCE 4C3HF 5M5WF 2R7ZE 1I6HE 3GTJF 4YFKE 2BE5E 5IYBE 5C4XE 4LK1E 3K7AE
chains in the Genus database with same CATH topology
4A3DF 3HOYF 2WB1I 3EQLE 4OIOE 3HKZK 4KN4E 4C2MF 4A3KF 1YNNK 3H0GF 4QIWK 3GTGF 4XLNE 3HOVF 3HOWF 2NVYF 4G7OE 3S1RF 3S15F 4OIQE 1HQME 5M5XF 4MEXE 5IP7F 2E2HF 2A68E 4MEYE 4AYBK 5BYHE 4A3MF 3GTQF 5D4CE 3DXJE 1WCMF 4G7ZE 1TWGF 4BBSF 5FLMF 1I3QF 2JA6F 4X6AF 4A3FF 3S14F 2JA7F 4YG2E 4C3JF 2O5IE 3GTMF 3HOZF 4XSXE 2JA8F 3GTPF 3PO3F 5D4DE 5E18E 4XSZE 2NVQF 5C3EF 4GZYE 3GTKF 4Y7NF 1R9TF 4A3EF 4A3JF 1TWFF 3HOXF 4KMUE 4BY1F 5M5YF 2E2IF 2CW0E 4OIRE 5M3FF 3S2DF 3RZDF 4KN7E 3M3YF 2JA5F 2R92F 4Q4ZE 4A3BF 4A3LF 4YFXE 2A6EE 3GTLF 4LK0E 3S16F 1Y1VF 4Q5SE 1TWCF 1QKLA 4BY7F 2E2JF 4LJZE 3I4NF 4G7HE 4Y52F 4JK1E 1TWHF 3S1QF 5E17E 5TMFE 1Y1WF 1YNJK 2PMZK 3S1NF 5IPLE 5C44F 2O5JE 4YFNE 2Y0SI 3CQZF 2R7ZF 4A3CF 1I6HF 2VUMF 4A3IF 5FJ8F 2R93F 3I4MF 4C3IF 2B63F 1TWAF 2A6HE 1IW7E 5IYCF 3GTOF 5IP9F 2KRXA 3WODE 3M4OF 2A69E 1SMYE 3PO2F 5D4EE 3S17F 1ZYRE 2YU9F 4MQ9E 1SFOF 2WAQK 5M3MF 2PPBE 1K83F 4ZH4E 3H3VG 1I6VE 2NVTF 3RZOF 3S1MF 4A3GF 3S2HF 5IYDF 4BBRF 1I50F 5C4JF 4OINE 2NVXF 5IYBF 5C4XF 3K7AF 4XLPE 3HOUF 4OIPE 3FKIF 4A93F 4LLGE 4BXXF 5TMCE 4C3HF 5M5WF 3GTJF 4YFKE 2BE5E 4LK1E
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4A3D F;  3HOY F;  2WB1 I;  3EQL E;  4OIO E;  3HKZ K;  4KN4 E;  4C2M F;  4A3K F;  1YNN K;  3H0G F;  3GTG F;  4XLN E;  3HOV F;  3HOW F;  2NVY F;  4G7O E;  3S1R F;  3S15 F;  4OIQ E;  1HQM E;  5M5X F;  4MEX E;  5IP7 F;  2E2H F;  2A68 E;  4MEY E;  4AYB K;  5BYH E;  4A3M F;  3GTQ F;  5D4C E;  3DXJ E;  1WCM F;  4G7Z E;  1TWG F;  4BBS F;  5FLM F;  1I3Q F;  2JA6 F;  4X6A F;  4A3F F;  3S14 F;  2JA7 F;  4YG2 E;  4C3J F;  2O5I E;  3GTM F;  3HOZ F;  4XSX E;  2JA8 F;  3GTP F;  3PO3 F;  5D4D E;  5E18 E;  4XSZ E;  2NVQ F;  5C3E F;  4GZY E;  3GTK F;  4Y7N F;  1R9T F;  4A3E F;  4A3J F;  1TWF F;  3HOX F;  4KMU E;  4BY1 F;  5M5Y F;  2E2I F;  2CW0 E;  4OIR E;  5M3F F;  3S2D F;  3RZD F;  4KN7 E;  3M3Y F;  2JA5 F;  2R92 F;  4Q4Z E;  4A3B F;  4A3L F;  4YFX E;  2A6E E;  3GTL F;  4LK0 E;  3S16 F;  1Y1V F;  4Q5S E;  1TWC F;  1QKL A;  4BY7 F;  2E2J F;  4LJZ E;  3I4N F;  4G7H E;  4Y52 F;  4JK1 E;  1TWH F;  3S1Q F;  5E17 E;  5TMF E;  1Y1W F;  1YNJ K;  2PMZ K;  3S1N F;  5IPL E;  5C44 F;  2O5J E;  4YFN E;  2Y0S I;  3CQZ F;  2R7Z F;  4A3C F;  1I6H F;  2VUM F;  4A3I F;  5FJ8 F;  2R93 F;  3I4M F;  4C3I F;  2B63 F;  1TWA F;  2A6H E;  1IW7 E;  5IYC F;  3GTO F;  5IP9 F;  3WOD E;  3M4O F;  2A69 E;  1SMY E;  3PO2 F;  5D4E E;  3S17 F;  1ZYR E;  2YU9 F;  4MQ9 E;  1SFO F;  2WAQ K;  5M3M F;  2PPB E;  1K83 F;  4ZH4 E;  3H3V G;  1I6V E;  2NVT F;  3RZO F;  3S1M F;  4A3G F;  3S2H F;  5IYD F;  4BBR F;  1I50 F;  5C4J F;  4OIN E;  2NVX F;  5IYB F;  5C4X F;  3K7A F;  4XLP E;  3HOU F;  4OIP E;  3FKI F;  4A93 F;  4LLG E;  4BXX F;  5TMC E;  4C3H F;  5M5W F;  3GTJ F;  4YFK E;  2BE5 E;  4LK1 E; 
#chains in the Genus database with same CATH topology
 4A3D F;  3HOY F;  2R93 E;  2WB1 I;  3EQL E;  4OIO E;  3HKZ K;  4KN4 E;  4C2M F;  4C3I E;  4A3K F;  2WAQ H;  1YNN K;  3H0G F;  4QIW K;  2B63 E;  3FKI E;  4XLN E;  1TWA E;  3GTG F;  3HOU E;  3HOV F;  5IYC E;  3HOW F;  2NVY F;  4G7O E;  5IP9 E;  3S1R F;  3S15 F;  4OIQ E;  4C3H E;  1HQM E;  5M5W E;  5M5X F;  4AYB H;  3GTJ E;  4MEX E;  5IP7 F;  2E2H F;  2A68 E;  4MEY E;  4AYB K;  5BYH E;  4A3M F;  3GTQ F;  5D4C E;  3DXJ E;  1WCM F;  4G7Z E;  1TWG F;  3HOY E;  3PO2 E;  3S17 E;  4BBS F;  2YU9 E;  4C2M E;  5FLM F;  1I3Q F;  4A3K E;  1SFO E;  3I4M E;  3GTG E;  2JA6 F;  5M3M E;  3HOV E;  4X6A F;  4A3F F;  2NVY E;  1K83 E;  3HOW E;  2JA7 F;  4YG2 E;  4C3J F;  3S1R E;  2O5I E;  3GTM F;  3HOZ F;  4XSX E;  2JA8 F;  3GTP F;  3RZO E;  5M5X E;  3S1M E;  3PO3 F;  3S2H E;  5IP7 E;  5E18 E;  5D4D E;  4BBR E;  5C4J E;  4XSZ E;  4A3M E;  4BBS E;  1WCM E;  2NVQ F;  2NVX E;  5C3E F;  4GZY E;  1I3Q E;  3HKZ H;  4QIW H;  4Y7N F;  3GTK F;  4X6A E;  1R9T F;  3S14 E;  4A3E F;  3GTM E;  4C3J E;  3HOZ E;  4A93 E;  4A3J F;  1TWF F;  3HOX F;  4KMU E;  4BY1 F;  5M5Y F;  2E2I F;  2CW0 E;  4BXX E;  4OIR E;  5M3F F;  3S2D F;  3RZD F;  5C3E E;  4KN7 E;  3M3Y F;  2JA5 F;  2R92 F;  4Q4Z E;  4A3B F;  4A3L F;  4YFX E;  3GTK E;  4Y7N E;  2A6E E;  1DZF A;  3H0G E;  4LK0 E;  4A3E E;  1Y1V F;  3GTL F;  4Q5S E;  3S16 F;  1TWC F;  1TWF E;  3HOX E;  1QKL A;  4BY7 F;  5M5Y E;  4LJZ E;  2E2J F;  2E2I E;  4BY1 E;  5M3F E;  3I4N F;  4A3D E;  4G7H E;  4Y52 F;  3RZD E;  2E2H E;  4JK1 E;  1TWH F;  3S1Q F;  3M3Y E;  2JA5 E;  3GTQ E;  4A3B E;  4A3L E;  2R92 E;  5E17 E;  1TWG E;  5TMF E;  1Y1W F;  1YNJ K;  5FLM E;  2WB1 H;  2PMZ K;  3S16 E;  3S1N F;  1EIK A;  5IPL E;  5C44 F;  2JA6 E;  1TWC E;  2O5J E;  4A3F E;  4BY7 E;  3I4N E;  4YFN E;  2JA7 E;  2Y0S I;  3CQZ F;  2JA8 E;  3GTP E;  2R7Z F;  3PO3 E;  1I6H F;  2VUM F;  4A3C F;  4Y52 E;  3H3V F;  1TWH E;  4A3I F;  3S1Q E;  5FJ8 F;  2R93 F;  2NVQ E;  3I4M F;  4C3I F;  2B63 F;  3S1N E;  1TWA F;  5C44 E;  2A6H E;  1IW7 E;  1R9T E;  5IYC F;  3GTO F;  5IP9 F;  4A3J E;  2KRX A;  4A3C E;  2VUM E;  3WOD E;  3M4O F;  3S2D E;  2A69 E;  1SMY E;  4A3I E;  3PO2 F;  5D4E E;  3S17 F;  1ZYR E;  2YU9 F;  4MQ9 E;  3S14 F;  1SFO F;  2PMZ H;  2WAQ K;  3S15 E;  5M3M F;  2PPB E;  3GTL E;  1K83 F;  1Y1V E;  4ZH4 E;  3GTO E;  3H3V G;  1I6V E;  2NVT F;  3RZO F;  2E2J E;  3S1M F;  4A3G F;  3M4O E;  3S2H F;  2Y0S H;  5IYD F;  4BBR F;  1I50 F;  5FJ8 E;  5C4J F;  4OIN E;  2NVX F;  5IYB F;  5C4X F;  3K7A F;  1Y1W E;  4XLP E;  3HOU F;  4OIP E;  3FKI F;  4A93 F;  2NVT E;  4LLG E;  4A3G E;  4BXX F;  5IYD E;  3CQZ E;  1I50 E;  5TMC E;  4C3H F;  5M5W F;  2R7Z E;  1I6H E;  3GTJ F;  4YFK E;  2BE5 E;  5IYB E;  5C4X E;  4LK1 E;  3K7A E; 
#chains in the Genus database with same CATH homology
 4A3D F;  3HOY F;  2WB1 I;  3EQL E;  4OIO E;  3HKZ K;  4KN4 E;  4C2M F;  4A3K F;  1YNN K;  3H0G F;  4QIW K;  3GTG F;  4XLN E;  3HOV F;  3HOW F;  2NVY F;  4G7O E;  3S1R F;  3S15 F;  4OIQ E;  1HQM E;  5M5X F;  4MEX E;  5IP7 F;  2E2H F;  2A68 E;  4MEY E;  4AYB K;  5BYH E;  4A3M F;  3GTQ F;  5D4C E;  3DXJ E;  1WCM F;  4G7Z E;  1TWG F;  4BBS F;  5FLM F;  1I3Q F;  2JA6 F;  4X6A F;  4A3F F;  3S14 F;  2JA7 F;  4YG2 E;  4C3J F;  2O5I E;  3GTM F;  3HOZ F;  4XSX E;  2JA8 F;  3GTP F;  3PO3 F;  5D4D E;  5E18 E;  4XSZ E;  2NVQ F;  5C3E F;  4GZY E;  3GTK F;  4Y7N F;  1R9T F;  4A3E F;  4A3J F;  1TWF F;  3HOX F;  4KMU E;  4BY1 F;  5M5Y F;  2E2I F;  2CW0 E;  4OIR E;  5M3F F;  3S2D F;  3RZD F;  4KN7 E;  3M3Y F;  2JA5 F;  2R92 F;  4Q4Z E;  4A3B F;  4A3L F;  4YFX E;  2A6E E;  3GTL F;  4LK0 E;  3S16 F;  1Y1V F;  4Q5S E;  1TWC F;  1QKL A;  4BY7 F;  2E2J F;  4LJZ E;  3I4N F;  4G7H E;  4Y52 F;  4JK1 E;  1TWH F;  3S1Q F;  5E17 E;  5TMF E;  1Y1W F;  1YNJ K;  2PMZ K;  3S1N F;  5IPL E;  5C44 F;  2O5J E;  4YFN E;  2Y0S I;  3CQZ F;  2R7Z F;  4A3C F;  1I6H F;  2VUM F;  4A3I F;  5FJ8 F;  2R93 F;  3I4M F;  4C3I F;  2B63 F;  1TWA F;  2A6H E;  1IW7 E;  5IYC F;  3GTO F;  5IP9 F;  2KRX A;  3WOD E;  3M4O F;  2A69 E;  1SMY E;  3PO2 F;  5D4E E;  3S17 F;  1ZYR E;  2YU9 F;  4MQ9 E;  1SFO F;  2WAQ K;  5M3M F;  2PPB E;  1K83 F;  4ZH4 E;  3H3V G;  1I6V E;  2NVT F;  3RZO F;  3S1M F;  4A3G F;  3S2H F;  5IYD F;  4BBR F;  1I50 F;  5C4J F;  4OIN E;  2NVX F;  5IYB F;  5C4X F;  3K7A F;  4XLP E;  3HOU F;  4OIP E;  3FKI F;  4A93 F;  4LLG E;  4BXX F;  5TMC E;  4C3H F;  5M5W F;  3GTJ F;  4YFK E;  2BE5 E;  4LK1 E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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