4MEXE

Crystal structure of escherichia coli rna polymerase in complex with salinamide a
Total Genus 21
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
89
structure length
89
Chain Sequence
RVTVQDAVEKIGNRFDLVLVAARRARQMQVGGKDPLVPEENDKTTVIALREIEEGLINNQILDVRERQEQQEQEAAELQAVTAIAEGRR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Transcription inhibition by the depsipeptide antibiotic salinamide A.
pubmed doi rcsb
molecule tags Transferase/antibiotic
source organism Escherichia coli
molecule keywords DNA-directed RNA polymerase subunit alpha
total genus 21
structure length 89
sequence length 89
chains with identical sequence K
ec nomenclature ec 2.7.7.6: DNA-directed RNA polymerase.
pdb deposition date 2013-08-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01192 RNA_pol_Rpb6 RNA polymerase Rpb6
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.940.10 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit Eukaryotic RPB6 RNA polymerase subunit 4mexE00
5FJ8F 3HOYF 3K7AF 1I6VE 4YFNE 4C3HF 5E18E 2R93F 1R9TF 4A3CF 3GTQF 1YNJK 5TMFE 1TWAF 3RZDF 3I4MF 5M3FF 3GTPF 4JK1E 4YG2E 5IYBF 4A3EF 4BY7F 4BBRF 4Q4ZE 5C4JF 1TWGF 4LLGE 2JA5F 4ZH4E 1I50F 4YFKE 4OINE 4A3JF 3RZOF 3S1QF 1Y1VF 2WAQK 4A3LF 3S2DF 2O5JE 4MQ9E 4A3GF 4C3JF 2E2HF 2JA6F 4KN4E 3PO3F 3DXJE 2VUMF 4A3IF 4YFXE 4A3DF 3H0GF 4A3BF 2NVYF 4Y52F 4MEXE 4XLNE 3S17F 5E17E 1HQME 4A3FF 4KMUE 1I3QF 2A68E 1WCMF 1SFOF 5D4EE 4AYBK 1TWHF 4X6AF 5IP7F 4G7ZE 1Y1WF 4OIRE 1ZYRE 5M3MF 3HOZF 3GTLF 3GTOF 3S14F 2PPBE 2A69E 3GTJF 2CW0E 1YNNK 3S1RF 2A6EE 4XSZE 5IYCF 2B63F 3GTKF 3HOUF 1SMYE 2Y0SI 3CQZF 4Y7NF 2YU9F 4OIPE 4BY1F 4C3IF 5BYHE 2NVQF 1I6HF 3HOWF 2BE5E 4KN7E 5IPLE 3GTMF 5IYDF 5C4XF 3S15F 2NVXF 3HKZK 4G7HE 5TMCE 4C2MF 3S2HF 5FLMF 4OIOE 3PO2F 2JA7F 2PMZK 3S1NF 1K83F 3GTGF 1QKLA 4MEYE 5C3EF 4BXXF 3M3YF 2R7ZF 5M5WF 3H3VG 4LJZE 4BBSF 5D4CE 2A6HE 3EQLE 4A93F 4GZYE 4A3MF 3FKIF 3I4NF 4G7OE 4LK0E 2O5IE 1TWCF 2WB1I 4Q5SE 2E2JF 3S1MF 4A3KF 3HOVF 3S16F 4LK1E 3HOXF 4XLPE 1IW7E 4XSXE 2NVTF 2R92F 2JA8F 3M4OF 5IP9F 4OIQE 2E2IF 5M5YF 5D4DE 5M5XF 1TWFF 3WODE 5C44F
chains in the Genus database with same CATH superfamily
3FKIE 5FJ8F 3RZDE 3I4NE 3I4ME 3HOYF 5M3FE 3GTPE 3H3VF 1TWCE 3K7AF 5IYBE 2E2JE 4A3EE 3S16E 4BY7E 5C4JE 1I6VE 1TWGE 4YFNE 3HOXE 4C3HF 2JA5E 5E18E 3RZOE 2NVTE 4A3JE 2R93F 1R9TF 2JA8E 4A3LE 4A3CF 3GTQF 3S2DE 2E2IE 1YNJK 5TMFE 4C3JE 1TWAF 4A3GE 2E2HE 2JA6E 1TWFE 3RZDF 3I4MF 5M3FF 3GTPF 4JK1E 3PO3E 4YG2E 5IYBF 4A3IE 4A3EF 3K7AE 4BY7F 4BBRF 4Q4ZE 5C4JF 1TWGF 4LLGE 2JA5F 4ZH4E 1I50F 4YFKE 4OINE 4A3JF 1TWAE 3RZOF 1Y1VF 2WAQK 3H0GE 4A3DE 3S1QF 2NVYE 3S2DF 4A3BE 4A3LF 2O5JE 4MQ9E 4A3GF 4A3CE 4C3JF 3S17E 2E2HF 2JA6F 4KN4E 4A3FE 1DZFA 1I3QE 3PO3F 3DXJE 1SFOE 2VUMF 4A3IF 4YFXE 4BBRE 4X6AE 5IP7E 4A3DF 1I50E 3H0GF 3S1QE 4A3BF 2NVYF 5M3ME 1Y1VE 3GTLE 4Y52F 3HOZE 4MEXE 4XLNE 3S17F 5E17E 1HQME 3GTJE 4A3FF 2WAQH 3S1RE 4KMUE 1I3QF 2A68E 2B63E 1WCMF 1SFOF 3HOUE 2VUME 5D4EE 3CQZE 2Y0SH 4AYBK 4Y7NE 1TWHF 4X6AF 5IP7F 2YU9E 4G7ZE 1Y1WF 4OIRE 1ZYRE 4C3IE 5M3MF 2NVQE 3GTLF 3GTOF 3HOWE 3HOZF 3S14F 1I6HE 2PPBE 4Y52E 2A69E 3GTJF 2CW0E 1YNNK 3S1RF 2A6EE 4XSZE 5IYCF 2B63F 3S15E 5C4XE 2NVXE 3GTKF 1EIKA 1WCME 3HOUF 1SMYE 2Y0SI 3CQZF 4Y7NF 5FLME 2YU9F 1TWHE 2JA7E 4OIPE 4BY1F 4C3IF 5BYHE 2NVQF 1Y1WE 1I6HF 3HOWF 2BE5E 1K83E 4KN7E 3GTOE 3S14E 4AYBH 3GTGE 3S1NE 5IPLE 5C3EE 3GTMF 5IYDF 5C4XF 3S15F 2NVXF 3HKZK 5IYCE 4G7HE 2R7ZE 3M3YE 3GTKE 5TMCE 4C2MF 4BBSE 3S2HF 5FLMF 4OIOE 3PO2F 4A93E 2JA7F 4QIWK 4A3ME 2PMZK 4BY1E 3S1NF 1K83F 3GTGF 1QKLA 4MEYE 5C3EF 4BXXF 3GTME 4A3KE 3HOVE 2WB1H 3M3YF 5IYDE 2R7ZF 5M5WF 3H3VG 3S1ME 4LJZE 4BBSF 5D4CE 2A6HE 2R92E 4C2ME 3EQLE 3M4OE 4A93F 2KRXA 5IP9E 3S2HE 4GZYE 3HKZH 3PO2E 4A3MF 5M5YE 5M5XE 3FKIF 3I4NF 4G7OE 5C44E 4LK0E 5FJ8E 2O5IE 3HOYE 1TWCF 2WB1I 4QIWH 4Q5SE 2E2JF 3S1MF 4A3KF 2PMZH 3HOVF 4LK1E 3S16F 4BXXE 3HOXF 4XLPE 1IW7E 5M5WE 4XSXE 2NVTF 4C3HE 2R92F 2JA8F 3M4OF 2R93E 1R9TE 5IP9F 4OIQE 2E2IF 3GTQE 5M5YF 5D4DE 5M5XF 1TWFF 3WODE 5C44F
chains in the Genus database with same CATH topology
5FJ8F 3HOYF 3K7AF 1I6VE 4YFNE 4C3HF 5E18E 2R93F 1R9TF 4A3CF 3GTQF 1YNJK 5TMFE 1TWAF 3RZDF 3I4MF 5M3FF 3GTPF 4JK1E 4YG2E 5IYBF 4A3EF 4BY7F 4BBRF 4Q4ZE 5C4JF 1TWGF 4LLGE 2JA5F 4ZH4E 1I50F 4YFKE 4OINE 4A3JF 3RZOF 3S1QF 1Y1VF 2WAQK 4A3LF 3S2DF 2O5JE 4MQ9E 4A3GF 4C3JF 2E2HF 2JA6F 4KN4E 3PO3F 3DXJE 2VUMF 4A3IF 4YFXE 4A3DF 3H0GF 4A3BF 2NVYF 4Y52F 4MEXE 4XLNE 3S17F 5E17E 1HQME 4A3FF 4KMUE 1I3QF 2A68E 1WCMF 1SFOF 5D4EE 4AYBK 1TWHF 4X6AF 5IP7F 4G7ZE 1Y1WF 4OIRE 1ZYRE 5M3MF 3HOZF 3GTLF 3GTOF 3S14F 2PPBE 2A69E 3GTJF 2CW0E 1YNNK 3S1RF 2A6EE 4XSZE 5IYCF 2B63F 3GTKF 3HOUF 1SMYE 2Y0SI 3CQZF 4Y7NF 2YU9F 4OIPE 4BY1F 4C3IF 5BYHE 2NVQF 1I6HF 3HOWF 2BE5E 4KN7E 5IPLE 3GTMF 5IYDF 5C4XF 3S15F 2NVXF 3HKZK 4G7HE 5TMCE 4C2MF 3S2HF 5FLMF 4OIOE 3PO2F 2JA7F 4QIWK 2PMZK 3S1NF 1K83F 3GTGF 1QKLA 4MEYE 5C3EF 4BXXF 3M3YF 2R7ZF 5M5WF 3H3VG 4LJZE 4BBSF 5D4CE 2A6HE 3EQLE 4A93F 2KRXA 4GZYE 4A3MF 3FKIF 3I4NF 4G7OE 4LK0E 2O5IE 1TWCF 2WB1I 4Q5SE 2E2JF 3S1MF 4A3KF 3HOVF 3S16F 4LK1E 3HOXF 4XLPE 1IW7E 4XSXE 2NVTF 2R92F 2JA8F 3M4OF 5IP9F 4OIQE 2E2IF 5M5YF 5D4DE 5M5XF 1TWFF 3WODE 5C44F
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5FJ8 F;  3HOY F;  3K7A F;  1I6V E;  4YFN E;  4C3H F;  5E18 E;  2R93 F;  1R9T F;  4A3C F;  3GTQ F;  1YNJ K;  5TMF E;  1TWA F;  3RZD F;  3I4M F;  5M3F F;  3GTP F;  4JK1 E;  4YG2 E;  5IYB F;  4A3E F;  4BY7 F;  4BBR F;  4Q4Z E;  5C4J F;  1TWG F;  4LLG E;  2JA5 F;  4ZH4 E;  1I50 F;  4YFK E;  4OIN E;  4A3J F;  3RZO F;  3S1Q F;  1Y1V F;  2WAQ K;  4A3L F;  3S2D F;  2O5J E;  4MQ9 E;  4A3G F;  4C3J F;  2E2H F;  2JA6 F;  4KN4 E;  3PO3 F;  3DXJ E;  2VUM F;  4A3I F;  4YFX E;  4A3D F;  3H0G F;  4A3B F;  2NVY F;  4Y52 F;  4MEX E;  4XLN E;  3S17 F;  5E17 E;  1HQM E;  4A3F F;  4KMU E;  1I3Q F;  2A68 E;  1WCM F;  1SFO F;  5D4E E;  4AYB K;  1TWH F;  4X6A F;  5IP7 F;  4G7Z E;  1Y1W F;  4OIR E;  1ZYR E;  5M3M F;  3HOZ F;  3GTL F;  3GTO F;  3S14 F;  2PPB E;  2A69 E;  3GTJ F;  2CW0 E;  1YNN K;  3S1R F;  2A6E E;  4XSZ E;  5IYC F;  2B63 F;  3GTK F;  3HOU F;  1SMY E;  2Y0S I;  3CQZ F;  4Y7N F;  2YU9 F;  4OIP E;  4BY1 F;  4C3I F;  5BYH E;  2NVQ F;  1I6H F;  3HOW F;  2BE5 E;  4KN7 E;  5IPL E;  3GTM F;  5IYD F;  5C4X F;  3S15 F;  2NVX F;  3HKZ K;  4G7H E;  5TMC E;  4C2M F;  3S2H F;  5FLM F;  4OIO E;  3PO2 F;  2JA7 F;  2PMZ K;  3S1N F;  1K83 F;  3GTG F;  1QKL A;  4MEY E;  5C3E F;  4BXX F;  3M3Y F;  2R7Z F;  5M5W F;  3H3V G;  4LJZ E;  4BBS F;  5D4C E;  2A6H E;  3EQL E;  4A93 F;  4GZY E;  4A3M F;  3FKI F;  3I4N F;  4G7O E;  4LK0 E;  2O5I E;  1TWC F;  2WB1 I;  4Q5S E;  2E2J F;  3S1M F;  4A3K F;  3HOV F;  3S16 F;  4LK1 E;  3HOX F;  4XLP E;  1IW7 E;  4XSX E;  2NVT F;  2R92 F;  2JA8 F;  3M4O F;  5IP9 F;  4OIQ E;  2E2I F;  5M5Y F;  5D4D E;  5M5X F;  1TWF F;  3WOD E;  5C44 F; 
#chains in the Genus database with same CATH topology
 3FKI E;  5FJ8 F;  3RZD E;  3I4N E;  3I4M E;  3HOY F;  5M3F E;  3GTP E;  3H3V F;  1TWC E;  3K7A F;  5IYB E;  2E2J E;  4A3E E;  3S16 E;  4BY7 E;  5C4J E;  1I6V E;  1TWG E;  4YFN E;  3HOX E;  4C3H F;  2JA5 E;  5E18 E;  3RZO E;  2NVT E;  4A3J E;  2R93 F;  1R9T F;  2JA8 E;  4A3L E;  4A3C F;  3GTQ F;  3S2D E;  2E2I E;  1YNJ K;  5TMF E;  4C3J E;  1TWA F;  4A3G E;  2E2H E;  2JA6 E;  1TWF E;  3RZD F;  3I4M F;  5M3F F;  3GTP F;  4JK1 E;  3PO3 E;  4YG2 E;  5IYB F;  4A3I E;  4A3E F;  3K7A E;  4BY7 F;  4BBR F;  4Q4Z E;  5C4J F;  1TWG F;  4LLG E;  2JA5 F;  4ZH4 E;  1I50 F;  4YFK E;  4OIN E;  4A3J F;  1TWA E;  3RZO F;  1Y1V F;  2WAQ K;  3H0G E;  4A3D E;  3S1Q F;  2NVY E;  3S2D F;  4A3B E;  4A3L F;  2O5J E;  4MQ9 E;  4A3G F;  4A3C E;  4C3J F;  3S17 E;  2E2H F;  2JA6 F;  4KN4 E;  4A3F E;  1DZF A;  1I3Q E;  3PO3 F;  3DXJ E;  1SFO E;  2VUM F;  4A3I F;  4YFX E;  4BBR E;  4X6A E;  5IP7 E;  4A3D F;  1I50 E;  3H0G F;  3S1Q E;  4A3B F;  2NVY F;  5M3M E;  1Y1V E;  3GTL E;  4Y52 F;  3HOZ E;  4MEX E;  4XLN E;  3S17 F;  5E17 E;  1HQM E;  3GTJ E;  4A3F F;  2WAQ H;  3S1R E;  4KMU E;  1I3Q F;  2A68 E;  2B63 E;  1WCM F;  1SFO F;  3HOU E;  2VUM E;  5D4E E;  3CQZ E;  2Y0S H;  4AYB K;  4Y7N E;  1TWH F;  4X6A F;  5IP7 F;  2YU9 E;  4G7Z E;  1Y1W F;  4OIR E;  1ZYR E;  4C3I E;  5M3M F;  2NVQ E;  3GTL F;  3GTO F;  3HOW E;  3HOZ F;  3S14 F;  1I6H E;  2PPB E;  4Y52 E;  2A69 E;  3GTJ F;  2CW0 E;  1YNN K;  3S1R F;  2A6E E;  4XSZ E;  5IYC F;  2B63 F;  3S15 E;  5C4X E;  2NVX E;  3GTK F;  1EIK A;  1WCM E;  3HOU F;  1SMY E;  2Y0S I;  3CQZ F;  4Y7N F;  5FLM E;  2YU9 F;  1TWH E;  2JA7 E;  4OIP E;  4BY1 F;  4C3I F;  5BYH E;  2NVQ F;  1Y1W E;  1I6H F;  3HOW F;  2BE5 E;  1K83 E;  4KN7 E;  3GTO E;  3S14 E;  4AYB H;  3GTG E;  3S1N E;  5IPL E;  5C3E E;  3GTM F;  5IYD F;  5C4X F;  3S15 F;  2NVX F;  3HKZ K;  5IYC E;  4G7H E;  2R7Z E;  3M3Y E;  3GTK E;  5TMC E;  4C2M F;  4BBS E;  3S2H F;  5FLM F;  4OIO E;  3PO2 F;  4A93 E;  2JA7 F;  4QIW K;  4A3M E;  2PMZ K;  4BY1 E;  3S1N F;  1K83 F;  3GTG F;  1QKL A;  4MEY E;  5C3E F;  4BXX F;  3GTM E;  4A3K E;  3HOV E;  2WB1 H;  3M3Y F;  5IYD E;  2R7Z F;  5M5W F;  3H3V G;  3S1M E;  4LJZ E;  4BBS F;  5D4C E;  2A6H E;  2R92 E;  4C2M E;  3EQL E;  3M4O E;  4A93 F;  2KRX A;  5IP9 E;  3S2H E;  4GZY E;  3HKZ H;  3PO2 E;  4A3M F;  5M5Y E;  5M5X E;  3FKI F;  3I4N F;  4G7O E;  5C44 E;  4LK0 E;  5FJ8 E;  2O5I E;  3HOY E;  1TWC F;  2WB1 I;  4QIW H;  4Q5S E;  2E2J F;  3S1M F;  4A3K F;  2PMZ H;  3HOV F;  4LK1 E;  3S16 F;  4BXX E;  3HOX F;  4XLP E;  1IW7 E;  5M5W E;  4XSX E;  2NVT F;  4C3H E;  2R92 F;  2JA8 F;  3M4O F;  2R93 E;  1R9T E;  5IP9 F;  4OIQ E;  2E2I F;  3GTQ E;  5M5Y F;  5D4D E;  5M5X F;  1TWF F;  3WOD E;  5C44 F; 
#chains in the Genus database with same CATH homology
 5FJ8 F;  3HOY F;  3K7A F;  1I6V E;  4YFN E;  4C3H F;  5E18 E;  2R93 F;  1R9T F;  4A3C F;  3GTQ F;  1YNJ K;  5TMF E;  1TWA F;  3RZD F;  3I4M F;  5M3F F;  3GTP F;  4JK1 E;  4YG2 E;  5IYB F;  4A3E F;  4BY7 F;  4BBR F;  4Q4Z E;  5C4J F;  1TWG F;  4LLG E;  2JA5 F;  4ZH4 E;  1I50 F;  4YFK E;  4OIN E;  4A3J F;  3RZO F;  3S1Q F;  1Y1V F;  2WAQ K;  4A3L F;  3S2D F;  2O5J E;  4MQ9 E;  4A3G F;  4C3J F;  2E2H F;  2JA6 F;  4KN4 E;  3PO3 F;  3DXJ E;  2VUM F;  4A3I F;  4YFX E;  4A3D F;  3H0G F;  4A3B F;  2NVY F;  4Y52 F;  4MEX E;  4XLN E;  3S17 F;  5E17 E;  1HQM E;  4A3F F;  4KMU E;  1I3Q F;  2A68 E;  1WCM F;  1SFO F;  5D4E E;  4AYB K;  1TWH F;  4X6A F;  5IP7 F;  4G7Z E;  1Y1W F;  4OIR E;  1ZYR E;  5M3M F;  3HOZ F;  3GTL F;  3GTO F;  3S14 F;  2PPB E;  2A69 E;  3GTJ F;  2CW0 E;  1YNN K;  3S1R F;  2A6E E;  4XSZ E;  5IYC F;  2B63 F;  3GTK F;  3HOU F;  1SMY E;  2Y0S I;  3CQZ F;  4Y7N F;  2YU9 F;  4OIP E;  4BY1 F;  4C3I F;  5BYH E;  2NVQ F;  1I6H F;  3HOW F;  2BE5 E;  4KN7 E;  5IPL E;  3GTM F;  5IYD F;  5C4X F;  3S15 F;  2NVX F;  3HKZ K;  4G7H E;  5TMC E;  4C2M F;  3S2H F;  5FLM F;  4OIO E;  3PO2 F;  2JA7 F;  4QIW K;  2PMZ K;  3S1N F;  1K83 F;  3GTG F;  1QKL A;  4MEY E;  5C3E F;  4BXX F;  3M3Y F;  2R7Z F;  5M5W F;  3H3V G;  4LJZ E;  4BBS F;  5D4C E;  2A6H E;  3EQL E;  4A93 F;  2KRX A;  4GZY E;  4A3M F;  3FKI F;  3I4N F;  4G7O E;  4LK0 E;  2O5I E;  1TWC F;  2WB1 I;  4Q5S E;  2E2J F;  3S1M F;  4A3K F;  3HOV F;  3S16 F;  4LK1 E;  3HOX F;  4XLP E;  1IW7 E;  4XSX E;  2NVT F;  2R92 F;  2JA8 F;  3M4O F;  5IP9 F;  4OIQ E;  2E2I F;  5M5Y F;  5D4D E;  5M5X F;  1TWF F;  3WOD E;  5C44 F; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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