4NTXB

Structure of acid-sensing ion channel in complex with snake toxin and amiloride
Total Genus 14
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
14
sequence length
60
structure length
60
Chain Sequence
EIRPAFCYEDPPFFQKCGAFVDSYYFNRSRITCVHFFYGQCDVNQNHFTTMSECNRVCHG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title X-ray structure of Acid-sensing ion channel 1-snake toxin complex reveals open state of a na(+)-selective channel.
pubmed doi rcsb
molecule tags Transport protein/toxin
source organism Gallus gallus
molecule keywords Acid-sensing ion channel 1
total genus 14
structure length 60
sequence length 60
ec nomenclature
pdb deposition date 2013-12-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 4ntxB00
1EJMB 1OA55 2J6DA 1ADZA 3GYMI 3AUGA 2M99A 1LD6A 1YKTB 2KCRA 1UUAA 1T8LB 3BTEI 2JOTA 2DDIA 1QLQA 2M01A 1JC6A 3TGJI 2PTCI 3BTTI 1BPTA 2KAII 1OA65 1TAWB 3TGII 3BYBA 5PTIA 3AUBA 3FP7J 3U1JE 1D0DB 3FP8I 2FI5I 1BF0A 1BTHP 1T8NB 2ODYE 4Y11I 3LDJA 1CA0D 3BTHI 1DTKA 1DEMA 3UOUB 1JV8A 1DENA 3BTKI 4TPII 1TPAI 1BUNB 1KNTA 3P92E 3TGKI 2ZVXA 4BNRI 8PTIA 3TPII 1FAKI 3BTWI 1KUNA 3T62D 1D0DA 1FANA 4Y10I 1TFXC 1BRBI 1PITA 1KIGI 1AALA 1P2QB 3D65I 5JB6A 2W8XA 2UUYB 4BD9B 1IRHA 1YLCB 4BQDA 6PTIA 4NTWB 3LDIA 2HEXA 2TPII 2ZJXA 4DTGK 1F5RI 2KNTA 2FI4I 5JB5A 1T7CB 3L3TE 1ZR0B 1BIKA 2FTLI 1YC0I 1BTIA 1P2JI 4U32X 1BRCI 1Y62A 5JB4A 1B0CA 1P2MB 3LDMA 5C67C 4ISNB 4DG4C 2CA7A 3AUDA 3BTQI 3BTMI 1LD5A 1KTHA 9PTIA 1BPIA 2LFLA 2UUXA 1CBWD 4WXVC 3AUHA 2TGPI 1NAGA 1TCPA 3BTGI 4WWYC 3AUEA 2LFKA 1SHPA 1F7ZI 1YLDB 1TAPA 2R9PE 3WNYA 3M7QB 4Y0ZI 3L33E 2RA3C 1BHCA 4ISOB 1P2KI 1P2NB 2FI3I 3UIRC 1FY8I 4PTIA 1P2OB 1CO7I 1ZJDB 2IJOI 3OFWA 4Y0YI 3AUCA 1AAPA 1MTND 3FP6I 7PTIA 3CI7A 1DTXA 3AUIA 3BTDI 3BTFI 3OTJI 2FTMB 4ISLB 4NTXB 1TOCR 1P2II 1UUBA 4NTYB 1EAWB 1JV9A 1T8MB 2DDJA 1BZXI 3P95E 1G6XA 1K6UA 5JB7A 4U30W 1T8OB 1BZ5A
chains in the Genus database with same CATH superfamily
1EJMB 1OA55 2J6DA 1ADZA 3GYMI 3AUGA 2M99A 1LD6A 1YKTB 2KCRA 1UUAA 1T8LB 3BTEI 2JOTA 2DDIA 1QLQA 2M01A 1JC6A 3TGJI 2PTCI 3BTTI 1BPTA 2KAII 1OA65 1TAWB 3TGII 3BYBA 5PTIA 3AUBA 3FP7J 3U1JE 1D0DB 3FP8I 2FI5I 1BF0A 1BTHP 1T8NB 2ODYE 4Y11I 3LDJA 1CA0D 3BTHI 1DTKA 1DEMA 3UOUB 1JV8A 1DENA 3BTKI 4TPII 1TPAI 1BUNB 1KNTA 3P92E 3TGKI 2ZVXA 4BNRI 8PTIA 3TPII 1FAKI 3BTWI 1KUNA 3T62D 1D0DA 1FANA 4Y10I 1TFXC 1BRBI 1PITA 1KIGI 1AALA 1P2QB 3D65I 5JB6A 2W8XA 2UUYB 4BD9B 1IRHA 1YLCB 4BQDA 6PTIA 4NTWB 3LDIA 2HEXA 2TPII 2ZJXA 4DTGK 1F5RI 2KNTA 2FI4I 5JB5A 1T7CB 3L3TE 1ZR0B 1BIKA 2FTLI 1YC0I 1BTIA 1P2JI 4U32X 1BRCI 1Y62A 5JB4A 1B0CA 1P2MB 3LDMA 5C67C 4ISNB 4DG4C 2CA7A 3AUDA 3BTQI 3BTMI 1LD5A 1KTHA 9PTIA 1BPIA 2LFLA 2UUXA 1CBWD 4WXVC 3AUHA 2TGPI 1NAGA 1TCPA 3BTGI 4WWYC 3AUEA 2LFKA 1SHPA 1F7ZI 1YLDB 1TAPA 2R9PE 3WNYA 3M7QB 4Y0ZI 3L33E 2RA3C 1BHCA 4ISOB 1P2KI 1P2NB 2FI3I 3UIRC 1FY8I 4PTIA 1P2OB 1CO7I 1ZJDB 2IJOI 3OFWA 4Y0YI 3AUCA 1AAPA 1MTND 3FP6I 7PTIA 3CI7A 1DTXA 3AUIA 3BTDI 3BTFI 3OTJI 2FTMB 4ISLB 4NTXB 1TOCR 1P2II 1UUBA 4NTYB 1EAWB 1JV9A 1T8MB 2DDJA 1BZXI 3P95E 1G6XA 1K6UA 5JB7A 4U30W 1T8OB 1BZ5A
chains in the Genus database with same CATH topology
1EJMB 1OA55 2J6DA 1ADZA 3GYMI 3AUGA 2M99A 1LD6A 1YKTB 2KCRA 1UUAA 1T8LB 3BTEI 2JOTA 2DDIA 1QLQA 2M01A 1JC6A 3TGJI 2PTCI 3BTTI 1BPTA 2KAII 1OA65 1TAWB 3TGII 3BYBA 5PTIA 3AUBA 3FP7J 3U1JE 1D0DB 3FP8I 2FI5I 1BF0A 1BTHP 1T8NB 2ODYE 4Y11I 3LDJA 1CA0D 3BTHI 1DTKA 1DEMA 3UOUB 1JV8A 1DENA 3BTKI 4TPII 1TPAI 1BUNB 1KNTA 3P92E 3TGKI 2ZVXA 4BNRI 8PTIA 3TPII 1FAKI 3BTWI 1KUNA 3T62D 1D0DA 1FANA 4Y10I 1TFXC 1BRBI 1PITA 1KIGI 1AALA 1P2QB 3D65I 5JB6A 2W8XA 2UUYB 4BD9B 1IRHA 1YLCB 4BQDA 6PTIA 4NTWB 3LDIA 2HEXA 2TPII 2ZJXA 4DTGK 1F5RI 2KNTA 2FI4I 5JB5A 1T7CB 3L3TE 1ZR0B 1BIKA 2FTLI 1YC0I 1BTIA 1P2JI 4U32X 1BRCI 1Y62A 5JB4A 1B0CA 1P2MB 3LDMA 5C67C 4ISNB 4DG4C 2CA7A 3AUDA 3BTQI 3BTMI 1LD5A 1KTHA 9PTIA 1BPIA 2LFLA 2UUXA 1CBWD 4WXVC 3AUHA 2TGPI 1NAGA 1TCPA 3BTGI 4WWYC 3AUEA 2LFKA 1SHPA 1F7ZI 1YLDB 1TAPA 2R9PE 3WNYA 3M7QB 4Y0ZI 3L33E 2RA3C 1BHCA 4ISOB 1P2KI 1P2NB 2FI3I 3UIRC 1FY8I 4PTIA 1P2OB 1CO7I 1ZJDB 2IJOI 3OFWA 4Y0YI 3AUCA 1AAPA 1MTND 3FP6I 7PTIA 3CI7A 1DTXA 3AUIA 3BTDI 3BTFI 3OTJI 2FTMB 4ISLB 4NTXB 1TOCR 1P2II 1UUBA 4NTYB 1EAWB 1JV9A 1T8MB 2DDJA 1BZXI 3P95E 1G6XA 1K6UA 5JB7A 4U30W 1T8OB 1BZ5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1EJM B;  1OA5 5;  2J6D A;  1ADZ A;  3GYM I;  3AUG A;  2M99 A;  1LD6 A;  1YKT B;  2KCR A;  1UUA A;  1T8L B;  3BTE I;  2JOT A;  2DDI A;  1QLQ A;  2M01 A;  1JC6 A;  3TGJ I;  2PTC I;  3BTT I;  1BPT A;  2KAI I;  1OA6 5;  1TAW B;  3TGI I;  3BYB A;  5PTI A;  3AUB A;  3FP7 J;  3U1J E;  1D0D B;  3FP8 I;  2FI5 I;  1BF0 A;  1BTH P;  1T8N B;  2ODY E;  4Y11 I;  3LDJ A;  1CA0 D;  3BTH I;  1DTK A;  1DEM A;  3UOU B;  1JV8 A;  1DEN A;  3BTK I;  4TPI I;  1TPA I;  1BUN B;  1KNT A;  3P92 E;  3TGK I;  2ZVX A;  4BNR I;  8PTI A;  3TPI I;  1FAK I;  3BTW I;  1KUN A;  3T62 D;  1D0D A;  1FAN A;  4Y10 I;  1TFX C;  1BRB I;  1PIT A;  1KIG I;  1AAL A;  1P2Q B;  3D65 I;  5JB6 A;  2W8X A;  2UUY B;  4BD9 B;  1IRH A;  1YLC B;  4BQD A;  6PTI A;  4NTW B;  3LDI A;  2HEX A;  2TPI I;  2ZJX A;  4DTG K;  1F5R I;  2KNT A;  2FI4 I;  5JB5 A;  1T7C B;  3L3T E;  1ZR0 B;  1BIK A;  2FTL I;  1YC0 I;  1BTI A;  1P2J I;  4U32 X;  1BRC I;  1Y62 A;  5JB4 A;  1B0C A;  1P2M B;  3LDM A;  5C67 C;  4ISN B;  4DG4 C;  2CA7 A;  3AUD A;  3BTQ I;  3BTM I;  1LD5 A;  1KTH A;  9PTI A;  1BPI A;  2LFL A;  2UUX A;  1CBW D;  4WXV C;  3AUH A;  2TGP I;  1NAG A;  1TCP A;  3BTG I;  4WWY C;  3AUE A;  2LFK A;  1SHP A;  1F7Z I;  1YLD B;  1TAP A;  2R9P E;  3WNY A;  3M7Q B;  4Y0Z I;  3L33 E;  2RA3 C;  1BHC A;  4ISO B;  1P2K I;  1P2N B;  2FI3 I;  3UIR C;  1FY8 I;  4PTI A;  1P2O B;  1CO7 I;  1ZJD B;  2IJO I;  3OFW A;  4Y0Y I;  3AUC A;  1AAP A;  1MTN D;  3FP6 I;  7PTI A;  3CI7 A;  1DTX A;  3AUI A;  3BTD I;  3BTF I;  3OTJ I;  2FTM B;  4ISL B;  4NTX B;  1TOC R;  1P2I I;  1UUB A;  4NTY B;  1EAW B;  1JV9 A;  1T8M B;  2DDJ A;  1BZX I;  3P95 E;  1G6X A;  1K6U A;  5JB7 A;  4U30 W;  1T8O B;  1BZ5 A; 
#chains in the Genus database with same CATH topology
 1EJM B;  1OA5 5;  2J6D A;  1ADZ A;  3GYM I;  3AUG A;  2M99 A;  1LD6 A;  1YKT B;  2KCR A;  1UUA A;  1T8L B;  3BTE I;  2JOT A;  2DDI A;  1QLQ A;  2M01 A;  1JC6 A;  3TGJ I;  2PTC I;  3BTT I;  1BPT A;  2KAI I;  1OA6 5;  1TAW B;  3TGI I;  3BYB A;  5PTI A;  3AUB A;  3FP7 J;  3U1J E;  1D0D B;  3FP8 I;  2FI5 I;  1BF0 A;  1BTH P;  1T8N B;  2ODY E;  4Y11 I;  3LDJ A;  1CA0 D;  3BTH I;  1DTK A;  1DEM A;  3UOU B;  1JV8 A;  1DEN A;  3BTK I;  4TPI I;  1TPA I;  1BUN B;  1KNT A;  3P92 E;  3TGK I;  2ZVX A;  4BNR I;  8PTI A;  3TPI I;  1FAK I;  3BTW I;  1KUN A;  3T62 D;  1D0D A;  1FAN A;  4Y10 I;  1TFX C;  1BRB I;  1PIT A;  1KIG I;  1AAL A;  1P2Q B;  3D65 I;  5JB6 A;  2W8X A;  2UUY B;  4BD9 B;  1IRH A;  1YLC B;  4BQD A;  6PTI A;  4NTW B;  3LDI A;  2HEX A;  2TPI I;  2ZJX A;  4DTG K;  1F5R I;  2KNT A;  2FI4 I;  5JB5 A;  1T7C B;  3L3T E;  1ZR0 B;  1BIK A;  2FTL I;  1YC0 I;  1BTI A;  1P2J I;  4U32 X;  1BRC I;  1Y62 A;  5JB4 A;  1B0C A;  1P2M B;  3LDM A;  5C67 C;  4ISN B;  4DG4 C;  2CA7 A;  3AUD A;  3BTQ I;  3BTM I;  1LD5 A;  1KTH A;  9PTI A;  1BPI A;  2LFL A;  2UUX A;  1CBW D;  4WXV C;  3AUH A;  2TGP I;  1NAG A;  1TCP A;  3BTG I;  4WWY C;  3AUE A;  2LFK A;  1SHP A;  1F7Z I;  1YLD B;  1TAP A;  2R9P E;  3WNY A;  3M7Q B;  4Y0Z I;  3L33 E;  2RA3 C;  1BHC A;  4ISO B;  1P2K I;  1P2N B;  2FI3 I;  3UIR C;  1FY8 I;  4PTI A;  1P2O B;  1CO7 I;  1ZJD B;  2IJO I;  3OFW A;  4Y0Y I;  3AUC A;  1AAP A;  1MTN D;  3FP6 I;  7PTI A;  3CI7 A;  1DTX A;  3AUI A;  3BTD I;  3BTF I;  3OTJ I;  2FTM B;  4ISL B;  4NTX B;  1TOC R;  1P2I I;  1UUB A;  4NTY B;  1EAW B;  1JV9 A;  1T8M B;  2DDJ A;  1BZX I;  3P95 E;  1G6X A;  1K6U A;  5JB7 A;  4U30 W;  1T8O B;  1BZ5 A; 
#chains in the Genus database with same CATH homology
 1EJM B;  1OA5 5;  2J6D A;  1ADZ A;  3GYM I;  3AUG A;  2M99 A;  1LD6 A;  1YKT B;  2KCR A;  1UUA A;  1T8L B;  3BTE I;  2JOT A;  2DDI A;  1QLQ A;  2M01 A;  1JC6 A;  3TGJ I;  2PTC I;  3BTT I;  1BPT A;  2KAI I;  1OA6 5;  1TAW B;  3TGI I;  3BYB A;  5PTI A;  3AUB A;  3FP7 J;  3U1J E;  1D0D B;  3FP8 I;  2FI5 I;  1BF0 A;  1BTH P;  1T8N B;  2ODY E;  4Y11 I;  3LDJ A;  1CA0 D;  3BTH I;  1DTK A;  1DEM A;  3UOU B;  1JV8 A;  1DEN A;  3BTK I;  4TPI I;  1TPA I;  1BUN B;  1KNT A;  3P92 E;  3TGK I;  2ZVX A;  4BNR I;  8PTI A;  3TPI I;  1FAK I;  3BTW I;  1KUN A;  3T62 D;  1D0D A;  1FAN A;  4Y10 I;  1TFX C;  1BRB I;  1PIT A;  1KIG I;  1AAL A;  1P2Q B;  3D65 I;  5JB6 A;  2W8X A;  2UUY B;  4BD9 B;  1IRH A;  1YLC B;  4BQD A;  6PTI A;  4NTW B;  3LDI A;  2HEX A;  2TPI I;  2ZJX A;  4DTG K;  1F5R I;  2KNT A;  2FI4 I;  5JB5 A;  1T7C B;  3L3T E;  1ZR0 B;  1BIK A;  2FTL I;  1YC0 I;  1BTI A;  1P2J I;  4U32 X;  1BRC I;  1Y62 A;  5JB4 A;  1B0C A;  1P2M B;  3LDM A;  5C67 C;  4ISN B;  4DG4 C;  2CA7 A;  3AUD A;  3BTQ I;  3BTM I;  1LD5 A;  1KTH A;  9PTI A;  1BPI A;  2LFL A;  2UUX A;  1CBW D;  4WXV C;  3AUH A;  2TGP I;  1NAG A;  1TCP A;  3BTG I;  4WWY C;  3AUE A;  2LFK A;  1SHP A;  1F7Z I;  1YLD B;  1TAP A;  2R9P E;  3WNY A;  3M7Q B;  4Y0Z I;  3L33 E;  2RA3 C;  1BHC A;  4ISO B;  1P2K I;  1P2N B;  2FI3 I;  3UIR C;  1FY8 I;  4PTI A;  1P2O B;  1CO7 I;  1ZJD B;  2IJO I;  3OFW A;  4Y0Y I;  3AUC A;  1AAP A;  1MTN D;  3FP6 I;  7PTI A;  3CI7 A;  1DTX A;  3AUI A;  3BTD I;  3BTF I;  3OTJ I;  2FTM B;  4ISL B;  4NTX B;  1TOC R;  1P2I I;  1UUB A;  4NTY B;  1EAW B;  1JV9 A;  1T8M B;  2DDJ A;  1BZX I;  3P95 E;  1G6X A;  1K6U A;  5JB7 A;  4U30 W;  1T8O B;  1BZ5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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