4OIOE

Crystal structure of thermus thermophilus pre-insertion substrate complex for de novo transcription initiation
Total Genus 24
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
24
sequence length
94
structure length
94
Chain Sequence
AEPGIDKLFGMVDSKYRLTVVVAKRAQQLLRHGFKNTVLEPEERPKMQTLEGLFDDPNAVTWAMKELLTGRLVFGENLVPEDRLQKEMERLYPV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides.
pubmed rcsb
molecule tags Transcription, transferase
source organism Thermus thermophilus
molecule keywords DNA-directed RNA polymerase subunit alpha
total genus 24
structure length 94
sequence length 94
ec nomenclature ec 2.7.7.6: DNA-directed RNA polymerase.
pdb deposition date 2014-01-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01192 RNA_pol_Rpb6 RNA polymerase Rpb6
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.940.10 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit Eukaryotic RPB6 RNA polymerase subunit 4oioE00
4YFNE 2BE5E 2A68E 5M3FF 5FLMF 3GTLF 2NVYF 5IP7F 1Y1WF 4LK0E 5IYCF 1IW7E 5C44F 3PO2F 5TMFE 1R9TF 2O5IE 5D4DE 2R7ZF 4MQ9E 3S14F 3WODE 4A3EF 3S15F 4A3GF 4BY7F 2E2IF 4OINE 2VUMF 2WB1I 2O5JE 4OIOE 3PO3F 5TMCE 4A3KF 3M4OF 3S1MF 2YU9F 2A6EE 4A3CF 5D4CE 3GTMF 3HOWF 2WAQK 1YNJK 4C3HF 5IYDF 4G7HE 1ZYRE 2CW0E 4MEXE 4GZYE 3GTOF 3H0GF 1TWGF 3GTGF 5C4JF 4C3IF 3S17F 3HOYF 5C4XF 1YNNK 3GTJF 2JA6F 3HOXF 5M3MF 2PMZK 3CQZF 4KN4E 2JA8F 1QKLA 1TWHF 2E2HF 5D4EE 4LLGE 4LJZE 4YG2E 5IP9F 4LK1E 4BBRF 5C3EF 4A3BF 2R93F 2Y0SI 3EQLE 4BXXF 2NVTF 4A3DF 5BYHE 3HKZK 4BY1F 3HOUF 4A93F 1I6VE 4YFXE 4OIRE 5E18E 5E17E 4A3FF 2NVXF 4OIPE 2JA7F 1SFOF 4X6AF 1SMYE 4C2MF 3GTQF 3RZOF 3S1QF 3DXJE 4KMUE 5M5WF 2JA5F 4G7OE 4JK1E 4Q5SE 3GTPF 2E2JF 1K83F 2A6HE 3S1NF 1I6HF 3S16F 4YFKE 2R92F 3HOVF 3FKIF 3I4NF 5IPLE 5FJ8F 1I50F 3I4MF 4ZH4E 1WCMF 4Y52F 3S2HF 4A3LF 2A69E 4KN7E 3S2DF 3HOZF 4XSZE 4A3MF 3M3YF 4OIQE 4C3JF 1TWAF 4Y7NF 2PPBE 5IYBF 3GTKF 4AYBK 4Q4ZE 3RZDF 4XLNE 4XSXE 3K7AF 5M5YF 3S1RF 4MEYE 4A3IF 4XLPE 1TWFF 1Y1VF 2B63F 3H3VG 5M5XF 4A3JF 1I3QF 1TWCF 4BBSF 2NVQF 4G7ZE 1HQME
chains in the Genus database with same CATH superfamily
4YFNE 4A3LE 2BE5E 2A68E 5M3FF 3GTLE 4Y52E 2NVYE 5IP7E 5FLMF 4A3ME 3GTLF 1Y1WE 3M3YE 4C3JE 2NVYF 5IYCE 5IP7F 5IYBE 4Y7NE 3PO2E 3RZDE 1Y1WF 1R9TE 4LK0E 5IYCF 1IW7E 5C44F 3PO2F 5TMFE 3K7AE 1R9TF 3S15E 4A3EE 4A3GE 4BY7E 2E2IE 2O5IE 5D4DE 2R7ZF 4MQ9E 4A3IE 3WODE 4A3EF 3S14F 3S15F 4BY7F 2E2IF 4A3GF 4OINE 2VUMF 2B63E 5M5XE 4A3JE 2WB1I 1I3QE 2O5JE 1TWCE 4A3KE 4OIOE 1EIKA 3M4OE 3PO3F 4QIWH 5TMCE 4A3KF 2NVQE 2YU9E 3M4OF 3S1MF 2YU9F 2A6EE 5FLME 2Y0SH 4AYBH 4A3CF 5IYDE 5D4CE 3GTMF 3HOWF 2WAQK 3GTOE 1YNJK 4C3HF 5IYDF 4G7HE 1ZYRE 2CW0E 4MEXE 5C44E 4GZYE 3GTOF 3GTGE 5C4JE 3H0GF 3S17E 1TWGF 3GTGF 2JA6E 5C4JF 4C3IF 2R7ZE 3S14E 3S17F 3HOYF 5C4XF 1YNNK 5M3ME 3GTJF 2JA6F 3HOXF 5M3MF 2PMZK 3H3VF 3CQZF 4KN4E 2JA8F 1QKLA 1TWHF 5IP9E 2E2HF 3PO3E 5D4EE 4LLGE 2KRXA 4BBRE 4LJZE 5C3EE 4A3BE 4YG2E 2R93E 5IP9F 4LK1E 2WAQH 3S1ME 1DZFA 4A3DE 4BBRF 5C3EF 4A3BF 2R93F 2Y0SI 4BY1E 3EQLE 4BXXF 2NVTF 3HOUE 4A93E 5BYHE 3HKZK 4A3DF 4A3CE 4BY1F 3GTME 3HOWE 3HOUF 4A3FE 1I6VE 4YFXE 4OIRE 5E18E 4A93F 4C3HE 2JA7E 1SFOE 3GTQE 4C2ME 4A3FF 3RZOE 2NVXF 3S1QE 5E17E 4OIPE 3H0GE 1SFOF 2JA7F 4X6AF 1SMYE 1TWGE 4C2MF 5M5WE 2JA5E 2PMZH 3GTQF 3RZOF 3DXJE 3S1QF 4KMUE 4C3IE 5C4XE 5M5WF 2JA5F 4G7OE 4JK1E 3GTJE 4Q5SE 3HOXE 3GTPF 2E2JF 1K83F 3S1NE 2A6HE 3S16E 3CQZE 2JA8E 3S1NF 1TWHE 2E2HE 1I6HF 3S16F 2WB1H 3HKZH 4YFKE 3FKIE 2R92F 3I4NE 3HOVF 5FJ8E 1I50E 3I4ME 3FKIF 3I4NF 5IPLE 1WCME 4BXXE 5FJ8F 2NVTE 1I50F 3I4MF 4ZH4E 1WCMF 3S2DE 4Y52F 3S2HF 3HOZE 4QIWK 2A69E 4A3LF 4KN7E 3S2DF 1TWAE 3GTKE 3HOZF 4XSZE 4A3MF 2NVXE 4OIQE 3M3YF 4C3JF 1TWAF 4Y7NF 2PPBE 5IYBF 3GTKF 4AYBK 4X6AE 4Q4ZE 3RZDF 5M5YE 4XLNE 3S1RE 4XSXE 3K7AF 5M5YF 3S1RF 3GTPE 2E2JE 1K83E 1TWFE 4MEYE 4A3IF 1Y1VE 4XLPE 1TWFF 1I6HE 1Y1VF 2B63F 3H3VG 2R92E 5M5XF 4A3JF 3HOVE 1I3QF 4BBSE 1TWCF 2VUME 3HOYE 4BBSF 2NVQF 5M3FE 4G7ZE 1HQME 3S2HE
chains in the Genus database with same CATH topology
4YFNE 2BE5E 2A68E 5M3FF 5FLMF 3GTLF 2NVYF 5IP7F 1Y1WF 4LK0E 5IYCF 1IW7E 5C44F 3PO2F 5TMFE 1R9TF 2O5IE 5D4DE 2R7ZF 4MQ9E 3S14F 3WODE 4A3EF 3S15F 4A3GF 4BY7F 2E2IF 4OINE 2VUMF 2WB1I 2O5JE 4OIOE 3PO3F 5TMCE 4A3KF 3M4OF 3S1MF 2YU9F 2A6EE 4A3CF 5D4CE 3GTMF 3HOWF 2WAQK 1YNJK 4C3HF 5IYDF 4G7HE 1ZYRE 2CW0E 4MEXE 4GZYE 3GTOF 3H0GF 1TWGF 3GTGF 5C4JF 4C3IF 3S17F 3HOYF 5C4XF 1YNNK 3GTJF 2JA6F 3HOXF 5M3MF 2PMZK 3CQZF 4KN4E 2JA8F 1QKLA 1TWHF 2E2HF 5D4EE 4LLGE 2KRXA 4LJZE 4YG2E 5IP9F 4LK1E 4BBRF 5C3EF 4A3BF 2R93F 2Y0SI 3EQLE 4BXXF 2NVTF 4A3DF 5BYHE 3HKZK 4BY1F 3HOUF 4A93F 1I6VE 4YFXE 4OIRE 5E18E 5E17E 4A3FF 2NVXF 4OIPE 2JA7F 1SFOF 4X6AF 1SMYE 4C2MF 3GTQF 3RZOF 3S1QF 3DXJE 4KMUE 5M5WF 2JA5F 4G7OE 4JK1E 4Q5SE 3GTPF 2E2JF 1K83F 2A6HE 3S1NF 1I6HF 3S16F 4YFKE 2R92F 3HOVF 3FKIF 3I4NF 5IPLE 5FJ8F 1I50F 3I4MF 4ZH4E 1WCMF 4Y52F 3S2HF 4QIWK 2A69E 4A3LF 4KN7E 3S2DF 3HOZF 4XSZE 4A3MF 3M3YF 4OIQE 4C3JF 1TWAF 4Y7NF 2PPBE 5IYBF 3GTKF 4AYBK 4Q4ZE 3RZDF 4XLNE 4XSXE 3K7AF 5M5YF 3S1RF 4MEYE 4A3IF 4XLPE 1TWFF 1Y1VF 2B63F 3H3VG 5M5XF 4A3JF 1I3QF 1TWCF 4BBSF 2NVQF 4G7ZE 1HQME
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4YFN E;  2BE5 E;  2A68 E;  5M3F F;  5FLM F;  3GTL F;  2NVY F;  5IP7 F;  1Y1W F;  4LK0 E;  5IYC F;  1IW7 E;  5C44 F;  3PO2 F;  5TMF E;  1R9T F;  2O5I E;  5D4D E;  2R7Z F;  4MQ9 E;  3S14 F;  3WOD E;  4A3E F;  3S15 F;  4A3G F;  4BY7 F;  2E2I F;  4OIN E;  2VUM F;  2WB1 I;  2O5J E;  4OIO E;  3PO3 F;  5TMC E;  4A3K F;  3M4O F;  3S1M F;  2YU9 F;  2A6E E;  4A3C F;  5D4C E;  3GTM F;  3HOW F;  2WAQ K;  1YNJ K;  4C3H F;  5IYD F;  4G7H E;  1ZYR E;  2CW0 E;  4MEX E;  4GZY E;  3GTO F;  3H0G F;  1TWG F;  3GTG F;  5C4J F;  4C3I F;  3S17 F;  3HOY F;  5C4X F;  1YNN K;  3GTJ F;  2JA6 F;  3HOX F;  5M3M F;  2PMZ K;  3CQZ F;  4KN4 E;  2JA8 F;  1QKL A;  1TWH F;  2E2H F;  5D4E E;  4LLG E;  4LJZ E;  4YG2 E;  5IP9 F;  4LK1 E;  4BBR F;  5C3E F;  4A3B F;  2R93 F;  2Y0S I;  3EQL E;  4BXX F;  2NVT F;  4A3D F;  5BYH E;  3HKZ K;  4BY1 F;  3HOU F;  4A93 F;  1I6V E;  4YFX E;  4OIR E;  5E18 E;  5E17 E;  4A3F F;  2NVX F;  4OIP E;  2JA7 F;  1SFO F;  4X6A F;  1SMY E;  4C2M F;  3GTQ F;  3RZO F;  3S1Q F;  3DXJ E;  4KMU E;  5M5W F;  2JA5 F;  4G7O E;  4JK1 E;  4Q5S E;  3GTP F;  2E2J F;  1K83 F;  2A6H E;  3S1N F;  1I6H F;  3S16 F;  4YFK E;  2R92 F;  3HOV F;  3FKI F;  3I4N F;  5IPL E;  5FJ8 F;  1I50 F;  3I4M F;  4ZH4 E;  1WCM F;  4Y52 F;  3S2H F;  4A3L F;  2A69 E;  4KN7 E;  3S2D F;  3HOZ F;  4XSZ E;  4A3M F;  3M3Y F;  4OIQ E;  4C3J F;  1TWA F;  4Y7N F;  2PPB E;  5IYB F;  3GTK F;  4AYB K;  4Q4Z E;  3RZD F;  4XLN E;  4XSX E;  3K7A F;  5M5Y F;  3S1R F;  4MEY E;  4A3I F;  4XLP E;  1TWF F;  1Y1V F;  2B63 F;  3H3V G;  5M5X F;  4A3J F;  1I3Q F;  1TWC F;  4BBS F;  2NVQ F;  4G7Z E;  1HQM E; 
#chains in the Genus database with same CATH topology
 4YFN E;  4A3L E;  2BE5 E;  2A68 E;  5M3F F;  3GTL E;  4Y52 E;  2NVY E;  5IP7 E;  5FLM F;  4A3M E;  3GTL F;  1Y1W E;  3M3Y E;  4C3J E;  2NVY F;  5IYC E;  5IP7 F;  5IYB E;  4Y7N E;  3PO2 E;  3RZD E;  1Y1W F;  1R9T E;  4LK0 E;  5IYC F;  1IW7 E;  5C44 F;  3PO2 F;  5TMF E;  3K7A E;  1R9T F;  3S15 E;  4A3E E;  4A3G E;  4BY7 E;  2E2I E;  2O5I E;  5D4D E;  2R7Z F;  4MQ9 E;  4A3I E;  3WOD E;  4A3E F;  3S14 F;  3S15 F;  4BY7 F;  2E2I F;  4A3G F;  4OIN E;  2VUM F;  2B63 E;  5M5X E;  4A3J E;  2WB1 I;  1I3Q E;  2O5J E;  1TWC E;  4A3K E;  4OIO E;  1EIK A;  3M4O E;  3PO3 F;  4QIW H;  5TMC E;  4A3K F;  2NVQ E;  2YU9 E;  3M4O F;  3S1M F;  2YU9 F;  2A6E E;  5FLM E;  2Y0S H;  4AYB H;  4A3C F;  5IYD E;  5D4C E;  3GTM F;  3HOW F;  2WAQ K;  3GTO E;  1YNJ K;  4C3H F;  5IYD F;  4G7H E;  1ZYR E;  2CW0 E;  4MEX E;  5C44 E;  4GZY E;  3GTO F;  3GTG E;  5C4J E;  3H0G F;  3S17 E;  1TWG F;  3GTG F;  2JA6 E;  5C4J F;  4C3I F;  2R7Z E;  3S14 E;  3S17 F;  3HOY F;  5C4X F;  1YNN K;  5M3M E;  3GTJ F;  2JA6 F;  3HOX F;  5M3M F;  2PMZ K;  3H3V F;  3CQZ F;  4KN4 E;  2JA8 F;  1QKL A;  1TWH F;  5IP9 E;  2E2H F;  3PO3 E;  5D4E E;  4LLG E;  2KRX A;  4BBR E;  4LJZ E;  5C3E E;  4A3B E;  4YG2 E;  2R93 E;  5IP9 F;  4LK1 E;  2WAQ H;  3S1M E;  1DZF A;  4A3D E;  4BBR F;  5C3E F;  4A3B F;  2R93 F;  2Y0S I;  4BY1 E;  3EQL E;  4BXX F;  2NVT F;  3HOU E;  4A93 E;  5BYH E;  3HKZ K;  4A3D F;  4A3C E;  4BY1 F;  3GTM E;  3HOW E;  3HOU F;  4A3F E;  1I6V E;  4YFX E;  4OIR E;  5E18 E;  4A93 F;  4C3H E;  2JA7 E;  1SFO E;  3GTQ E;  4C2M E;  4A3F F;  3RZO E;  2NVX F;  3S1Q E;  5E17 E;  4OIP E;  3H0G E;  1SFO F;  2JA7 F;  4X6A F;  1SMY E;  1TWG E;  4C2M F;  5M5W E;  2JA5 E;  2PMZ H;  3GTQ F;  3RZO F;  3DXJ E;  3S1Q F;  4KMU E;  4C3I E;  5C4X E;  5M5W F;  2JA5 F;  4G7O E;  4JK1 E;  3GTJ E;  4Q5S E;  3HOX E;  3GTP F;  2E2J F;  1K83 F;  3S1N E;  2A6H E;  3S16 E;  3CQZ E;  2JA8 E;  3S1N F;  1TWH E;  2E2H E;  1I6H F;  3S16 F;  2WB1 H;  3HKZ H;  4YFK E;  3FKI E;  2R92 F;  3I4N E;  3HOV F;  5FJ8 E;  1I50 E;  3I4M E;  3FKI F;  3I4N F;  5IPL E;  1WCM E;  4BXX E;  5FJ8 F;  2NVT E;  1I50 F;  3I4M F;  4ZH4 E;  1WCM F;  3S2D E;  4Y52 F;  3S2H F;  3HOZ E;  4QIW K;  2A69 E;  4A3L F;  4KN7 E;  3S2D F;  1TWA E;  3GTK E;  3HOZ F;  4XSZ E;  4A3M F;  2NVX E;  4OIQ E;  3M3Y F;  4C3J F;  1TWA F;  4Y7N F;  2PPB E;  5IYB F;  3GTK F;  4AYB K;  4X6A E;  4Q4Z E;  3RZD F;  5M5Y E;  4XLN E;  3S1R E;  4XSX E;  3K7A F;  5M5Y F;  3S1R F;  3GTP E;  2E2J E;  1K83 E;  1TWF E;  4MEY E;  4A3I F;  1Y1V E;  4XLP E;  1TWF F;  1I6H E;  1Y1V F;  2B63 F;  3H3V G;  2R92 E;  5M5X F;  4A3J F;  3HOV E;  1I3Q F;  4BBS E;  1TWC F;  2VUM E;  3HOY E;  4BBS F;  2NVQ F;  5M3F E;  4G7Z E;  1HQM E;  3S2H E; 
#chains in the Genus database with same CATH homology
 4YFN E;  2BE5 E;  2A68 E;  5M3F F;  5FLM F;  3GTL F;  2NVY F;  5IP7 F;  1Y1W F;  4LK0 E;  5IYC F;  1IW7 E;  5C44 F;  3PO2 F;  5TMF E;  1R9T F;  2O5I E;  5D4D E;  2R7Z F;  4MQ9 E;  3S14 F;  3WOD E;  4A3E F;  3S15 F;  4A3G F;  4BY7 F;  2E2I F;  4OIN E;  2VUM F;  2WB1 I;  2O5J E;  4OIO E;  3PO3 F;  5TMC E;  4A3K F;  3M4O F;  3S1M F;  2YU9 F;  2A6E E;  4A3C F;  5D4C E;  3GTM F;  3HOW F;  2WAQ K;  1YNJ K;  4C3H F;  5IYD F;  4G7H E;  1ZYR E;  2CW0 E;  4MEX E;  4GZY E;  3GTO F;  3H0G F;  1TWG F;  3GTG F;  5C4J F;  4C3I F;  3S17 F;  3HOY F;  5C4X F;  1YNN K;  3GTJ F;  2JA6 F;  3HOX F;  5M3M F;  2PMZ K;  3CQZ F;  4KN4 E;  2JA8 F;  1QKL A;  1TWH F;  2E2H F;  5D4E E;  4LLG E;  2KRX A;  4LJZ E;  4YG2 E;  5IP9 F;  4LK1 E;  4BBR F;  5C3E F;  4A3B F;  2R93 F;  2Y0S I;  3EQL E;  4BXX F;  2NVT F;  4A3D F;  5BYH E;  3HKZ K;  4BY1 F;  3HOU F;  4A93 F;  1I6V E;  4YFX E;  4OIR E;  5E18 E;  5E17 E;  4A3F F;  2NVX F;  4OIP E;  2JA7 F;  1SFO F;  4X6A F;  1SMY E;  4C2M F;  3GTQ F;  3RZO F;  3S1Q F;  3DXJ E;  4KMU E;  5M5W F;  2JA5 F;  4G7O E;  4JK1 E;  4Q5S E;  3GTP F;  2E2J F;  1K83 F;  2A6H E;  3S1N F;  1I6H F;  3S16 F;  4YFK E;  2R92 F;  3HOV F;  3FKI F;  3I4N F;  5IPL E;  5FJ8 F;  1I50 F;  3I4M F;  4ZH4 E;  1WCM F;  4Y52 F;  3S2H F;  4QIW K;  2A69 E;  4A3L F;  4KN7 E;  3S2D F;  3HOZ F;  4XSZ E;  4A3M F;  3M3Y F;  4OIQ E;  4C3J F;  1TWA F;  4Y7N F;  2PPB E;  5IYB F;  3GTK F;  4AYB K;  4Q4Z E;  3RZD F;  4XLN E;  4XSX E;  3K7A F;  5M5Y F;  3S1R F;  4MEY E;  4A3I F;  4XLP E;  1TWF F;  1Y1V F;  2B63 F;  3H3V G;  5M5X F;  4A3J F;  1I3Q F;  1TWC F;  4BBS F;  2NVQ F;  4G7Z E;  1HQM E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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