4OIPE

Crystal structure of thermus thermophilus transcription initiation complex soaked with ge23077, atp, and cmpcpp
Total Genus 23
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
94
structure length
94
Chain Sequence
AEPGIDKLFGMVDSKYRLTVVVAKRAQQLLRHGFKNTVLEPEERPKMQTLEGLFDDPNAVTWAMKELLTGRLVFGENLVPEDRLQKEMERLYPV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides.
pubmed rcsb
molecule tags Transcription, transferase/antibiotic
source organism Thermus thermophilus
molecule keywords DNA-directed RNA polymerase subunit alpha
total genus 23
structure length 94
sequence length 94
ec nomenclature ec 2.7.7.6: DNA-directed RNA polymerase.
pdb deposition date 2014-01-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01192 RNA_pol_Rpb6 RNA polymerase Rpb6
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.940.10 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit Eukaryotic RPB6 RNA polymerase subunit 4oipE00
2A6EE 4MEYE 3H3VG 3HOUF 3WODE 5IP7F 1I6VE 4LLGE 3GTOF 4G7OE 3HOZF 5M3MF 4BBSF 4C3IF 1TWHF 4YG2E 3S2DF 1K83F 4KMUE 3GTGF 2E2JF 1TWGF 4A3DF 4OINE 3GTPF 4A3MF 3S15F 4A3KF 3GTJF 4A3LF 2B63F 3HOXF 2A6HE 2YU9F 4A93F 4JK1E 4KN7E 3PO2F 4MEXE 5M5YF 1SFOF 4OIQE 4BBRF 2VUMF 4YFKE 4C3HF 2WB1I 3FKIF 4LJZE 2E2HF 1QKLA 4BXXF 3S16F 3DXJE 5D4CE 4C2MF 2JA8F 3S1NF 1YNNK 3GTLF 4OIOE 2JA7F 4GZYE 1HQME 3M4OF 5E17E 1Y1VF 3H0GF 2R92F 2NVXF 1R9TF 4A3EF 4ZH4E 4KN4E 3HOVF 4AYBK 2JA5F 4A3BF 4Q5SE 4YFNE 5BYHE 5TMCE 2NVQF 5FJ8F 3HOWF 4C3JF 4XLNE 2O5JE 4G7ZE 2A69E 4YFXE 4G7HE 4XLPE 3PO3F 4LK1E 3GTMF 3K7AF 4BY1F 5IYCF 4LK0E 2E2IF 5E18E 3CQZF 3RZDF 2JA6F 3GTKF 4Q4ZE 5IYDF 5IYBF 5C3EF 1TWAF 1YNJK 1TWCF 3HKZK 3GTQF 3I4MF 4MQ9E 4XSZE 4OIPE 2R7ZF 5C44F 3EQLE 1SMYE 1ZYRE 5M3FF 3S1MF 2NVYF 1Y1WF 4A3JF 5C4JF 3S1RF 3RZOF 1IW7E 2A68E 4OIRE 3HOYF 3I4NF 4BY7F 3S17F 2O5IE 2BE5E 4Y52F 5C4XF 4XSXE 5M5XF 1TWFF 1I50F 4A3GF 2R93F 2WAQK 1I3QF 5IP9F 5FLMF 2CW0E 2PMZK 5D4EE 3S2HF 5TMFE 1WCMF 4Y7NF 5M5WF 2NVTF 3M3YF 5D4DE 4A3IF 4X6AF 2Y0SI 4A3FF 4A3CF 3S1QF 1I6HF 5IPLE 3S14F 2PPBE
chains in the Genus database with same CATH superfamily
2A6EE 4MEYE 3H3VG 5C4JE 3HOUF 3H3VF 3WODE 5IP7F 1I6VE 4LLGE 3GTOF 4G7OE 3HOUE 3HOZF 3HOYE 3GTOE 5M3MF 4BBSF 4QIWH 3HOZE 3S17E 4C3IF 1TWHF 4YG2E 5M3ME 1K83F 3S2DF 4BBSE 4KMUE 3GTGF 2E2JF 4C3IE 1TWGF 4A3DF 1I50E 1K83E 2R93E 2E2JE 4OINE 3GTPF 1TWGE 4A3DE 4A3MF 3S15F 4A3KF 4AYBH 3S2HE 3GTJF 5M5WE 2B63F 4A3ME 3HOXF 3M3YE 3S15E 4A3LF 2A6HE 4A3KE 2YU9F 4A93F 4JK1E 4KN7E 3HOXE 2B63E 3PO2F 4MEXE 2YU9E 4A93E 5M5YF 1SFOF 4OIQE 4BBRF 2VUMF 1I6HE 3PO2E 3S14E 4YFKE 1SFOE 4C3HF 4BBRE 2VUME 2WB1I 3FKIF 4LJZE 2E2HF 1QKLA 4BXXF 4C3HE 5IP7E 2E2HE 3S16F 2Y0SH 3DXJE 5D4CE 4C2MF 4QIWK 2JA8F 3S16E 3S1NF 1YNNK 3GTLF 4C2ME 4OIOE 2JA8E 2JA7F 3S1NE 4GZYE 1TWHE 1HQME 3M4OF 3S2DE 5E17E 3GTGE 2JA7E 1DZFA 1Y1VF 3H0GF 2NVXF 1R9TF 2R92F 3M4OE 4A3EF 3GTPE 1Y1VE 3H0GE 4ZH4E 4KN4E 1R9TE 3HOVF 4AYBK 2JA5F 4A3EE 4A3BF 4Q5SE 4YFNE 5TMCE 5BYHE 3GTJE 2NVQF 2JA5E 4A3LE 5FJ8F 3HOWF 4C3JF 4XLNE 2KRXA 2O5JE 4G7ZE 2A69E 4YFXE 5FJ8E 4C3JE 4XLPE 4LK1E 4G7HE 3GTMF 3HOWE 5M5YE 3K7AF 4BY1F 5IYCF 3PO3F 4LK0E 2E2IF 3PO3E 3GTME 5E18E 3CQZF 3FKIE 3RZDF 2JA6F 2E2IE 4Q4ZE 5IYDF 3GTKF 4BXXE 3CQZE 2PMZH 5IYBF 3RZDE 5IYDE 1TWAF 5C3EF 1YNJK 1TWCF 3HKZH 3HKZK 5IYBE 3GTQF 1TWAE 3GTLE 3I4MF 4MQ9E 4XSZE 4OIPE 1TWCE 2R7ZF 2WB1H 3GTQE 5C44F 3EQLE 1SMYE 1ZYRE 5M3FF 3S1MF 2NVYF 2R7ZE 2R92E 2NVXE 5C44E 5M3FE 1Y1WF 4A3JF 5C4JF 3S1RF 3S1ME 3RZOF 1IW7E 3HOVE 1Y1WE 2A68E 4A3JE 3S1RE 4OIRE 3RZOE 3I4NF 3HOYF 1EIKA 4A3BE 2NVQE 3I4NE 4BY7F 3S17F 2O5IE 2BE5E 4Y52F 5C4XF 4BY7E 4XSXE 5M5XF 1TWFF 1I50F 4A3GF 3K7AE 5IYCE 4BY1E 2R93F 2WAQH 4Y52E 2WAQK 5C4XE 5M5XE 1TWFE 1I3QF 5IP9F 5FLMF 4A3GE 2CW0E 2PMZK 2JA6E 3GTKE 5D4EE 1I3QE 5IP9E 5FLME 3S2HF 5TMFE 1WCMF 4Y7NF 5M5WF 2NVTF 3M3YF 5C3EE 5D4DE 4A3IF 4X6AF 4Y7NE 1WCME 2NVTE 2Y0SI 4A3FF 3I4ME 4A3IE 4A3CF 4X6AE 3S1QF 1I6HF 5IPLE 4A3FE 3S14F 2PPBE 4A3CE 3S1QE 2NVYE
chains in the Genus database with same CATH topology
2A6EE 4MEYE 3H3VG 3HOUF 3WODE 5IP7F 1I6VE 4LLGE 3GTOF 4G7OE 3HOZF 5M3MF 4BBSF 4C3IF 1TWHF 4YG2E 3S2DF 1K83F 4KMUE 3GTGF 2E2JF 1TWGF 4A3DF 4OINE 3GTPF 4A3MF 3S15F 4A3KF 3GTJF 4A3LF 2B63F 3HOXF 2A6HE 2YU9F 4A93F 4JK1E 4KN7E 3PO2F 4MEXE 5M5YF 1SFOF 4OIQE 4BBRF 2VUMF 4YFKE 4C3HF 2WB1I 3FKIF 4LJZE 2E2HF 1QKLA 4BXXF 3S16F 3DXJE 5D4CE 4C2MF 4QIWK 2JA8F 3S1NF 1YNNK 3GTLF 4OIOE 2JA7F 4GZYE 1HQME 3M4OF 5E17E 1Y1VF 3H0GF 2R92F 2NVXF 1R9TF 4A3EF 4ZH4E 4KN4E 3HOVF 4AYBK 2JA5F 4A3BF 4Q5SE 4YFNE 5BYHE 5TMCE 2NVQF 5FJ8F 3HOWF 4C3JF 4XLNE 2KRXA 2O5JE 4G7ZE 2A69E 4YFXE 4G7HE 4XLPE 3PO3F 4LK1E 3GTMF 3K7AF 4BY1F 5IYCF 4LK0E 2E2IF 5E18E 3CQZF 3RZDF 2JA6F 3GTKF 4Q4ZE 5IYDF 5IYBF 5C3EF 1TWAF 1YNJK 1TWCF 3HKZK 3GTQF 3I4MF 4MQ9E 4XSZE 4OIPE 2R7ZF 5C44F 3EQLE 1SMYE 1ZYRE 5M3FF 3S1MF 2NVYF 1Y1WF 4A3JF 5C4JF 3S1RF 3RZOF 1IW7E 2A68E 4OIRE 3HOYF 3I4NF 4BY7F 3S17F 2O5IE 2BE5E 4Y52F 5C4XF 4XSXE 5M5XF 1TWFF 1I50F 4A3GF 2R93F 2WAQK 1I3QF 5IP9F 5FLMF 2CW0E 2PMZK 5D4EE 3S2HF 5TMFE 1WCMF 4Y7NF 5M5WF 2NVTF 3M3YF 5D4DE 4A3IF 4X6AF 2Y0SI 4A3FF 4A3CF 3S1QF 1I6HF 5IPLE 3S14F 2PPBE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2A6E E;  4MEY E;  3H3V G;  3HOU F;  3WOD E;  5IP7 F;  1I6V E;  4LLG E;  3GTO F;  4G7O E;  3HOZ F;  5M3M F;  4BBS F;  4C3I F;  1TWH F;  4YG2 E;  3S2D F;  1K83 F;  4KMU E;  3GTG F;  2E2J F;  1TWG F;  4A3D F;  4OIN E;  3GTP F;  4A3M F;  3S15 F;  4A3K F;  3GTJ F;  4A3L F;  2B63 F;  3HOX F;  2A6H E;  2YU9 F;  4A93 F;  4JK1 E;  4KN7 E;  3PO2 F;  4MEX E;  5M5Y F;  1SFO F;  4OIQ E;  4BBR F;  2VUM F;  4YFK E;  4C3H F;  2WB1 I;  3FKI F;  4LJZ E;  2E2H F;  1QKL A;  4BXX F;  3S16 F;  3DXJ E;  5D4C E;  4C2M F;  2JA8 F;  3S1N F;  1YNN K;  3GTL F;  4OIO E;  2JA7 F;  4GZY E;  1HQM E;  3M4O F;  5E17 E;  1Y1V F;  3H0G F;  2R92 F;  2NVX F;  1R9T F;  4A3E F;  4ZH4 E;  4KN4 E;  3HOV F;  4AYB K;  2JA5 F;  4A3B F;  4Q5S E;  4YFN E;  5BYH E;  5TMC E;  2NVQ F;  5FJ8 F;  3HOW F;  4C3J F;  4XLN E;  2O5J E;  4G7Z E;  2A69 E;  4YFX E;  4G7H E;  4XLP E;  3PO3 F;  4LK1 E;  3GTM F;  3K7A F;  4BY1 F;  5IYC F;  4LK0 E;  2E2I F;  5E18 E;  3CQZ F;  3RZD F;  2JA6 F;  3GTK F;  4Q4Z E;  5IYD F;  5IYB F;  5C3E F;  1TWA F;  1YNJ K;  1TWC F;  3HKZ K;  3GTQ F;  3I4M F;  4MQ9 E;  4XSZ E;  4OIP E;  2R7Z F;  5C44 F;  3EQL E;  1SMY E;  1ZYR E;  5M3F F;  3S1M F;  2NVY F;  1Y1W F;  4A3J F;  5C4J F;  3S1R F;  3RZO F;  1IW7 E;  2A68 E;  4OIR E;  3HOY F;  3I4N F;  4BY7 F;  3S17 F;  2O5I E;  2BE5 E;  4Y52 F;  5C4X F;  4XSX E;  5M5X F;  1TWF F;  1I50 F;  4A3G F;  2R93 F;  2WAQ K;  1I3Q F;  5IP9 F;  5FLM F;  2CW0 E;  2PMZ K;  5D4E E;  3S2H F;  5TMF E;  1WCM F;  4Y7N F;  5M5W F;  2NVT F;  3M3Y F;  5D4D E;  4A3I F;  4X6A F;  2Y0S I;  4A3F F;  4A3C F;  3S1Q F;  1I6H F;  5IPL E;  3S14 F;  2PPB E; 
#chains in the Genus database with same CATH topology
 2A6E E;  4MEY E;  3H3V G;  5C4J E;  3HOU F;  3H3V F;  3WOD E;  5IP7 F;  1I6V E;  4LLG E;  3GTO F;  4G7O E;  3HOU E;  3HOZ F;  3HOY E;  3GTO E;  5M3M F;  4BBS F;  4QIW H;  3HOZ E;  3S17 E;  4C3I F;  1TWH F;  4YG2 E;  5M3M E;  1K83 F;  3S2D F;  4BBS E;  4KMU E;  3GTG F;  2E2J F;  4C3I E;  1TWG F;  4A3D F;  1I50 E;  1K83 E;  2R93 E;  2E2J E;  4OIN E;  3GTP F;  1TWG E;  4A3D E;  4A3M F;  3S15 F;  4A3K F;  4AYB H;  3S2H E;  3GTJ F;  5M5W E;  2B63 F;  4A3M E;  3HOX F;  3M3Y E;  3S15 E;  4A3L F;  2A6H E;  4A3K E;  2YU9 F;  4A93 F;  4JK1 E;  4KN7 E;  3HOX E;  2B63 E;  3PO2 F;  4MEX E;  2YU9 E;  4A93 E;  5M5Y F;  1SFO F;  4OIQ E;  4BBR F;  2VUM F;  1I6H E;  3PO2 E;  3S14 E;  4YFK E;  1SFO E;  4C3H F;  4BBR E;  2VUM E;  2WB1 I;  3FKI F;  4LJZ E;  2E2H F;  1QKL A;  4BXX F;  4C3H E;  5IP7 E;  2E2H E;  3S16 F;  2Y0S H;  3DXJ E;  5D4C E;  4C2M F;  4QIW K;  2JA8 F;  3S16 E;  3S1N F;  1YNN K;  3GTL F;  4C2M E;  4OIO E;  2JA8 E;  2JA7 F;  3S1N E;  4GZY E;  1TWH E;  1HQM E;  3M4O F;  3S2D E;  5E17 E;  3GTG E;  2JA7 E;  1DZF A;  1Y1V F;  3H0G F;  2NVX F;  1R9T F;  2R92 F;  3M4O E;  4A3E F;  3GTP E;  1Y1V E;  3H0G E;  4ZH4 E;  4KN4 E;  1R9T E;  3HOV F;  4AYB K;  2JA5 F;  4A3E E;  4A3B F;  4Q5S E;  4YFN E;  5TMC E;  5BYH E;  3GTJ E;  2NVQ F;  2JA5 E;  4A3L E;  5FJ8 F;  3HOW F;  4C3J F;  4XLN E;  2KRX A;  2O5J E;  4G7Z E;  2A69 E;  4YFX E;  5FJ8 E;  4C3J E;  4XLP E;  4LK1 E;  4G7H E;  3GTM F;  3HOW E;  5M5Y E;  3K7A F;  4BY1 F;  5IYC F;  3PO3 F;  4LK0 E;  2E2I F;  3PO3 E;  3GTM E;  5E18 E;  3CQZ F;  3FKI E;  3RZD F;  2JA6 F;  2E2I E;  4Q4Z E;  5IYD F;  3GTK F;  4BXX E;  3CQZ E;  2PMZ H;  5IYB F;  3RZD E;  5IYD E;  1TWA F;  5C3E F;  1YNJ K;  1TWC F;  3HKZ H;  3HKZ K;  5IYB E;  3GTQ F;  1TWA E;  3GTL E;  3I4M F;  4MQ9 E;  4XSZ E;  4OIP E;  1TWC E;  2R7Z F;  2WB1 H;  3GTQ E;  5C44 F;  3EQL E;  1SMY E;  1ZYR E;  5M3F F;  3S1M F;  2NVY F;  2R7Z E;  2R92 E;  2NVX E;  5C44 E;  5M3F E;  1Y1W F;  4A3J F;  5C4J F;  3S1R F;  3S1M E;  3RZO F;  1IW7 E;  3HOV E;  1Y1W E;  2A68 E;  4A3J E;  3S1R E;  4OIR E;  3RZO E;  3I4N F;  3HOY F;  1EIK A;  4A3B E;  2NVQ E;  3I4N E;  4BY7 F;  3S17 F;  2O5I E;  2BE5 E;  4Y52 F;  5C4X F;  4BY7 E;  4XSX E;  5M5X F;  1TWF F;  1I50 F;  4A3G F;  3K7A E;  5IYC E;  4BY1 E;  2R93 F;  2WAQ H;  4Y52 E;  2WAQ K;  5C4X E;  5M5X E;  1TWF E;  1I3Q F;  5IP9 F;  5FLM F;  4A3G E;  2CW0 E;  2PMZ K;  2JA6 E;  3GTK E;  5D4E E;  1I3Q E;  5IP9 E;  5FLM E;  3S2H F;  5TMF E;  1WCM F;  4Y7N F;  5M5W F;  2NVT F;  3M3Y F;  5C3E E;  5D4D E;  4A3I F;  4X6A F;  4Y7N E;  1WCM E;  2NVT E;  2Y0S I;  4A3F F;  3I4M E;  4A3I E;  4A3C F;  4X6A E;  3S1Q F;  1I6H F;  5IPL E;  4A3F E;  3S14 F;  2PPB E;  4A3C E;  3S1Q E;  2NVY E; 
#chains in the Genus database with same CATH homology
 2A6E E;  4MEY E;  3H3V G;  3HOU F;  3WOD E;  5IP7 F;  1I6V E;  4LLG E;  3GTO F;  4G7O E;  3HOZ F;  5M3M F;  4BBS F;  4C3I F;  1TWH F;  4YG2 E;  3S2D F;  1K83 F;  4KMU E;  3GTG F;  2E2J F;  1TWG F;  4A3D F;  4OIN E;  3GTP F;  4A3M F;  3S15 F;  4A3K F;  3GTJ F;  4A3L F;  2B63 F;  3HOX F;  2A6H E;  2YU9 F;  4A93 F;  4JK1 E;  4KN7 E;  3PO2 F;  4MEX E;  5M5Y F;  1SFO F;  4OIQ E;  4BBR F;  2VUM F;  4YFK E;  4C3H F;  2WB1 I;  3FKI F;  4LJZ E;  2E2H F;  1QKL A;  4BXX F;  3S16 F;  3DXJ E;  5D4C E;  4C2M F;  4QIW K;  2JA8 F;  3S1N F;  1YNN K;  3GTL F;  4OIO E;  2JA7 F;  4GZY E;  1HQM E;  3M4O F;  5E17 E;  1Y1V F;  3H0G F;  2R92 F;  2NVX F;  1R9T F;  4A3E F;  4ZH4 E;  4KN4 E;  3HOV F;  4AYB K;  2JA5 F;  4A3B F;  4Q5S E;  4YFN E;  5BYH E;  5TMC E;  2NVQ F;  5FJ8 F;  3HOW F;  4C3J F;  4XLN E;  2KRX A;  2O5J E;  4G7Z E;  2A69 E;  4YFX E;  4G7H E;  4XLP E;  3PO3 F;  4LK1 E;  3GTM F;  3K7A F;  4BY1 F;  5IYC F;  4LK0 E;  2E2I F;  5E18 E;  3CQZ F;  3RZD F;  2JA6 F;  3GTK F;  4Q4Z E;  5IYD F;  5IYB F;  5C3E F;  1TWA F;  1YNJ K;  1TWC F;  3HKZ K;  3GTQ F;  3I4M F;  4MQ9 E;  4XSZ E;  4OIP E;  2R7Z F;  5C44 F;  3EQL E;  1SMY E;  1ZYR E;  5M3F F;  3S1M F;  2NVY F;  1Y1W F;  4A3J F;  5C4J F;  3S1R F;  3RZO F;  1IW7 E;  2A68 E;  4OIR E;  3HOY F;  3I4N F;  4BY7 F;  3S17 F;  2O5I E;  2BE5 E;  4Y52 F;  5C4X F;  4XSX E;  5M5X F;  1TWF F;  1I50 F;  4A3G F;  2R93 F;  2WAQ K;  1I3Q F;  5IP9 F;  5FLM F;  2CW0 E;  2PMZ K;  5D4E E;  3S2H F;  5TMF E;  1WCM F;  4Y7N F;  5M5W F;  2NVT F;  3M3Y F;  5D4D E;  4A3I F;  4X6A F;  2Y0S I;  4A3F F;  4A3C F;  3S1Q F;  1I6H F;  5IPL E;  3S14 F;  2PPB E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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