4TPII

The refined 2.2-angstroms (0.22-nm) x-ray crystal structure of the ternary complex formed by bovine trypsinogen, valine-valine and the arg15 analogue of bovine pancreatic trypsin inhibitor
Total Genus 12
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
58
structure length
58
Chain Sequence
RPDFCLEPPYTGPCRARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The refined 2.2-A (0.22-nm) X-ray crystal structure of the ternary complex formed by bovine trypsinogen, valine-valine and the Arg15 analogue of bovine pancreatic trypsin inhibitor
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
molecule keywords TRYPSINOGEN
total genus 12
structure length 58
sequence length 58
ec nomenclature
pdb deposition date 1985-06-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 4tpiI00
1YKTB 1BPIA 1G6XA 5JB5A 1D0DA 2FI4I 3BTMI 1CA0D 1DENA 1BTIA 2ZVXA 3D65I 4Y0YI 3FP7J 1OA65 3BTKI 7PTIA 4BD9B 2LFKA 3T62D 1P2QB 1TFXC 5C67C 3FP6I 1K6UA 3LDIA 2TPII 2CA7A 2W8XA 4NTXB 4U32X 3BYBA 1B0CA 4NTWB 2J6DA 1QLQA 1BZ5A 3CI7A 1P2KI 4DTGK 3BTDI 1BRBI 3L33E 1YLCB 1T7CB 2M99A 2R9PE 2KCRA 3LDMA 1AALA 1D0DB 1IRHA 1PITA 3AUIA 8PTIA 1BIKA 1ZR0B 1NAGA 9PTIA 2HEXA 3TGJI 1T8LB 3BTHI 1T8NB 1KNTA 1TAPA 1TAWB 1UUBA 1OA55 3GYMI 1TCPA 4Y0ZI 5PTIA 2LFLA 1LD5A 1AAPA 1T8OB 1DTXA 1P2II 2KNTA 3P95E 4DG4C 1KUNA 3FP8I 1FY8I 3AUDA 1CBWD 1JV8A 4PTIA 1KIGI 1SHPA 2FTLI 1F7ZI 1P2NB 4BNRI 5JB6A 2FI3I 2ZJXA 2JOTA 3UOUB 1FANA 1DEMA 2UUYB 2PTCI 4ISOB 4Y11I 3BTEI 4U30W 2M01A 1JV9A 3U1JE 3TPII 3BTGI 1ADZA 1LD6A 2FTMB 1JC6A 2IJOI 1P2JI 3WNYA 1TOCR 1YC0I 1BPTA 1BZXI 4WXVC 2KAII 1BRCI 5JB4A 1EAWB 1P2MB 3AUHA 1BTHP 3TGKI 1KTHA 1TPAI 1EJMB 4NTYB 4ISLB 2ODYE 1MTND 2UUXA 3OFWA 1UUAA 2FI5I 3P92E 3M7QB 1F5RI 4ISNB 3BTWI 3TGII 3AUGA 3AUCA 1BHCA 2RA3C 1BUNB 1ZJDB 1CO7I 3AUEA 4Y10I 4TPII 6PTIA 1DTKA 3OTJI 1P2OB 3AUBA 2TGPI 2DDJA 1YLDB 1T8MB 3BTFI 3BTQI 1FAKI 3LDJA 1BF0A 3L3TE 2DDIA 4WWYC 4BQDA 3UIRC 3BTTI 1Y62A 5JB7A
chains in the Genus database with same CATH superfamily
1YKTB 1BPIA 1G6XA 5JB5A 1D0DA 2FI4I 3BTMI 1CA0D 1DENA 1BTIA 2ZVXA 3D65I 4Y0YI 3FP7J 1OA65 3BTKI 7PTIA 4BD9B 2LFKA 3T62D 1P2QB 1TFXC 5C67C 3FP6I 1K6UA 3LDIA 2TPII 2CA7A 2W8XA 4NTXB 4U32X 3BYBA 1B0CA 4NTWB 2J6DA 1QLQA 1BZ5A 3CI7A 1P2KI 4DTGK 3BTDI 1BRBI 3L33E 1YLCB 1T7CB 2M99A 2R9PE 2KCRA 3LDMA 1AALA 1D0DB 1IRHA 1PITA 3AUIA 8PTIA 1BIKA 1ZR0B 1NAGA 9PTIA 2HEXA 3TGJI 1T8LB 3BTHI 1T8NB 1KNTA 1TAPA 1TAWB 1UUBA 1OA55 3GYMI 1TCPA 4Y0ZI 5PTIA 2LFLA 1LD5A 1AAPA 1T8OB 1DTXA 1P2II 2KNTA 3P95E 4DG4C 1KUNA 3FP8I 1FY8I 3AUDA 1CBWD 1JV8A 4PTIA 1KIGI 1SHPA 2FTLI 1F7ZI 1P2NB 4BNRI 5JB6A 2FI3I 2ZJXA 2JOTA 3UOUB 1FANA 1DEMA 2UUYB 2PTCI 4ISOB 4Y11I 3BTEI 4U30W 2M01A 1JV9A 3U1JE 3TPII 3BTGI 1ADZA 1LD6A 2FTMB 1JC6A 2IJOI 1P2JI 3WNYA 1TOCR 1YC0I 1BPTA 1BZXI 4WXVC 2KAII 1BRCI 5JB4A 1EAWB 1P2MB 3AUHA 1BTHP 3TGKI 1KTHA 1TPAI 1EJMB 4NTYB 4ISLB 2ODYE 1MTND 2UUXA 3OFWA 1UUAA 2FI5I 3P92E 3M7QB 1F5RI 4ISNB 3BTWI 3TGII 3AUGA 3AUCA 1BHCA 2RA3C 1BUNB 1ZJDB 1CO7I 3AUEA 4Y10I 4TPII 6PTIA 1DTKA 3OTJI 1P2OB 3AUBA 2TGPI 2DDJA 1YLDB 1T8MB 3BTFI 3BTQI 1FAKI 3LDJA 1BF0A 3L3TE 2DDIA 4WWYC 4BQDA 3UIRC 3BTTI 1Y62A 5JB7A
chains in the Genus database with same CATH topology
1YKTB 1BPIA 1G6XA 5JB5A 1D0DA 2FI4I 3BTMI 1CA0D 1DENA 1BTIA 2ZVXA 3D65I 4Y0YI 3FP7J 1OA65 3BTKI 7PTIA 4BD9B 2LFKA 3T62D 1P2QB 1TFXC 5C67C 3FP6I 1K6UA 3LDIA 2TPII 2CA7A 2W8XA 4NTXB 4U32X 3BYBA 1B0CA 4NTWB 2J6DA 1QLQA 1BZ5A 3CI7A 1P2KI 4DTGK 3BTDI 1BRBI 3L33E 1YLCB 1T7CB 2M99A 2R9PE 2KCRA 3LDMA 1AALA 1D0DB 1IRHA 1PITA 3AUIA 8PTIA 1BIKA 1ZR0B 1NAGA 9PTIA 2HEXA 3TGJI 1T8LB 3BTHI 1T8NB 1KNTA 1TAPA 1TAWB 1UUBA 1OA55 3GYMI 1TCPA 4Y0ZI 5PTIA 2LFLA 1LD5A 1AAPA 1T8OB 1DTXA 1P2II 2KNTA 3P95E 4DG4C 1KUNA 3FP8I 1FY8I 3AUDA 1CBWD 1JV8A 4PTIA 1KIGI 1SHPA 2FTLI 1F7ZI 1P2NB 4BNRI 5JB6A 2FI3I 2ZJXA 2JOTA 3UOUB 1FANA 1DEMA 2UUYB 2PTCI 4ISOB 4Y11I 3BTEI 4U30W 2M01A 1JV9A 3U1JE 3TPII 3BTGI 1ADZA 1LD6A 2FTMB 1JC6A 2IJOI 1P2JI 3WNYA 1TOCR 1YC0I 1BPTA 1BZXI 4WXVC 2KAII 1BRCI 5JB4A 1EAWB 1P2MB 3AUHA 1BTHP 3TGKI 1KTHA 1TPAI 1EJMB 4NTYB 4ISLB 2ODYE 1MTND 2UUXA 3OFWA 1UUAA 2FI5I 3P92E 3M7QB 1F5RI 4ISNB 3BTWI 3TGII 3AUGA 3AUCA 1BHCA 2RA3C 1BUNB 1ZJDB 1CO7I 3AUEA 4Y10I 4TPII 6PTIA 1DTKA 3OTJI 1P2OB 3AUBA 2TGPI 2DDJA 1YLDB 1T8MB 3BTFI 3BTQI 1FAKI 3LDJA 1BF0A 3L3TE 2DDIA 4WWYC 4BQDA 3UIRC 3BTTI 1Y62A 5JB7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YKT B;  1BPI A;  1G6X A;  5JB5 A;  1D0D A;  2FI4 I;  3BTM I;  1CA0 D;  1DEN A;  1BTI A;  2ZVX A;  3D65 I;  4Y0Y I;  3FP7 J;  1OA6 5;  3BTK I;  7PTI A;  4BD9 B;  2LFK A;  3T62 D;  1P2Q B;  1TFX C;  5C67 C;  3FP6 I;  1K6U A;  3LDI A;  2TPI I;  2CA7 A;  2W8X A;  4NTX B;  4U32 X;  3BYB A;  1B0C A;  4NTW B;  2J6D A;  1QLQ A;  1BZ5 A;  3CI7 A;  1P2K I;  4DTG K;  3BTD I;  1BRB I;  3L33 E;  1YLC B;  1T7C B;  2M99 A;  2R9P E;  2KCR A;  3LDM A;  1AAL A;  1D0D B;  1IRH A;  1PIT A;  3AUI A;  8PTI A;  1BIK A;  1ZR0 B;  1NAG A;  9PTI A;  2HEX A;  3TGJ I;  1T8L B;  3BTH I;  1T8N B;  1KNT A;  1TAP A;  1TAW B;  1UUB A;  1OA5 5;  3GYM I;  1TCP A;  4Y0Z I;  5PTI A;  2LFL A;  1LD5 A;  1AAP A;  1T8O B;  1DTX A;  1P2I I;  2KNT A;  3P95 E;  4DG4 C;  1KUN A;  3FP8 I;  1FY8 I;  3AUD A;  1CBW D;  1JV8 A;  4PTI A;  1KIG I;  1SHP A;  2FTL I;  1F7Z I;  1P2N B;  4BNR I;  5JB6 A;  2FI3 I;  2ZJX A;  2JOT A;  3UOU B;  1FAN A;  1DEM A;  2UUY B;  2PTC I;  4ISO B;  4Y11 I;  3BTE I;  4U30 W;  2M01 A;  1JV9 A;  3U1J E;  3TPI I;  3BTG I;  1ADZ A;  1LD6 A;  2FTM B;  1JC6 A;  2IJO I;  1P2J I;  3WNY A;  1TOC R;  1YC0 I;  1BPT A;  1BZX I;  4WXV C;  2KAI I;  1BRC I;  5JB4 A;  1EAW B;  1P2M B;  3AUH A;  1BTH P;  3TGK I;  1KTH A;  1TPA I;  1EJM B;  4NTY B;  4ISL B;  2ODY E;  1MTN D;  2UUX A;  3OFW A;  1UUA A;  2FI5 I;  3P92 E;  3M7Q B;  1F5R I;  4ISN B;  3BTW I;  3TGI I;  3AUG A;  3AUC A;  1BHC A;  2RA3 C;  1BUN B;  1ZJD B;  1CO7 I;  3AUE A;  4Y10 I;  4TPI I;  6PTI A;  1DTK A;  3OTJ I;  1P2O B;  3AUB A;  2TGP I;  2DDJ A;  1YLD B;  1T8M B;  3BTF I;  3BTQ I;  1FAK I;  3LDJ A;  1BF0 A;  3L3T E;  2DDI A;  4WWY C;  4BQD A;  3UIR C;  3BTT I;  1Y62 A;  5JB7 A; 
#chains in the Genus database with same CATH topology
 1YKT B;  1BPI A;  1G6X A;  5JB5 A;  1D0D A;  2FI4 I;  3BTM I;  1CA0 D;  1DEN A;  1BTI A;  2ZVX A;  3D65 I;  4Y0Y I;  3FP7 J;  1OA6 5;  3BTK I;  7PTI A;  4BD9 B;  2LFK A;  3T62 D;  1P2Q B;  1TFX C;  5C67 C;  3FP6 I;  1K6U A;  3LDI A;  2TPI I;  2CA7 A;  2W8X A;  4NTX B;  4U32 X;  3BYB A;  1B0C A;  4NTW B;  2J6D A;  1QLQ A;  1BZ5 A;  3CI7 A;  1P2K I;  4DTG K;  3BTD I;  1BRB I;  3L33 E;  1YLC B;  1T7C B;  2M99 A;  2R9P E;  2KCR A;  3LDM A;  1AAL A;  1D0D B;  1IRH A;  1PIT A;  3AUI A;  8PTI A;  1BIK A;  1ZR0 B;  1NAG A;  9PTI A;  2HEX A;  3TGJ I;  1T8L B;  3BTH I;  1T8N B;  1KNT A;  1TAP A;  1TAW B;  1UUB A;  1OA5 5;  3GYM I;  1TCP A;  4Y0Z I;  5PTI A;  2LFL A;  1LD5 A;  1AAP A;  1T8O B;  1DTX A;  1P2I I;  2KNT A;  3P95 E;  4DG4 C;  1KUN A;  3FP8 I;  1FY8 I;  3AUD A;  1CBW D;  1JV8 A;  4PTI A;  1KIG I;  1SHP A;  2FTL I;  1F7Z I;  1P2N B;  4BNR I;  5JB6 A;  2FI3 I;  2ZJX A;  2JOT A;  3UOU B;  1FAN A;  1DEM A;  2UUY B;  2PTC I;  4ISO B;  4Y11 I;  3BTE I;  4U30 W;  2M01 A;  1JV9 A;  3U1J E;  3TPI I;  3BTG I;  1ADZ A;  1LD6 A;  2FTM B;  1JC6 A;  2IJO I;  1P2J I;  3WNY A;  1TOC R;  1YC0 I;  1BPT A;  1BZX I;  4WXV C;  2KAI I;  1BRC I;  5JB4 A;  1EAW B;  1P2M B;  3AUH A;  1BTH P;  3TGK I;  1KTH A;  1TPA I;  1EJM B;  4NTY B;  4ISL B;  2ODY E;  1MTN D;  2UUX A;  3OFW A;  1UUA A;  2FI5 I;  3P92 E;  3M7Q B;  1F5R I;  4ISN B;  3BTW I;  3TGI I;  3AUG A;  3AUC A;  1BHC A;  2RA3 C;  1BUN B;  1ZJD B;  1CO7 I;  3AUE A;  4Y10 I;  4TPI I;  6PTI A;  1DTK A;  3OTJ I;  1P2O B;  3AUB A;  2TGP I;  2DDJ A;  1YLD B;  1T8M B;  3BTF I;  3BTQ I;  1FAK I;  3LDJ A;  1BF0 A;  3L3T E;  2DDI A;  4WWY C;  4BQD A;  3UIR C;  3BTT I;  1Y62 A;  5JB7 A; 
#chains in the Genus database with same CATH homology
 1YKT B;  1BPI A;  1G6X A;  5JB5 A;  1D0D A;  2FI4 I;  3BTM I;  1CA0 D;  1DEN A;  1BTI A;  2ZVX A;  3D65 I;  4Y0Y I;  3FP7 J;  1OA6 5;  3BTK I;  7PTI A;  4BD9 B;  2LFK A;  3T62 D;  1P2Q B;  1TFX C;  5C67 C;  3FP6 I;  1K6U A;  3LDI A;  2TPI I;  2CA7 A;  2W8X A;  4NTX B;  4U32 X;  3BYB A;  1B0C A;  4NTW B;  2J6D A;  1QLQ A;  1BZ5 A;  3CI7 A;  1P2K I;  4DTG K;  3BTD I;  1BRB I;  3L33 E;  1YLC B;  1T7C B;  2M99 A;  2R9P E;  2KCR A;  3LDM A;  1AAL A;  1D0D B;  1IRH A;  1PIT A;  3AUI A;  8PTI A;  1BIK A;  1ZR0 B;  1NAG A;  9PTI A;  2HEX A;  3TGJ I;  1T8L B;  3BTH I;  1T8N B;  1KNT A;  1TAP A;  1TAW B;  1UUB A;  1OA5 5;  3GYM I;  1TCP A;  4Y0Z I;  5PTI A;  2LFL A;  1LD5 A;  1AAP A;  1T8O B;  1DTX A;  1P2I I;  2KNT A;  3P95 E;  4DG4 C;  1KUN A;  3FP8 I;  1FY8 I;  3AUD A;  1CBW D;  1JV8 A;  4PTI A;  1KIG I;  1SHP A;  2FTL I;  1F7Z I;  1P2N B;  4BNR I;  5JB6 A;  2FI3 I;  2ZJX A;  2JOT A;  3UOU B;  1FAN A;  1DEM A;  2UUY B;  2PTC I;  4ISO B;  4Y11 I;  3BTE I;  4U30 W;  2M01 A;  1JV9 A;  3U1J E;  3TPI I;  3BTG I;  1ADZ A;  1LD6 A;  2FTM B;  1JC6 A;  2IJO I;  1P2J I;  3WNY A;  1TOC R;  1YC0 I;  1BPT A;  1BZX I;  4WXV C;  2KAI I;  1BRC I;  5JB4 A;  1EAW B;  1P2M B;  3AUH A;  1BTH P;  3TGK I;  1KTH A;  1TPA I;  1EJM B;  4NTY B;  4ISL B;  2ODY E;  1MTN D;  2UUX A;  3OFW A;  1UUA A;  2FI5 I;  3P92 E;  3M7Q B;  1F5R I;  4ISN B;  3BTW I;  3TGI I;  3AUG A;  3AUC A;  1BHC A;  2RA3 C;  1BUN B;  1ZJD B;  1CO7 I;  3AUE A;  4Y10 I;  4TPI I;  6PTI A;  1DTK A;  3OTJ I;  1P2O B;  3AUB A;  2TGP I;  2DDJ A;  1YLD B;  1T8M B;  3BTF I;  3BTQ I;  1FAK I;  3LDJ A;  1BF0 A;  3L3T E;  2DDI A;  4WWY C;  4BQD A;  3UIR C;  3BTT I;  1Y62 A;  5JB7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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