4U32X

Human mesotrypsin complexed with hai-2 kunitz domain 1
Total Genus 12
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
54
structure length
54
Chain Sequence
HDFCLVSKVVGRCRASMPRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKC
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Sequence and Conformational Specificity in Substrate Recognition: SEVERAL HUMAN KUNITZ PROTEASE INHIBITOR DOMAINS ARE SPECIFIC SUBSTRATES OF MESOTRYPSIN.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Kunitz-type protease inhibitor 2
total genus 12
structure length 54
sequence length 54
ec nomenclature
pdb deposition date 2014-07-18
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 4u32X00
1DEMA 1F7ZI 1BTHP 2ZVXA 2PTCI 4Y0ZI 3TGII 1LD5A 1KNTA 2FTLI 3BTMI 1YKTB 4DG4C 2TPII 3AUCA 1KIGI 4WWYC 1D0DB 1SHPA 3CI7A 7PTIA 1BIKA 2LFKA 1P2MB 1P2QB 4Y0YI 3BTHI 2DDJA 1DTXA 2CA7A 2HEXA 3AUEA 1K6UA 4NTYB 1LD6A 1TOCR 2FI5I 3AUBA 1DTKA 3L3TE 1BPTA 1TPAI 1P2II 2KNTA 4DTGK 3BTEI 1KUNA 4ISOB 3AUIA 3TGJI 2W8XA 2UUXA 6PTIA 2TGPI 3LDIA 1JV8A 1TFXC 3TPII 1PITA 5JB7A 2LFLA 9PTIA 1D0DA 2ODYE 4WXVC 1CA0D 4Y10I 3BYBA 5PTIA 1BTIA 1NAGA 2IJOI 2FI4I 1OA55 1FY8I 1UUAA 5C67C 3BTDI 1BRBI 4U32X 1BUNB 1ZR0B 3BTFI 4BD9B 4BQDA 1OA65 1T7CB 1BZ5A 3P95E 3P92E 3OFWA 4TPII 1CBWD 1KTHA 2UUYB 1QLQA 8PTIA 3WNYA 4Y11I 1UUBA 1TAPA 2KAII 3D65I 3LDJA 2ZJXA 3BTGI 3L33E 1JV9A 1P2OB 2J6DA 1F5RI 1EJMB 3BTWI 3UOUB 1T8OB 3T62D 3AUGA 3GYMI 3U1JE 3FP6I 4ISLB 1YC0I 2FI3I 3M7QB 1FAKI 3BTTI 2FTMB 4U30W 3BTKI 1P2KI 2M99A 3BTQI 1P2NB 2RA3C 3FP7J 1G6XA 5JB4A 1BRCI 1YLCB 1ADZA 1BF0A 2JOTA 1T8NB 1IRHA 1ZJDB 1CO7I 1YLDB 4NTWB 4PTIA 1JC6A 1AALA 1BZXI 5JB5A 1BHCA 4NTXB 2M01A 3AUDA 3AUHA 1DENA 2KCRA 1AAPA 1TAWB 1T8LB 1TCPA 1B0CA 1EAWB 3OTJI 1T8MB 1FANA 4BNRI 5JB6A 3TGKI 1BPIA 3FP8I 1Y62A 3LDMA 1P2JI 3UIRC 2DDIA 1MTND 2R9PE 4ISNB
chains in the Genus database with same CATH superfamily
1DEMA 1F7ZI 1BTHP 2ZVXA 2PTCI 4Y0ZI 3TGII 1LD5A 1KNTA 2FTLI 3BTMI 1YKTB 4DG4C 2TPII 3AUCA 1KIGI 4WWYC 1D0DB 1SHPA 3CI7A 7PTIA 1BIKA 2LFKA 1P2MB 1P2QB 4Y0YI 3BTHI 2DDJA 1DTXA 2CA7A 2HEXA 3AUEA 1K6UA 4NTYB 1LD6A 1TOCR 2FI5I 3AUBA 1DTKA 3L3TE 1BPTA 1TPAI 1P2II 2KNTA 4DTGK 3BTEI 1KUNA 4ISOB 3AUIA 3TGJI 2W8XA 2UUXA 6PTIA 2TGPI 3LDIA 1JV8A 1TFXC 3TPII 1PITA 5JB7A 2LFLA 9PTIA 1D0DA 2ODYE 4WXVC 1CA0D 4Y10I 3BYBA 5PTIA 1BTIA 1NAGA 2IJOI 2FI4I 1OA55 1FY8I 1UUAA 5C67C 3BTDI 1BRBI 4U32X 1BUNB 1ZR0B 3BTFI 4BD9B 4BQDA 1OA65 1T7CB 1BZ5A 3P95E 3P92E 3OFWA 4TPII 1CBWD 1KTHA 2UUYB 1QLQA 8PTIA 3WNYA 4Y11I 1UUBA 1TAPA 2KAII 3D65I 3LDJA 2ZJXA 3BTGI 3L33E 1JV9A 1P2OB 2J6DA 1F5RI 1EJMB 3BTWI 3UOUB 1T8OB 3T62D 3AUGA 3GYMI 3U1JE 3FP6I 4ISLB 1YC0I 2FI3I 3M7QB 1FAKI 3BTTI 2FTMB 4U30W 3BTKI 1P2KI 2M99A 3BTQI 1P2NB 2RA3C 3FP7J 1G6XA 5JB4A 1BRCI 1YLCB 1ADZA 1BF0A 2JOTA 1T8NB 1IRHA 1ZJDB 1CO7I 1YLDB 4NTWB 4PTIA 1JC6A 1AALA 1BZXI 5JB5A 1BHCA 4NTXB 2M01A 3AUDA 3AUHA 1DENA 2KCRA 1AAPA 1TAWB 1T8LB 1TCPA 1B0CA 1EAWB 3OTJI 1T8MB 1FANA 4BNRI 5JB6A 3TGKI 1BPIA 3FP8I 1Y62A 3LDMA 1P2JI 3UIRC 2DDIA 1MTND 2R9PE 4ISNB
chains in the Genus database with same CATH topology
1DEMA 1F7ZI 1BTHP 2ZVXA 2PTCI 4Y0ZI 3TGII 1LD5A 1KNTA 2FTLI 3BTMI 1YKTB 4DG4C 2TPII 3AUCA 1KIGI 4WWYC 1D0DB 1SHPA 3CI7A 7PTIA 1BIKA 2LFKA 1P2MB 1P2QB 4Y0YI 3BTHI 2DDJA 1DTXA 2CA7A 2HEXA 3AUEA 1K6UA 4NTYB 1LD6A 1TOCR 2FI5I 3AUBA 1DTKA 3L3TE 1BPTA 1TPAI 1P2II 2KNTA 4DTGK 3BTEI 1KUNA 4ISOB 3AUIA 3TGJI 2W8XA 2UUXA 6PTIA 2TGPI 3LDIA 1JV8A 1TFXC 3TPII 1PITA 5JB7A 2LFLA 9PTIA 1D0DA 2ODYE 4WXVC 1CA0D 4Y10I 3BYBA 5PTIA 1BTIA 1NAGA 2IJOI 2FI4I 1OA55 1FY8I 1UUAA 5C67C 3BTDI 1BRBI 4U32X 1BUNB 1ZR0B 3BTFI 4BD9B 4BQDA 1OA65 1T7CB 1BZ5A 3P95E 3P92E 3OFWA 4TPII 1CBWD 1KTHA 2UUYB 1QLQA 8PTIA 3WNYA 4Y11I 1UUBA 1TAPA 2KAII 3D65I 3LDJA 2ZJXA 3BTGI 3L33E 1JV9A 1P2OB 2J6DA 1F5RI 1EJMB 3BTWI 3UOUB 1T8OB 3T62D 3AUGA 3GYMI 3U1JE 3FP6I 4ISLB 1YC0I 2FI3I 3M7QB 1FAKI 3BTTI 2FTMB 4U30W 3BTKI 1P2KI 2M99A 3BTQI 1P2NB 2RA3C 3FP7J 1G6XA 5JB4A 1BRCI 1YLCB 1ADZA 1BF0A 2JOTA 1T8NB 1IRHA 1ZJDB 1CO7I 1YLDB 4NTWB 4PTIA 1JC6A 1AALA 1BZXI 5JB5A 1BHCA 4NTXB 2M01A 3AUDA 3AUHA 1DENA 2KCRA 1AAPA 1TAWB 1T8LB 1TCPA 1B0CA 1EAWB 3OTJI 1T8MB 1FANA 4BNRI 5JB6A 3TGKI 1BPIA 3FP8I 1Y62A 3LDMA 1P2JI 3UIRC 2DDIA 1MTND 2R9PE 4ISNB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DEM A;  1F7Z I;  1BTH P;  2ZVX A;  2PTC I;  4Y0Z I;  3TGI I;  1LD5 A;  1KNT A;  2FTL I;  3BTM I;  1YKT B;  4DG4 C;  2TPI I;  3AUC A;  1KIG I;  4WWY C;  1D0D B;  1SHP A;  3CI7 A;  7PTI A;  1BIK A;  2LFK A;  1P2M B;  1P2Q B;  4Y0Y I;  3BTH I;  2DDJ A;  1DTX A;  2CA7 A;  2HEX A;  3AUE A;  1K6U A;  4NTY B;  1LD6 A;  1TOC R;  2FI5 I;  3AUB A;  1DTK A;  3L3T E;  1BPT A;  1TPA I;  1P2I I;  2KNT A;  4DTG K;  3BTE I;  1KUN A;  4ISO B;  3AUI A;  3TGJ I;  2W8X A;  2UUX A;  6PTI A;  2TGP I;  3LDI A;  1JV8 A;  1TFX C;  3TPI I;  1PIT A;  5JB7 A;  2LFL A;  9PTI A;  1D0D A;  2ODY E;  4WXV C;  1CA0 D;  4Y10 I;  3BYB A;  5PTI A;  1BTI A;  1NAG A;  2IJO I;  2FI4 I;  1OA5 5;  1FY8 I;  1UUA A;  5C67 C;  3BTD I;  1BRB I;  4U32 X;  1BUN B;  1ZR0 B;  3BTF I;  4BD9 B;  4BQD A;  1OA6 5;  1T7C B;  1BZ5 A;  3P95 E;  3P92 E;  3OFW A;  4TPI I;  1CBW D;  1KTH A;  2UUY B;  1QLQ A;  8PTI A;  3WNY A;  4Y11 I;  1UUB A;  1TAP A;  2KAI I;  3D65 I;  3LDJ A;  2ZJX A;  3BTG I;  3L33 E;  1JV9 A;  1P2O B;  2J6D A;  1F5R I;  1EJM B;  3BTW I;  3UOU B;  1T8O B;  3T62 D;  3AUG A;  3GYM I;  3U1J E;  3FP6 I;  4ISL B;  1YC0 I;  2FI3 I;  3M7Q B;  1FAK I;  3BTT I;  2FTM B;  4U30 W;  3BTK I;  1P2K I;  2M99 A;  3BTQ I;  1P2N B;  2RA3 C;  3FP7 J;  1G6X A;  5JB4 A;  1BRC I;  1YLC B;  1ADZ A;  1BF0 A;  2JOT A;  1T8N B;  1IRH A;  1ZJD B;  1CO7 I;  1YLD B;  4NTW B;  4PTI A;  1JC6 A;  1AAL A;  1BZX I;  5JB5 A;  1BHC A;  4NTX B;  2M01 A;  3AUD A;  3AUH A;  1DEN A;  2KCR A;  1AAP A;  1TAW B;  1T8L B;  1TCP A;  1B0C A;  1EAW B;  3OTJ I;  1T8M B;  1FAN A;  4BNR I;  5JB6 A;  3TGK I;  1BPI A;  3FP8 I;  1Y62 A;  3LDM A;  1P2J I;  3UIR C;  2DDI A;  1MTN D;  2R9P E;  4ISN B; 
#chains in the Genus database with same CATH topology
 1DEM A;  1F7Z I;  1BTH P;  2ZVX A;  2PTC I;  4Y0Z I;  3TGI I;  1LD5 A;  1KNT A;  2FTL I;  3BTM I;  1YKT B;  4DG4 C;  2TPI I;  3AUC A;  1KIG I;  4WWY C;  1D0D B;  1SHP A;  3CI7 A;  7PTI A;  1BIK A;  2LFK A;  1P2M B;  1P2Q B;  4Y0Y I;  3BTH I;  2DDJ A;  1DTX A;  2CA7 A;  2HEX A;  3AUE A;  1K6U A;  4NTY B;  1LD6 A;  1TOC R;  2FI5 I;  3AUB A;  1DTK A;  3L3T E;  1BPT A;  1TPA I;  1P2I I;  2KNT A;  4DTG K;  3BTE I;  1KUN A;  4ISO B;  3AUI A;  3TGJ I;  2W8X A;  2UUX A;  6PTI A;  2TGP I;  3LDI A;  1JV8 A;  1TFX C;  3TPI I;  1PIT A;  5JB7 A;  2LFL A;  9PTI A;  1D0D A;  2ODY E;  4WXV C;  1CA0 D;  4Y10 I;  3BYB A;  5PTI A;  1BTI A;  1NAG A;  2IJO I;  2FI4 I;  1OA5 5;  1FY8 I;  1UUA A;  5C67 C;  3BTD I;  1BRB I;  4U32 X;  1BUN B;  1ZR0 B;  3BTF I;  4BD9 B;  4BQD A;  1OA6 5;  1T7C B;  1BZ5 A;  3P95 E;  3P92 E;  3OFW A;  4TPI I;  1CBW D;  1KTH A;  2UUY B;  1QLQ A;  8PTI A;  3WNY A;  4Y11 I;  1UUB A;  1TAP A;  2KAI I;  3D65 I;  3LDJ A;  2ZJX A;  3BTG I;  3L33 E;  1JV9 A;  1P2O B;  2J6D A;  1F5R I;  1EJM B;  3BTW I;  3UOU B;  1T8O B;  3T62 D;  3AUG A;  3GYM I;  3U1J E;  3FP6 I;  4ISL B;  1YC0 I;  2FI3 I;  3M7Q B;  1FAK I;  3BTT I;  2FTM B;  4U30 W;  3BTK I;  1P2K I;  2M99 A;  3BTQ I;  1P2N B;  2RA3 C;  3FP7 J;  1G6X A;  5JB4 A;  1BRC I;  1YLC B;  1ADZ A;  1BF0 A;  2JOT A;  1T8N B;  1IRH A;  1ZJD B;  1CO7 I;  1YLD B;  4NTW B;  4PTI A;  1JC6 A;  1AAL A;  1BZX I;  5JB5 A;  1BHC A;  4NTX B;  2M01 A;  3AUD A;  3AUH A;  1DEN A;  2KCR A;  1AAP A;  1TAW B;  1T8L B;  1TCP A;  1B0C A;  1EAW B;  3OTJ I;  1T8M B;  1FAN A;  4BNR I;  5JB6 A;  3TGK I;  1BPI A;  3FP8 I;  1Y62 A;  3LDM A;  1P2J I;  3UIR C;  2DDI A;  1MTN D;  2R9P E;  4ISN B; 
#chains in the Genus database with same CATH homology
 1DEM A;  1F7Z I;  1BTH P;  2ZVX A;  2PTC I;  4Y0Z I;  3TGI I;  1LD5 A;  1KNT A;  2FTL I;  3BTM I;  1YKT B;  4DG4 C;  2TPI I;  3AUC A;  1KIG I;  4WWY C;  1D0D B;  1SHP A;  3CI7 A;  7PTI A;  1BIK A;  2LFK A;  1P2M B;  1P2Q B;  4Y0Y I;  3BTH I;  2DDJ A;  1DTX A;  2CA7 A;  2HEX A;  3AUE A;  1K6U A;  4NTY B;  1LD6 A;  1TOC R;  2FI5 I;  3AUB A;  1DTK A;  3L3T E;  1BPT A;  1TPA I;  1P2I I;  2KNT A;  4DTG K;  3BTE I;  1KUN A;  4ISO B;  3AUI A;  3TGJ I;  2W8X A;  2UUX A;  6PTI A;  2TGP I;  3LDI A;  1JV8 A;  1TFX C;  3TPI I;  1PIT A;  5JB7 A;  2LFL A;  9PTI A;  1D0D A;  2ODY E;  4WXV C;  1CA0 D;  4Y10 I;  3BYB A;  5PTI A;  1BTI A;  1NAG A;  2IJO I;  2FI4 I;  1OA5 5;  1FY8 I;  1UUA A;  5C67 C;  3BTD I;  1BRB I;  4U32 X;  1BUN B;  1ZR0 B;  3BTF I;  4BD9 B;  4BQD A;  1OA6 5;  1T7C B;  1BZ5 A;  3P95 E;  3P92 E;  3OFW A;  4TPI I;  1CBW D;  1KTH A;  2UUY B;  1QLQ A;  8PTI A;  3WNY A;  4Y11 I;  1UUB A;  1TAP A;  2KAI I;  3D65 I;  3LDJ A;  2ZJX A;  3BTG I;  3L33 E;  1JV9 A;  1P2O B;  2J6D A;  1F5R I;  1EJM B;  3BTW I;  3UOU B;  1T8O B;  3T62 D;  3AUG A;  3GYM I;  3U1J E;  3FP6 I;  4ISL B;  1YC0 I;  2FI3 I;  3M7Q B;  1FAK I;  3BTT I;  2FTM B;  4U30 W;  3BTK I;  1P2K I;  2M99 A;  3BTQ I;  1P2N B;  2RA3 C;  3FP7 J;  1G6X A;  5JB4 A;  1BRC I;  1YLC B;  1ADZ A;  1BF0 A;  2JOT A;  1T8N B;  1IRH A;  1ZJD B;  1CO7 I;  1YLD B;  4NTW B;  4PTI A;  1JC6 A;  1AAL A;  1BZX I;  5JB5 A;  1BHC A;  4NTX B;  2M01 A;  3AUD A;  3AUH A;  1DEN A;  2KCR A;  1AAP A;  1TAW B;  1T8L B;  1TCP A;  1B0C A;  1EAW B;  3OTJ I;  1T8M B;  1FAN A;  4BNR I;  5JB6 A;  3TGK I;  1BPI A;  3FP8 I;  1Y62 A;  3LDM A;  1P2J I;  3UIR C;  2DDI A;  1MTN D;  2R9P E;  4ISN B; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...