4UI3C

Crystal structure of human tankyrase 2 in complex with ta-26
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
47
structure length
47
Chain Sequence
MAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure-Activity Relationships of 2-Arylquinazolin-4-Ones as Highly Selective and Potent Inhibitors of the Tankyrases.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords TANKYRASE-2
total genus 1
structure length 47
sequence length 47
chains with identical sequence D
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2015-03-27
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1620.50 Alpha Beta 3-Layer(aba) Sandwich YefM-like fold YefM-like fold 4ui3C00
4L0IC 4HKIC 4L34C 4UI5C 5ADTB 4UI7C 5C5PC 5ADSB 4HLHC 4HMHC 4L0VC 5C5QC 4L10C 4L0SC 4L31C 4HLMC 4KZQC 4UI6C 4HLGC 4UI8C 4UI4C 4KZLC 4UVPB 5C5RC 4KZUC 4L2KC 5FPFC 5ADQB 4L0TC 4HLFC 4HL5C 4L33C 4HKKB 4L2FC 4UI3C 4HLKC 4L0BC 5ADRB 4L2GC 4L09C 4L32C 4HKNC
chains in the Genus database with same CATH superfamily
4L0IC 4HKIC 4L34C 4UI5C 3K33B 5ADTB 4UI7C 5C5PC 5ADSB 3HS2A 4HLHC 4HMHC 4L0VC 5C5QC 4L10C 4L0SC 4L31C 4ZM2A 2ODKA 4HLMC 4KZQC 4UI6C 3OEIE 3HRYA 4HLGC 4UI8C 4UI4C 4KZLC 4UVPB 5C5RC 3K6QA 4ZLXA 3CTOA 3HJ6A 4KZUC 4L2KC 5FPFC 4ZM0A 5ADQB 3G5OA 4L0TC 3OEIA 4HL5C 4HLFC 4L33C 2ZIXB 4HKKB 4L2FC 4UI3C 3KH2E 2A6QA 4HLKC 4L0BC 3D55A 4L2GC 5ADRB 4L09C 4L32C 4HKNC
chains in the Genus database with same CATH topology
4L0IC 4HKIC 4L34C 4UI5C 5ADTB 4UI7C 5C5PC 5ADSB 4HLHC 4HMHC 4L0VC 5C5QC 4L10C 4L0SC 4L31C 4HLMC 4KZQC 4UI6C 4HLGC 4UI8C 4UI4C 4KZLC 4UVPB 5C5RC 3HJ6A 4KZUC 4L2KC 5FPFC 5ADQB 4L0TC 4HLFC 4HL5C 4L33C 2ZIXB 4HKKB 4L2FC 4UI3C 4HLKC 4L0BC 5ADRB 4L2GC 4L09C 4L32C 4HKNC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4L0I C;  4HKI C;  4L34 C;  4UI5 C;  5ADT B;  4UI7 C;  5C5P C;  5ADS B;  4HLH C;  4HMH C;  4L0V C;  5C5Q C;  4L10 C;  4L0S C;  4L31 C;  4HLM C;  4KZQ C;  4UI6 C;  4HLG C;  4UI8 C;  4UI4 C;  4KZL C;  4UVP B;  5C5R C;  4KZU C;  4L2K C;  5FPF C;  5ADQ B;  4L0T C;  4HLF C;  4HL5 C;  4L33 C;  4HKK B;  4L2F C;  4UI3 C;  4HLK C;  4L0B C;  5ADR B;  4L2G C;  4L09 C;  4L32 C;  4HKN C; 
#chains in the Genus database with same CATH topology
 4L0I C;  4HKI C;  4L34 C;  4UI5 C;  3K33 B;  5ADT B;  4UI7 C;  5C5P C;  5ADS B;  3HS2 A;  4HLH C;  4HMH C;  4L0V C;  5C5Q C;  4L10 C;  4L0S C;  4L31 C;  4ZM2 A;  2ODK A;  4HLM C;  4KZQ C;  4UI6 C;  3OEI E;  3HRY A;  4HLG C;  4UI8 C;  4UI4 C;  4KZL C;  4UVP B;  5C5R C;  3K6Q A;  4ZLX A;  3CTO A;  3HJ6 A;  4KZU C;  4L2K C;  5FPF C;  4ZM0 A;  5ADQ B;  3G5O A;  4L0T C;  3OEI A;  4HL5 C;  4HLF C;  4L33 C;  2ZIX B;  4HKK B;  4L2F C;  4UI3 C;  3KH2 E;  2A6Q A;  4HLK C;  4L0B C;  3D55 A;  4L2G C;  5ADR B;  4L09 C;  4L32 C;  4HKN C; 
#chains in the Genus database with same CATH homology
 4L0I C;  4HKI C;  4L34 C;  4UI5 C;  5ADT B;  4UI7 C;  5C5P C;  5ADS B;  4HLH C;  4HMH C;  4L0V C;  5C5Q C;  4L10 C;  4L0S C;  4L31 C;  4HLM C;  4KZQ C;  4UI6 C;  4HLG C;  4UI8 C;  4UI4 C;  4KZL C;  4UVP B;  5C5R C;  3HJ6 A;  4KZU C;  4L2K C;  5FPF C;  5ADQ B;  4L0T C;  4HLF C;  4HL5 C;  4L33 C;  2ZIX B;  4HKK B;  4L2F C;  4UI3 C;  4HLK C;  4L0B C;  5ADR B;  4L2G C;  4L09 C;  4L32 C;  4HKN C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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