4UI3C

Crystal structure of human tankyrase 2 in complex with ta-26
Total Genus 1
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
47
structure length
47
Chain Sequence
MAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure-Activity Relationships of 2-Arylquinazolin-4-Ones as Highly Selective and Potent Inhibitors of the Tankyrases.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords TANKYRASE-2
total genus 1
structure length 47
sequence length 47
chains with identical sequence D
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2015-03-27
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1620.50 Alpha Beta 3-Layer(aba) Sandwich YefM-like fold YefM-like fold 4ui3C00
4HLHC 4KZLC 4UI8C 5FPFC 4UI7C 4HKNC 4L0IC 5C5PC 4L0VC 4L10C 4L0BC 4L33C 5C5RC 4UI3C 5ADQB 4HLGC 4KZUC 4HMHC 4L0TC 4L2KC 4KZQC 4L0SC 4L09C 4L31C 5ADTB 4HKIC 4UI6C 4L32C 4UI5C 4HL5C 4L2GC 4HLMC 4HKKB 4HLFC 4L2FC 5C5QC 4UVPB 4L34C 4UI4C 5ADSB 4HLKC 5ADRB
chains in the Genus database with same CATH superfamily
4ZM0A 2A6QA 4HLHC 4KZLC 3HS2A 4UI8C 5FPFC 4UI7C 4HKNC 4L0IC 5C5PC 4L0VC 2ZIXB 4L0BC 4L10C 4L33C 5C5RC 4UI3C 5ADQB 4HLGC 4KZUC 4HMHC 3CTOA 3OEIA 4L0TC 4L2KC 4ZLXA 4KZQC 3HJ6A 4L0SC 3G5OA 3K33B 4L09C 4L31C 3D55A 5ADTB 3KH2E 2ODKA 4HKIC 4UI6C 4L32C 4ZM2A 4UI5C 4HL5C 3OEIE 4L2GC 4HLMC 4HKKB 4HLFC 4L2FC 5C5QC 4UVPB 4L34C 3HRYA 4UI4C 5ADSB 4HLKC 3K6QA 5ADRB
chains in the Genus database with same CATH topology
4HLHC 4KZLC 4UI8C 5FPFC 4UI7C 4HKNC 4L0IC 5C5PC 4L0VC 2ZIXB 4L0BC 4L10C 4L33C 5C5RC 4UI3C 5ADQB 4HLGC 4KZUC 4HMHC 4L0TC 4L2KC 4KZQC 3HJ6A 4L0SC 4L09C 4L31C 5ADTB 4HKIC 4UI6C 4L32C 4UI5C 4HL5C 4L2GC 4HLMC 4HKKB 4HLFC 4L2FC 5C5QC 4UVPB 4L34C 4UI4C 5ADSB 4HLKC 5ADRB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4HLH C;  4KZL C;  4UI8 C;  5FPF C;  4UI7 C;  4HKN C;  4L0I C;  5C5P C;  4L0V C;  4L10 C;  4L0B C;  4L33 C;  5C5R C;  4UI3 C;  5ADQ B;  4HLG C;  4KZU C;  4HMH C;  4L0T C;  4L2K C;  4KZQ C;  4L0S C;  4L09 C;  4L31 C;  5ADT B;  4HKI C;  4UI6 C;  4L32 C;  4UI5 C;  4HL5 C;  4L2G C;  4HLM C;  4HKK B;  4HLF C;  4L2F C;  5C5Q C;  4UVP B;  4L34 C;  4UI4 C;  5ADS B;  4HLK C;  5ADR B; 
#chains in the Genus database with same CATH topology
 4ZM0 A;  2A6Q A;  4HLH C;  4KZL C;  3HS2 A;  4UI8 C;  5FPF C;  4UI7 C;  4HKN C;  4L0I C;  5C5P C;  4L0V C;  2ZIX B;  4L0B C;  4L10 C;  4L33 C;  5C5R C;  4UI3 C;  5ADQ B;  4HLG C;  4KZU C;  4HMH C;  3CTO A;  3OEI A;  4L0T C;  4L2K C;  4ZLX A;  4KZQ C;  3HJ6 A;  4L0S C;  3G5O A;  3K33 B;  4L09 C;  4L31 C;  3D55 A;  5ADT B;  3KH2 E;  2ODK A;  4HKI C;  4UI6 C;  4L32 C;  4ZM2 A;  4UI5 C;  4HL5 C;  3OEI E;  4L2G C;  4HLM C;  4HKK B;  4HLF C;  4L2F C;  5C5Q C;  4UVP B;  4L34 C;  3HRY A;  4UI4 C;  5ADS B;  4HLK C;  3K6Q A;  5ADR B; 
#chains in the Genus database with same CATH homology
 4HLH C;  4KZL C;  4UI8 C;  5FPF C;  4UI7 C;  4HKN C;  4L0I C;  5C5P C;  4L0V C;  2ZIX B;  4L0B C;  4L10 C;  4L33 C;  5C5R C;  4UI3 C;  5ADQ B;  4HLG C;  4KZU C;  4HMH C;  4L0T C;  4L2K C;  4KZQ C;  3HJ6 A;  4L0S C;  4L09 C;  4L31 C;  5ADT B;  4HKI C;  4UI6 C;  4L32 C;  4UI5 C;  4HL5 C;  4L2G C;  4HLM C;  4HKK B;  4HLF C;  4L2F C;  5C5Q C;  4UVP B;  4L34 C;  4UI4 C;  5ADS B;  4HLK C;  5ADR B; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...