4UI4C

Crystal structure of human tankyrase 2 in complex with ta-29
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
47
structure length
47
Chain Sequence
MAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure-Activity Relationships of 2-Arylquinazolin-4-Ones as Highly Selective and Potent Inhibitors of the Tankyrases.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords TANKYRASE-2
total genus 1
structure length 47
sequence length 47
chains with identical sequence D
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2015-03-27
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1620.50 Alpha Beta 3-Layer(aba) Sandwich YefM-like fold YefM-like fold 4ui4C00
4L0TC 4HL5C 4L09C 4L0SC 4L34C 5ADTB 4KZQC 5FPFC 4HLFC 4L2KC 4UI3C 4UI4C 4L0VC 4UI5C 5ADRB 4HKKB 4HLKC 5C5QC 4HLGC 4UI6C 4HLHC 4L32C 4L2FC 4L2GC 4HLMC 4HKNC 4UI8C 5ADSB 4L0BC 4L0IC 4L31C 4KZLC 4HMHC 4L10C 4UI7C 5C5RC 5C5PC 5ADQB 4L33C 4HKIC 4UVPB 4KZUC
chains in the Genus database with same CATH superfamily
4L0TC 4HL5C 4L09C 3CTOA 2ODKA 4L0SC 4L34C 5ADTB 3KH2E 4KZQC 5FPFC 3HRYA 4HLFC 3OEIA 4L2KC 4UI3C 4UI4C 3OEIE 4ZM0A 4L0VC 4HKIC 4UI5C 5ADRB 3K6QA 4HKKB 3HS2A 4HLKC 5C5QC 2A6QA 4UI6C 4HLHC 4L32C 4L2FC 4L2GC 3D55A 4ZM2A 2ZIXB 4HLMC 4HKNC 4UI8C 3G5OA 5ADSB 4ZLXA 4L0BC 4L0IC 4L31C 4KZLC 4HMHC 4L10C 3HJ6A 4UI7C 5C5RC 3K33B 5C5PC 5ADQB 4L33C 4HLGC 4UVPB 4KZUC
chains in the Genus database with same CATH topology
4L0TC 4HL5C 4L09C 4L0SC 4L34C 5ADTB 4KZQC 5FPFC 4HLFC 4L2KC 4UI3C 4UI4C 4L0VC 4UI5C 5ADRB 4HKKB 4HLKC 5C5QC 4HLGC 4UI6C 4HLHC 4L32C 4L2FC 4L2GC 2ZIXB 4HLMC 4HKNC 4UI8C 5ADSB 4L0BC 4L0IC 4L31C 4KZLC 4HMHC 4L10C 3HJ6A 4UI7C 5C5RC 5C5PC 5ADQB 4L33C 4HKIC 4UVPB 4KZUC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4L0T C;  4HL5 C;  4L09 C;  4L0S C;  4L34 C;  5ADT B;  4KZQ C;  5FPF C;  4HLF C;  4L2K C;  4UI3 C;  4UI4 C;  4L0V C;  4UI5 C;  5ADR B;  4HKK B;  4HLK C;  5C5Q C;  4HLG C;  4UI6 C;  4HLH C;  4L32 C;  4L2F C;  4L2G C;  4HLM C;  4HKN C;  4UI8 C;  5ADS B;  4L0B C;  4L0I C;  4L31 C;  4KZL C;  4HMH C;  4L10 C;  4UI7 C;  5C5R C;  5C5P C;  5ADQ B;  4L33 C;  4HKI C;  4UVP B;  4KZU C; 
#chains in the Genus database with same CATH topology
 4L0T C;  4HL5 C;  4L09 C;  3CTO A;  2ODK A;  4L0S C;  4L34 C;  5ADT B;  3KH2 E;  4KZQ C;  5FPF C;  3HRY A;  4HLF C;  3OEI A;  4L2K C;  4UI3 C;  4UI4 C;  3OEI E;  4ZM0 A;  4L0V C;  4HKI C;  4UI5 C;  5ADR B;  3K6Q A;  4HKK B;  3HS2 A;  4HLK C;  5C5Q C;  2A6Q A;  4UI6 C;  4HLH C;  4L32 C;  4L2F C;  4L2G C;  3D55 A;  4ZM2 A;  2ZIX B;  4HLM C;  4HKN C;  4UI8 C;  3G5O A;  5ADS B;  4ZLX A;  4L0B C;  4L0I C;  4L31 C;  4KZL C;  4HMH C;  4L10 C;  3HJ6 A;  4UI7 C;  5C5R C;  3K33 B;  5C5P C;  5ADQ B;  4L33 C;  4HLG C;  4UVP B;  4KZU C; 
#chains in the Genus database with same CATH homology
 4L0T C;  4HL5 C;  4L09 C;  4L0S C;  4L34 C;  5ADT B;  4KZQ C;  5FPF C;  4HLF C;  4L2K C;  4UI3 C;  4UI4 C;  4L0V C;  4UI5 C;  5ADR B;  4HKK B;  4HLK C;  5C5Q C;  4HLG C;  4UI6 C;  4HLH C;  4L32 C;  4L2F C;  4L2G C;  2ZIX B;  4HLM C;  4HKN C;  4UI8 C;  5ADS B;  4L0B C;  4L0I C;  4L31 C;  4KZL C;  4HMH C;  4L10 C;  3HJ6 A;  4UI7 C;  5C5R C;  5C5P C;  5ADQ B;  4L33 C;  4HKI C;  4UVP B;  4KZU C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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