4UI5C

Crystal structure of human tankyrase 2 in complex with ta-41
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
47
structure length
47
Chain Sequence
MAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure-Activity Relationships of 2-Arylquinazolin-4-Ones as Highly Selective and Potent Inhibitors of the Tankyrases.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords TANKYRASE-2
total genus 1
structure length 47
sequence length 47
chains with identical sequence D
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2015-03-27
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1620.50 Alpha Beta 3-Layer(aba) Sandwich YefM-like fold YefM-like fold 4ui5C00
4L34C 4KZQC 4L10C 5C5RC 5FPFC 4KZLC 5ADTB 5C5PC 5C5QC 4L09C 4L2KC 4L2FC 4UI4C 4UI5C 5ADQB 4L32C 5ADSB 4UI7C 4HLHC 4HLGC 4HMHC 4HLFC 4L0TC 4HLMC 4L0BC 4HKIC 4L0IC 4L31C 4L0SC 4UI3C 4UI8C 4HLKC 4KZUC 4HKKB 4HKNC 4UI6C 5ADRB 4L2GC 4UVPB 4L33C 4HL5C 4L0VC
chains in the Genus database with same CATH superfamily
4L34C 4KZQC 4L10C 2ZIXB 5C5RC 5FPFC 3HS2A 3OEIE 4KZLC 3HRYA 5ADTB 5C5PC 5C5QC 4L09C 4L2KC 2A6QA 4L0VC 4L2FC 3KH2E 4UI4C 4UI5C 5ADQB 3G5OA 3CTOA 4L32C 4ZM2A 5ADSB 3K6QA 3D55A 4UI7C 4HLHC 4HLGC 4HMHC 4HLFC 4L0TC 3HJ6A 3OEIA 4HLMC 4HKIC 4L0BC 4L0IC 4L31C 4L0SC 4UI3C 4UI8C 4HLKC 4KZUC 4HKKB 4HKNC 4UI6C 5ADRB 4L2GC 4UVPB 4ZM0A 4ZLXA 4L33C 3K33B 4HL5C 2ODKA
chains in the Genus database with same CATH topology
4L34C 4KZQC 4L10C 2ZIXB 5C5RC 5FPFC 4KZLC 5ADTB 5C5PC 5C5QC 4L09C 4L2KC 4L2FC 4UI4C 4UI5C 5ADQB 4L32C 5ADSB 4UI7C 4HLHC 4HLGC 4HMHC 4HLFC 4L0TC 3HJ6A 4HLMC 4L0BC 4HKIC 4L0IC 4L31C 4L0SC 4UI3C 4UI8C 4HLKC 4KZUC 4HKKB 4HKNC 4UI6C 5ADRB 4L2GC 4UVPB 4L33C 4HL5C 4L0VC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4L34 C;  4KZQ C;  4L10 C;  5C5R C;  5FPF C;  4KZL C;  5ADT B;  5C5P C;  5C5Q C;  4L09 C;  4L2K C;  4L2F C;  4UI4 C;  4UI5 C;  5ADQ B;  4L32 C;  5ADS B;  4UI7 C;  4HLH C;  4HLG C;  4HMH C;  4HLF C;  4L0T C;  4HLM C;  4L0B C;  4HKI C;  4L0I C;  4L31 C;  4L0S C;  4UI3 C;  4UI8 C;  4HLK C;  4KZU C;  4HKK B;  4HKN C;  4UI6 C;  5ADR B;  4L2G C;  4UVP B;  4L33 C;  4HL5 C;  4L0V C; 
#chains in the Genus database with same CATH topology
 4L34 C;  4KZQ C;  4L10 C;  2ZIX B;  5C5R C;  5FPF C;  3HS2 A;  3OEI E;  4KZL C;  3HRY A;  5ADT B;  5C5P C;  5C5Q C;  4L09 C;  4L2K C;  2A6Q A;  4L0V C;  4L2F C;  3KH2 E;  4UI4 C;  4UI5 C;  5ADQ B;  3G5O A;  3CTO A;  4L32 C;  4ZM2 A;  5ADS B;  3K6Q A;  3D55 A;  4UI7 C;  4HLH C;  4HLG C;  4HMH C;  4HLF C;  4L0T C;  3HJ6 A;  3OEI A;  4HLM C;  4HKI C;  4L0B C;  4L0I C;  4L31 C;  4L0S C;  4UI3 C;  4UI8 C;  4HLK C;  4KZU C;  4HKK B;  4HKN C;  4UI6 C;  5ADR B;  4L2G C;  4UVP B;  4ZM0 A;  4ZLX A;  4L33 C;  3K33 B;  4HL5 C;  2ODK A; 
#chains in the Genus database with same CATH homology
 4L34 C;  4KZQ C;  4L10 C;  2ZIX B;  5C5R C;  5FPF C;  4KZL C;  5ADT B;  5C5P C;  5C5Q C;  4L09 C;  4L2K C;  4L2F C;  4UI4 C;  4UI5 C;  5ADQ B;  4L32 C;  5ADS B;  4UI7 C;  4HLH C;  4HLG C;  4HMH C;  4HLF C;  4L0T C;  3HJ6 A;  4HLM C;  4L0B C;  4HKI C;  4L0I C;  4L31 C;  4L0S C;  4UI3 C;  4UI8 C;  4HLK C;  4KZU C;  4HKK B;  4HKN C;  4UI6 C;  5ADR B;  4L2G C;  4UVP B;  4L33 C;  4HL5 C;  4L0V C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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