4UI5C

Crystal structure of human tankyrase 2 in complex with ta-41
Total Genus 1
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
47
structure length
47
Chain Sequence
MAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure-Activity Relationships of 2-Arylquinazolin-4-Ones as Highly Selective and Potent Inhibitors of the Tankyrases.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords TANKYRASE-2
total genus 1
structure length 47
sequence length 47
chains with identical sequence D
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2015-03-27
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1620.50 Alpha Beta 3-Layer(aba) Sandwich YefM-like fold YefM-like fold 4ui5C00
5C5PC 4HKKB 4L0TC 4L33C 4UI4C 4UI6C 5C5RC 5ADQB 4L0VC 4HLFC 4L2KC 4HL5C 4L10C 4HLKC 4KZLC 4HLHC 4HLMC 4L2GC 4UI5C 5ADTB 4KZUC 4UVPB 4L0IC 4L2FC 4UI8C 4HLGC 4L0SC 5C5QC 5ADSB 4KZQC 4L34C 4HKIC 5ADRB 4HKNC 4HMHC 4L0BC 4L09C 4L32C 4UI7C 4UI3C 5FPFC 4L31C
chains in the Genus database with same CATH superfamily
2A6QA 5C5PC 3D55A 3OEIA 4HKKB 4L0TC 4L33C 4UI4C 4UI6C 5C5RC 5ADQB 4L0VC 4HLFC 4L2KC 2ODKA 4HL5C 4HLKC 4L10C 4KZLC 4ZLXA 4HLHC 4HLMC 4L2GC 4ZM2A 4UI5C 3K6QA 5ADTB 4KZUC 3KH2E 3OEIE 4ZM0A 4UVPB 4L0IC 3CTOA 4L2FC 4UI8C 3HRYA 3HS2A 4HLGC 2ZIXB 4L0SC 5C5QC 5ADSB 3G5OA 4KZQC 4L34C 4HKIC 5ADRB 3K33B 3HJ6A 4HKNC 4HMHC 4L0BC 4L09C 4L32C 4UI3C 4UI7C 5FPFC 4L31C
chains in the Genus database with same CATH topology
5C5PC 4HKKB 4L0TC 4L33C 4UI4C 4UI6C 5C5RC 5ADQB 4L0VC 4HLFC 4L2KC 4HL5C 4L10C 4HLKC 4KZLC 4HLHC 4HLMC 4L2GC 4UI5C 5ADTB 4KZUC 4UVPB 4L0IC 4L2FC 4UI8C 4HLGC 4L0SC 2ZIXB 5C5QC 5ADSB 4KZQC 4L34C 4HKIC 5ADRB 4HKNC 3HJ6A 4HMHC 4L0BC 4L09C 4L32C 4UI3C 4UI7C 5FPFC 4L31C
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5C5P C;  4HKK B;  4L0T C;  4L33 C;  4UI4 C;  4UI6 C;  5C5R C;  5ADQ B;  4L0V C;  4HLF C;  4L2K C;  4HL5 C;  4L10 C;  4HLK C;  4KZL C;  4HLH C;  4HLM C;  4L2G C;  4UI5 C;  5ADT B;  4KZU C;  4UVP B;  4L0I C;  4L2F C;  4UI8 C;  4HLG C;  4L0S C;  5C5Q C;  5ADS B;  4KZQ C;  4L34 C;  4HKI C;  5ADR B;  4HKN C;  4HMH C;  4L0B C;  4L09 C;  4L32 C;  4UI7 C;  4UI3 C;  5FPF C;  4L31 C; 
#chains in the Genus database with same CATH topology
 2A6Q A;  5C5P C;  3D55 A;  3OEI A;  4HKK B;  4L0T C;  4L33 C;  4UI4 C;  4UI6 C;  5C5R C;  5ADQ B;  4L0V C;  4HLF C;  4L2K C;  2ODK A;  4HL5 C;  4HLK C;  4L10 C;  4KZL C;  4ZLX A;  4HLH C;  4HLM C;  4L2G C;  4ZM2 A;  4UI5 C;  3K6Q A;  5ADT B;  4KZU C;  3KH2 E;  3OEI E;  4ZM0 A;  4UVP B;  4L0I C;  3CTO A;  4L2F C;  4UI8 C;  3HRY A;  3HS2 A;  4HLG C;  2ZIX B;  4L0S C;  5C5Q C;  5ADS B;  3G5O A;  4KZQ C;  4L34 C;  4HKI C;  5ADR B;  3K33 B;  3HJ6 A;  4HKN C;  4HMH C;  4L0B C;  4L09 C;  4L32 C;  4UI3 C;  4UI7 C;  5FPF C;  4L31 C; 
#chains in the Genus database with same CATH homology
 5C5P C;  4HKK B;  4L0T C;  4L33 C;  4UI4 C;  4UI6 C;  5C5R C;  5ADQ B;  4L0V C;  4HLF C;  4L2K C;  4HL5 C;  4L10 C;  4HLK C;  4KZL C;  4HLH C;  4HLM C;  4L2G C;  4UI5 C;  5ADT B;  4KZU C;  4UVP B;  4L0I C;  4L2F C;  4UI8 C;  4HLG C;  4L0S C;  2ZIX B;  5C5Q C;  5ADS B;  4KZQ C;  4L34 C;  4HKI C;  5ADR B;  4HKN C;  3HJ6 A;  4HMH C;  4L0B C;  4L09 C;  4L32 C;  4UI3 C;  4UI7 C;  5FPF C;  4L31 C; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...