4X6AF

Crystal structure of yeast rna polymerase ii encountering oxidative cyclopurine dna lesions
Total Genus 17
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
17
sequence length
84
structure length
84
Chain Sequence
KAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDLEGETDPLRIAMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Mechanism of RNA polymerase II bypass of oxidative cyclopurine DNA lesions.
pubmed doi rcsb
molecule tags Transcription/dna
molecule keywords DNA-directed RNA polymerase II subunit RPB1
total genus 17
structure length 84
sequence length 84
ec nomenclature
pdb deposition date 2014-12-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
F PF01192 RNA_pol_Rpb6 RNA polymerase Rpb6
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.940.10 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit Eukaryotic RPB6 RNA polymerase subunit 4x6aF00
4A3MF 2Y0SI 2O5JE 4G7ZE 3S2HF 5E18E 3GTKF 4KN7E 1HQME 4Y52F 3CQZF 4OIOE 4BY7F 4C3HF 3M4OF 4Q4ZE 2O5IE 2A69E 4MEYE 1Y1WF 3H3VG 2WAQK 5M5XF 2E2IF 3HOUF 3H0GF 2JA6F 1SFOF 5IYDF 3S1QF 4MEXE 4OINE 2CW0E 1TWAF 4ZH4E 4BBRF 5M3MF 2PPBE 5BYHE 2A68E 5FLMF 1Y1VF 3I4NF 2NVYF 4Y7NF 4A3IF 3GTPF 3S16F 1TWGF 2R7ZF 4A93F 4BY1F 4XLNE 4C2MF 4C3JF 3GTGF 5IPLE 3GTQF 2BE5E 1K83F 4LJZE 4KN4E 2JA7F 1TWCF 2R92F 4KMUE 1I3QF 5IP7F 5C3EF 2NVTF 3HOZF 1TWHF 1YNNK 3S14F 2A6HE 4MQ9E 3S17F 5M5YF 4XSZE 5E17E 5C44F 3HOWF 3S1RF 2JA8F 3RZDF 4OIRE 1I50F 3PO2F 5D4EE 1WCMF 4LLGE 3S2DF 3PO3F 3RZOF 5IYCF 4XLPE 3HOVF 3FKIF 5D4DE 3GTMF 5C4JF 3GTOF 1R9TF 5FJ8F 2NVQF 5TMCE 4JK1E 4LK0E 2A6EE 3EQLE 4A3BF 3HKZK 4YFKE 3K7AF 1ZYRE 4AYBK 5M5WF 4Q5SE 2R93F 4GZYE 4X6AF 4OIQE 3DXJE 3S1NF 4A3JF 4A3DF 3M3YF 4YG2E 2E2HF 2E2JF 2WB1I 1TWFF 3HOXF 5IYBF 4LK1E 2PMZK 2B63F 4A3CF 1IW7E 4A3FF 4G7OE 5IP9F 5TMFE 3S15F 5C4XF 1I6VE 4A3KF 4YFXE 4A3GF 4A3EF 2VUMF 2JA5F 4G7HE 3S1MF 4YFNE 3GTLF 1SMYE 2NVXF 4BBSF 3I4MF 1YNJK 4A3LF 1QKLA 4C3IF 3GTJF 5M3FF 2YU9F 4BXXF 1I6HF 3HOYF 3WODE 4XSXE 4OIPE 5D4CE
chains in the Genus database with same CATH superfamily
4A3MF 2Y0SI 2O5JE 4G7ZE 3I4ME 3S2HF 5E18E 3GTKF 4A3LE 4KN7E 4C3IE 5M3FE 2YU9E 1HQME 2E2HE 4BXXE 4BBSE 4Y52F 3H3VF 3HOYE 3CQZF 1I6HE 4OIOE 4A3DE 4BY7F 4C3HF 4A3ME 3S2HE 3M4OF 3GTKE 4Q4ZE 2O5IE 2A69E 4MEYE 1Y1WF 3H3VG 4Y52E 3CQZE 4BY7E 4C3HE 2WAQK 5M5XF 2E2IF 3HOUF 3M4OE 1DZFA 3H0GF 2JA6F 1SFOF 1Y1WE 5IYDF 3S1QF 4MEXE 4OINE 2CW0E 1TWAF 4ZH4E 2JA5E 5M5XE 3HOUE 4BBRF 3H0GE 5M3MF 2PPBE 5BYHE 2A68E 5FLMF 1SFOE 2JA6E 1Y1VF 3GTLE 5IYDE 2NVYF 4Y7NF 3I4NF 3S1QE 4A3IF 4AYBH 3GTPF 1TWAE 3S16F 1TWGF 4BBRE 5M3ME 2R7ZF 4A93F 4BY1F 5FLME 3GTJE 1Y1VE 4XLNE 4C2MF 2NVYE 4C3JF 4Y7NE 3GTGF 3I4NE 4A3IE 2BE5E 3GTQF 3HOYF 5IPLE 3GTPE 1K83F 4LJZE 3S16E 1TWGE 2R7ZE 4A93E 4BY1E 4KN4E 2PMZH 4C2ME 4C3JE 3GTGE 3GTQE 2JA7F 1K83E 1TWCF 2R92F 4KMUE 1I3QF 5IP7F 5C3EF 2NVTF 3HOZF 1TWHF 1YNNK 4QIWK 2A6HE 4MQ9E 3S17F 5M5YF 4XSZE 5E17E 5C44F 3HOWF 3S1RF 3S14F 1TWCE 2WAQH 2R92E 5C3EE 1I3QE 5IP7E 3RZDF 2E2IE 4OIRE 1TWHE 2JA8F 2NVTE 3HOZE 3S17E 1I50F 5M5YE 5D4EE 1WCMF 3PO2F 4LLGE 3S2DF 5C44E 3PO3F 3S1RE 3RZOF 5IYCF 2JA8E 3RZDE 4XLPE 3HOVF 2WB1H 3FKIF 5D4DE 3GTMF 1I50E 5C4JF 3PO2E 1WCME 1R9TF 5FJ8F 2NVQF 3GTOF 3S2DE 3PO3E 5TMCE 3RZOE 5IYCE 4JK1E 4LK0E 2A6EE 3HOVE 3EQLE 4A3BF 3FKIE 3GTME 3HKZK 5C4JE 3GTOE 1R9TE 5FJ8E 2NVQE 4YFKE 3K7AF 1ZYRE 4AYBK 5M5WF 4Q5SE 2R93F 4GZYE 4X6AF 4OIQE 3DXJE 3S1NF 4A3JF 4A3DF 3M3YF 4YG2E 2E2HF 2E2JF 2JA7E 2WB1I 3K7AE 5M5WE 2KRXA 4QIWH 3S14E 2R93E 1TWFF 3HOXF 4X6AE 3S1NE 4A3JE 5IYBF 3M3YE 4LK1E 3HOWE 2E2JE 2PMZK 2B63F 1TWFE 4A3CF 3HOXE 2Y0SH 1IW7E 5IYBE 4A3FF 4G7OE 5IP9F 5TMFE 3S15F 5C4XF 2B63E 1I6VE 4A3KF 4YFXE 4A3GF 4A3EF 2VUMF 4A3CE 2JA5F 4G7HE 3S1MF 4A3FE 4YFNE 3GTLF 5IP9E 1SMYE 3S15E 5C4XE 1EIKA 4A3KE 2NVXF 4A3GE 4A3EE 4BBSF 2VUME 3HKZH 4A3BE 3S1ME 3I4MF 1YNJK 4A3LF 1QKLA 4C3IF 3GTJF 5M3FF 2YU9F 4BXXF 1I6HF 2NVXE 3WODE 4XSXE 4OIPE 5D4CE
chains in the Genus database with same CATH topology
4A3MF 2Y0SI 2O5JE 4G7ZE 3S2HF 5E18E 3GTKF 4KN7E 1HQME 4Y52F 3CQZF 4OIOE 4BY7F 4C3HF 3M4OF 4Q4ZE 2O5IE 2A69E 4MEYE 1Y1WF 3H3VG 2WAQK 5M5XF 2E2IF 3HOUF 3H0GF 2JA6F 1SFOF 5IYDF 3S1QF 4MEXE 4OINE 2CW0E 1TWAF 4ZH4E 4BBRF 5M3MF 2PPBE 5BYHE 2A68E 5FLMF 1Y1VF 3I4NF 2NVYF 4Y7NF 4A3IF 3GTPF 3S16F 1TWGF 2R7ZF 4A93F 4BY1F 4XLNE 4C2MF 4C3JF 3GTGF 5IPLE 3GTQF 2BE5E 1K83F 4LJZE 4KN4E 2JA7F 1TWCF 2R92F 4KMUE 1I3QF 5IP7F 5C3EF 2NVTF 3HOZF 1TWHF 1YNNK 4QIWK 2A6HE 4MQ9E 3S17F 5M5YF 4XSZE 5E17E 5C44F 3HOWF 3S1RF 3S14F 2JA8F 3RZDF 4OIRE 1I50F 3PO2F 5D4EE 1WCMF 4LLGE 3S2DF 3PO3F 3RZOF 5IYCF 4XLPE 3HOVF 3FKIF 5D4DE 3GTMF 5C4JF 3GTOF 1R9TF 5FJ8F 2NVQF 5TMCE 4JK1E 4LK0E 2A6EE 3EQLE 4A3BF 3HKZK 4YFKE 3K7AF 1ZYRE 4AYBK 5M5WF 4Q5SE 2R93F 4GZYE 4X6AF 4OIQE 3DXJE 3S1NF 4A3JF 4A3DF 3M3YF 4YG2E 2E2HF 2E2JF 2WB1I 2KRXA 1TWFF 3HOXF 5IYBF 4LK1E 2PMZK 2B63F 4A3CF 1IW7E 4A3FF 4G7OE 5IP9F 5TMFE 3S15F 5C4XF 1I6VE 4A3KF 4YFXE 4A3GF 4A3EF 2VUMF 2JA5F 4G7HE 3S1MF 4YFNE 3GTLF 1SMYE 2NVXF 4BBSF 3I4MF 1YNJK 4A3LF 1QKLA 4C3IF 3GTJF 5M3FF 2YU9F 4BXXF 1I6HF 3HOYF 3WODE 4XSXE 4OIPE 5D4CE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4A3M F;  2Y0S I;  2O5J E;  4G7Z E;  3S2H F;  5E18 E;  3GTK F;  4KN7 E;  1HQM E;  4Y52 F;  3CQZ F;  4OIO E;  4BY7 F;  4C3H F;  3M4O F;  4Q4Z E;  2O5I E;  2A69 E;  4MEY E;  1Y1W F;  3H3V G;  2WAQ K;  5M5X F;  2E2I F;  3HOU F;  3H0G F;  2JA6 F;  1SFO F;  5IYD F;  3S1Q F;  4MEX E;  4OIN E;  2CW0 E;  1TWA F;  4ZH4 E;  4BBR F;  5M3M F;  2PPB E;  5BYH E;  2A68 E;  5FLM F;  1Y1V F;  3I4N F;  2NVY F;  4Y7N F;  4A3I F;  3GTP F;  3S16 F;  1TWG F;  2R7Z F;  4A93 F;  4BY1 F;  4XLN E;  4C2M F;  4C3J F;  3GTG F;  5IPL E;  3GTQ F;  2BE5 E;  1K83 F;  4LJZ E;  4KN4 E;  2JA7 F;  1TWC F;  2R92 F;  4KMU E;  1I3Q F;  5IP7 F;  5C3E F;  2NVT F;  3HOZ F;  1TWH F;  1YNN K;  3S14 F;  2A6H E;  4MQ9 E;  3S17 F;  5M5Y F;  4XSZ E;  5E17 E;  5C44 F;  3HOW F;  3S1R F;  2JA8 F;  3RZD F;  4OIR E;  1I50 F;  3PO2 F;  5D4E E;  1WCM F;  4LLG E;  3S2D F;  3PO3 F;  3RZO F;  5IYC F;  4XLP E;  3HOV F;  3FKI F;  5D4D E;  3GTM F;  5C4J F;  3GTO F;  1R9T F;  5FJ8 F;  2NVQ F;  5TMC E;  4JK1 E;  4LK0 E;  2A6E E;  3EQL E;  4A3B F;  3HKZ K;  4YFK E;  3K7A F;  1ZYR E;  4AYB K;  5M5W F;  4Q5S E;  2R93 F;  4GZY E;  4X6A F;  4OIQ E;  3DXJ E;  3S1N F;  4A3J F;  4A3D F;  3M3Y F;  4YG2 E;  2E2H F;  2E2J F;  2WB1 I;  1TWF F;  3HOX F;  5IYB F;  4LK1 E;  2PMZ K;  2B63 F;  4A3C F;  1IW7 E;  4A3F F;  4G7O E;  5IP9 F;  5TMF E;  3S15 F;  5C4X F;  1I6V E;  4A3K F;  4YFX E;  4A3G F;  4A3E F;  2VUM F;  2JA5 F;  4G7H E;  3S1M F;  4YFN E;  3GTL F;  1SMY E;  2NVX F;  4BBS F;  3I4M F;  1YNJ K;  4A3L F;  1QKL A;  4C3I F;  3GTJ F;  5M3F F;  2YU9 F;  4BXX F;  1I6H F;  3HOY F;  3WOD E;  4XSX E;  4OIP E;  5D4C E; 
#chains in the Genus database with same CATH topology
 4A3M F;  2Y0S I;  2O5J E;  4G7Z E;  3I4M E;  3S2H F;  5E18 E;  3GTK F;  4A3L E;  4KN7 E;  4C3I E;  5M3F E;  2YU9 E;  1HQM E;  2E2H E;  4BXX E;  4BBS E;  4Y52 F;  3H3V F;  3HOY E;  3CQZ F;  1I6H E;  4OIO E;  4A3D E;  4BY7 F;  4C3H F;  4A3M E;  3S2H E;  3M4O F;  3GTK E;  4Q4Z E;  2O5I E;  2A69 E;  4MEY E;  1Y1W F;  3H3V G;  4Y52 E;  3CQZ E;  4BY7 E;  4C3H E;  2WAQ K;  5M5X F;  2E2I F;  3HOU F;  3M4O E;  1DZF A;  3H0G F;  2JA6 F;  1SFO F;  1Y1W E;  5IYD F;  3S1Q F;  4MEX E;  4OIN E;  2CW0 E;  1TWA F;  4ZH4 E;  2JA5 E;  5M5X E;  3HOU E;  4BBR F;  3H0G E;  5M3M F;  2PPB E;  5BYH E;  2A68 E;  5FLM F;  1SFO E;  2JA6 E;  1Y1V F;  3GTL E;  5IYD E;  2NVY F;  4Y7N F;  3I4N F;  3S1Q E;  4A3I F;  4AYB H;  3GTP F;  1TWA E;  3S16 F;  1TWG F;  4BBR E;  5M3M E;  2R7Z F;  4A93 F;  4BY1 F;  5FLM E;  3GTJ E;  1Y1V E;  4XLN E;  4C2M F;  2NVY E;  4C3J F;  4Y7N E;  3GTG F;  3I4N E;  4A3I E;  2BE5 E;  3GTQ F;  3HOY F;  5IPL E;  3GTP E;  1K83 F;  4LJZ E;  3S16 E;  1TWG E;  2R7Z E;  4A93 E;  4BY1 E;  4KN4 E;  2PMZ H;  4C2M E;  4C3J E;  3GTG E;  3GTQ E;  2JA7 F;  1K83 E;  1TWC F;  2R92 F;  4KMU E;  1I3Q F;  5IP7 F;  5C3E F;  2NVT F;  3HOZ F;  1TWH F;  1YNN K;  4QIW K;  2A6H E;  4MQ9 E;  3S17 F;  5M5Y F;  4XSZ E;  5E17 E;  5C44 F;  3HOW F;  3S1R F;  3S14 F;  1TWC E;  2WAQ H;  2R92 E;  5C3E E;  1I3Q E;  5IP7 E;  3RZD F;  2E2I E;  4OIR E;  1TWH E;  2JA8 F;  2NVT E;  3HOZ E;  3S17 E;  1I50 F;  5M5Y E;  5D4E E;  1WCM F;  3PO2 F;  4LLG E;  3S2D F;  5C44 E;  3PO3 F;  3S1R E;  3RZO F;  5IYC F;  2JA8 E;  3RZD E;  4XLP E;  3HOV F;  2WB1 H;  3FKI F;  5D4D E;  3GTM F;  1I50 E;  5C4J F;  3PO2 E;  1WCM E;  1R9T F;  5FJ8 F;  2NVQ F;  3GTO F;  3S2D E;  3PO3 E;  5TMC E;  3RZO E;  5IYC E;  4JK1 E;  4LK0 E;  2A6E E;  3HOV E;  3EQL E;  4A3B F;  3FKI E;  3GTM E;  3HKZ K;  5C4J E;  3GTO E;  1R9T E;  5FJ8 E;  2NVQ E;  4YFK E;  3K7A F;  1ZYR E;  4AYB K;  5M5W F;  4Q5S E;  2R93 F;  4GZY E;  4X6A F;  4OIQ E;  3DXJ E;  3S1N F;  4A3J F;  4A3D F;  3M3Y F;  4YG2 E;  2E2H F;  2E2J F;  2JA7 E;  2WB1 I;  3K7A E;  5M5W E;  2KRX A;  4QIW H;  3S14 E;  2R93 E;  1TWF F;  3HOX F;  4X6A E;  3S1N E;  4A3J E;  5IYB F;  3M3Y E;  4LK1 E;  3HOW E;  2E2J E;  2PMZ K;  2B63 F;  1TWF E;  4A3C F;  3HOX E;  2Y0S H;  1IW7 E;  5IYB E;  4A3F F;  4G7O E;  5IP9 F;  5TMF E;  3S15 F;  5C4X F;  2B63 E;  1I6V E;  4A3K F;  4YFX E;  4A3G F;  4A3E F;  2VUM F;  4A3C E;  2JA5 F;  4G7H E;  3S1M F;  4A3F E;  4YFN E;  3GTL F;  5IP9 E;  1SMY E;  3S15 E;  5C4X E;  1EIK A;  4A3K E;  2NVX F;  4A3G E;  4A3E E;  4BBS F;  2VUM E;  3HKZ H;  4A3B E;  3S1M E;  3I4M F;  1YNJ K;  4A3L F;  1QKL A;  4C3I F;  3GTJ F;  5M3F F;  2YU9 F;  4BXX F;  1I6H F;  2NVX E;  3WOD E;  4XSX E;  4OIP E;  5D4C E; 
#chains in the Genus database with same CATH homology
 4A3M F;  2Y0S I;  2O5J E;  4G7Z E;  3S2H F;  5E18 E;  3GTK F;  4KN7 E;  1HQM E;  4Y52 F;  3CQZ F;  4OIO E;  4BY7 F;  4C3H F;  3M4O F;  4Q4Z E;  2O5I E;  2A69 E;  4MEY E;  1Y1W F;  3H3V G;  2WAQ K;  5M5X F;  2E2I F;  3HOU F;  3H0G F;  2JA6 F;  1SFO F;  5IYD F;  3S1Q F;  4MEX E;  4OIN E;  2CW0 E;  1TWA F;  4ZH4 E;  4BBR F;  5M3M F;  2PPB E;  5BYH E;  2A68 E;  5FLM F;  1Y1V F;  3I4N F;  2NVY F;  4Y7N F;  4A3I F;  3GTP F;  3S16 F;  1TWG F;  2R7Z F;  4A93 F;  4BY1 F;  4XLN E;  4C2M F;  4C3J F;  3GTG F;  5IPL E;  3GTQ F;  2BE5 E;  1K83 F;  4LJZ E;  4KN4 E;  2JA7 F;  1TWC F;  2R92 F;  4KMU E;  1I3Q F;  5IP7 F;  5C3E F;  2NVT F;  3HOZ F;  1TWH F;  1YNN K;  4QIW K;  2A6H E;  4MQ9 E;  3S17 F;  5M5Y F;  4XSZ E;  5E17 E;  5C44 F;  3HOW F;  3S1R F;  3S14 F;  2JA8 F;  3RZD F;  4OIR E;  1I50 F;  3PO2 F;  5D4E E;  1WCM F;  4LLG E;  3S2D F;  3PO3 F;  3RZO F;  5IYC F;  4XLP E;  3HOV F;  3FKI F;  5D4D E;  3GTM F;  5C4J F;  3GTO F;  1R9T F;  5FJ8 F;  2NVQ F;  5TMC E;  4JK1 E;  4LK0 E;  2A6E E;  3EQL E;  4A3B F;  3HKZ K;  4YFK E;  3K7A F;  1ZYR E;  4AYB K;  5M5W F;  4Q5S E;  2R93 F;  4GZY E;  4X6A F;  4OIQ E;  3DXJ E;  3S1N F;  4A3J F;  4A3D F;  3M3Y F;  4YG2 E;  2E2H F;  2E2J F;  2WB1 I;  2KRX A;  1TWF F;  3HOX F;  5IYB F;  4LK1 E;  2PMZ K;  2B63 F;  4A3C F;  1IW7 E;  4A3F F;  4G7O E;  5IP9 F;  5TMF E;  3S15 F;  5C4X F;  1I6V E;  4A3K F;  4YFX E;  4A3G F;  4A3E F;  2VUM F;  2JA5 F;  4G7H E;  3S1M F;  4YFN E;  3GTL F;  1SMY E;  2NVX F;  4BBS F;  3I4M F;  1YNJ K;  4A3L F;  1QKL A;  4C3I F;  3GTJ F;  5M3F F;  2YU9 F;  4BXX F;  1I6H F;  3HOY F;  3WOD E;  4XSX E;  4OIP E;  5D4C E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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