4XSXE

Crystal structure of cbr 703 bound to escherichia coli rna polymerase holoenzyme
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
89
structure length
89
Chain Sequence
ARVTVQDAVEKIGNRFDLVLVAARRARQMQVGGKDPLVPEENDKTTVIALREIEEGLINNQILDVRERQEQQEQEAAELQAVTAIAEGR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title CBR antimicrobials inhibit RNA polymerase via at least two bridge-helix cap-mediated effects on nucleotide addition.
pubmed doi rcsb
molecule tags Transcription/antibiotic
source organism Escherichia coli (strain k12)
molecule keywords DNA-directed RNA polymerase subunit alpha
total genus 25
structure length 89
sequence length 89
chains with identical sequence K
ec nomenclature ec 2.7.7.6: DNA-directed RNA polymerase.
pdb deposition date 2015-01-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01192 RNA_pol_Rpb6 RNA polymerase Rpb6
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.940.10 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit Eukaryotic RPB6 RNA polymerase subunit 4xsxE00
4BXXF 2B63F 4A3BF 3FKIF 3PO3F 3S15F 4BBRF 1Y1VF 2BE5E 4KMUE 4YG2E 2VUMF 4A3DF 1I3QF 1HQME 1K83F 1WCMF 4LJZE 1SMYE 2WB1I 2E2IF 4A3GF 4X6AF 4OIQE 5FLMF 3S2DF 5C4XF 4A3IF 3HOXF 3EQLE 5C3EF 2WAQK 3CQZF 1TWFF 5TMFE 1YNNK 2A6EE 3K7AF 4XLNE 4C3HF 3HOUF 4XSXE 5M5YF 4G7OE 4C3IF 4A3MF 1I50F 5E17E 3RZDF 3HOZF 4BY7F 4BY1F 3H0GF 1I6VE 2JA6F 2NVTF 2Y0SI 4YFKE 4Q5SE 2R92F 3S1QF 3HOYF 3HOWF 4BBSF 3DXJE 4A3KF 3GTQF 3RZOF 4KN7E 4A3CF 2A69E 1R9TF 3GTOF 5IYCF 5M3MF 3PO2F 4A3LF 4OIOE 4OIRE 2CW0E 4AYBK 5D4DE 1YNJK 4LK1E 4MEYE 2NVYF 2A68E 4KN4E 3GTPF 3S16F 1Y1WF 5C44F 3S1MF 2PPBE 5D4CE 5IYBF 4Q4ZE 3GTKF 3H3VG 4C2MF 1TWCF 2JA7F 5C4JF 4OINE 5IP7F 3S2HF 2R93F 2YU9F 4LLGE 4XSZE 4C3JF 3M4OF 5E18E 4G7HE 2O5IE 2A6HE 3I4MF 2R7ZF 1ZYRE 4JK1E 1I6HF 3S17F 3S1NF 4A93F 1IW7E 5IPLE 5D4EE 5BYHE 2E2JF 3S14F 4Y7NF 4LK0E 2E2HF 2JA5F 3GTJF 4OIPE 3M3YF 2NVQF 1TWAF 4YFXE 2JA8F 3GTGF 2O5JE 4MEXE 5M5WF 4G7ZE 4A3FF 4A3EF 4XLPE 3HOVF 4MQ9E 1TWHF 4A3JF 3HKZK 1QKLA 5M5XF 3I4NF 5IYDF 3S1RF 3GTMF 2PMZK 4YFNE 5IP9F 3WODE 3GTLF 5M3FF 1TWGF 4Y52F 1SFOF 5FJ8F 4GZYE 5TMCE 4ZH4E 2NVXF
chains in the Genus database with same CATH superfamily
3S17E 1R9TE 4BXXF 2B63F 4A3BF 4A3LE 3FKIF 4A93E 3S1NE 3PO3F 3S15F 4BBRF 1Y1VF 2BE5E 4KMUE 2E2JE 3S14E 4Y7NE 2E2HE 4YG2E 2JA5E 3GTJE 2VUMF 2NVYE 4A3DF 3M3YE 1I3QF 1HQME 1K83F 1TWAE 1WCMF 4LJZE 2JA8E 2NVQE 3GTGE 1SMYE 2WB1I 2E2IF 5M5WE 4A3GF 4X6AF 2KRXA 4A3FE 4A3EE 4OIQE 5FLMF 3HOVE 3S2DF 5C4XF 4AYBH 1TWHE 4A3JE 5M5XE 3I4NE 5IYDE 4C2ME 4A3IF 3S1RE 3GTME 4QIWH 3HOXF 3EQLE 5IP9E 3GTLE 5C3EF 2WAQK 3CQZF 1TWGE 5M3FE 4Y52E 1TWFF 1SFOE 5TMFE 3I4ME 1YNNK 2A6EE 3K7AF 5FJ8E 4XLNE 4C3HF 1I6HE 3HOUF 2NVXE 4XSXE 5M5YF 4BXXE 2B63E 4A3BE 4C3IF 3FKIE 4A3MF 4G7OE 1I50F 5E17E 3PO3E 3RZDF 3HOZF 4BY7F 3S15E 4BY1F 1Y1VE 3H0GF 1I6VE 2JA6F 2NVTF 2VUME 4A3DE 2Y0SI 4YFKE 4Q5SE 1I3QE 2R92F 1K83E 1WCME 3S1QF 3HOYF 3HOWF 2E2IE 4BBSF 4A3GE 4X6AE 3DXJE 5FLME 4A3KF 3S2DE 3GTQF 3RZOF 4KN7E 4A3CF 2A69E 5C4XE 1EIKA 1R9TF 3GTOF 5IYCF 5M3MF 4A3IE 3PO2F 4A3LF 3HOXE 4OIOE 4OIRE 2CW0E 4AYBK 5C3EE 3CQZE 5D4DE 1YNJK 4LK1E 1TWFE 4MEYE 2NVYF 4QIWK 3K7AE 3HKZH 2A68E 4C3HE 4KN4E 3HOUE 3GTPF 5M5YE 2PMZH 3S16F 4C3IE 1Y1WF 4BBRE 5C44F 4A3ME 1DZFA 2PPBE 3RZDE 3S1MF 2WB1H 3HOZE 4BY7E 5D4CE 4BY1E 5IYBF 4Q4ZE 3H0GE 3GTKF 3H3VG 2JA6E 2NVTE 4C2MF 1TWCF 2JA7F 5C4JF 4OINE 5IP7F 3S2HF 2R93F 2YU9F 4LLGE 3H3VF 3HOYE 4XSZE 4C3JF 3M4OF 3HOWE 5E18E 4G7HE 4BBSE 2O5IE 2A6HE 3I4MF 2R7ZF 1ZYRE 4JK1E 4A3KE 1I6HF 3S17F 3GTQE 3RZOE 3S1NF 4A93F 4A3CE 1IW7E 3GTOE 5IYCE 5M3ME 3PO2E 5IPLE 5D4EE 5BYHE 2E2JF 3S14F 4Y7NF 4LK0E 2E2HF 2JA5F 3GTJF 4OIPE 3M3YF 2NVQF 1TWAF 4YFXE 2JA8F 3GTGF 2Y0SH 3GTPE 4MEXE 2O5JE 5M5WF 1I50E 4G7ZE 3S16E 4A3FF 1Y1WE 5C44E 4XLPE 4A3EF 3HOVF 3S1ME 4MQ9E 1TWHF 4A3JF 2WAQH 1QKLA 3HKZK 5M5XF 3I4NF 5IYDF 5IYBE 3S1RF 3GTMF 3GTKE 2PMZK 4YFNE 5IP9F 1TWCE 2JA7E 3S1QE 2R92E 5C4JE 3S2HE 5IP7E 3WODE 3GTLF 2R93E 2YU9E 5M3FF 1TWGF 4Y52F 4C3JE 1SFOF 3M4OE 5FJ8F 4GZYE 2R7ZE 5TMCE 4ZH4E 2NVXF
chains in the Genus database with same CATH topology
4BXXF 2B63F 4A3BF 3FKIF 3PO3F 3S15F 4BBRF 1Y1VF 2BE5E 4KMUE 4YG2E 2VUMF 4A3DF 1I3QF 1HQME 1K83F 1WCMF 4LJZE 1SMYE 2WB1I 2E2IF 4A3GF 4X6AF 2KRXA 4OIQE 5FLMF 3S2DF 5C4XF 4A3IF 3HOXF 3EQLE 5C3EF 2WAQK 3CQZF 1TWFF 5TMFE 1YNNK 2A6EE 3K7AF 4XLNE 4C3HF 3HOUF 4XSXE 5M5YF 4G7OE 4C3IF 4A3MF 1I50F 5E17E 3RZDF 3HOZF 4BY7F 4BY1F 3H0GF 1I6VE 2JA6F 2NVTF 2Y0SI 4YFKE 4Q5SE 2R92F 3S1QF 3HOYF 3HOWF 4BBSF 3DXJE 4A3KF 3GTQF 3RZOF 4KN7E 4A3CF 2A69E 1R9TF 3GTOF 5IYCF 5M3MF 3PO2F 4A3LF 4OIOE 4OIRE 2CW0E 4AYBK 5D4DE 1YNJK 4LK1E 4MEYE 2NVYF 4QIWK 2A68E 4KN4E 3GTPF 3S16F 1Y1WF 5C44F 3S1MF 2PPBE 5D4CE 5IYBF 4Q4ZE 3GTKF 3H3VG 4C2MF 1TWCF 2JA7F 5C4JF 4OINE 5IP7F 3S2HF 2R93F 2YU9F 4LLGE 4XSZE 4C3JF 3M4OF 5E18E 4G7HE 2O5IE 2A6HE 3I4MF 2R7ZF 1ZYRE 4JK1E 1I6HF 3S17F 3S1NF 4A93F 1IW7E 5IPLE 5D4EE 5BYHE 2E2JF 3S14F 4Y7NF 4LK0E 2E2HF 2JA5F 3GTJF 4OIPE 3M3YF 2NVQF 1TWAF 4YFXE 2JA8F 3GTGF 2O5JE 4MEXE 5M5WF 4G7ZE 4A3FF 4A3EF 4XLPE 3HOVF 4MQ9E 1TWHF 4A3JF 3HKZK 1QKLA 5M5XF 3I4NF 5IYDF 3S1RF 3GTMF 2PMZK 4YFNE 5IP9F 3WODE 3GTLF 5M3FF 1TWGF 4Y52F 1SFOF 5FJ8F 4GZYE 5TMCE 4ZH4E 2NVXF
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4BXX F;  2B63 F;  4A3B F;  3FKI F;  3PO3 F;  3S15 F;  4BBR F;  1Y1V F;  2BE5 E;  4KMU E;  4YG2 E;  2VUM F;  4A3D F;  1I3Q F;  1HQM E;  1K83 F;  1WCM F;  4LJZ E;  1SMY E;  2WB1 I;  2E2I F;  4A3G F;  4X6A F;  4OIQ E;  5FLM F;  3S2D F;  5C4X F;  4A3I F;  3HOX F;  3EQL E;  5C3E F;  2WAQ K;  3CQZ F;  1TWF F;  5TMF E;  1YNN K;  2A6E E;  3K7A F;  4XLN E;  4C3H F;  3HOU F;  4XSX E;  5M5Y F;  4G7O E;  4C3I F;  4A3M F;  1I50 F;  5E17 E;  3RZD F;  3HOZ F;  4BY7 F;  4BY1 F;  3H0G F;  1I6V E;  2JA6 F;  2NVT F;  2Y0S I;  4YFK E;  4Q5S E;  2R92 F;  3S1Q F;  3HOY F;  3HOW F;  4BBS F;  3DXJ E;  4A3K F;  3GTQ F;  3RZO F;  4KN7 E;  4A3C F;  2A69 E;  1R9T F;  3GTO F;  5IYC F;  5M3M F;  3PO2 F;  4A3L F;  4OIO E;  4OIR E;  2CW0 E;  4AYB K;  5D4D E;  1YNJ K;  4LK1 E;  4MEY E;  2NVY F;  2A68 E;  4KN4 E;  3GTP F;  3S16 F;  1Y1W F;  5C44 F;  3S1M F;  2PPB E;  5D4C E;  5IYB F;  4Q4Z E;  3GTK F;  3H3V G;  4C2M F;  1TWC F;  2JA7 F;  5C4J F;  4OIN E;  5IP7 F;  3S2H F;  2R93 F;  2YU9 F;  4LLG E;  4XSZ E;  4C3J F;  3M4O F;  5E18 E;  4G7H E;  2O5I E;  2A6H E;  3I4M F;  2R7Z F;  1ZYR E;  4JK1 E;  1I6H F;  3S17 F;  3S1N F;  4A93 F;  1IW7 E;  5IPL E;  5D4E E;  5BYH E;  2E2J F;  3S14 F;  4Y7N F;  4LK0 E;  2E2H F;  2JA5 F;  3GTJ F;  4OIP E;  3M3Y F;  2NVQ F;  1TWA F;  4YFX E;  2JA8 F;  3GTG F;  2O5J E;  4MEX E;  5M5W F;  4G7Z E;  4A3F F;  4A3E F;  4XLP E;  3HOV F;  4MQ9 E;  1TWH F;  4A3J F;  3HKZ K;  1QKL A;  5M5X F;  3I4N F;  5IYD F;  3S1R F;  3GTM F;  2PMZ K;  4YFN E;  5IP9 F;  3WOD E;  3GTL F;  5M3F F;  1TWG F;  4Y52 F;  1SFO F;  5FJ8 F;  4GZY E;  5TMC E;  4ZH4 E;  2NVX F; 
#chains in the Genus database with same CATH topology
 3S17 E;  1R9T E;  4BXX F;  2B63 F;  4A3B F;  4A3L E;  3FKI F;  4A93 E;  3S1N E;  3PO3 F;  3S15 F;  4BBR F;  1Y1V F;  2BE5 E;  4KMU E;  2E2J E;  3S14 E;  4Y7N E;  2E2H E;  4YG2 E;  2JA5 E;  3GTJ E;  2VUM F;  2NVY E;  4A3D F;  3M3Y E;  1I3Q F;  1HQM E;  1K83 F;  1TWA E;  1WCM F;  4LJZ E;  2JA8 E;  2NVQ E;  3GTG E;  1SMY E;  2WB1 I;  2E2I F;  5M5W E;  4A3G F;  4X6A F;  2KRX A;  4A3F E;  4A3E E;  4OIQ E;  5FLM F;  3HOV E;  3S2D F;  5C4X F;  4AYB H;  1TWH E;  4A3J E;  5M5X E;  3I4N E;  5IYD E;  4C2M E;  4A3I F;  3S1R E;  3GTM E;  4QIW H;  3HOX F;  3EQL E;  5IP9 E;  3GTL E;  5C3E F;  2WAQ K;  3CQZ F;  1TWG E;  5M3F E;  4Y52 E;  1TWF F;  1SFO E;  5TMF E;  3I4M E;  1YNN K;  2A6E E;  3K7A F;  5FJ8 E;  4XLN E;  4C3H F;  1I6H E;  3HOU F;  2NVX E;  4XSX E;  5M5Y F;  4BXX E;  2B63 E;  4A3B E;  4C3I F;  3FKI E;  4A3M F;  4G7O E;  1I50 F;  5E17 E;  3PO3 E;  3RZD F;  3HOZ F;  4BY7 F;  3S15 E;  4BY1 F;  1Y1V E;  3H0G F;  1I6V E;  2JA6 F;  2NVT F;  2VUM E;  4A3D E;  2Y0S I;  4YFK E;  4Q5S E;  1I3Q E;  2R92 F;  1K83 E;  1WCM E;  3S1Q F;  3HOY F;  3HOW F;  2E2I E;  4BBS F;  4A3G E;  4X6A E;  3DXJ E;  5FLM E;  4A3K F;  3S2D E;  3GTQ F;  3RZO F;  4KN7 E;  4A3C F;  2A69 E;  5C4X E;  1EIK A;  1R9T F;  3GTO F;  5IYC F;  5M3M F;  4A3I E;  3PO2 F;  4A3L F;  3HOX E;  4OIO E;  4OIR E;  2CW0 E;  4AYB K;  5C3E E;  3CQZ E;  5D4D E;  1YNJ K;  4LK1 E;  1TWF E;  4MEY E;  2NVY F;  4QIW K;  3K7A E;  3HKZ H;  2A68 E;  4C3H E;  4KN4 E;  3HOU E;  3GTP F;  5M5Y E;  2PMZ H;  3S16 F;  4C3I E;  1Y1W F;  4BBR E;  5C44 F;  4A3M E;  1DZF A;  2PPB E;  3RZD E;  3S1M F;  2WB1 H;  3HOZ E;  4BY7 E;  5D4C E;  4BY1 E;  5IYB F;  4Q4Z E;  3H0G E;  3GTK F;  3H3V G;  2JA6 E;  2NVT E;  4C2M F;  1TWC F;  2JA7 F;  5C4J F;  4OIN E;  5IP7 F;  3S2H F;  2R93 F;  2YU9 F;  4LLG E;  3H3V F;  3HOY E;  4XSZ E;  4C3J F;  3M4O F;  3HOW E;  5E18 E;  4G7H E;  4BBS E;  2O5I E;  2A6H E;  3I4M F;  2R7Z F;  1ZYR E;  4JK1 E;  4A3K E;  1I6H F;  3S17 F;  3GTQ E;  3RZO E;  3S1N F;  4A93 F;  4A3C E;  1IW7 E;  3GTO E;  5IYC E;  5M3M E;  3PO2 E;  5IPL E;  5D4E E;  5BYH E;  2E2J F;  3S14 F;  4Y7N F;  4LK0 E;  2E2H F;  2JA5 F;  3GTJ F;  4OIP E;  3M3Y F;  2NVQ F;  1TWA F;  4YFX E;  2JA8 F;  3GTG F;  2Y0S H;  3GTP E;  4MEX E;  2O5J E;  5M5W F;  1I50 E;  4G7Z E;  3S16 E;  4A3F F;  1Y1W E;  5C44 E;  4XLP E;  4A3E F;  3HOV F;  3S1M E;  4MQ9 E;  1TWH F;  4A3J F;  2WAQ H;  1QKL A;  3HKZ K;  5M5X F;  3I4N F;  5IYD F;  5IYB E;  3S1R F;  3GTM F;  3GTK E;  2PMZ K;  4YFN E;  5IP9 F;  1TWC E;  2JA7 E;  3S1Q E;  2R92 E;  5C4J E;  3S2H E;  5IP7 E;  3WOD E;  3GTL F;  2R93 E;  2YU9 E;  5M3F F;  1TWG F;  4Y52 F;  4C3J E;  1SFO F;  3M4O E;  5FJ8 F;  4GZY E;  2R7Z E;  5TMC E;  4ZH4 E;  2NVX F; 
#chains in the Genus database with same CATH homology
 4BXX F;  2B63 F;  4A3B F;  3FKI F;  3PO3 F;  3S15 F;  4BBR F;  1Y1V F;  2BE5 E;  4KMU E;  4YG2 E;  2VUM F;  4A3D F;  1I3Q F;  1HQM E;  1K83 F;  1WCM F;  4LJZ E;  1SMY E;  2WB1 I;  2E2I F;  4A3G F;  4X6A F;  2KRX A;  4OIQ E;  5FLM F;  3S2D F;  5C4X F;  4A3I F;  3HOX F;  3EQL E;  5C3E F;  2WAQ K;  3CQZ F;  1TWF F;  5TMF E;  1YNN K;  2A6E E;  3K7A F;  4XLN E;  4C3H F;  3HOU F;  4XSX E;  5M5Y F;  4G7O E;  4C3I F;  4A3M F;  1I50 F;  5E17 E;  3RZD F;  3HOZ F;  4BY7 F;  4BY1 F;  3H0G F;  1I6V E;  2JA6 F;  2NVT F;  2Y0S I;  4YFK E;  4Q5S E;  2R92 F;  3S1Q F;  3HOY F;  3HOW F;  4BBS F;  3DXJ E;  4A3K F;  3GTQ F;  3RZO F;  4KN7 E;  4A3C F;  2A69 E;  1R9T F;  3GTO F;  5IYC F;  5M3M F;  3PO2 F;  4A3L F;  4OIO E;  4OIR E;  2CW0 E;  4AYB K;  5D4D E;  1YNJ K;  4LK1 E;  4MEY E;  2NVY F;  4QIW K;  2A68 E;  4KN4 E;  3GTP F;  3S16 F;  1Y1W F;  5C44 F;  3S1M F;  2PPB E;  5D4C E;  5IYB F;  4Q4Z E;  3GTK F;  3H3V G;  4C2M F;  1TWC F;  2JA7 F;  5C4J F;  4OIN E;  5IP7 F;  3S2H F;  2R93 F;  2YU9 F;  4LLG E;  4XSZ E;  4C3J F;  3M4O F;  5E18 E;  4G7H E;  2O5I E;  2A6H E;  3I4M F;  2R7Z F;  1ZYR E;  4JK1 E;  1I6H F;  3S17 F;  3S1N F;  4A93 F;  1IW7 E;  5IPL E;  5D4E E;  5BYH E;  2E2J F;  3S14 F;  4Y7N F;  4LK0 E;  2E2H F;  2JA5 F;  3GTJ F;  4OIP E;  3M3Y F;  2NVQ F;  1TWA F;  4YFX E;  2JA8 F;  3GTG F;  2O5J E;  4MEX E;  5M5W F;  4G7Z E;  4A3F F;  4A3E F;  4XLP E;  3HOV F;  4MQ9 E;  1TWH F;  4A3J F;  3HKZ K;  1QKL A;  5M5X F;  3I4N F;  5IYD F;  3S1R F;  3GTM F;  2PMZ K;  4YFN E;  5IP9 F;  3WOD E;  3GTL F;  5M3F F;  1TWG F;  4Y52 F;  1SFO F;  5FJ8 F;  4GZY E;  5TMC E;  4ZH4 E;  2NVX F; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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