4Y0ZI

Trypsin in complex with with bpti mutant aminobutyric acid
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
57
structure length
56
Chain Sequence
PDFCLEPPYTGPCARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Fluorine teams up with water to restore inhibitor activity to mutant BPTI.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor complex
molecule keywords Cationic trypsin
total genus 11
structure length 56
sequence length 57
ec nomenclature
pdb deposition date 2015-02-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 4y0zI00
1YKTB 1B0CA 1OA55 2TPII 2ZVXA 1FAKI 4ISOB 3TGJI 1CBWD 1MTND 1P2JI 1LD5A 4Y0ZI 6PTIA 3UIRC 2R9PE 3BYBA 4TPII 3WNYA 3LDJA 4ISLB 3BTHI 2KNTA 3P95E 2JOTA 3BTMI 2J6DA 1AALA 2UUYB 1P2KI 1CO7I 1P2II 1T8NB 1DEMA 3FP7J 2W8XA 1T7CB 2KCRA 4NTXB 1BF0A 2FTLI 2LFKA 1AAPA 3TGII 2TGPI 4ISNB 1UUAA 1P2MB 3TPII 1P2NB 1T8OB 3BTDI 1NAGA 3FP8I 4NTWB 3BTFI 3FP6I 1T8MB 4BNRI 1BPTA 4Y0YI 1OA65 3OFWA 1BTIA 3UOUB 3AUHA 1BUNB 4BQDA 1KNTA 1BTHP 1BZXI 1FY8I 1YC0I 3LDIA 1TAPA 1D0DA 2UUXA 1BRCI 3AUCA 2ODYE 3BTWI 1JV9A 3L33E 3OTJI 1EAWB 2FI5I 3D65I 5JB7A 2M99A 7PTIA 1DTXA 4BD9B 2IJOI 3AUEA 3GYMI 4Y11I 3U1JE 3P92E 5JB5A 2DDIA 1BIKA 2CA7A 1TAWB 3T62D 3BTKI 1BPIA 1EJMB 5JB6A 2FI3I 3L3TE 1YLCB 2M01A 1TOCR 4DTGK 3M7QB 1PITA 5PTIA 1KUNA 1G6XA 1KTHA 5JB4A 4NTYB 1F5RI 3AUGA 1Y62A 1BHCA 2FI4I 3LDMA 1P2QB 2FTMB 2DDJA 1TPAI 2ZJXA 1F7ZI 3AUDA 4DG4C 1ZJDB 2LFLA 1FANA 9PTIA 3BTGI 1KIGI 2HEXA 4U30W 1CA0D 4U32X 1D0DB 1ADZA 3BTTI 3BTEI 1P2OB 3TGKI 1DTKA 3AUIA 3BTQI 1TFXC 1TCPA 1DENA 1T8LB 4WWYC 4PTIA 4Y10I 1QLQA 2KAII 5C67C 1SHPA 2RA3C 1UUBA 1LD6A 1K6UA 4WXVC 1BZ5A 1JV8A 3CI7A 8PTIA 1YLDB 2PTCI 3AUBA 1IRHA 1BRBI 1ZR0B 1JC6A
chains in the Genus database with same CATH superfamily
1YKTB 1B0CA 1OA55 2TPII 2ZVXA 1FAKI 4ISOB 3TGJI 1CBWD 1MTND 1P2JI 1LD5A 4Y0ZI 6PTIA 3UIRC 2R9PE 3BYBA 4TPII 3WNYA 3LDJA 4ISLB 3BTHI 2KNTA 3P95E 2JOTA 3BTMI 2J6DA 1AALA 2UUYB 1P2KI 1CO7I 1P2II 1T8NB 1DEMA 3FP7J 2W8XA 1T7CB 2KCRA 4NTXB 1BF0A 2FTLI 2LFKA 1AAPA 3TGII 2TGPI 4ISNB 1UUAA 1P2MB 3TPII 1P2NB 1T8OB 3BTDI 1NAGA 3FP8I 4NTWB 3BTFI 3FP6I 1T8MB 4BNRI 1BPTA 4Y0YI 1OA65 3OFWA 1BTIA 3UOUB 3AUHA 1BUNB 4BQDA 1KNTA 1BTHP 1BZXI 1FY8I 1YC0I 3LDIA 1TAPA 1D0DA 2UUXA 1BRCI 3AUCA 2ODYE 3BTWI 1JV9A 3L33E 3OTJI 1EAWB 2FI5I 3D65I 5JB7A 2M99A 7PTIA 1DTXA 4BD9B 2IJOI 3AUEA 3GYMI 4Y11I 3U1JE 3P92E 5JB5A 2DDIA 1BIKA 2CA7A 1TAWB 3T62D 3BTKI 1BPIA 1EJMB 5JB6A 2FI3I 3L3TE 1YLCB 2M01A 1TOCR 4DTGK 3M7QB 1PITA 5PTIA 1KUNA 1G6XA 1KTHA 5JB4A 4NTYB 1F5RI 3AUGA 1Y62A 1BHCA 2FI4I 3LDMA 1P2QB 2FTMB 2DDJA 1TPAI 2ZJXA 1F7ZI 3AUDA 4DG4C 1ZJDB 2LFLA 1FANA 9PTIA 3BTGI 1KIGI 2HEXA 4U30W 1CA0D 4U32X 1D0DB 1ADZA 3BTTI 3BTEI 1P2OB 3TGKI 1DTKA 3AUIA 3BTQI 1TFXC 1TCPA 1DENA 1T8LB 4WWYC 4PTIA 4Y10I 1QLQA 2KAII 5C67C 1SHPA 2RA3C 1UUBA 1LD6A 1K6UA 4WXVC 1BZ5A 1JV8A 3CI7A 8PTIA 1YLDB 2PTCI 3AUBA 1IRHA 1BRBI 1ZR0B 1JC6A
chains in the Genus database with same CATH topology
1YKTB 1B0CA 1OA55 2TPII 2ZVXA 1FAKI 4ISOB 3TGJI 1CBWD 1MTND 1P2JI 1LD5A 4Y0ZI 6PTIA 3UIRC 2R9PE 3BYBA 4TPII 3WNYA 3LDJA 4ISLB 3BTHI 2KNTA 3P95E 2JOTA 3BTMI 2J6DA 1AALA 2UUYB 1P2KI 1CO7I 1P2II 1T8NB 1DEMA 3FP7J 2W8XA 1T7CB 2KCRA 4NTXB 1BF0A 2FTLI 2LFKA 1AAPA 3TGII 2TGPI 4ISNB 1UUAA 1P2MB 3TPII 1P2NB 1T8OB 3BTDI 1NAGA 3FP8I 4NTWB 3BTFI 3FP6I 1T8MB 4BNRI 1BPTA 4Y0YI 1OA65 3OFWA 1BTIA 3UOUB 3AUHA 1BUNB 4BQDA 1KNTA 1BTHP 1BZXI 1FY8I 1YC0I 3LDIA 1TAPA 1D0DA 2UUXA 1BRCI 3AUCA 2ODYE 3BTWI 1JV9A 3L33E 3OTJI 1EAWB 2FI5I 3D65I 5JB7A 2M99A 7PTIA 1DTXA 4BD9B 2IJOI 3AUEA 3GYMI 4Y11I 3U1JE 3P92E 5JB5A 2DDIA 1BIKA 2CA7A 1TAWB 3T62D 3BTKI 1BPIA 1EJMB 5JB6A 2FI3I 3L3TE 1YLCB 2M01A 1TOCR 4DTGK 3M7QB 1PITA 5PTIA 1KUNA 1G6XA 1KTHA 5JB4A 4NTYB 1F5RI 3AUGA 1Y62A 1BHCA 2FI4I 3LDMA 1P2QB 2FTMB 2DDJA 1TPAI 2ZJXA 1F7ZI 3AUDA 4DG4C 1ZJDB 2LFLA 1FANA 9PTIA 3BTGI 1KIGI 2HEXA 4U30W 1CA0D 4U32X 1D0DB 1ADZA 3BTTI 3BTEI 1P2OB 3TGKI 1DTKA 3AUIA 3BTQI 1TFXC 1TCPA 1DENA 1T8LB 4WWYC 4PTIA 4Y10I 1QLQA 2KAII 5C67C 1SHPA 2RA3C 1UUBA 1LD6A 1K6UA 4WXVC 1BZ5A 1JV8A 3CI7A 8PTIA 1YLDB 2PTCI 3AUBA 1IRHA 1BRBI 1ZR0B 1JC6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YKT B;  1B0C A;  1OA5 5;  2TPI I;  2ZVX A;  1FAK I;  4ISO B;  3TGJ I;  1CBW D;  1MTN D;  1P2J I;  1LD5 A;  4Y0Z I;  6PTI A;  3UIR C;  2R9P E;  3BYB A;  4TPI I;  3WNY A;  3LDJ A;  4ISL B;  3BTH I;  2KNT A;  3P95 E;  2JOT A;  3BTM I;  2J6D A;  1AAL A;  2UUY B;  1P2K I;  1CO7 I;  1P2I I;  1T8N B;  1DEM A;  3FP7 J;  2W8X A;  1T7C B;  2KCR A;  4NTX B;  1BF0 A;  2FTL I;  2LFK A;  1AAP A;  3TGI I;  2TGP I;  4ISN B;  1UUA A;  1P2M B;  3TPI I;  1P2N B;  1T8O B;  3BTD I;  1NAG A;  3FP8 I;  4NTW B;  3BTF I;  3FP6 I;  1T8M B;  4BNR I;  1BPT A;  4Y0Y I;  1OA6 5;  3OFW A;  1BTI A;  3UOU B;  3AUH A;  1BUN B;  4BQD A;  1KNT A;  1BTH P;  1BZX I;  1FY8 I;  1YC0 I;  3LDI A;  1TAP A;  1D0D A;  2UUX A;  1BRC I;  3AUC A;  2ODY E;  3BTW I;  1JV9 A;  3L33 E;  3OTJ I;  1EAW B;  2FI5 I;  3D65 I;  5JB7 A;  2M99 A;  7PTI A;  1DTX A;  4BD9 B;  2IJO I;  3AUE A;  3GYM I;  4Y11 I;  3U1J E;  3P92 E;  5JB5 A;  2DDI A;  1BIK A;  2CA7 A;  1TAW B;  3T62 D;  3BTK I;  1BPI A;  1EJM B;  5JB6 A;  2FI3 I;  3L3T E;  1YLC B;  2M01 A;  1TOC R;  4DTG K;  3M7Q B;  1PIT A;  5PTI A;  1KUN A;  1G6X A;  1KTH A;  5JB4 A;  4NTY B;  1F5R I;  3AUG A;  1Y62 A;  1BHC A;  2FI4 I;  3LDM A;  1P2Q B;  2FTM B;  2DDJ A;  1TPA I;  2ZJX A;  1F7Z I;  3AUD A;  4DG4 C;  1ZJD B;  2LFL A;  1FAN A;  9PTI A;  3BTG I;  1KIG I;  2HEX A;  4U30 W;  1CA0 D;  4U32 X;  1D0D B;  1ADZ A;  3BTT I;  3BTE I;  1P2O B;  3TGK I;  1DTK A;  3AUI A;  3BTQ I;  1TFX C;  1TCP A;  1DEN A;  1T8L B;  4WWY C;  4PTI A;  4Y10 I;  1QLQ A;  2KAI I;  5C67 C;  1SHP A;  2RA3 C;  1UUB A;  1LD6 A;  1K6U A;  4WXV C;  1BZ5 A;  1JV8 A;  3CI7 A;  8PTI A;  1YLD B;  2PTC I;  3AUB A;  1IRH A;  1BRB I;  1ZR0 B;  1JC6 A; 
#chains in the Genus database with same CATH topology
 1YKT B;  1B0C A;  1OA5 5;  2TPI I;  2ZVX A;  1FAK I;  4ISO B;  3TGJ I;  1CBW D;  1MTN D;  1P2J I;  1LD5 A;  4Y0Z I;  6PTI A;  3UIR C;  2R9P E;  3BYB A;  4TPI I;  3WNY A;  3LDJ A;  4ISL B;  3BTH I;  2KNT A;  3P95 E;  2JOT A;  3BTM I;  2J6D A;  1AAL A;  2UUY B;  1P2K I;  1CO7 I;  1P2I I;  1T8N B;  1DEM A;  3FP7 J;  2W8X A;  1T7C B;  2KCR A;  4NTX B;  1BF0 A;  2FTL I;  2LFK A;  1AAP A;  3TGI I;  2TGP I;  4ISN B;  1UUA A;  1P2M B;  3TPI I;  1P2N B;  1T8O B;  3BTD I;  1NAG A;  3FP8 I;  4NTW B;  3BTF I;  3FP6 I;  1T8M B;  4BNR I;  1BPT A;  4Y0Y I;  1OA6 5;  3OFW A;  1BTI A;  3UOU B;  3AUH A;  1BUN B;  4BQD A;  1KNT A;  1BTH P;  1BZX I;  1FY8 I;  1YC0 I;  3LDI A;  1TAP A;  1D0D A;  2UUX A;  1BRC I;  3AUC A;  2ODY E;  3BTW I;  1JV9 A;  3L33 E;  3OTJ I;  1EAW B;  2FI5 I;  3D65 I;  5JB7 A;  2M99 A;  7PTI A;  1DTX A;  4BD9 B;  2IJO I;  3AUE A;  3GYM I;  4Y11 I;  3U1J E;  3P92 E;  5JB5 A;  2DDI A;  1BIK A;  2CA7 A;  1TAW B;  3T62 D;  3BTK I;  1BPI A;  1EJM B;  5JB6 A;  2FI3 I;  3L3T E;  1YLC B;  2M01 A;  1TOC R;  4DTG K;  3M7Q B;  1PIT A;  5PTI A;  1KUN A;  1G6X A;  1KTH A;  5JB4 A;  4NTY B;  1F5R I;  3AUG A;  1Y62 A;  1BHC A;  2FI4 I;  3LDM A;  1P2Q B;  2FTM B;  2DDJ A;  1TPA I;  2ZJX A;  1F7Z I;  3AUD A;  4DG4 C;  1ZJD B;  2LFL A;  1FAN A;  9PTI A;  3BTG I;  1KIG I;  2HEX A;  4U30 W;  1CA0 D;  4U32 X;  1D0D B;  1ADZ A;  3BTT I;  3BTE I;  1P2O B;  3TGK I;  1DTK A;  3AUI A;  3BTQ I;  1TFX C;  1TCP A;  1DEN A;  1T8L B;  4WWY C;  4PTI A;  4Y10 I;  1QLQ A;  2KAI I;  5C67 C;  1SHP A;  2RA3 C;  1UUB A;  1LD6 A;  1K6U A;  4WXV C;  1BZ5 A;  1JV8 A;  3CI7 A;  8PTI A;  1YLD B;  2PTC I;  3AUB A;  1IRH A;  1BRB I;  1ZR0 B;  1JC6 A; 
#chains in the Genus database with same CATH homology
 1YKT B;  1B0C A;  1OA5 5;  2TPI I;  2ZVX A;  1FAK I;  4ISO B;  3TGJ I;  1CBW D;  1MTN D;  1P2J I;  1LD5 A;  4Y0Z I;  6PTI A;  3UIR C;  2R9P E;  3BYB A;  4TPI I;  3WNY A;  3LDJ A;  4ISL B;  3BTH I;  2KNT A;  3P95 E;  2JOT A;  3BTM I;  2J6D A;  1AAL A;  2UUY B;  1P2K I;  1CO7 I;  1P2I I;  1T8N B;  1DEM A;  3FP7 J;  2W8X A;  1T7C B;  2KCR A;  4NTX B;  1BF0 A;  2FTL I;  2LFK A;  1AAP A;  3TGI I;  2TGP I;  4ISN B;  1UUA A;  1P2M B;  3TPI I;  1P2N B;  1T8O B;  3BTD I;  1NAG A;  3FP8 I;  4NTW B;  3BTF I;  3FP6 I;  1T8M B;  4BNR I;  1BPT A;  4Y0Y I;  1OA6 5;  3OFW A;  1BTI A;  3UOU B;  3AUH A;  1BUN B;  4BQD A;  1KNT A;  1BTH P;  1BZX I;  1FY8 I;  1YC0 I;  3LDI A;  1TAP A;  1D0D A;  2UUX A;  1BRC I;  3AUC A;  2ODY E;  3BTW I;  1JV9 A;  3L33 E;  3OTJ I;  1EAW B;  2FI5 I;  3D65 I;  5JB7 A;  2M99 A;  7PTI A;  1DTX A;  4BD9 B;  2IJO I;  3AUE A;  3GYM I;  4Y11 I;  3U1J E;  3P92 E;  5JB5 A;  2DDI A;  1BIK A;  2CA7 A;  1TAW B;  3T62 D;  3BTK I;  1BPI A;  1EJM B;  5JB6 A;  2FI3 I;  3L3T E;  1YLC B;  2M01 A;  1TOC R;  4DTG K;  3M7Q B;  1PIT A;  5PTI A;  1KUN A;  1G6X A;  1KTH A;  5JB4 A;  4NTY B;  1F5R I;  3AUG A;  1Y62 A;  1BHC A;  2FI4 I;  3LDM A;  1P2Q B;  2FTM B;  2DDJ A;  1TPA I;  2ZJX A;  1F7Z I;  3AUD A;  4DG4 C;  1ZJD B;  2LFL A;  1FAN A;  9PTI A;  3BTG I;  1KIG I;  2HEX A;  4U30 W;  1CA0 D;  4U32 X;  1D0D B;  1ADZ A;  3BTT I;  3BTE I;  1P2O B;  3TGK I;  1DTK A;  3AUI A;  3BTQ I;  1TFX C;  1TCP A;  1DEN A;  1T8L B;  4WWY C;  4PTI A;  4Y10 I;  1QLQ A;  2KAI I;  5C67 C;  1SHP A;  2RA3 C;  1UUB A;  1LD6 A;  1K6U A;  4WXV C;  1BZ5 A;  1JV8 A;  3CI7 A;  8PTI A;  1YLD B;  2PTC I;  3AUB A;  1IRH A;  1BRB I;  1ZR0 B;  1JC6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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