4Y11I

Trypsin in complex with with bpti mutant (2s)-2-amino-4,4,4-trifluorobutanoic acid
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
57
structure length
56
Chain Sequence
PDFCLEPPYTGPCARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Fluorine teams up with water to restore inhibitor activity to mutant BPTI.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Cationic trypsin
total genus 11
structure length 56
sequence length 57
ec nomenclature
pdb deposition date 2015-02-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 4y11I00
1EAWB 1AAPA 1F7ZI 2FI5I 1K6UA 1T8LB 3AUCA 4Y0YI 5PTIA 1P2MB 3BTFI 4Y10I 1FANA 2HEXA 2KCRA 1JV9A 1BRCI 3D65I 1CBWD 3LDIA 3TGII 1SHPA 4BQDA 3FP7J 1T8MB 1DENA 1FY8I 2TGPI 3BYBA 1BUNB 1PITA 3BTEI 1ZR0B 2FI4I 1BZ5A 1YKTB 1T8NB 4BD9B 5C67C 1BTIA 2R9PE 3BTMI 1BPTA 4Y0ZI 1CO7I 3GYMI 8PTIA 3M7QB 5JB7A 4NTXB 1G6XA 9PTIA 1OA55 3TGKI 7PTIA 1JV8A 2ZVXA 3AUGA 2ZJXA 4PTIA 1TAPA 1FAKI 3FP8I 3L3TE 3BTQI 3U1JE 1UUBA 1F5RI 2J6DA 1DEMA 2FI3I 5JB5A 1DTXA 1YLDB 3AUEA 1IRHA 3UIRC 3LDJA 3BTKI 4ISLB 3AUDA 1P2II 1EJMB 2W8XA 1P2QB 1T7CB 1Y62A 3AUBA 2M01A 1MTND 2LFLA 3WNYA 1D0DA 1BF0A 2RA3C 5JB4A 3BTHI 1BTHP 1TFXC 2DDIA 3AUIA 1T8OB 1TAWB 1LD5A 4Y11I 1P2NB 1KUNA 2PTCI 1BZXI 1BIKA 2KAII 3BTWI 3LDMA 1NAGA 1ADZA 2CA7A 2KNTA 3P92E 2FTLI 3T62D 1OA65 1AALA 2M99A 1P2JI 4ISNB 4ISOB 3TPII 2ODYE 1DTKA 4TPII 1B0CA 1BHCA 3BTGI 3P95E 3FP6I 4DTGK 1TPAI 2DDJA 1BRBI 2JOTA 3UOUB 3OFWA 1YLCB 1TCPA 1KIGI 5JB6A 3TGJI 3L33E 2LFKA 1CA0D 3OTJI 2TPII 1BPIA 1P2OB 4WWYC 1P2KI 1ZJDB 1QLQA 3BTTI 2UUYB 1YC0I 1LD6A 4NTYB 4U30W 1JC6A 3AUHA 1KTHA 1UUAA 6PTIA 1KNTA 1TOCR 3BTDI 4NTWB 4WXVC 4DG4C 2IJOI 2UUXA 3CI7A 4BNRI 2FTMB 1D0DB 4U32X
chains in the Genus database with same CATH superfamily
1EAWB 1AAPA 1F7ZI 2FI5I 1K6UA 1T8LB 3AUCA 4Y0YI 5PTIA 1P2MB 3BTFI 4Y10I 1FANA 2HEXA 2KCRA 1JV9A 1BRCI 3D65I 1CBWD 3LDIA 3TGII 1SHPA 4BQDA 3FP7J 1T8MB 1DENA 1FY8I 2TGPI 3BYBA 1BUNB 1PITA 3BTEI 1ZR0B 2FI4I 1BZ5A 1YKTB 1T8NB 4BD9B 5C67C 1BTIA 2R9PE 3BTMI 1BPTA 4Y0ZI 1CO7I 3GYMI 8PTIA 3M7QB 5JB7A 4NTXB 1G6XA 9PTIA 1OA55 3TGKI 7PTIA 1JV8A 2ZVXA 3AUGA 2ZJXA 4PTIA 1TAPA 1FAKI 3FP8I 3L3TE 3BTQI 3U1JE 1UUBA 1F5RI 2J6DA 1DEMA 2FI3I 5JB5A 1DTXA 1YLDB 3AUEA 1IRHA 3UIRC 3LDJA 3BTKI 4ISLB 3AUDA 1P2II 1EJMB 2W8XA 1P2QB 1T7CB 1Y62A 3AUBA 2M01A 1MTND 2LFLA 3WNYA 1D0DA 1BF0A 2RA3C 5JB4A 3BTHI 1BTHP 1TFXC 2DDIA 3AUIA 1T8OB 1TAWB 1LD5A 4Y11I 1P2NB 1KUNA 2PTCI 1BZXI 1BIKA 2KAII 3BTWI 3LDMA 1NAGA 1ADZA 2CA7A 2KNTA 3P92E 2FTLI 3T62D 1OA65 1AALA 2M99A 1P2JI 4ISNB 4ISOB 3TPII 2ODYE 1DTKA 4TPII 1B0CA 1BHCA 3BTGI 3P95E 3FP6I 4DTGK 1TPAI 2DDJA 1BRBI 2JOTA 3UOUB 3OFWA 1YLCB 1TCPA 1KIGI 5JB6A 3TGJI 3L33E 2LFKA 1CA0D 3OTJI 2TPII 1BPIA 1P2OB 4WWYC 1P2KI 1ZJDB 1QLQA 3BTTI 2UUYB 1YC0I 1LD6A 4NTYB 4U30W 1JC6A 3AUHA 1KTHA 1UUAA 6PTIA 1KNTA 1TOCR 3BTDI 4NTWB 4WXVC 4DG4C 2IJOI 2UUXA 3CI7A 4BNRI 2FTMB 1D0DB 4U32X
chains in the Genus database with same CATH topology
1EAWB 1AAPA 1F7ZI 2FI5I 1K6UA 1T8LB 3AUCA 4Y0YI 5PTIA 1P2MB 3BTFI 4Y10I 1FANA 2HEXA 2KCRA 1JV9A 1BRCI 3D65I 1CBWD 3LDIA 3TGII 1SHPA 4BQDA 3FP7J 1T8MB 1DENA 1FY8I 2TGPI 3BYBA 1BUNB 1PITA 3BTEI 1ZR0B 2FI4I 1BZ5A 1YKTB 1T8NB 4BD9B 5C67C 1BTIA 2R9PE 3BTMI 1BPTA 4Y0ZI 1CO7I 3GYMI 8PTIA 3M7QB 5JB7A 4NTXB 1G6XA 9PTIA 1OA55 3TGKI 7PTIA 1JV8A 2ZVXA 3AUGA 2ZJXA 4PTIA 1TAPA 1FAKI 3FP8I 3L3TE 3BTQI 3U1JE 1UUBA 1F5RI 2J6DA 1DEMA 2FI3I 5JB5A 1DTXA 1YLDB 3AUEA 1IRHA 3UIRC 3LDJA 3BTKI 4ISLB 3AUDA 1P2II 1EJMB 2W8XA 1P2QB 1T7CB 1Y62A 3AUBA 2M01A 1MTND 2LFLA 3WNYA 1D0DA 1BF0A 2RA3C 5JB4A 3BTHI 1BTHP 1TFXC 2DDIA 3AUIA 1T8OB 1TAWB 1LD5A 4Y11I 1P2NB 1KUNA 2PTCI 1BZXI 1BIKA 2KAII 3BTWI 3LDMA 1NAGA 1ADZA 2CA7A 2KNTA 3P92E 2FTLI 3T62D 1OA65 1AALA 2M99A 1P2JI 4ISNB 4ISOB 3TPII 2ODYE 1DTKA 4TPII 1B0CA 1BHCA 3BTGI 3P95E 3FP6I 4DTGK 1TPAI 2DDJA 1BRBI 2JOTA 3UOUB 3OFWA 1YLCB 1TCPA 1KIGI 5JB6A 3TGJI 3L33E 2LFKA 1CA0D 3OTJI 2TPII 1BPIA 1P2OB 4WWYC 1P2KI 1ZJDB 1QLQA 3BTTI 2UUYB 1YC0I 1LD6A 4NTYB 4U30W 1JC6A 3AUHA 1KTHA 1UUAA 6PTIA 1KNTA 1TOCR 3BTDI 4NTWB 4WXVC 4DG4C 2IJOI 2UUXA 3CI7A 4BNRI 2FTMB 1D0DB 4U32X
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1EAW B;  1AAP A;  1F7Z I;  2FI5 I;  1K6U A;  1T8L B;  3AUC A;  4Y0Y I;  5PTI A;  1P2M B;  3BTF I;  4Y10 I;  1FAN A;  2HEX A;  2KCR A;  1JV9 A;  1BRC I;  3D65 I;  1CBW D;  3LDI A;  3TGI I;  1SHP A;  4BQD A;  3FP7 J;  1T8M B;  1DEN A;  1FY8 I;  2TGP I;  3BYB A;  1BUN B;  1PIT A;  3BTE I;  1ZR0 B;  2FI4 I;  1BZ5 A;  1YKT B;  1T8N B;  4BD9 B;  5C67 C;  1BTI A;  2R9P E;  3BTM I;  1BPT A;  4Y0Z I;  1CO7 I;  3GYM I;  8PTI A;  3M7Q B;  5JB7 A;  4NTX B;  1G6X A;  9PTI A;  1OA5 5;  3TGK I;  7PTI A;  1JV8 A;  2ZVX A;  3AUG A;  2ZJX A;  4PTI A;  1TAP A;  1FAK I;  3FP8 I;  3L3T E;  3BTQ I;  3U1J E;  1UUB A;  1F5R I;  2J6D A;  1DEM A;  2FI3 I;  5JB5 A;  1DTX A;  1YLD B;  3AUE A;  1IRH A;  3UIR C;  3LDJ A;  3BTK I;  4ISL B;  3AUD A;  1P2I I;  1EJM B;  2W8X A;  1P2Q B;  1T7C B;  1Y62 A;  3AUB A;  2M01 A;  1MTN D;  2LFL A;  3WNY A;  1D0D A;  1BF0 A;  2RA3 C;  5JB4 A;  3BTH I;  1BTH P;  1TFX C;  2DDI A;  3AUI A;  1T8O B;  1TAW B;  1LD5 A;  4Y11 I;  1P2N B;  1KUN A;  2PTC I;  1BZX I;  1BIK A;  2KAI I;  3BTW I;  3LDM A;  1NAG A;  1ADZ A;  2CA7 A;  2KNT A;  3P92 E;  2FTL I;  3T62 D;  1OA6 5;  1AAL A;  2M99 A;  1P2J I;  4ISN B;  4ISO B;  3TPI I;  2ODY E;  1DTK A;  4TPI I;  1B0C A;  1BHC A;  3BTG I;  3P95 E;  3FP6 I;  4DTG K;  1TPA I;  2DDJ A;  1BRB I;  2JOT A;  3UOU B;  3OFW A;  1YLC B;  1TCP A;  1KIG I;  5JB6 A;  3TGJ I;  3L33 E;  2LFK A;  1CA0 D;  3OTJ I;  2TPI I;  1BPI A;  1P2O B;  4WWY C;  1P2K I;  1ZJD B;  1QLQ A;  3BTT I;  2UUY B;  1YC0 I;  1LD6 A;  4NTY B;  4U30 W;  1JC6 A;  3AUH A;  1KTH A;  1UUA A;  6PTI A;  1KNT A;  1TOC R;  3BTD I;  4NTW B;  4WXV C;  4DG4 C;  2IJO I;  2UUX A;  3CI7 A;  4BNR I;  2FTM B;  1D0D B;  4U32 X; 
#chains in the Genus database with same CATH topology
 1EAW B;  1AAP A;  1F7Z I;  2FI5 I;  1K6U A;  1T8L B;  3AUC A;  4Y0Y I;  5PTI A;  1P2M B;  3BTF I;  4Y10 I;  1FAN A;  2HEX A;  2KCR A;  1JV9 A;  1BRC I;  3D65 I;  1CBW D;  3LDI A;  3TGI I;  1SHP A;  4BQD A;  3FP7 J;  1T8M B;  1DEN A;  1FY8 I;  2TGP I;  3BYB A;  1BUN B;  1PIT A;  3BTE I;  1ZR0 B;  2FI4 I;  1BZ5 A;  1YKT B;  1T8N B;  4BD9 B;  5C67 C;  1BTI A;  2R9P E;  3BTM I;  1BPT A;  4Y0Z I;  1CO7 I;  3GYM I;  8PTI A;  3M7Q B;  5JB7 A;  4NTX B;  1G6X A;  9PTI A;  1OA5 5;  3TGK I;  7PTI A;  1JV8 A;  2ZVX A;  3AUG A;  2ZJX A;  4PTI A;  1TAP A;  1FAK I;  3FP8 I;  3L3T E;  3BTQ I;  3U1J E;  1UUB A;  1F5R I;  2J6D A;  1DEM A;  2FI3 I;  5JB5 A;  1DTX A;  1YLD B;  3AUE A;  1IRH A;  3UIR C;  3LDJ A;  3BTK I;  4ISL B;  3AUD A;  1P2I I;  1EJM B;  2W8X A;  1P2Q B;  1T7C B;  1Y62 A;  3AUB A;  2M01 A;  1MTN D;  2LFL A;  3WNY A;  1D0D A;  1BF0 A;  2RA3 C;  5JB4 A;  3BTH I;  1BTH P;  1TFX C;  2DDI A;  3AUI A;  1T8O B;  1TAW B;  1LD5 A;  4Y11 I;  1P2N B;  1KUN A;  2PTC I;  1BZX I;  1BIK A;  2KAI I;  3BTW I;  3LDM A;  1NAG A;  1ADZ A;  2CA7 A;  2KNT A;  3P92 E;  2FTL I;  3T62 D;  1OA6 5;  1AAL A;  2M99 A;  1P2J I;  4ISN B;  4ISO B;  3TPI I;  2ODY E;  1DTK A;  4TPI I;  1B0C A;  1BHC A;  3BTG I;  3P95 E;  3FP6 I;  4DTG K;  1TPA I;  2DDJ A;  1BRB I;  2JOT A;  3UOU B;  3OFW A;  1YLC B;  1TCP A;  1KIG I;  5JB6 A;  3TGJ I;  3L33 E;  2LFK A;  1CA0 D;  3OTJ I;  2TPI I;  1BPI A;  1P2O B;  4WWY C;  1P2K I;  1ZJD B;  1QLQ A;  3BTT I;  2UUY B;  1YC0 I;  1LD6 A;  4NTY B;  4U30 W;  1JC6 A;  3AUH A;  1KTH A;  1UUA A;  6PTI A;  1KNT A;  1TOC R;  3BTD I;  4NTW B;  4WXV C;  4DG4 C;  2IJO I;  2UUX A;  3CI7 A;  4BNR I;  2FTM B;  1D0D B;  4U32 X; 
#chains in the Genus database with same CATH homology
 1EAW B;  1AAP A;  1F7Z I;  2FI5 I;  1K6U A;  1T8L B;  3AUC A;  4Y0Y I;  5PTI A;  1P2M B;  3BTF I;  4Y10 I;  1FAN A;  2HEX A;  2KCR A;  1JV9 A;  1BRC I;  3D65 I;  1CBW D;  3LDI A;  3TGI I;  1SHP A;  4BQD A;  3FP7 J;  1T8M B;  1DEN A;  1FY8 I;  2TGP I;  3BYB A;  1BUN B;  1PIT A;  3BTE I;  1ZR0 B;  2FI4 I;  1BZ5 A;  1YKT B;  1T8N B;  4BD9 B;  5C67 C;  1BTI A;  2R9P E;  3BTM I;  1BPT A;  4Y0Z I;  1CO7 I;  3GYM I;  8PTI A;  3M7Q B;  5JB7 A;  4NTX B;  1G6X A;  9PTI A;  1OA5 5;  3TGK I;  7PTI A;  1JV8 A;  2ZVX A;  3AUG A;  2ZJX A;  4PTI A;  1TAP A;  1FAK I;  3FP8 I;  3L3T E;  3BTQ I;  3U1J E;  1UUB A;  1F5R I;  2J6D A;  1DEM A;  2FI3 I;  5JB5 A;  1DTX A;  1YLD B;  3AUE A;  1IRH A;  3UIR C;  3LDJ A;  3BTK I;  4ISL B;  3AUD A;  1P2I I;  1EJM B;  2W8X A;  1P2Q B;  1T7C B;  1Y62 A;  3AUB A;  2M01 A;  1MTN D;  2LFL A;  3WNY A;  1D0D A;  1BF0 A;  2RA3 C;  5JB4 A;  3BTH I;  1BTH P;  1TFX C;  2DDI A;  3AUI A;  1T8O B;  1TAW B;  1LD5 A;  4Y11 I;  1P2N B;  1KUN A;  2PTC I;  1BZX I;  1BIK A;  2KAI I;  3BTW I;  3LDM A;  1NAG A;  1ADZ A;  2CA7 A;  2KNT A;  3P92 E;  2FTL I;  3T62 D;  1OA6 5;  1AAL A;  2M99 A;  1P2J I;  4ISN B;  4ISO B;  3TPI I;  2ODY E;  1DTK A;  4TPI I;  1B0C A;  1BHC A;  3BTG I;  3P95 E;  3FP6 I;  4DTG K;  1TPA I;  2DDJ A;  1BRB I;  2JOT A;  3UOU B;  3OFW A;  1YLC B;  1TCP A;  1KIG I;  5JB6 A;  3TGJ I;  3L33 E;  2LFK A;  1CA0 D;  3OTJ I;  2TPI I;  1BPI A;  1P2O B;  4WWY C;  1P2K I;  1ZJD B;  1QLQ A;  3BTT I;  2UUY B;  1YC0 I;  1LD6 A;  4NTY B;  4U30 W;  1JC6 A;  3AUH A;  1KTH A;  1UUA A;  6PTI A;  1KNT A;  1TOC R;  3BTD I;  4NTW B;  4WXV C;  4DG4 C;  2IJO I;  2UUX A;  3CI7 A;  4BNR I;  2FTM B;  1D0D B;  4U32 X; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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