4A3DE

Rna polymerase ii initial transcribing complex with a 6nt dna-rna hybrid
Total Genus 68
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
68
sequence length
214
structure length
214
Chain Sequence
DQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSFQANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSAMKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQRADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of initial RNA polymerase II transcription.
pubmed doi rcsb
molecule tags Transcription
molecule keywords DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1
total genus 68
structure length 214
sequence length 214
ec nomenclature
pdb deposition date 2011-09-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01191 RNA_pol_Rpb5_C RNA polymerase Rpb5, C-terminal domain
E PF03871 RNA_pol_Rpb5_N RNA polymerase Rpb5, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1340.10 Alpha Beta 3-Layer(aba) Sandwich Dna-directed Rna Polymerases I, Ii, And Iii 27 Kd Polypeptide; Chain: A; domain 1 RNA polymerase, Rpb5, N-terminal domain 4a3dE01
3.90.940.20 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit RPB5-like RNA polymerase subunit 4a3dE02
4C2ME 1SFOE 5IYBE 1I6HE 5C44E 1I50E 5M5WE 1Y1WE 3S1ME 5IP7E 3S2HE 3PO2E 5C3EE 4A3KE 2E2HE 4QIWH 5IYDE 4BBRE 4A3CE 2JA6E 3FKIE 3S16E 4C3IE 2B63E 4BY1E 4X6AE 1DZFA 2NVTE 4A3GE 2VUME 1K83E 2E2JE 3RZDE 2JA5E 3S1NE 5IP9E 4A3DE 3CQZE 5M5YE 4C3HE 3GTQE 3HOXE 5C4JE 3GTKE 1TWGE 4A3LE 3HKZH 3HOZE 3GTGE 3HOUE 3M3YE 4A3JE 2NVQE 5C4XE 2R93E 3RZOE 2NVYE 1TWCE 4Y52E 2WAQH 2E2IE 2Y0SH 1TWHE 3H0GE 5IYCE 3S17E 4A93E 4BXXE 3GTJE 3K7AE 3S14E 3S2DE 4Y7NE 3HOVE 3H3VF 3S1QE 3PO3E 3HOYE 4BY7E 4C3JE 2NVXE 1R9TE 2JA8E 3I4NE 1TWFE 2R92E 2PMZH 1I3QE 1TWAE 4A3FE 3M4OE 1EIKA 2WB1H 1Y1VE 3GTLE 3S15E 2JA7E 3GTPE 3S1RE 4A3BE 4A3EE 3HOWE 4BBSE 3I4ME 5M5XE 4A3IE 1WCME 4AYBH 5M3ME 3GTME 5FJ8E 5M3FE 2R7ZE 2YU9E 5FLME 3GTOE 4A3ME
chains in the Genus database with same CATH superfamily
3RZDF 2JA5F 4C2ME 1SFOE 3S1NF 5IYBE 1I6HE 5C44E 5IP9F 4A3DF 3CQZF 1I50E 5M5WE 5M5YF 4C3HF 1Y1WE 3S1ME 5IP7E 4LLGE 3GTQF 3HOXF 3S2HE 3PO2E 5C4JF 2E2HF 2BE5E 3GTKF 5C3EE 1TWGF 4A3LF 4A3KE 2E2HE 3HOZF 3GTGF 4QIWH 5IYDE 1HQME 3M3YF 4BBRE 4A3JF 2NVQF 5C4XF 2R93F 4A3CE 3RZOF 2NVYF 3DXJE 2JA6E 4Y52F 3FKIE 3S16E 4MQ9E 4X6AF 4C3IE 2E2IF 2B63E 4BY1E 4BBSF 4X6AE 2WAQK 4XSXE 1TWHF 3H0GF 1DZFA 5IYCF 3S17F 4G7ZE 4A93F 2NVTE 4YFNE 4BXXF 2E2JF 3GTJF 4A3GE 4XSZE 5BYHE 2VUME 1SMYE 3K7AF 1K83E 3S14F 2E2JE 2KRXA 3RZDE 2JA5E 4Y7NF 3S2DF 3HOVF 3PO3F 3S1QF 3S1NE 2A6EE 5IP9E 3HOYF 2A6HE 4A3DE 3CQZE 4BY7F 5M5YE 4GZYE 4C3JF 4OIPE 4C3HE 2NVXF 1R9TF 3GTQE 4YG2E 3HOXE 4AYBK 5C4JE 3GTKE 4Q4ZE 5E18E 4OIRE 1TWGE 2JA8F 4YFXE 5D4DE 4A3LE 3HOUF 3I4NF 1TWFF 3HOZE 3HKZH 3GTGE 3WODE 2R92F 3HOUE 3M3YE 1TWCF 4A3JE 2NVQE 5C4XE 2R93E 1I3QF 1TWAF 3RZOE 1YNJK 2NVYE 2PMZK 4A3FF 3M4OF 1TWCE 4Y52E 4ZH4E 2PPBE 4OINE 2WAQH 1Y1VF 2E2IE 4JK1E 3GTLF 3S15F 2Y0SH 1TWHE 3H0GE 5IYCE 3S17E 4A93E 3GTPF 4BXXE 1I6VE 3GTJE 2O5JE 4A3BF 3K7AE 4KMUE 3S14E 4QIWK 5TMCE 4Q5SE 3S2DE 4Y7NE 4XLNE 4A3EF 3HOVE 2Y0SI 3HOWF 3H3VF 3S1QE 3PO3E 3I4MF 3HOYE 5M5XF 4BY7E 1WCMF 2CW0E 4A3IF 2O5IE 5M3MF 4C3JE 4LK0E 3GTMF 4LK1E 4YFKE 2NVXE 1R9TE 5FJ8F 5M3FF 4OIOE 2YU9F 2JA8E 3I4NE 1TWFE 3GTOF 2R92E 4C2MF 2PMZH 1SFOF 1I3QE 1TWAE 5IYBF 1I6HF 4A3FE 5C44F 3M4OE 1I50F 2A69E 5M5WF 1EIKA 3H3VG 2WB1H 1Y1WF 3S1MF 4MEXE 5IP7F 4KN4E 1Y1VE 2JA7F 3S2HF 3GTLE 3PO2F 5D4EE 3S15E 5C3EF 3S1RF 3EQLE 2JA7E 5D4CE 4A3KF 5IYDF 1ZYRE 3GTPE 3S1RE 4MEYE 4BBRF 4A3BE 2WB1I 4A3CF 1IW7E 1YNNK 3HKZK 2JA6F 4KN7E 5E17E 3FKIF 3S16F 4A3EE 4G7OE 3HOWE 4C3IF 4OIQE 4BBSE 3I4ME 5M5XE 4A3IE 1WCME 4LJZE 4AYBH 4BY1F 2B63F 5M3ME 3GTME 5TMFE 2R7ZF 1QKLA 5IPLE 4G7HE 5FJ8E 2NVTF 5M3FE 5FLMF 2R7ZE 2YU9E 4A3MF 4A3GF 2VUMF 1K83F 4XLPE 5FLME 3GTOE 4A3ME 2A68E
chains in the Genus database with same CATH topology
4C2ME 1SFOE 5IYBE 1I6HE 5C44E 1I50E 5M5WE 1Y1WE 3S1ME 5IP7E 3S2HE 3PO2E 5C3EE 4A3KE 2E2HE 4QIWH 5IYDE 4BBRE 4A3CE 2JA6E 3FKIE 3S16E 4C3IE 2B63E 4BY1E 4X6AE 1DZFA 2NVTE 4A3GE 2VUME 1K83E 2E2JE 3RZDE 2JA5E 3S1NE 5IP9E 4A3DE 3CQZE 5M5YE 4C3HE 3GTQE 3HOXE 5C4JE 3GTKE 1TWGE 4A3LE 3HKZH 3HOZE 3GTGE 3HOUE 3M3YE 4A3JE 2NVQE 5C4XE 2R93E 3RZOE 2NVYE 1TWCE 4Y52E 2WAQH 2E2IE 2Y0SH 1TWHE 3H0GE 5IYCE 3S17E 4A93E 4BXXE 3GTJE 3K7AE 3S14E 3S2DE 4Y7NE 3HOVE 3H3VF 3S1QE 3PO3E 3HOYE 4BY7E 4C3JE 2NVXE 1R9TE 2JA8E 3I4NE 1TWFE 2R92E 2PMZH 1I3QE 1TWAE 4A3FE 3M4OE 1EIKA 2WB1H 1Y1VE 3GTLE 3S15E 2JA7E 3GTPE 3S1RE 4A3BE 4A3EE 3HOWE 4BBSE 3I4ME 5M5XE 4A3IE 1WCME 4AYBH 5M3ME 3GTME 5FJ8E 5M3FE 2R7ZE 2YU9E 5FLME 3GTOE 4A3ME
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4C2M E;  1SFO E;  5IYB E;  1I6H E;  5C44 E;  1I50 E;  5M5W E;  1Y1W E;  3S1M E;  5IP7 E;  3S2H E;  3PO2 E;  5C3E E;  4A3K E;  2E2H E;  4QIW H;  5IYD E;  4BBR E;  4A3C E;  2JA6 E;  3FKI E;  3S16 E;  4C3I E;  2B63 E;  4BY1 E;  4X6A E;  1DZF A;  2NVT E;  4A3G E;  2VUM E;  1K83 E;  2E2J E;  3RZD E;  2JA5 E;  3S1N E;  5IP9 E;  4A3D E;  3CQZ E;  5M5Y E;  4C3H E;  3GTQ E;  3HOX E;  5C4J E;  3GTK E;  1TWG E;  4A3L E;  3HKZ H;  3HOZ E;  3GTG E;  3HOU E;  3M3Y E;  4A3J E;  2NVQ E;  5C4X E;  2R93 E;  3RZO E;  2NVY E;  1TWC E;  4Y52 E;  2WAQ H;  2E2I E;  2Y0S H;  1TWH E;  3H0G E;  5IYC E;  3S17 E;  4A93 E;  4BXX E;  3GTJ E;  3K7A E;  3S14 E;  3S2D E;  4Y7N E;  3HOV E;  3H3V F;  3S1Q E;  3PO3 E;  3HOY E;  4BY7 E;  4C3J E;  2NVX E;  1R9T E;  2JA8 E;  3I4N E;  1TWF E;  2R92 E;  2PMZ H;  1I3Q E;  1TWA E;  4A3F E;  3M4O E;  1EIK A;  2WB1 H;  1Y1V E;  3GTL E;  3S15 E;  2JA7 E;  3GTP E;  3S1R E;  4A3B E;  4A3E E;  3HOW E;  4BBS E;  3I4M E;  5M5X E;  4A3I E;  1WCM E;  4AYB H;  5M3M E;  3GTM E;  5FJ8 E;  5M3F E;  2R7Z E;  2YU9 E;  5FLM E;  3GTO E;  4A3M E; 
#chains in the Genus database with same CATH topology
 3RZD F;  2JA5 F;  4C2M E;  1SFO E;  3S1N F;  5IYB E;  1I6H E;  5C44 E;  5IP9 F;  4A3D F;  3CQZ F;  1I50 E;  5M5W E;  5M5Y F;  4C3H F;  1Y1W E;  3S1M E;  5IP7 E;  4LLG E;  3GTQ F;  3HOX F;  3S2H E;  3PO2 E;  5C4J F;  2E2H F;  2BE5 E;  3GTK F;  5C3E E;  1TWG F;  4A3L F;  4A3K E;  2E2H E;  3HOZ F;  3GTG F;  4QIW H;  5IYD E;  1HQM E;  3M3Y F;  4BBR E;  4A3J F;  2NVQ F;  5C4X F;  2R93 F;  4A3C E;  3RZO F;  2NVY F;  3DXJ E;  2JA6 E;  4Y52 F;  3FKI E;  3S16 E;  4MQ9 E;  4X6A F;  4C3I E;  2E2I F;  2B63 E;  4BY1 E;  4BBS F;  4X6A E;  2WAQ K;  4XSX E;  1TWH F;  3H0G F;  1DZF A;  5IYC F;  3S17 F;  4G7Z E;  4A93 F;  2NVT E;  4YFN E;  4BXX F;  2E2J F;  3GTJ F;  4A3G E;  4XSZ E;  5BYH E;  2VUM E;  1SMY E;  3K7A F;  1K83 E;  3S14 F;  2E2J E;  2KRX A;  3RZD E;  2JA5 E;  4Y7N F;  3S2D F;  3HOV F;  3PO3 F;  3S1Q F;  3S1N E;  2A6E E;  5IP9 E;  3HOY F;  2A6H E;  4A3D E;  3CQZ E;  4BY7 F;  5M5Y E;  4GZY E;  4C3J F;  4OIP E;  4C3H E;  2NVX F;  1R9T F;  3GTQ E;  4YG2 E;  3HOX E;  4AYB K;  5C4J E;  3GTK E;  4Q4Z E;  5E18 E;  4OIR E;  1TWG E;  2JA8 F;  4YFX E;  5D4D E;  4A3L E;  3HOU F;  3I4N F;  1TWF F;  3HOZ E;  3HKZ H;  3GTG E;  3WOD E;  2R92 F;  3HOU E;  3M3Y E;  1TWC F;  4A3J E;  2NVQ E;  5C4X E;  2R93 E;  1I3Q F;  1TWA F;  3RZO E;  1YNJ K;  2NVY E;  2PMZ K;  4A3F F;  3M4O F;  1TWC E;  4Y52 E;  4ZH4 E;  2PPB E;  4OIN E;  2WAQ H;  1Y1V F;  2E2I E;  4JK1 E;  3GTL F;  3S15 F;  2Y0S H;  1TWH E;  3H0G E;  5IYC E;  3S17 E;  4A93 E;  3GTP F;  4BXX E;  1I6V E;  3GTJ E;  2O5J E;  4A3B F;  3K7A E;  4KMU E;  3S14 E;  4QIW K;  5TMC E;  4Q5S E;  3S2D E;  4Y7N E;  4XLN E;  4A3E F;  3HOV E;  2Y0S I;  3HOW F;  3H3V F;  3S1Q E;  3PO3 E;  3I4M F;  3HOY E;  5M5X F;  4BY7 E;  1WCM F;  2CW0 E;  4A3I F;  2O5I E;  5M3M F;  4C3J E;  4LK0 E;  3GTM F;  4LK1 E;  4YFK E;  2NVX E;  1R9T E;  5FJ8 F;  5M3F F;  4OIO E;  2YU9 F;  2JA8 E;  3I4N E;  1TWF E;  3GTO F;  2R92 E;  4C2M F;  2PMZ H;  1SFO F;  1I3Q E;  1TWA E;  5IYB F;  1I6H F;  4A3F E;  5C44 F;  3M4O E;  1I50 F;  2A69 E;  5M5W F;  1EIK A;  3H3V G;  2WB1 H;  1Y1W F;  3S1M F;  4MEX E;  5IP7 F;  4KN4 E;  1Y1V E;  2JA7 F;  3S2H F;  3GTL E;  3PO2 F;  5D4E E;  3S15 E;  5C3E F;  3S1R F;  3EQL E;  2JA7 E;  5D4C E;  4A3K F;  5IYD F;  1ZYR E;  3GTP E;  3S1R E;  4MEY E;  4BBR F;  4A3B E;  2WB1 I;  4A3C F;  1IW7 E;  1YNN K;  3HKZ K;  2JA6 F;  4KN7 E;  5E17 E;  3FKI F;  3S16 F;  4A3E E;  4G7O E;  3HOW E;  4C3I F;  4OIQ E;  4BBS E;  3I4M E;  5M5X E;  4A3I E;  1WCM E;  4LJZ E;  4AYB H;  4BY1 F;  2B63 F;  5M3M E;  3GTM E;  5TMF E;  2R7Z F;  1QKL A;  5IPL E;  4G7H E;  5FJ8 E;  2NVT F;  5M3F E;  5FLM F;  2R7Z E;  2YU9 E;  4A3M F;  4A3G F;  2VUM F;  1K83 F;  4XLP E;  5FLM E;  3GTO E;  4A3M E;  2A68 E; 
#chains in the Genus database with same CATH homology
 4C2M E;  1SFO E;  5IYB E;  1I6H E;  5C44 E;  1I50 E;  5M5W E;  1Y1W E;  3S1M E;  5IP7 E;  3S2H E;  3PO2 E;  5C3E E;  4A3K E;  2E2H E;  4QIW H;  5IYD E;  4BBR E;  4A3C E;  2JA6 E;  3FKI E;  3S16 E;  4C3I E;  2B63 E;  4BY1 E;  4X6A E;  1DZF A;  2NVT E;  4A3G E;  2VUM E;  1K83 E;  2E2J E;  3RZD E;  2JA5 E;  3S1N E;  5IP9 E;  4A3D E;  3CQZ E;  5M5Y E;  4C3H E;  3GTQ E;  3HOX E;  5C4J E;  3GTK E;  1TWG E;  4A3L E;  3HKZ H;  3HOZ E;  3GTG E;  3HOU E;  3M3Y E;  4A3J E;  2NVQ E;  5C4X E;  2R93 E;  3RZO E;  2NVY E;  1TWC E;  4Y52 E;  2WAQ H;  2E2I E;  2Y0S H;  1TWH E;  3H0G E;  5IYC E;  3S17 E;  4A93 E;  4BXX E;  3GTJ E;  3K7A E;  3S14 E;  3S2D E;  4Y7N E;  3HOV E;  3H3V F;  3S1Q E;  3PO3 E;  3HOY E;  4BY7 E;  4C3J E;  2NVX E;  1R9T E;  2JA8 E;  3I4N E;  1TWF E;  2R92 E;  2PMZ H;  1I3Q E;  1TWA E;  4A3F E;  3M4O E;  1EIK A;  2WB1 H;  1Y1V E;  3GTL E;  3S15 E;  2JA7 E;  3GTP E;  3S1R E;  4A3B E;  4A3E E;  3HOW E;  4BBS E;  3I4M E;  5M5X E;  4A3I E;  1WCM E;  4AYB H;  5M3M E;  3GTM E;  5FJ8 E;  5M3F E;  2R7Z E;  2YU9 E;  5FLM E;  3GTO E;  4A3M E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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