4A3EE

Rna polymerase ii initial transcribing complex with a 5nt dna-rna hybrid and soaked with ampcpp
Total Genus 63
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
63
sequence length
214
structure length
214
Chain Sequence
DQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSFQANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSAMKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQRADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of initial RNA polymerase II transcription.
pubmed doi rcsb
molecule tags Transcription
molecule keywords DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1
total genus 63
structure length 214
sequence length 214
ec nomenclature
pdb deposition date 2011-09-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01191 RNA_pol_Rpb5_C RNA polymerase Rpb5, C-terminal domain
E PF03871 RNA_pol_Rpb5_N RNA polymerase Rpb5, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1340.10 Alpha Beta 3-Layer(aba) Sandwich Dna-directed Rna Polymerases I, Ii, And Iii 27 Kd Polypeptide; Chain: A; domain 1 RNA polymerase, Rpb5, N-terminal domain 4a3eE01
3.90.940.20 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit RPB5-like RNA polymerase subunit 4a3eE02
4C2ME 5IYCE 3GTJE 3S1ME 2E2IE 4A3EE 3M4OE 4C3JE 1Y1WE 4C3IE 1SFOE 4A3JE 2R7ZE 4QIWH 3H3VF 3HOUE 2JA5E 3PO3E 1R9TE 4AYBH 4A3GE 5C4JE 5FLME 4Y52E 4Y7NE 5C3EE 2NVYE 5FJ8E 2B63E 4BBRE 4BY7E 4BXXE 3S17E 1TWGE 4BY1E 3K7AE 1I6HE 4A3FE 3FKIE 1I3QE 1TWHE 1I50E 3S2DE 2R93E 3S15E 1TWCE 3GTLE 3S14E 3S2HE 3H0GE 3HOXE 4A93E 5M5YE 5M3ME 4A3BE 3PO2E 1K83E 2WB1H 3I4ME 3GTGE 3HKZH 3GTKE 3HOVE 3S1RE 2E2HE 3GTOE 4BBSE 2YU9E 2NVXE 2Y0SH 2JA7E 2R92E 2VUME 5M5XE 1TWFE 2JA8E 3GTQE 3CQZE 1EIKA 4A3KE 2NVQE 4A3CE 5C44E 1Y1VE 2E2JE 5IP7E 5IYDE 1WCME 4X6AE 5M3FE 3HOYE 4A3ME 3I4NE 1DZFA 5M5WE 5C4XE 3S1QE 4A3DE 4A3LE 3GTPE 3HOZE 3S16E 3RZOE 5IP9E 1TWAE 5IYBE 3RZDE 4A3IE 2NVTE 2WAQH 3HOWE 4C3HE 2JA6E 3GTME 3S1NE 3M3YE 2PMZH
chains in the Genus database with same CATH superfamily
1EIKA 4C2ME 5IYCE 3S2DF 3GTJE 3S1ME 4KMUE 2E2IE 4A3EE 4YFXE 3M4OE 5E18E 4KN7E 2E2HF 2NVXF 2YU9F 2R92F 4A3FF 4C3JE 2WB1I 1Y1WE 4C3IE 1SFOE 4YG2E 2VUMF 3GTLF 4A3JE 5M5XF 1TWFF 2JA8F 3CQZF 5TMFE 4A3KF 2R7ZE 2NVQF 4A3CF 4QIWH 4YFNE 1Y1VF 2E2JF 2BE5E 5IP7F 4XLNE 2PPBE 4LLGE 5IYDF 3H3VF 1WCMF 2Y0SI 4X6AF 5M3FF 5M3MF 3HOUE 3HOYF 4A3MF 2JA5E 3PO3E 1R9TE 2WAQK 3I4NF 4GZYE 4AYBK 3H3VG 5TMCE 4AYBH 4A3GE 5M5WF 5C4XF 4OIRE 1QKLA 3WODE 3GTGF 3S1QF 4A3DF 5C4JE 4A3LF 4JK1E 3GTPF 2PMZK 5FLME 4Y52E 3HOZF 3S16F 2O5JE 3S1RF 5IP9F 4Y7NE 3RZDF 5IYBF 5C3EE 4A3IF 3GTOF 2NVTF 5D4EE 2NVYE 5FJ8E 2JA7F 2B63E 4BBRE 3S15F 4BY7E 4LK0E 1I6HF 4BXXE 3S17E 4C3HF 3GTMF 1TWGE 4BY1E 3K7AE 3GTQF 3S1NF 1I6HE 4A3FE 3FKIE 3M3YF 4QIWK 1I3QE 4C2MF 1TWHE 5IYCF 3S1MF 5E17E 1I50E 3S2DE 2R93E 5C44F 4YFKE 3S15E 4A3EF 3M4OF 4C3JF 3PO3F 1Y1WF 4C3IF 1SFOF 1TWCE 4KN4E 4A3JF 4LJZE 3GTLE 4BBSF 3S14E 1YNNK 2R7ZF 3S2HE 4ZH4E 1HQME 4MEYE 4OIQE 3H0GE 4Q4ZE 3HOXE 2A69E 3DXJE 4A93E 3HOUF 3RZOF 5M5YE 2A6HE 1TWAF 5M3ME 4A3BE 5BYHE 4XLPE 5D4DE 1R9TF 2JA5F 3PO2E 1YNJK 3HOWF 4G7OE 1K83E 4A3GF 2WB1H 3I4ME 3GTGE 5C4JF 2JA6F 1ZYRE 2CW0E 4Y52F 5FLMF 3HKZH 4XSZE 3GTKE 3HOVE 4Q5SE 4Y7NF 3GTJF 5C3EF 3S1RE 1I6VE 2E2IF 3HOVF 2E2HE 3GTOE 4BBSE 2YU9E 5FJ8F 4OIOE 2B63F 2NVXE 2Y0SH 4BY7F 2JA7E 2R92E 4BXXF 3S17F 1TWGF 4BY1F 2VUME 5M5XE 1TWFE 2JA8E 3GTQE 3CQZE 3FKIF 4A3KE 1I3QF 4XSXE 1TWHF 2NVQE 2KRXA 1IW7E 4A3CE 1I50F 2R93F 5C44E 1Y1VE 2E2JE 5IP7E 4OINE 2A6EE 2A68E 5IYDE 1WCME 4X6AE 1TWCF 2O5IE 5M3FE 3HOYE 3S14F 4A3ME 3I4NE 3S2HF 4LK1E 1DZFA 5D4CE 3H0GF 5IPLE 5M5WE 5C4XE 3S1QE 1SMYE 4A3DE 4G7HE 3HKZK 3HOXF 4A93F 4A3LE 4G7ZE 3GTPE 3HOZE 3S16E 5M5YF 3EQLE 4A3BF 3RZOE 5IP9E 1TWAE 5IYBE 3RZDE 4MEXE 4A3IE 3PO2F 2NVTE 2NVYF 2WAQH 1K83F 3HOWE 4BBRF 4MQ9E 4OIPE 3I4MF 3K7AF 4C3HE 2JA6E 3GTME 3S1NE 3GTKF 3M3YE 2PMZH
chains in the Genus database with same CATH topology
4C2ME 5IYCE 3GTJE 3S1ME 2E2IE 4A3EE 3M4OE 4C3JE 1Y1WE 4C3IE 1SFOE 4A3JE 2R7ZE 4QIWH 3H3VF 3HOUE 2JA5E 3PO3E 1R9TE 4AYBH 4A3GE 5C4JE 5FLME 4Y52E 4Y7NE 5C3EE 2NVYE 5FJ8E 2B63E 4BBRE 4BY7E 4BXXE 3S17E 1TWGE 4BY1E 3K7AE 1I6HE 4A3FE 3FKIE 1I3QE 1TWHE 1I50E 3S2DE 2R93E 3S15E 1TWCE 3GTLE 3S14E 3S2HE 3H0GE 3HOXE 4A93E 5M5YE 5M3ME 4A3BE 3PO2E 1K83E 2WB1H 3I4ME 3GTGE 3HKZH 3GTKE 3HOVE 3S1RE 2E2HE 3GTOE 4BBSE 2YU9E 2NVXE 2Y0SH 2JA7E 2R92E 2VUME 5M5XE 1TWFE 2JA8E 3GTQE 3CQZE 1EIKA 4A3KE 2NVQE 4A3CE 5C44E 1Y1VE 2E2JE 5IP7E 5IYDE 1WCME 4X6AE 5M3FE 3HOYE 4A3ME 3I4NE 1DZFA 5M5WE 5C4XE 3S1QE 4A3DE 4A3LE 3GTPE 3HOZE 3S16E 3RZOE 5IP9E 1TWAE 5IYBE 3RZDE 4A3IE 2NVTE 2WAQH 3HOWE 4C3HE 2JA6E 3GTME 3S1NE 3M3YE 2PMZH
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4C2M E;  5IYC E;  3GTJ E;  3S1M E;  2E2I E;  4A3E E;  3M4O E;  4C3J E;  1Y1W E;  4C3I E;  1SFO E;  4A3J E;  2R7Z E;  4QIW H;  3H3V F;  3HOU E;  2JA5 E;  3PO3 E;  1R9T E;  4AYB H;  4A3G E;  5C4J E;  5FLM E;  4Y52 E;  4Y7N E;  5C3E E;  2NVY E;  5FJ8 E;  2B63 E;  4BBR E;  4BY7 E;  4BXX E;  3S17 E;  1TWG E;  4BY1 E;  3K7A E;  1I6H E;  4A3F E;  3FKI E;  1I3Q E;  1TWH E;  1I50 E;  3S2D E;  2R93 E;  3S15 E;  1TWC E;  3GTL E;  3S14 E;  3S2H E;  3H0G E;  3HOX E;  4A93 E;  5M5Y E;  5M3M E;  4A3B E;  3PO2 E;  1K83 E;  2WB1 H;  3I4M E;  3GTG E;  3HKZ H;  3GTK E;  3HOV E;  3S1R E;  2E2H E;  3GTO E;  4BBS E;  2YU9 E;  2NVX E;  2Y0S H;  2JA7 E;  2R92 E;  2VUM E;  5M5X E;  1TWF E;  2JA8 E;  3GTQ E;  3CQZ E;  1EIK A;  4A3K E;  2NVQ E;  4A3C E;  5C44 E;  1Y1V E;  2E2J E;  5IP7 E;  5IYD E;  1WCM E;  4X6A E;  5M3F E;  3HOY E;  4A3M E;  3I4N E;  1DZF A;  5M5W E;  5C4X E;  3S1Q E;  4A3D E;  4A3L E;  3GTP E;  3HOZ E;  3S16 E;  3RZO E;  5IP9 E;  1TWA E;  5IYB E;  3RZD E;  4A3I E;  2NVT E;  2WAQ H;  3HOW E;  4C3H E;  2JA6 E;  3GTM E;  3S1N E;  3M3Y E;  2PMZ H; 
#chains in the Genus database with same CATH topology
 1EIK A;  4C2M E;  5IYC E;  3S2D F;  3GTJ E;  3S1M E;  4KMU E;  2E2I E;  4A3E E;  4YFX E;  3M4O E;  5E18 E;  4KN7 E;  2E2H F;  2NVX F;  2YU9 F;  2R92 F;  4A3F F;  4C3J E;  2WB1 I;  1Y1W E;  4C3I E;  1SFO E;  4YG2 E;  2VUM F;  3GTL F;  4A3J E;  5M5X F;  1TWF F;  2JA8 F;  3CQZ F;  5TMF E;  4A3K F;  2R7Z E;  2NVQ F;  4A3C F;  4QIW H;  4YFN E;  1Y1V F;  2E2J F;  2BE5 E;  5IP7 F;  4XLN E;  2PPB E;  4LLG E;  5IYD F;  3H3V F;  1WCM F;  2Y0S I;  4X6A F;  5M3F F;  5M3M F;  3HOU E;  3HOY F;  4A3M F;  2JA5 E;  3PO3 E;  1R9T E;  2WAQ K;  3I4N F;  4GZY E;  4AYB K;  3H3V G;  5TMC E;  4AYB H;  4A3G E;  5M5W F;  5C4X F;  4OIR E;  1QKL A;  3WOD E;  3GTG F;  3S1Q F;  4A3D F;  5C4J E;  4A3L F;  4JK1 E;  3GTP F;  2PMZ K;  5FLM E;  4Y52 E;  3HOZ F;  3S16 F;  2O5J E;  3S1R F;  5IP9 F;  4Y7N E;  3RZD F;  5IYB F;  5C3E E;  4A3I F;  3GTO F;  2NVT F;  5D4E E;  2NVY E;  5FJ8 E;  2JA7 F;  2B63 E;  4BBR E;  3S15 F;  4BY7 E;  4LK0 E;  1I6H F;  4BXX E;  3S17 E;  4C3H F;  3GTM F;  1TWG E;  4BY1 E;  3K7A E;  3GTQ F;  3S1N F;  1I6H E;  4A3F E;  3FKI E;  3M3Y F;  4QIW K;  1I3Q E;  4C2M F;  1TWH E;  5IYC F;  3S1M F;  5E17 E;  1I50 E;  3S2D E;  2R93 E;  5C44 F;  4YFK E;  3S15 E;  4A3E F;  3M4O F;  4C3J F;  3PO3 F;  1Y1W F;  4C3I F;  1SFO F;  1TWC E;  4KN4 E;  4A3J F;  4LJZ E;  3GTL E;  4BBS F;  3S14 E;  1YNN K;  2R7Z F;  3S2H E;  4ZH4 E;  1HQM E;  4MEY E;  4OIQ E;  3H0G E;  4Q4Z E;  3HOX E;  2A69 E;  3DXJ E;  4A93 E;  3HOU F;  3RZO F;  5M5Y E;  2A6H E;  1TWA F;  5M3M E;  4A3B E;  5BYH E;  4XLP E;  5D4D E;  1R9T F;  2JA5 F;  3PO2 E;  1YNJ K;  3HOW F;  4G7O E;  1K83 E;  4A3G F;  2WB1 H;  3I4M E;  3GTG E;  5C4J F;  2JA6 F;  1ZYR E;  2CW0 E;  4Y52 F;  5FLM F;  3HKZ H;  4XSZ E;  3GTK E;  3HOV E;  4Q5S E;  4Y7N F;  3GTJ F;  5C3E F;  3S1R E;  1I6V E;  2E2I F;  3HOV F;  2E2H E;  3GTO E;  4BBS E;  2YU9 E;  5FJ8 F;  4OIO E;  2B63 F;  2NVX E;  2Y0S H;  4BY7 F;  2JA7 E;  2R92 E;  4BXX F;  3S17 F;  1TWG F;  4BY1 F;  2VUM E;  5M5X E;  1TWF E;  2JA8 E;  3GTQ E;  3CQZ E;  3FKI F;  4A3K E;  1I3Q F;  4XSX E;  1TWH F;  2NVQ E;  2KRX A;  1IW7 E;  4A3C E;  1I50 F;  2R93 F;  5C44 E;  1Y1V E;  2E2J E;  5IP7 E;  4OIN E;  2A6E E;  2A68 E;  5IYD E;  1WCM E;  4X6A E;  1TWC F;  2O5I E;  5M3F E;  3HOY E;  3S14 F;  4A3M E;  3I4N E;  3S2H F;  4LK1 E;  1DZF A;  5D4C E;  3H0G F;  5IPL E;  5M5W E;  5C4X E;  3S1Q E;  1SMY E;  4A3D E;  4G7H E;  3HKZ K;  3HOX F;  4A93 F;  4A3L E;  4G7Z E;  3GTP E;  3HOZ E;  3S16 E;  5M5Y F;  3EQL E;  4A3B F;  3RZO E;  5IP9 E;  1TWA E;  5IYB E;  3RZD E;  4MEX E;  4A3I E;  3PO2 F;  2NVT E;  2NVY F;  2WAQ H;  1K83 F;  3HOW E;  4BBR F;  4MQ9 E;  4OIP E;  3I4M F;  3K7A F;  4C3H E;  2JA6 E;  3GTM E;  3S1N E;  3GTK F;  3M3Y E;  2PMZ H; 
#chains in the Genus database with same CATH homology
 4C2M E;  5IYC E;  3GTJ E;  3S1M E;  2E2I E;  4A3E E;  3M4O E;  4C3J E;  1Y1W E;  4C3I E;  1SFO E;  4A3J E;  2R7Z E;  4QIW H;  3H3V F;  3HOU E;  2JA5 E;  3PO3 E;  1R9T E;  4AYB H;  4A3G E;  5C4J E;  5FLM E;  4Y52 E;  4Y7N E;  5C3E E;  2NVY E;  5FJ8 E;  2B63 E;  4BBR E;  4BY7 E;  4BXX E;  3S17 E;  1TWG E;  4BY1 E;  3K7A E;  1I6H E;  4A3F E;  3FKI E;  1I3Q E;  1TWH E;  1I50 E;  3S2D E;  2R93 E;  3S15 E;  1TWC E;  3GTL E;  3S14 E;  3S2H E;  3H0G E;  3HOX E;  4A93 E;  5M5Y E;  5M3M E;  4A3B E;  3PO2 E;  1K83 E;  2WB1 H;  3I4M E;  3GTG E;  3HKZ H;  3GTK E;  3HOV E;  3S1R E;  2E2H E;  3GTO E;  4BBS E;  2YU9 E;  2NVX E;  2Y0S H;  2JA7 E;  2R92 E;  2VUM E;  5M5X E;  1TWF E;  2JA8 E;  3GTQ E;  3CQZ E;  1EIK A;  4A3K E;  2NVQ E;  4A3C E;  5C44 E;  1Y1V E;  2E2J E;  5IP7 E;  5IYD E;  1WCM E;  4X6A E;  5M3F E;  3HOY E;  4A3M E;  3I4N E;  1DZF A;  5M5W E;  5C4X E;  3S1Q E;  4A3D E;  4A3L E;  3GTP E;  3HOZ E;  3S16 E;  3RZO E;  5IP9 E;  1TWA E;  5IYB E;  3RZD E;  4A3I E;  2NVT E;  2WAQ H;  3HOW E;  4C3H E;  2JA6 E;  3GTM E;  3S1N E;  3M3Y E;  2PMZ H; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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