4A3GE

Rna polymerase ii initial transcribing complex with a 2nt dna-rna hybrid
Total Genus 63
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
63
sequence length
214
structure length
214
Chain Sequence
DQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSFQANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSAMKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQRADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of initial RNA polymerase II transcription.
pubmed doi rcsb
molecule tags Transcription
molecule keywords DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1
total genus 63
structure length 214
sequence length 214
ec nomenclature
pdb deposition date 2011-09-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01191 RNA_pol_Rpb5_C RNA polymerase Rpb5, C-terminal domain
E PF03871 RNA_pol_Rpb5_N RNA polymerase Rpb5, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1340.10 Alpha Beta 3-Layer(aba) Sandwich Dna-directed Rna Polymerases I, Ii, And Iii 27 Kd Polypeptide; Chain: A; domain 1 RNA polymerase, Rpb5, N-terminal domain 4a3gE01
3.90.940.20 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit RPB5-like RNA polymerase subunit 4a3gE02
1I50E 1TWGE 2NVQE 3H3VF 3S16E 2VUME 5FLME 4A3JE 2Y0SH 4C3IE 4QIWH 4X6AE 1TWHE 1TWCE 4BXXE 5IP9E 3CQZE 4A3EE 5C4JE 5C4XE 4BY1E 4C3HE 4BBSE 1R9TE 2WAQH 2JA5E 1WCME 1Y1VE 3S15E 2B63E 5IP7E 5C3EE 4A3KE 3K7AE 4C2ME 3GTGE 3I4NE 1TWFE 3HOVE 5IYDE 2E2JE 5C44E 3M4OE 3S2HE 3HOYE 3S14E 3GTPE 4A3GE 4A3FE 3HKZH 5M5WE 5M5XE 4A3ME 3GTOE 2JA6E 2PMZH 4A3DE 2JA7E 2JA8E 4A93E 3HOWE 4BY7E 4A3CE 2E2HE 3GTLE 5M3ME 4A3BE 3S1ME 3S1QE 5IYBE 3S1NE 4AYBH 2NVTE 3HOUE 1TWAE 3RZOE 2NVYE 4A3IE 3I4ME 2R92E 3M3YE 1I6HE 3S1RE 2YU9E 1K83E 3GTKE 3PO2E 3FKIE 3PO3E 3GTJE 4BBRE 1I3QE 2E2IE 2R7ZE 3S2DE 1DZFA 1Y1WE 5M5YE 4Y52E 3GTQE 5IYCE 3RZDE 1EIKA 5M3FE 4A3LE 3S17E 2WB1H 4Y7NE 5FJ8E 3GTME 2R93E 4C3JE 3HOXE 2NVXE 3HOZE 1SFOE 3H0GE
chains in the Genus database with same CATH superfamily
1I50F 2B63F 1I50E 1TWGF 4XSZE 4OIPE 4A3KF 1TWGE 3K7AF 4XLPE 3H3VG 5FLMF 2NVQE 3H3VF 3S16E 1TWFF 3HOVF 2VUME 5FLME 3I4NF 4G7OE 3S2HF 3HOYF 4A3JE 3S14F 1IW7E 2Y0SH 4C3IF 3GTPF 4C3IE 4X6AF 4KMUE 4QIWH 2JA8F 4X6AE 1TWHE 5E18E 1YNJK 4AYBK 5M5XF 1TWCE 2A6HE 2WB1I 4JK1E 5D4CE 1SMYE 4BXXF 4A3DF 4OIQE 5IP9F 4BXXE 4A93F 4Q5SE 5IP9E 4A3EF 3CQZE 5C4JF 2E2HF 4A3CF 3HOWF 4A3EE 4BY1F 5C4JE 5C4XE 4A3BF 4BY1E 4C3HF 1R9TF 4LLGE 4C3HE 4BBSE 1R9TE 4OIOE 2WAQH 2JA5E 1WCMF 1Y1VF 1WCME 2NVTF 3S15F 1Y1VE 3HOUF 1TWAF 3S15E 2B63E 2PMZK 5IP7F 5C3EF 5IP7E 2BE5E 4C2MF 5C3EE 3GTGF 4A3KE 3K7AE 4C2ME 4MEXE 3GTGE 4MQ9E 5IYDF 5C44F 3I4NE 1TWFE 3HOVE 5IYDE 2E2JE 5C44E 3M4OE 3DXJE 2Y0SI 3S2HE 3HOYE 4XSXE 3S14E 4G7HE 4A3IF 4YFXE 4A3GF 3GTPE 4A3GE 4A3FF 3I4MF 5M5WF 4A3FE 3M3YF 3HKZH 1I6HF 5M5WE 3S1RF 5M5XE 4A3MF 1YNNK 1HQME 3GTOF 2JA6F 2O5JE 4A3ME 3GTOE 2JA7F 2JA6E 1QKLA 4A3DE 2PMZH 2JA7E 3EQLE 4BY7F 1K83F 2JA8E 4A93E 5D4DE 3HOWE 4BY7E 3GTKF 2KRXA 3GTLF 4A3CE 5M3MF 2E2HE 3PO2F 3GTJF 3PO3F 3GTLE 4GZYE 5M3ME 3S1MF 4A3BE 1I3QF 2E2IF 3S1ME 2R7ZF 3S2DF 3S1QF 3S1QE 4KN7E 2A69E 4YFNE 5IYBF 5IYBE 1Y1WF 3S1NF 4Y52F 3S1NE 4AYBH 4LJZE 3GTQF 2NVTE 3RZOF 3HOUE 1TWAE 2NVYF 3RZOE 2NVYE 3M4OF 4A3IE 4Q4ZE 3GTMF 4LK0E 2R92F 4C3JF 3I4ME 2R92E 2NVXF 3M3YE 1I6HE 3S1RE 1SFOF 5IPLE 4XLNE 2YU9F 2YU9E 1K83E 3GTKE 3FKIF 3PO2E 2A68E 4YG2E 5TMCE 3FKIE 4BBRF 3PO3E 3GTJE 4BBRE 5TMFE 1I3QE 2E2IE 2R7ZE 3S2DE 4OIRE 2NVQF 2VUMF 4OINE 1DZFA 3S16F 5E17E 5M5YF 1Y1WE 4A3JF 5M5YE 4Y52E 5IYCF 3GTQE 3RZDF 5M3FF 4A3LF 5IYCE 3RZDE 1EIKA 2WAQK 5M3FE 4A3LE 1TWHF 3S17F 3S17E 1TWCF 4ZH4E 4Y7NF 4KN4E 2WB1H 4Y7NE 2E2JF 5D4EE 4LK1E 5FJ8F 2PPBE 2A6EE 5FJ8E 4G7ZE 4YFKE 3GTME 3CQZF 2R93F 3HOXF 2R93E 4C3JE 5C4XF 3HOZF 2O5IE 3HOXE 2NVXE 3WODE 5BYHE 3HOZE 3H0GF 4QIWK 4BBSF 1SFOE 1ZYRE 3H0GE 2JA5F 1I6VE 4MEYE 3HKZK 2CW0E
chains in the Genus database with same CATH topology
1I50E 1TWGE 2NVQE 3H3VF 3S16E 2VUME 5FLME 4A3JE 2Y0SH 4C3IE 4QIWH 4X6AE 1TWHE 1TWCE 4BXXE 5IP9E 3CQZE 4A3EE 5C4JE 5C4XE 4BY1E 4C3HE 4BBSE 1R9TE 2WAQH 2JA5E 1WCME 1Y1VE 3S15E 2B63E 5IP7E 5C3EE 4A3KE 3K7AE 4C2ME 3GTGE 3I4NE 1TWFE 3HOVE 5IYDE 2E2JE 5C44E 3M4OE 3S2HE 3HOYE 3S14E 3GTPE 4A3GE 4A3FE 3HKZH 5M5WE 5M5XE 4A3ME 3GTOE 2JA6E 2PMZH 4A3DE 2JA7E 2JA8E 4A93E 3HOWE 4BY7E 4A3CE 2E2HE 3GTLE 5M3ME 4A3BE 3S1ME 3S1QE 5IYBE 3S1NE 4AYBH 2NVTE 3HOUE 1TWAE 3RZOE 2NVYE 4A3IE 3I4ME 2R92E 3M3YE 1I6HE 3S1RE 2YU9E 1K83E 3GTKE 3PO2E 3FKIE 3PO3E 3GTJE 4BBRE 1I3QE 2E2IE 2R7ZE 3S2DE 1DZFA 1Y1WE 5M5YE 4Y52E 3GTQE 5IYCE 3RZDE 1EIKA 5M3FE 4A3LE 3S17E 2WB1H 4Y7NE 5FJ8E 3GTME 2R93E 4C3JE 3HOXE 2NVXE 3HOZE 1SFOE 3H0GE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1I50 E;  1TWG E;  2NVQ E;  3H3V F;  3S16 E;  2VUM E;  5FLM E;  4A3J E;  2Y0S H;  4C3I E;  4QIW H;  4X6A E;  1TWH E;  1TWC E;  4BXX E;  5IP9 E;  3CQZ E;  4A3E E;  5C4J E;  5C4X E;  4BY1 E;  4C3H E;  4BBS E;  1R9T E;  2WAQ H;  2JA5 E;  1WCM E;  1Y1V E;  3S15 E;  2B63 E;  5IP7 E;  5C3E E;  4A3K E;  3K7A E;  4C2M E;  3GTG E;  3I4N E;  1TWF E;  3HOV E;  5IYD E;  2E2J E;  5C44 E;  3M4O E;  3S2H E;  3HOY E;  3S14 E;  3GTP E;  4A3G E;  4A3F E;  3HKZ H;  5M5W E;  5M5X E;  4A3M E;  3GTO E;  2JA6 E;  2PMZ H;  4A3D E;  2JA7 E;  2JA8 E;  4A93 E;  3HOW E;  4BY7 E;  4A3C E;  2E2H E;  3GTL E;  5M3M E;  4A3B E;  3S1M E;  3S1Q E;  5IYB E;  3S1N E;  4AYB H;  2NVT E;  3HOU E;  1TWA E;  3RZO E;  2NVY E;  4A3I E;  3I4M E;  2R92 E;  3M3Y E;  1I6H E;  3S1R E;  2YU9 E;  1K83 E;  3GTK E;  3PO2 E;  3FKI E;  3PO3 E;  3GTJ E;  4BBR E;  1I3Q E;  2E2I E;  2R7Z E;  3S2D E;  1DZF A;  1Y1W E;  5M5Y E;  4Y52 E;  3GTQ E;  5IYC E;  3RZD E;  1EIK A;  5M3F E;  4A3L E;  3S17 E;  2WB1 H;  4Y7N E;  5FJ8 E;  3GTM E;  2R93 E;  4C3J E;  3HOX E;  2NVX E;  3HOZ E;  1SFO E;  3H0G E; 
#chains in the Genus database with same CATH topology
 1I50 F;  2B63 F;  1I50 E;  1TWG F;  4XSZ E;  4OIP E;  4A3K F;  1TWG E;  3K7A F;  4XLP E;  3H3V G;  5FLM F;  2NVQ E;  3H3V F;  3S16 E;  1TWF F;  3HOV F;  2VUM E;  5FLM E;  3I4N F;  4G7O E;  3S2H F;  3HOY F;  4A3J E;  3S14 F;  1IW7 E;  2Y0S H;  4C3I F;  3GTP F;  4C3I E;  4X6A F;  4KMU E;  4QIW H;  2JA8 F;  4X6A E;  1TWH E;  5E18 E;  1YNJ K;  4AYB K;  5M5X F;  1TWC E;  2A6H E;  2WB1 I;  4JK1 E;  5D4C E;  1SMY E;  4BXX F;  4A3D F;  4OIQ E;  5IP9 F;  4BXX E;  4A93 F;  4Q5S E;  5IP9 E;  4A3E F;  3CQZ E;  5C4J F;  2E2H F;  4A3C F;  3HOW F;  4A3E E;  4BY1 F;  5C4J E;  5C4X E;  4A3B F;  4BY1 E;  4C3H F;  1R9T F;  4LLG E;  4C3H E;  4BBS E;  1R9T E;  4OIO E;  2WAQ H;  2JA5 E;  1WCM F;  1Y1V F;  1WCM E;  2NVT F;  3S15 F;  1Y1V E;  3HOU F;  1TWA F;  3S15 E;  2B63 E;  2PMZ K;  5IP7 F;  5C3E F;  5IP7 E;  2BE5 E;  4C2M F;  5C3E E;  3GTG F;  4A3K E;  3K7A E;  4C2M E;  4MEX E;  3GTG E;  4MQ9 E;  5IYD F;  5C44 F;  3I4N E;  1TWF E;  3HOV E;  5IYD E;  2E2J E;  5C44 E;  3M4O E;  3DXJ E;  2Y0S I;  3S2H E;  3HOY E;  4XSX E;  3S14 E;  4G7H E;  4A3I F;  4YFX E;  4A3G F;  3GTP E;  4A3G E;  4A3F F;  3I4M F;  5M5W F;  4A3F E;  3M3Y F;  3HKZ H;  1I6H F;  5M5W E;  3S1R F;  5M5X E;  4A3M F;  1YNN K;  1HQM E;  3GTO F;  2JA6 F;  2O5J E;  4A3M E;  3GTO E;  2JA7 F;  2JA6 E;  1QKL A;  4A3D E;  2PMZ H;  2JA7 E;  3EQL E;  4BY7 F;  1K83 F;  2JA8 E;  4A93 E;  5D4D E;  3HOW E;  4BY7 E;  3GTK F;  2KRX A;  3GTL F;  4A3C E;  5M3M F;  2E2H E;  3PO2 F;  3GTJ F;  3PO3 F;  3GTL E;  4GZY E;  5M3M E;  3S1M F;  4A3B E;  1I3Q F;  2E2I F;  3S1M E;  2R7Z F;  3S2D F;  3S1Q F;  3S1Q E;  4KN7 E;  2A69 E;  4YFN E;  5IYB F;  5IYB E;  1Y1W F;  3S1N F;  4Y52 F;  3S1N E;  4AYB H;  4LJZ E;  3GTQ F;  2NVT E;  3RZO F;  3HOU E;  1TWA E;  2NVY F;  3RZO E;  2NVY E;  3M4O F;  4A3I E;  4Q4Z E;  3GTM F;  4LK0 E;  2R92 F;  4C3J F;  3I4M E;  2R92 E;  2NVX F;  3M3Y E;  1I6H E;  3S1R E;  1SFO F;  5IPL E;  4XLN E;  2YU9 F;  2YU9 E;  1K83 E;  3GTK E;  3FKI F;  3PO2 E;  2A68 E;  4YG2 E;  5TMC E;  3FKI E;  4BBR F;  3PO3 E;  3GTJ E;  4BBR E;  5TMF E;  1I3Q E;  2E2I E;  2R7Z E;  3S2D E;  4OIR E;  2NVQ F;  2VUM F;  4OIN E;  1DZF A;  3S16 F;  5E17 E;  5M5Y F;  1Y1W E;  4A3J F;  5M5Y E;  4Y52 E;  5IYC F;  3GTQ E;  3RZD F;  5M3F F;  4A3L F;  5IYC E;  3RZD E;  1EIK A;  2WAQ K;  5M3F E;  4A3L E;  1TWH F;  3S17 F;  3S17 E;  1TWC F;  4ZH4 E;  4Y7N F;  4KN4 E;  2WB1 H;  4Y7N E;  2E2J F;  5D4E E;  4LK1 E;  5FJ8 F;  2PPB E;  2A6E E;  5FJ8 E;  4G7Z E;  4YFK E;  3GTM E;  3CQZ F;  2R93 F;  3HOX F;  2R93 E;  4C3J E;  5C4X F;  3HOZ F;  2O5I E;  3HOX E;  2NVX E;  3WOD E;  5BYH E;  3HOZ E;  3H0G F;  4QIW K;  4BBS F;  1SFO E;  1ZYR E;  3H0G E;  2JA5 F;  1I6V E;  4MEY E;  3HKZ K;  2CW0 E; 
#chains in the Genus database with same CATH homology
 1I50 E;  1TWG E;  2NVQ E;  3H3V F;  3S16 E;  2VUM E;  5FLM E;  4A3J E;  2Y0S H;  4C3I E;  4QIW H;  4X6A E;  1TWH E;  1TWC E;  4BXX E;  5IP9 E;  3CQZ E;  4A3E E;  5C4J E;  5C4X E;  4BY1 E;  4C3H E;  4BBS E;  1R9T E;  2WAQ H;  2JA5 E;  1WCM E;  1Y1V E;  3S15 E;  2B63 E;  5IP7 E;  5C3E E;  4A3K E;  3K7A E;  4C2M E;  3GTG E;  3I4N E;  1TWF E;  3HOV E;  5IYD E;  2E2J E;  5C44 E;  3M4O E;  3S2H E;  3HOY E;  3S14 E;  3GTP E;  4A3G E;  4A3F E;  3HKZ H;  5M5W E;  5M5X E;  4A3M E;  3GTO E;  2JA6 E;  2PMZ H;  4A3D E;  2JA7 E;  2JA8 E;  4A93 E;  3HOW E;  4BY7 E;  4A3C E;  2E2H E;  3GTL E;  5M3M E;  4A3B E;  3S1M E;  3S1Q E;  5IYB E;  3S1N E;  4AYB H;  2NVT E;  3HOU E;  1TWA E;  3RZO E;  2NVY E;  4A3I E;  3I4M E;  2R92 E;  3M3Y E;  1I6H E;  3S1R E;  2YU9 E;  1K83 E;  3GTK E;  3PO2 E;  3FKI E;  3PO3 E;  3GTJ E;  4BBR E;  1I3Q E;  2E2I E;  2R7Z E;  3S2D E;  1DZF A;  1Y1W E;  5M5Y E;  4Y52 E;  3GTQ E;  5IYC E;  3RZD E;  1EIK A;  5M3F E;  4A3L E;  3S17 E;  2WB1 H;  4Y7N E;  5FJ8 E;  3GTM E;  2R93 E;  4C3J E;  3HOX E;  2NVX E;  3HOZ E;  1SFO E;  3H0G E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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